메뉴 건너뛰기




Volumn 321, Issue , 2013, Pages 83-99

Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis

Author keywords

Inflammatory response; Intestine; Mathematical model; TLR4; TLR9

Indexed keywords

DNA; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

EID: 84874520997     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2012.12.002     Document Type: Article
Times cited : (26)

References (63)
  • 1
    • 79951604923 scopus 로고    scopus 로고
    • New insights into the pathogenesis and treatment of necrotizing enterocolitis. Toll-like receptors and beyond
    • Afrazi A., Sodhi C., Richardson W., Neal M., Good M., Siggers R., Hackam D. New insights into the pathogenesis and treatment of necrotizing enterocolitis. Toll-like receptors and beyond. Pediatr. Res. 2011, 69(3):183-187.
    • (2011) Pediatr. Res. , vol.69 , Issue.3 , pp. 183-187
    • Afrazi, A.1    Sodhi, C.2    Richardson, W.3    Neal, M.4    Good, M.5    Siggers, R.6    Hackam, D.7
  • 2
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors. critical proteins linking innate and acquired immunity
    • Akira S., Takeda K., Kaisho T. Toll-like receptors. critical proteins linking innate and acquired immunity. Nat. Immunol. 2001, 2(8):675-680.
    • (2001) Nat. Immunol. , vol.2 , Issue.8 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 3
    • 79953272505 scopus 로고    scopus 로고
    • Probiotics for prevention of necrotizing enterocolitis in preterm infants
    • CD005496
    • AlFaleh K., Anabrees J., Bassler D., Al-Kharfi T. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst. Rev. 2011, 3(CD005496). 10.1002/14651858.CD005496.pub3.
    • (2011) Cochrane Database Syst. Rev. , vol.3
    • AlFaleh, K.1    Anabrees, J.2    Bassler, D.3    Al-Kharfi, T.4
  • 4
    • 84864247996 scopus 로고    scopus 로고
    • Computational and systems biology in trauma and sepsis. current state and future prospects
    • An G., Nieman G., Vodovotz Y. Computational and systems biology in trauma and sepsis. current state and future prospects. Int. J. Burns Trauma 2012, 2:1-10.
    • (2012) Int. J. Burns Trauma , vol.2 , pp. 1-10
    • An, G.1    Nieman, G.2    Vodovotz, Y.3
  • 5
    • 77956321525 scopus 로고    scopus 로고
    • Using a mathematical model to analyze the role of probiotics and inflammation in necrotizing enterocolitis
    • Arciero J., Ermentrout G., Upperman J., Vodovotz Y., Rubin J. Using a mathematical model to analyze the role of probiotics and inflammation in necrotizing enterocolitis. PLoS ONE 2010, 5(4):e10066. 10.1371/journal.pone.0010066.
    • (2010) PLoS ONE , vol.5 , Issue.4
    • Arciero, J.1    Ermentrout, G.2    Upperman, J.3    Vodovotz, Y.4    Rubin, J.5
  • 6
    • 63449101111 scopus 로고    scopus 로고
    • Dangers in and out
    • Bianchi M., Manfredi A. Dangers in and out. Science 2009, 323:1683-1684.
    • (2009) Science , vol.323 , pp. 1683-1684
    • Bianchi, M.1    Manfredi, A.2
  • 7
    • 23944480403 scopus 로고    scopus 로고
    • Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J. Pediatr
    • Bin-Nun, A., Bromiker, R., Wilschanski, M., Kaplan, M., Rudensky, B., Caplan, M., Hammerman, C., 2005. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J. Pediatr. 147 (2), 192-196.
    • (2005) , vol.147 , Issue.2 , pp. 192-196
    • Bin-Nun, A.1    Bromiker, R.2    Wilschanski, M.3    Kaplan, M.4    Rudensky, B.5    Caplan, M.6    Hammerman, C.7
  • 8
    • 72249112519 scopus 로고    scopus 로고
    • Role of LPS-CD14-TLR4-mediated inflammation in necrotizing enterocolitis. pathogenesis and therapeutic implications
    • Chan K., Wong K., Luk J. Role of LPS-CD14-TLR4-mediated inflammation in necrotizing enterocolitis. pathogenesis and therapeutic implications. World J. Gastroenterol. 2009, 15(38):4745-4752.
