Does platelet-rich plasma increase tendon metabolism?

Advances in Experimental Medicine and Biology

Volumn 920, Issue , 2016, Pages 263-273

  de Vos, Robert Jan ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Collagen structure; Growth factors; Neovascularisation; PRP; Tendinopathy; Tendon regeneration

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; EPIDERMAL GROWTH FACTOR; HEMOPOIETIC GROWTH FACTOR; INTERSTITIAL COLLAGENASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BB; SOMATOMEDIN C; STROMELYSIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN;

APOPTOSIS; CELL PROLIFERATION; CLINICAL EFFECTIVENESS; COLLAGEN SYNTHESIS; ECHOGRAPHY; GENE EXPRESSION; HUMAN; MECHANICAL STIMULATION; MECHANICAL TORSION; MUSCLE METABOLISM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; TENDINITIS; THROMBOCYTE RICH PLASMA; UPREGULATION; ANIMAL; CYTOLOGY; METABOLISM; PATHOPHYSIOLOGY; TENDON;

ANIMALS; HUMANS; PLATELET-RICH PLASMA; TENDINOPATHY; TENDONS;

EID: 84983380922     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-33943-6_25     Document Type: Chapter

References (71)

1. Maffulli N, Wong J, Almekinders LC (2003) Types and epidemiology of tendinopathy. Clin Sports Med 22(4):675–692
2. Nielsen RO, Parner ET, Nohr EA, So H, Lind M, Rasmussen S (2014) Excessive progression in weekly running distance and risk of running-related injuries: an association which varies according to type of injury. J Orthop Sports Phys Ther 44(10):739–747
3. Ackermann PW, Renstrom P (2012) Tendinopathy in sport. Sports Health 4(3):193–201
4. Alfredson H (2003) Chronic midportion Achilles tendinopathy: an update on research and treatment. Clin Sports Med 22(4):727–741
5. de Mos M, van El B, DeGroot J, Jahr H, van Schie HT, van Arkel ER et al (2007) Achilles tendinosis: changes in biochemical composition and collagen turnover rate. Am J Sports Med 35(9):1549–1556
6. Maffulli N, Barrass V, Ewen SW (2000) Light microscopic histology of achilles tendon ruptures. A comparison with unruptured tendons. Am J Sports Med 28 (6):857–863
7. Mishra A, Harmon K, Woodall J, Vieira A (2012) Sports medicine applications of platelet rich plasma. Curr Pharm Biotechnol 13(7):1185–1195
8. de Vos RJ, van Veldhoven PL, Moen MH, Weir A, Tol JL, Maffulli N (2010) Autologous growth factor injections in chronic tendinopathy: a systematic review. Br Med Bull 95:63–77
9. Sampson S, Gerhardt M, Mandelbaum B (2008) Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskelet Med 1 (3-4):165–174
10. Eppley BL, Woodell JE, Higgins J (2004) Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 114(6):1502–1508
11. Eppley BL, Pietrzak WS, Blanton M (2006) Plateletrich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg 118(6):147e-59e
12. Fufa D, Shealy B, Jacobson M, Kevy S, Murray MM (2008) Activation of platelet-rich plasma using soluble type I collagen. J Oral Maxillofac Surg 66 (4):684–690
13. Marx RE (2001) Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent 10 (4):225–228
14. Dohan Ehrenfest DM, Andia I, Zumstein MA, Zhang CQ, Pinto NR, Bielecki T (2014) Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J 4(1):3–9
15. Anitua E, Andia I, Sanchez M, Azofra J, del Mar Zalduendo M, de la Fuente M et al (2005) Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthop Res 23(2):281–286
16. Baksh N, Hannon CP, Murawski CD, Smyth NA, Kennedy JG (2013) Platelet-rich plasma in tendon models: a systematic review of basic science literature. Arthroscopy 29(3):596–607
