Relationship between neovascularization and clinical severity in Achilles tendinopathy in 556 paired measurements

Scandinavian Journal of Medicine and Science in Sports

Volumn 24, Issue 5, 2014, Pages 773-778

  De Jonge, S ^a,b   Warnaars, J L F ^a   De Vos, R J ^a   Weir, A ^a   van Schie, H T M ^b,c   Bierma Zeinstra, S M A ^a,b   Verhaar, J A N ^b   Tol, J L ^a  

^a Department of Sports Medicine Medical Centre the Hague   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Achilles tendinopathy; Neovascularization; Ultrasonography

Indexed keywords

ACHILLES TENDON; ADULT; ANGIOGENESIS; COMPLICATION; CROSS-SECTIONAL STUDY; ECHOGRAPHY; FACTUAL DATABASE; FEMALE; HUMAN; INJURIES; INJURY SCALE; MALE; MIDDLE AGED; MUSCULOSKELETAL PAIN; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); TENDINITIS; VASCULARIZATION;

ACHILLES TENDON; ADULT; CROSS-SECTIONAL STUDIES; DATABASES, FACTUAL; FEMALE; HUMANS; MALE; MIDDLE AGED; MUSCULOSKELETAL PAIN; NEOVASCULARIZATION, PHYSIOLOGIC; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TENDINOPATHY; TRAUMA SEVERITY INDICES;

EID: 84928824690     PISSN: 09057188     EISSN: 16000838     Source Type: Journal    
DOI: 10.1111/sms.12072     Document Type: Article

References (34)