    • (2009) World J. Gastroenterol. , vol.15 , Issue.38 , pp. 4745-4752
    • Chan, K.1    Wong, K.2    Luk, J.3
  • 9
    • 2442616098 scopus 로고    scopus 로고
    • Developmentally regulated I-kappaB expression in intestinal epithelium and susceptibility to flagellin-induce inflammation
    • Claud E., Lu L., Anton P., Savidge T., Walker W., Cherayil B. Developmentally regulated I-kappaB expression in intestinal epithelium and susceptibility to flagellin-induce inflammation. Proc. Natl. Acad. Sci. USA 2004, 101(19):7404-7408.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , Issue.19 , pp. 7404-7408
    • Claud, E.1    Lu, L.2    Anton, P.3    Savidge, T.4    Walker, W.5    Cherayil, B.6
  • 10
    • 85046982618 scopus 로고    scopus 로고
    • Microbial ecology and host-microbiota interactions during early life stages
    • Collado M., Cernada M., Bauer C., Vento M., Perez-Martinez G. Microbial ecology and host-microbiota interactions during early life stages. Gut Microbes 2012, 3(4):352-365.
    • (2012) Gut Microbes , vol.3 , Issue.4 , pp. 352-365
    • Collado, M.1    Cernada, M.2    Bauer, C.3    Vento, M.4    Perez-Martinez, G.5
  • 11
    • 67651231051 scopus 로고    scopus 로고
    • Intestinal mucus barrier in normal and inflamed colon
    • Corazziari E. Intestinal mucus barrier in normal and inflamed colon. J. Pediatr. Gastroenterol. Nutr. 2009, 48:S54-S55.
    • (2009) J. Pediatr. Gastroenterol. Nutr. , vol.48
    • Corazziari, E.1
  • 12
    • 0035993059 scopus 로고    scopus 로고
    • Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double-blind study
    • Dani C., Biadaioli R., Bertini G., Martelli E., Rubaltelli F. Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double-blind study. Biol. Neonate 2002, 82(2):103-108.
    • (2002) Biol. Neonate , vol.82 , Issue.2 , pp. 103-108
    • Dani, C.1    Biadaioli, R.2    Bertini, G.3    Martelli, E.4    Rubaltelli, F.5
  • 13
    • 0024370183 scopus 로고
    • Simple intestinal obstruction causes bacterial translocation in man
    • Deitch E. Simple intestinal obstruction causes bacterial translocation in man. Arch. Surg. 1989, 124:699-701.
    • (1989) Arch. Surg. , vol.124 , pp. 699-701
    • Deitch, E.1
  • 14
    • 0028320473 scopus 로고
    • Role of bacterial translocation in necrotizing enterocolitis
    • Deitch E. Role of bacterial translocation in necrotizing enterocolitis. Acta Pediatr. 1994, 396:33-36.
    • (1994) Acta Pediatr. , vol.396 , pp. 33-36
    • Deitch, E.1
  • 15
    • 70049099845 scopus 로고    scopus 로고
    • Immune responses to the microbiota at the intestinal mucosal surface
    • Duerkop B., Vaishnava S., Hooper L. Immune responses to the microbiota at the intestinal mucosal surface. Immunity 2009, 31:368-376.
    • (2009) Immunity , vol.31 , pp. 368-376
    • Duerkop, B.1    Vaishnava, S.2    Hooper, L.3
  • 17
    • 0033029932 scopus 로고    scopus 로고
    • Circulating pro- and counter inflammatory cytokine levels and severity in necrotizing enterocolitis
    • Edelson M., Bagwell C., Rozycki H. Circulating pro- and counter inflammatory cytokine levels and severity in necrotizing enterocolitis. Pediatrics 1999, 103(4):766-771.