17. Jo CH, Kim JE, Yoon KS, Shin S (2012) Platelet-rich plasma stimulates cell proliferation and enhances matrix gene expression and synthesis in tenocytes from human rotator cuff tendons with degenerative tears. Am J Sports Med 40(5):1035–1045
18. de Mos M, van der Windt AE, Jahr H, van Schie HT, Weinans H, Verhaar JA et al (2008) Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med 36(6):1171–1178
19. Parafioriti A, Armiraglio E, Del Bianco S, Tibalt E, Oliva F, Berardi AC (2011) Single injection of platelet-rich plasma in a rat Achilles tendon tear model. Muscles Ligaments Tendons J 1(2):41–47
20. Lyras D, Kazakos K, Verettas D, Polychronidis A, Simopoulos C, Botaitis S et al (2010) Immunohistochemical study of angiogenesis after local administration of platelet-rich plasma in a patellar tendon defect. Int Orthop 34(1):143–148
21. Bosch G, van Schie HT, de Groot MW, Cadby JA, van de Lest CH, Barneveld A et al (2010) Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: a placebo-controlled experimental study. J Orthop Res 28(2):211–217
22. Fernandez-Sarmiento JA, Dominguez JM, Granados MM, Morgaz J, Navarrete R, Carrillo JM et al (2013) Histological study of the influence of plasma rich in growth factors (PRGF) on the healing of divided Achilles tendons in sheep. J Bone Joint Surg Am 95 (3):246–255
23. Dolkart O, Chechik O, Zarfati Y, Brosh T, Alhajajra F, Maman E (2014) A single dose of platelet-rich plasma improves the organization and strength of a surgically repaired rotator cuff tendon in rats. Arch Orthop Trauma Surg 134 (9):1271–1277
24. McCarrel T, Fortier L (2009) Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J Orthop Res 27(8):1033–1042
25. Zhang J, Wang JH (2010) Platelet-rich plasma releasate promotes differentiation of tendon stem cells into active tenocytes. Am J Sports Med 38 (12):2477–2486
26. Lyras DN, Kazakos K, Verettas D, Botaitis S, Agrogiannis G, Kokka A et al (2009) The effect of platelet-rich plasma gel in the early phase of patellar tendon healing. Arch Orthop Trauma Surg 129 (11):1577–1582
27. Spang JT, Tischer T, Salzmann GM, Winkler T, Burgkart R, Wexel G et al (2011) Platelet concentrate vs. saline in a rat patellar tendon healing model. Knee Surg Sports Traumatol Arthrosc 19(3):495–502
28. Virchenko O, Aspenberg P (2006) How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation. Acta Orthop 77 (5):806–812
29. Chen L, Dong SW, Liu JP, Tao X, Tang KL, Xu JZ (2012) Synergy of tendon stem cells and platelet-rich plasma in tendon healing. J Orthop Res 30 (6):991–997
30. McCarrel TM, Minas T, Fortier LA (2012) Optimization of leukocyte concentration in platelet-rich plasma for the treatment of tendinopathy. J Bone Joint Surg Am 94(19):e143 (1–8)
31. Dragoo JL, Braun HJ, Durham JL, Ridley BA, Odegaard JI, Luong R et al (2012) Comparison of the acute inflammatory response of two commercial platelet-rich plasma systems in healthy rabbit tendons. Am J Sports Med 40(6):1274–1281
32. Boswell SG, Schnabel LV, Mohammed HO, Sundman EA, Minas T, Fortier LA (2014) Increasing platelet concentrations in leukocyte-reduced plateletrich plasma decrease collagen gene synthesis in tendons. Am J Sports Med 42(1):42–49
33. Zhang J, Middleton KK, Fu FH, Im HJ, Wang JH (2013) HGF mediates the anti-inflammatory effects of PRP on injured tendons. PLoS One 8(6):e67303
34. Kajikawa Y, Morihara T, Sakamoto H, Matsuda K, Oshima Y, Yoshida A et al (2008) Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol 215(3):837–845
35. Wasterlain AS, Braun HJ, Harris AH, Kim HJ, Dragoo JL (2013) The systemic effects of plateletrich plasma injection. Am J Sports Med 41 (1):186–193