1. Alfredson H. Chronic midportion Achilles tendinopathy: an update on research and treatment. Clin Sports Med 2003: 22: 727-741.
2. Alfredson H. Midportion Achilles tendinosis and the plantaris tendon. Br J Sports Med 2011: 45: 1023-1025.
3. Alfredson H, Ohberg L. Sclerosing injections to areas of neo-vascularisation reduce pain in chronic Achilles tendinopathy: a double-blind randomised controlled trial. Knee Surg Sports Traumatol Arthrosc 2005: 13: 338-344.
4. Alfredson H, Ohberg L. Increased intratendinous vascularity in the early period after sclerosing injection treatment in Achilles tendinosis: a healing response? Knee Surg Sports Traumatol Arthrosc 2006: 14: 399-401.
5. Alfredson H, Ohberg L, Forsgren S. Is vasculo-neural ingrowth the cause of pain in chronic Achilles tendinosis? An investigation using ultrasonography and colour Doppler, immunohistochemistry, and diagnostic injections. Knee Surg Sports Traumatol Arthrosc 2003: 11: 334-338.
6. Boesen MI, Koenig MJ, Torp-Pedersen S, Bliddal H, Langberg H. Tendinopathy and Doppler activity: the vascular response of the Achilles tendon to exercise. Scand J Med Sci Sports 2006: 16: 463-469.
7. Cook J. Tendinopathy: no longer a "one size fits all" diagnosis. Br J Sports Med 2011: 45: 385.
8. de Jonge S, de Vos RJ, Van Schie HT, Verhaar JA, Weir A, Tol JL. One-year follow-up of a randomised controlled trial on added splinting to eccentric exercises in chronic midportionAchilles tendinopathy. Br J Sports Med 2010: 44: 673-677.
9. de Jonge S, de Vos RJ, Weir A, van Schie HT, Bierma-Zeinstra SM, Verhaar JA, Weinans H, Tol JL. One-year follow-up of platelet-rich plasma treatment in chronic Achilles tendinopathy: a double-blind randomized placebo-controlled trial. Am J Sports Med 2011: 39: 1623-1629.
10. de Vos RJ, Heijboer MP, Weinans H, Verhaar JA, van Schie JT. Tendon structure's lack of relation to clinical outcome after eccentric exercises in chronic midportion Achilles tendinopathy. J Sport Rehabil 2012: 21: 34-43.
11. de Vos RJ, Weir A, Cobben LP, Tol JL. The value of power Doppler ultrasonography in Achilles tendinopathy: a prospective study. Am J Sports Med 2007a: 35: 1696-1701.
12. de Vos RJ, Weir A, Tol JL, Verhaar JA, Weinans H, van Schie HT. No effects of PRP on ultrasonographic tendon structure and neovascularisation in chronic midportion Achilles tendinopathy. Br J Sports Med 2011: 45: 387-392.
13. de Vos RJ, Weir A, van Schie HTM, Bierma-Zeinstra SMA, Verhaar JAN, Weinans H, Tol J. Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. JAMA 2010: 303: 144-149.
14. de Vos RJ, Weir A, Visser RJ, de Winter T, Tol JL. The additional value of a night splint to eccentric exercises in chronic midportion Achilles tendinopathy: a randomised controlled trial. Br J Sports Med 2007b: 41: e5.
15. Hoksrud A, Ohberg L, Alfredson H, Bahr R. Color Doppler ultrasound findings in patellar tendinopathy (jumper's knee). Am J Sports Med 2008: 36: 1813-1820.
16. Hoksrud A, Torgalsen T, Harstad H, Haugen S, Andersen TE, Risberg MA, Bahr R. Ultrasound-guided sclerosis of neovessels in patellar tendinopathy: a prospective study of 101 patients. Am J Sports Med 2012: 40: 542-547.
17. Lind B, Ohberg L, Alfredson H. Sclerosing polidocanol injections in mid-portion Achilles tendinosis: remaining good clinical results and decreased tendon thickness at 2-year follow-up. Knee Surg Sports Traumatol Arthrosc 2006: 14: 1327-1332.
18. Maffulli N, Longo UG, Denaro V. Novel approaches for the management of tendinopathy. J Bone Joint Surg 2010: 92: 2604-2613.
19. Maffulli N, Sharma P, Luscombe KL. Achilles tendinopathy: aetiology and management. J R Soc Med 2004: 97: 472-476.
20. Mahieu N, Van Tiggelen D, De Muynck M, Dumalin M, Witvrouw E. Blood flow of the Achilles tendon during military training. Int J Sports Med 2010: 31: 901-905.
21. Malliaras P, Chan O, Simran G, Martinez de Albornoz P, Morrissey D, Maffulli N. Doppler ultrasound signal in Achilles tendinopathy reduces immediately after activity. Int J Sports Med 2012: 33: 480-484.
22. Malliaras P, Purdam C, Maffulli N, Cook J. Temporal sequence of greyscale ultrasound changes and their relationship with neovascularity and pain in the patellar tendon. Br J Sports Med 2010: 44: 944-947.
23. Ohberg L, Alfredson H. Ultrasound guided sclerosis of neovessels in painful chronic Achilles tendinosis: pilot study of a new treatment. Br J Sports Med 2002: 36: 173-175; discussion 176-177.
24. Ohberg L, Lorentzon R, Alfredson H. Neovascularisation in Achilles tendons with painful tendinosis but not in normal tendons: an ultrasonographic investigation. Knee Surg Sports Traumatol Arthrosc 2001: 9: 233-238.
25. Peers KH, Brys PP, Lysens RJ. Correlation between power Doppler ultrasonography and clinical severity in Achilles tendinopathy. Int Orthop 2003: 27: 180-183.
26. Reiter M, Ulreich N, Dirisamer A, Tscholakoff D, Bucek RA. Colour and power Doppler sonography in symptomatic Achilles tendon disease. Int J Sports Med 2004: 25: 301-305.
27. Robinson JM, Cook JL, Purdam C, Visentini PJ, Ross J, Maffulli N, Taunton JE, Khan KM. The VISA-A questionnaire: a valid and reliable index of the clinical severity of Achilles tendinopathy. Br J Sports Med 2001: 35: 335-341.
28. Sengkerij PM, de Vos RJ, Weir A, van Weelde BJ, Tol JL. Interobserver reliability of neovascularization score using power Doppler ultrasonography in midportion Achilles tendinopathy. Am J Sports Med 2009: 37: 1627-1631.
29. Sharma P, Maffulli N. Biology of tendon injury: healing, modeling and remodeling. J Musculoskelet Neuronal Interact 2006: 6: 181-190.
30. Tol JL, Spiezia F, Maffulli N. Neovascularization in Achilles tendinopathy: have we been chasing a red herring? Knee Surg Sports Traumatol Arthrosc 2012: 20: 1891-1894.
31. van Sterkenburg MN, de Jonge MC, Sierevelt IN, van Dijk CN. Less promising results with sclerosing ethoxysclerol injections for midportion Achilles tendinopathy: a retrospective study. Am J Sports Med 2010: 38: 2226-2232.
32. Walther M, Radke S, Kirschner S, Ettl V, Gohlke F. Power Doppler findings in plantar fasciitis. Ultrasound Med Biol 2004: 30: 435-440.
33. Yang X, Pugh ND, Coleman DP, Nokes LD. Are Doppler studies a useful method of assessing neovascularization in human Achilles tendinopathy? A systematic review and suggestions for optimizing machine settings. J Med Eng Technol 2010: 34: 365-372.
34. Zanetti M, Metzdorf A, Kundert HP, Zollinger H, Vienne P, Seifert B, Hodler J. Achilles tendons: clinical relevance of neovascularization diagnosed with power Doppler US. Radiology 2003: 227: 556-560.