    • (1999) Pediatrics , vol.103 , Issue.4 , pp. 766-771
    • Edelson, M.1    Bagwell, C.2    Rozycki, H.3
  • 18
    • 84871622760 scopus 로고    scopus 로고
    • Double-blind, randomised clinical assay to evaluate the efficacy of probiotics in preterm newborns weighing less than 1500g in the prevention of necrotising enterocolitis. Arch. Dis. Child Fetal Neonatal Ed., doi:10.1136/archdischild-2011-300435
    • Fernandez-Carrocera, L., Solis-Herrera, A., Cabanillas-Ayon, M., Gallardo-Sarmiento, R., Garcia-Perez, C., Montano-Rodriguez, R., Echaniz-Aviles, M., 2012. Double-blind, randomised clinical assay to evaluate the efficacy of probiotics in preterm newborns weighing less than 1500g in the prevention of necrotising enterocolitis. Arch. Dis. Child Fetal Neonatal Ed., doi:10.1136/archdischild-2011-300435.
    • (2012)
    • Fernandez-Carrocera, L.1    Solis-Herrera, A.2    Cabanillas-Ayon, M.3    Gallardo-Sarmiento, R.4    Garcia-Perez, C.5    Montano-Rodriguez, R.6    Echaniz-Aviles, M.7
  • 22
    • 17644413577 scopus 로고    scopus 로고
    • Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis
    • Hackam D., Upperman J., Grishin A., Ford H. Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis. Semin. Pediatr. Surg. 2005, 14:49-57.
    • (2005) Semin. Pediatr. Surg. , vol.14 , pp. 49-57
    • Hackam, D.1    Upperman, J.2    Grishin, A.3    Ford, H.4
  • 23
    • 0002647979 scopus 로고    scopus 로고
    • Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures
    • Haller D., Bode C., Hammes W., Pfeifer A., Schiffrin E., Blum S. Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures. Gut 2000, 47:79-87.
    • (2000) Gut , vol.47 , pp. 79-87
    • Haller, D.1    Bode, C.2    Hammes, W.3    Pfeifer, A.4    Schiffrin, E.5    Blum, S.6
  • 24
    • 2642576322 scopus 로고    scopus 로고
    • Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice
    • Han X., Fink M., Yang R., Delude R. Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice. Shock 2004, 21(3):261-270.
    • (2004) Shock , vol.21 , Issue.3 , pp. 261-270
    • Han, X.1    Fink, M.2    Yang, R.3    Delude, R.4
  • 26
    • 0032875134 scopus 로고    scopus 로고
    • Innate mechanisms of epithelial host defense. spotlight on intestine
    • Hecht G. Innate mechanisms of epithelial host defense. spotlight on intestine. Am. J. Physiol. Cell Physiol. 1999, 277:351-358.
    • (1999) Am. J. Physiol. Cell Physiol. , vol.277 , pp. 351-358
    • Hecht, G.1
  • 27
    • 77649086402 scopus 로고    scopus 로고
    • Immune adaptations that maintain homeostasis with the intestinal microbiota
    • Hooper L., Macpherson A. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat. Rev. Immunol. 2010, 10:159-169.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 159-169
    • Hooper, L.1    Macpherson, A.2
  • 28
    • 38349138320 scopus 로고    scopus 로고
    • Understanding the susceptibility of the premature infant to necrotizing enterocolitis (NEC)
    • Hunter C., Upperman J., Ford H., Camerini V. Understanding the susceptibility of the premature infant to necrotizing enterocolitis (NEC). Pediatr. Res. 2008, 63(2):117-123.
    • (2008) Pediatr. Res. , vol.63 , Issue.2 , pp. 117-123
    • Hunter, C.1    Upperman, J.2    Ford, H.3    Camerini, V.4
  • 29
    • 37748999952 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent macrophage activation by entamoeba histolytica DNA
    • Ivory C., Prystajecky M., Jobin C., Chadee K. Toll-like receptor 9-dependent macrophage activation by entamoeba histolytica DNA. Inf. Immun. 2008, 76(1):289-297.