36. Dallaudiere B, Louedec L, Lenet MP, Pesquer L, Blaise E, Perozziello A et al (2015) The molecular systemic and local effects of intra-tendinous injection of Platelet Rich Plasma in tendinosis: preliminary results on a rat model with ELISA method. Muscles Ligaments Tendons J 5(2):99–105
37. de Vos RJ, d’Hooghe PPRN, de Leeuw P, Kerkhoffs GMMJ (2014) Chapter 19: Achilles Tendinopathy. In: d’Hooghe PPRN, Kerkhoffs GMMJ (eds) The ankle in football, sports and traumatology. Springer Verlag, Paris, pp 213–233
38. van Schie HT, de Vos RJ, de Jonge S, Bakker EM, Heijboer MP, Verhaar JA et al (2010) Ultrasonographic tissue characterisation of human Achilles tendons: quantification of tendon structure through a novel non-invasive approach. Br J Sports Med 44 (16):1153–1159
39. Sengkerij PM, de Vos RJ, Weir A, van Weelde BJ, Tol JL (2009) Interobserver reliability of neovascularization score using power Doppler ultrasonography in midportion achilles tendinopathy. Am J Sports Med 37(8):1627–1631
40. de Vos RJ, Weir A, Cobben LP, Tol JL (2007) The value of power Doppler ultrasonography in Achilles tendinopathy: a prospective study. Am J Sports Med 35(10):1696–1701
41. Bleakney RR, White LM (2005) Imaging of the Achilles tendon. Foot Ankle Clin 10(2):239–254
42. Gaweda K, Tarczynska M, Krzyzanowski W (2010) Treatment of Achilles tendinopathy with platelet-rich plasma. Int J Sports Med 31(8):577–583
43. Monto RR (2012) Platelet rich plasma treatment for chronic Achilles tendinosis. Foot Ankle Int 33 (5):379–385
44. Filardo G, Kon E, Di Matteo B, Pelotti P, Di Martino A, Marcacci M (2013) Platelet-rich plasma for the treatment of patellar tendinopathy: clinical and imaging findings at medium-term follow-up. Int Orthop 37(8):1583–1589
45. Oloff L, Elmi E, Nelson J, Crain J (2015) Retrospective analysis of the effectiveness of platelet-rich plasma in the treatment of Achilles tendinopathy: pretreatment and posttreatment correlation of magnetic resonance imaging and clinical assessment. Foot Ankle Spec 8:490–497
46. Owens RF Jr., Ginnetti J, Conti SF, Latona C (2011) Clinical and magnetic resonance imaging outcomes following platelet rich plasma injection for chronic midsubstance Achilles tendinopathy. Foot Ankle Int 32(11):1032–1039
47. de Vos RJ, Weir A, Tol JL, Verhaar JA, Weinans H, van Schie HT (2011) No effects of PRP on ultrasonographic tendon structure and neovascularisation in chronic midportion Achilles tendinopathy. Br J Sports Med 45(5):387–392
48. de Vos RJ (2014) Is tendon structure associated with symptoms in chronic Achilles tendinopathy? An update on tendon pain mechanisms. Aspetar Sports Med J 3(4):594–600
49. de Vos RJ, Heijboer MP, Weinans H, Verhaar JA, van Schie JT (2012) Tendon structure’s lack of relation to clinical outcome after eccentric exercises in chronic midportion Achilles tendinopathy. J Sport Rehabil 21 (1):34–43
50. de Jonge S, Warnaars JL, De Vos RJ, Weir A, van Schie HT, Bierma-Zeinstra SM et al (2013) Relationship between neovascularization and clinical severity in Achilles tendinopathy in 556 paired measurements. Scand J Med Sci Sports 24:773–778
51. de Vos RJ, Windt J, Weir A (2014) Strong evidence against platelet-rich plasma injections for chronic lateral epicondylar tendinopathy: a systematic review. Br J Sports Med 48(12):952–956
52. Mishra A, Woodall J Jr., Vieira A (2009) Treatment of tendon and muscle using platelet-rich plasma. Clin Sports Med 28(1):113–125
53. Mishra A, Pavelko T (2006) Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med 34(11):1774–1778
