Paneth cells in the developing gut: When do they arise and when are they immune competent?

Pediatric Research

Volumn 80, Issue 2, 2016, Pages 306-310

  Heida, Fardou H ^a,b   Beyduz, Gaia ^a,b   Bulthuis, Marian L C ^b   Kooi, Elisabeth M W ^a   Bos, Arend F ^a   Timmer, Albertus ^b   Hulscher, Jan B F ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL COUNT; CELL MATURATION; FEMALE; FETUS; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; IMMUNE COMPETENT PANETH CELL; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; INFANT; INTESTINE; MALE; PANETH CELL; PREMATURITY; PRIORITY JOURNAL; CYTOLOGY; EMBRYOLOGY; ILEUM; IMMUNE SYSTEM; IMMUNOLOGY; INCIDENCE; METABOLISM; NECROTIZING ENTEROCOLITIS; NEWBORN; OBSERVER VARIATION; TIME FACTOR;

ALPHA DEFENSIN;

ALPHA-DEFENSINS; ENTEROCOLITIS, NECROTIZING; FEMALE; GESTATIONAL AGE; HUMANS; ILEUM; IMMUNE SYSTEM; INCIDENCE; INFANT, NEWBORN; INFANT, PREMATURE; INTESTINES; MALE; OBSERVER VARIATION; PANETH CELLS; TIME FACTORS;

EID: 84983320132     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2016.67     Document Type: Article

References (23)

1. Gregory KE, Deforge CE, Natale KM, Phillips M, Van Marter LJ. Necrotizing enterocolitis in the premature infant: neonatal nursing assessment, disease pathogenesis, and clinical presentation. Adv Neonatal Care 2011; 11: 155-64; quiz 165-6
2. Underwood MA. Paneth cells and necrotizing enterocolitis. Gut Microbes 2012; 3: 562-5
3. Kandasamy J, Huda S, Ambalavanan N, Jilling T. Inflammatory signals that regulate intestinal epithelial renewal, differentiation, migration and cell death: Implications for necrotizing enterocolitis. Pathophysiology 2014; 21: 67-80
4. McElroy SJ, Underwood MA, Sherman MP. Paneth cells and necrotizing enterocolitis: a novel hypothesis for disease pathogenesis. Neonatology 2013; 103: 10-20
5. Salzman NH, Underwood MA, Bevins CL. Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin Immunol 2007; 19: 70-83
6. Gonzalez-Rivera R, Culverhouse RC, Hamvas A, Tarr PI, Warner BB. The age of necrotizing enterocolitis onset: an application of Sartwell's incubation period model. J Perinatol 2011; 31: 519-23
7. Yee WH, Soraisham AS, Shah VS, Aziz K, Yoon W, Lee SK; Canadian Neonatal Network. Incidence and timing of presentation of necrotizing enterocolitis in preterm infants. Pediatrics 2012; 129: e298-304
8. Clevers HC, Bevins CL. Paneth cells: maestros of the small intestinal crypts. Annu Rev Physiol 2013; 75: 289-311
9. Mallow EB, Harris A, Salzman N, et al. Human enteric defensins. Gene structure and developmental expression. J Biol Chem 1996; 271: 4038-45
10. Schonhoff SE, Giel-Moloney M, Leiter AB. Minireview: Development and differentiation of gut endocrine cells. Endocrinology 2004; 145: 2639-44
11. Ouellette AJ, Bevins CL. Development of the innate immunity in the small intestine. In: Sanderson IR, Walker WA (eds.). Development of the Gastrointestinal Tract. 1st edn. BC Decker Inc: Hamilton, Canada 1998: 147-64
12. Huff DS. Gastrointestinal tract. In: Color Atlas of Fetal and Neonatal Histology. 1st edn. Ernst LM, Ruchelli ED, Huff DS (eds.). Springer: London, UK 2011; 39-63
13. Puiman PJ, Burger-Van Paassen N, Schaart MW, et al. Paneth cell hyperplasia and metaplasia in necrotizing enterocolitis. Pediatr Res 2011; 69: 217-23
14. Adolph TE, Tomczak MF, Niederreiter L, et al. Paneth cells as a site of origin for intestinal inflammation. Nature 2013; 503: 272-6
15. Wehkamp J, Salzman NH, Porter E, et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci USA 2005; 102: 18129-34
16. Sherman MP, Bennett SH, Hwang FF, Sherman J, Bevins CL. Paneth cells and antibacterial host defense in neonatal small intestine. Infect Immun 2005; 73: 6143-6
17. Arciero J, Bard Ermentrout G, Siggers R, et al. Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis. J Theor Biol 2013; 321: 83-99
18. Hackam DJ, Good M, Sodhi CP. Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch. Semin Pediatr Surg 2013; 22: 76-82
19. Bevins CL, Salzman NH. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 2011; 9: 356-68
20. Heneghan AF, Pierre JF, Tandee K, et al. Parenteral nutrition decreases paneth cell function and intestinal bactericidal activity while increasing susceptibility to bacterial enteroinvasion. JPEN J Parenter Enteral Nutr 2014; 38: 817-24
21. Shen B, Porter EM, Reynoso E, et al. Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract. J Clin Pathol 2005; 58: 687-94
22. Salzman NH, Hung K, Haribhai D, et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 2010; 11: 76-83
23. Stappenbeck TS. Paneth cell development, differentiation, and function: new molecular cues. Gastroenterology 2009; 137: doi: 10.1053/j.gastro. 2009.05.013