    • (2008) Inf. Immun. , vol.76 , Issue.1 , pp. 289-297
    • Ivory, C.1    Prystajecky, M.2    Jobin, C.3    Chadee, K.4
  • 30
    • 84863272764 scopus 로고    scopus 로고
    • Immature oxidative stress management as a unifying principle in the pathogenesis of necrotizing enterocolitis. insights from an agent-based model
    • Kim M., Christley S., Alverdy J., Liu D., An G. Immature oxidative stress management as a unifying principle in the pathogenesis of necrotizing enterocolitis. insights from an agent-based model. Surg. Inf. 2012, 13(1). 10.1089/sur.2011.057.
    • (2012) Surg. Inf. , vol.13 , Issue.1
    • Kim, M.1    Christley, S.2    Alverdy, J.3    Liu, D.4    An, G.5
  • 31
    • 84864598303 scopus 로고    scopus 로고
    • Toll-like receptors promote mutually beneficial commensal-host interactions
    • Kubinak J., Round J. Toll-like receptors promote mutually beneficial commensal-host interactions. PLoS Pathogens 2012, 8(7):e1002785. 10.1371/journal.ppat.1002785.
    • (2012) PLoS Pathogens , vol.8 , Issue.7
    • Kubinak, J.1    Round, J.2
  • 33
    • 40749161012 scopus 로고    scopus 로고
    • A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair
    • Leaphart C., Cavallo J., Gribar S., Cetin S., Li J., Branca M., Dubowski T., Sodhi C., Hackam D. A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J. Immunol. 2007, 179:4808-4820.
    • (2007) J. Immunol. , vol.179 , pp. 4808-4820
    • Leaphart, C.1    Cavallo, J.2    Gribar, S.3    Cetin, S.4    Li, J.5    Branca, M.6    Dubowski, T.7    Sodhi, C.8    Hackam, D.9
  • 34
    • 69949088176 scopus 로고    scopus 로고
    • Better living through microbial action. the benefits of the mammalian gastrointestinal microbiota on the host
    • Leser T., Molbak L. Better living through microbial action. the benefits of the mammalian gastrointestinal microbiota on the host. Environ. Microbiol. 2009, 11(9):2194-2206.
    • (2009) Environ. Microbiol. , vol.11 , Issue.9 , pp. 2194-2206
    • Leser, T.1    Molbak, L.2
  • 35
    • 54049148570 scopus 로고    scopus 로고
    • Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants. a multicenter randomized controlled trial
    • Lin H., Hsu C., Chen H., Chung M., Hsu J., Lien R., Tsao L., Chen C., Su B. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants. a multicenter randomized controlled trial. Pediatrics 2008, 122(4):693-700.
    • (2008) Pediatrics , vol.122 , Issue.4 , pp. 693-700
    • Lin, H.1    Hsu, C.2    Chen, H.3    Chung, M.4    Hsu, J.5    Lien, R.6    Tsao, L.7    Chen, C.8    Su, B.9
  • 36
    • 40749116798 scopus 로고    scopus 로고
    • Necrotizing enterocolitis. recent scientific advances in pathophysiology and prevention
    • Lin P., Nasr T., Stoll B. Necrotizing enterocolitis. recent scientific advances in pathophysiology and prevention. Semin. Perinatol. 2008, 32(2):70-82.
    • (2008) Semin. Perinatol. , vol.32 , Issue.2 , pp. 70-82
    • Lin, P.1    Nasr, T.2    Stoll, B.3
  • 37
    • 69749095677 scopus 로고    scopus 로고
    • Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis
    • Liu Y., Zhu L., Fatheree N., Liu X., Pacheco S., Tatevian N., Rhoads J. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Gastroenterology 2009, 297:G442-G450.
    • (2009) Gastroenterology , vol.297
    • Liu, Y.1    Zhu, L.2    Fatheree, N.3    Liu, X.4    Pacheco, S.5    Tatevian, N.6    Rhoads, J.7
  • 38
    • 33645843063 scopus 로고    scopus 로고
    • Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells
    • Lotz M., Gutle D., Walther S., Menard S., Bogdan C., Hornef M. Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. J. Exp. Med. 2006, 203(4):973-984.