54. Kon E, Filardo G, Delcogliano M, Presti ML, Russo A, Bondi A et al (2009) Platelet-rich plasma: new clinical application: a pilot study for treatment of jumper’s knee. Injury 40(6):598–603
55. Paoloni J, De Vos RJ, Hamilton B, Murrell GA, Orchard J (2011) Platelet-rich plasma treatment for ligament and tendon injuries. Clin J Sport Med 21 (1):37–45
56. de Vos RJ, Weir A, van Schie HT, Bierma-Zeinstra SM, Verhaar JA, Weinans H et al (2010) Plateletrich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. JAMA 303(2):144–149
57. de Jonge S, de Vos RJ, Weir A, van Schie HT, Bierma-Zeinstra SM, Verhaar JA et al (2011) One-year follow-up of platelet-rich plasma treatment in chronic Achilles tendinopathy: a double-blind randomized placebo-controlled trial. Am J Sports Med 39(8):1623–1629
58. Kearney RS, Parsons N, Costa ML (2013) Achilles tendinopathy management: a pilot randomised controlled trial comparing platelet-richplasma injection with an eccentric loading programme. Bone Joint Res 2(10):227–232
59. Thanasas C, Papadimitriou G, Charalambidis C, Paraskevopoulos I, Papanikolaou A (2011) Plateletrich plasma versus autologous whole blood for the treatment of chronic lateral elbow epicondylitis: a randomized controlled clinical trial. Am J Sports Med 39(10):2130–2134
60. Creaney L, Wallace A, Curtis M, Connell D (2011) Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a prospective, single-blind, randomised trial of autologous blood injections versus plateletrich plasma injections. Br J Sports Med 45 (12):966–971
61. Ruiz-Moneo P, Molano-Munoz J, Prieto E, Algorta J (2013) Plasma rich in growth factors in arthroscopic rotator cuff repair: a randomized, double-blind, controlled clinical trial. Arthroscopy 29(1):2–9
62. Rodeo SA, Delos D, Williams RJ, Adler RS, Pearle A, Warren RF (2012) The effect of platelet-rich fibrin matrix on rotator cuff tendon healing: a prospective, randomized clinical study. Am J Sports Med 40 (6):1234–1241
63. Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med 38(2):255–262
64. Mishra AK, Skrepnik NV, Edwards SG, Jones GL, Sampson S, Vermillion DA et al (2014) Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. Am J Sports Med 42 (2):463–471
65. Scarpone M, Rabago D, Snell E, Demeo P, Ruppert K, Pritchard P et al (2013) Effectiveness of platelet-rich plasma injection for Rotator Cuff tendinopathy: a prospective open-label study. Glob Adv Health Med 2(2):26–31
66. de Vos RJ, Weir A, Brasher PM, Khan KM (2014) Platelet-rich plasma for chronic tennis elbow: letters to the editor. Am J Sports Med 42(1):NP3–NP5
67. Coombes BK, Bisset L, Vicenzino B (2010) Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: a systematic review of randomised controlled trials. Lancet 376(9754):1751–1767
68. Carr AJ, Murphy R, Dakin SG, Rombach I, Wheway K, Watkins B et al (2015) Platelet-rich plasma injection with arthroscopic acromioplasty for chronic Rotator Cuff tendinopathy: a randomized controlled trial. Am J Sports Med 43(12):2891–2897
69. Moraes VY, Lenza M, Tamaoki MJ, Faloppa F, Belloti JC (2014) Platelet-rich therapies for musculoskeletal soft tissue injuries. Cochrane Database Syst Rev 4:CD010071
70. Liddle AD, Rodriguez-Merchan EC (2014) Plateletrich plasma in the treatment of Patellar tendinopathy: a systematic review. Am J Sports Med 43:2583–2590
71. Warth RJ, Dornan GJ, James EW, Horan MP, Millett PJ (2015) Clinical and structural outcomes after arthroscopic repair of full-thickness rotator cuff tears with and without platelet-rich product supplementation: a meta-analysis and meta-regression. Arthroscopy 31(2):306–320