    • (2006) J. Exp. Med. , vol.203 , Issue.4 , pp. 973-984
    • Lotz, M.1    Gutle, D.2    Walther, S.3    Menard, S.4    Bogdan, C.5    Hornef, M.6
  • 43
    • 0034284803 scopus 로고    scopus 로고
    • Prokaryotic regulation by epithelial responses by inhibition of IkB-alpha ubiquitination
    • Neish A., Gewirtz A., Zeng H., Young A., Hobert M., Karmali V., Rao A., Madara J. Prokaryotic regulation by epithelial responses by inhibition of IkB-alpha ubiquitination. Science 2000, 289:1560-1563.
    • (2000) Science , vol.289 , pp. 1560-1563
    • Neish, A.1    Gewirtz, A.2    Zeng, H.3    Young, A.4    Hobert, M.5    Karmali, V.6    Rao, A.7    Madara, J.8
  • 45
    • 84866245274 scopus 로고    scopus 로고
    • Gut microbial translocation in critically ill children and effects of supplementation with pre- and probiotics
    • Papoff P., Ceccarelli G., d'Ettore G. Gut microbial translocation in critically ill children and effects of supplementation with pre- and probiotics. Int. J. Microbiol. 2012, 10.1155/2012/151393.
    • (2012) Int. J. Microbiol.
    • Papoff, P.1    Ceccarelli, G.2    d'Ettore, G.3
  • 46
    • 23444450713 scopus 로고    scopus 로고
    • Operative strategies for necrotizing enterocolitis. the prevention and treatment of short-bowel syndrome
    • Petty J., Ziegler M. Operative strategies for necrotizing enterocolitis. the prevention and treatment of short-bowel syndrome. Semin. Pediatr. Surg. 2005, 14(3):191-198.
    • (2005) Semin. Pediatr. Surg. , vol.14 , Issue.3 , pp. 191-198
    • Petty, J.1    Ziegler, M.2
  • 47
    • 17144430891 scopus 로고    scopus 로고
    • Increased expression and function of integrins in enterocytes by endotoxin impairs epithelial restitution
    • Qureshi F., Leaphart C., Cetin S., Li J., Grishin A., Watkins S., Ford H., Hackam D. Increased expression and function of integrins in enterocytes by endotoxin impairs epithelial restitution. Gastroenterology 2005, 128:1012-1022.
    • (2005) Gastroenterology , vol.128 , pp. 1012-1022
    • Qureshi, F.1    Leaphart, C.2    Cetin, S.3    Li, J.4    Grishin, A.5    Watkins, S.6    Ford, H.7    Hackam, D.8
  • 48
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F., Edberg S., Medzhitov R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 2004, 118:229-241.
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 49
    • 33747106908 scopus 로고    scopus 로고
    • A reduced mathematical model of the acute inflammatory response. I derivation of model and analysis of anti-inflammation
    • Reynolds A., Rubin J., Clermont G., Day J., Vodovotz Y., Ermentrout G. A reduced mathematical model of the acute inflammatory response. I derivation of model and analysis of anti-inflammation. J. Theor. Biol. 2006, 242:220-236.
    • (2006) J. Theor. Biol. , vol.242 , pp. 220-236
    • Reynolds, A.1    Rubin, J.2    Clermont, G.3    Day, J.4    Vodovotz, Y.5    Ermentrout, G.6
  • 50
    • 34248385244 scopus 로고    scopus 로고
    • Microscopy of bacterial translocation during small bowel obstruction and ischemia in vivo - a new animal model
    • Samel S., Keese M., Kleczka M., Lanig S., Gretz N., Hafner M., Sturm J., Post S. Microscopy of bacterial translocation during small bowel obstruction and ischemia in vivo - a new animal model. BMC Surg. 2002, 2.
    • (2002) BMC Surg. , vol.2
    • Samel, S.1    Keese, M.2    Kleczka, M.3    Lanig, S.4    Gretz, N.5    Hafner, M.6    Sturm, J.7    Post, S.8
  • 51
    • 77956146310 scopus 로고    scopus 로고
    • New concepts of microbial translocation in the neonatal intestine. mechanisms and prevention
    • Sherman M. New concepts of microbial translocation in the neonatal intestine. mechanisms and prevention. Clin. Perinatol. 2010, 37(3):565-579.
    • (2010) Clin. Perinatol. , vol.37 , Issue.3 , pp. 565-579
    • Sherman, M.1
  • 52
    • 23344446570 scopus 로고    scopus 로고
    • Intestinal macrophages. unique effector cells of the innate immune system
    • Smith P., Ochsenbauer-Jambor C., Smythies L. Intestinal macrophages. unique effector cells of the innate immune system. Immunol. Rev. 2005, 206:149-159.
    • (2005) Immunol. Rev. , vol.206 , pp. 149-159
    • Smith, P.1    Ochsenbauer-Jambor, C.2    Smythies, L.3
  • 57
    • 84861011960 scopus 로고    scopus 로고
    • Diversity of bifidobacteria within the infant gut microbiota.
    • doi:10.1371/journal.pone.0036957
    • Turroni, F., Peano, C., Pass, D., Foroni, E., et al., 2012. Diversity of bifidobacteria within the infant gut microbiota. PLoS ONE 7 (5), e36957. doi:10.1371/journal.pone.0036957.
    • (2012) , vol.7 , Issue.5 , pp. 36957
    • Turroni, F.1    Peano, C.2    Pass, D.3    Foroni, E.4
  • 58
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava S., Behrendt C., Ismail A., Eckmann L., Hooper L. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc. Natl. Acad. Sci. USA 2008, 105(52):20858-20863.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , Issue.52 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.2    Ismail, A.3    Eckmann, L.4    Hooper, L.5
  • 59
    • 57749172576 scopus 로고    scopus 로고
    • Mechanistic simulations of inflammation. current state and future prospects
    • Vodovotz Y., Constantine G., Rubin J., Csete M., Voit E., An G. Mechanistic simulations of inflammation. current state and future prospects. Math. Biosci. 2009, 217:1-10.
    • (2009) Math. Biosci. , vol.217 , pp. 1-10
    • Vodovotz, Y.1    Constantine, G.2    Rubin, J.3    Csete, M.4    Voit, E.5    An, G.6
  • 61
    • 84862915010 scopus 로고    scopus 로고
    • Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants. an updated meta-analysis of 20 randomized, controlled trials
    • Wang Q., Dong J., Zhu Y. Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants. an updated meta-analysis of 20 randomized, controlled trials. J. Pediatr. Surg. 2012, 47:241-248.
    • (2012) J. Pediatr. Surg. , vol.47 , pp. 241-248
    • Wang, Q.1    Dong, J.2    Zhu, Y.3
  • 62
    • 0035037452 scopus 로고    scopus 로고
    • Time course of spontaneous bacterial translocation from gastrointestinal tract and its relationship to intestinal microflora in conventionally reared infant rats
    • Wenzl H., Schimpl G., Feierl G., Steinwender G. Time course of spontaneous bacterial translocation from gastrointestinal tract and its relationship to intestinal microflora in conventionally reared infant rats. Dig. Dis. Sci. 2001, 46(5):1120-1126.
    • (2001) Dig. Dis. Sci. , vol.46 , Issue.5 , pp. 1120-1126
    • Wenzl, H.1    Schimpl, G.2    Feierl, G.3    Steinwender, G.4
  • 63
    • 0034268005 scopus 로고    scopus 로고
    • How to get along-friendly microbes in a hostile world
    • Xavier R., Podolsky D. How to get along-friendly microbes in a hostile world. Science 2000, 289:1483-1484.
    • (2000) Science , vol.289 , pp. 1483-1484
    • Xavier, R.1    Podolsky, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.