Immunomodulatory and antioxidant effects of polysaccharides from Gynostemma pentaphyllum Makino in immunosuppressed mice

Molecules

Volumn 21, Issue 8, 2016, Pages

  Shang, Xiaoya ^a   Chao, Yu ^b   Zhang, Yuan ^c   Lu, Chengyuan ^a   Xu, Chunlan ^a   Niu, Weining ^a  

^a NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

^b XI'AN MEDICAL UNIVERSITY   (China)

^c XIZANG MINZU UNIVERSITY   (China)

Author keywords

Antioxidant; Gynostemma pentaphyllum Makino; Immunomodulatory; In vivo; Polysaccharide

Indexed keywords

ANTIOXIDANT; IMMUNOLOGIC FACTOR; PLANT EXTRACT; POLYSACCHARIDE;

ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; GYNOSTEMMA; IMMUNOCOMPROMISED PATIENT; MACROPHAGE; MOUSE; NATURAL KILLER CELL; OXIDATIVE STRESS; SPLEEN; THYMUS;

ANIMALS; ANTIOXIDANTS; CELL LINE; GYNOSTEMMA; IMMUNOCOMPROMISED HOST; IMMUNOLOGIC FACTORS; KILLER CELLS, NATURAL; MACROPHAGES; MICE; OXIDATIVE STRESS; PLANT EXTRACTS; POLYSACCHARIDES; SPLEEN; THYMUS GLAND;

EID: 84983315392     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules21081085     Document Type: Article

References (41)

1. Lobo, V.; Phatak, A.; Chandra, N. Free radicals and functional foods: Impact on human health. Pharmacogn. Rev. 2010, 4, 118-126.
2. Lü, J.; Lin, P.H.; Yao, Q.; Chen, C. Chemical and molecular mechanisms of antioxidants: Experimental approaches and model systems. J. Cell. Mod. Med. 2010, 14, 840-860.
3. Singh, P.P.; Chandra, A.; Mahdi, F.; Ray, A.; Sharma, P. Reconvene and reconnect the antioxidant hypothesis in Human health and disease. Ind. J. Clin. Biochem. 2010, 25, 225-243.
4. Victor, V.M.; Rocha, M.; de la Fuente, M. Immune cells: Free radicals and antioxidants in sepsis. Int. Immunopharmacol. 2004, 4, 327-347.
5. Weitzman, S.A.; Gordon, L.I. Inflammation and cancer: Role of phagocyte-generated oxidants in carcinogenesis. Blood 1990, 76, 655-663.
6. De la Fuente, M. Effects of antioxidants on immune system ageing. Eur. J. Clin. Nutr. 2002, 56, S5-S8.
7. Macdonald, J.; Galley, H.F.; Webster, N.R. Oxidative stress and gene expression in sepsis. Br. J. Anaesth. 2003, 90, 221-232.
8. Gutteridge, J.M.; Michell, J. Redox imbalance in the critically ill. Br. Med. Bull. 1999, 55, 49-75.
9. De La Fuente, M.; Victor, V. Antioxidants as modulators of immune function. Immunol. Cell Biol. 2000, 78, 49-54.
10. Kong, F.L.; Li, F.E.; He, Z.M.; Jiang, Y.; Hao, R.Y.; Sun, X.; Tong, H.B. Anti-tumor and macrophage activation induced by alkali-extracted polysaccharide from pleurotus ostreatus. Int. J. Biol. Macromol. 2014, 69, 561-566.
11. Zhang, Y.; Ren, C.J.; Lu, G.B.; Cui, W.Z.; Mu, Z.M.; Gao, H.J.; Wang, Y.W. Purification, characterization and anti-diabetic activity of a polysaccharide from mulberry leaf. Regul. Toxicol. Pharm. 2014, 70, 687-695.
12. Pereira, J.G.; Mesquita, J.X.; Aragao, K.S.; Franco, A.X.; Souza, M.H.L.P.; Brito, T.V.; Dias, J.M.; Silva, R.O.; Medeiros, J.V.R.; Oliveira, J.S. Polysaccharides isolated from digenea simplex inhibit inflammatory and nociceptive responses. Carbohydr. Polym. 2014, 108, 17-25.
13. Zhang, X.H.; Liu, L.N.; Lin, C.W. Isolation, structural characterization and antioxidant activity of a neutral polysaccharide from Sisal waste. Food Hydrocolloid. 2014, 39, 10-18.
14. Wang, H.; Liu, Y.M.; Qi, Z.M.; Wang, S.Y.; Liu, S.X.; Li, X.; Wang, H.J.; Xia, X.C. An overview on natural polysaccharides with antioxidant properties. Curr. Med. Chem. 2013, 20, 2899-2913.
15. Li, Y.Q.; Hu, Y.K.; Shi, S.J.; Jiang, L. Evaluation of antioxidant and immune-enhancing activities of Purslane polysaccharides in gastric cancer rats. Int. J. Biol. Macromol. 2014, 68, 113-116.
16. Xie, Z.H.; Huang, H.Q.; Zhao, Y.; Shi, H.M.; Wang, S.K.; Wang, T.T.Y.; Chen, P.; Yu, L.L. Chemical composition and anti-proliferative and anti-inflammatory effects of the leaf and whole-plant samples of diploid and tetraploid Gynostemma pentaphyllum (Thunb.) Makino. Food Chem. 2012, 132, 125-133.
17. Razmovski-Naumovski, V.; Huang, T.H.W.; Tran, V.H.; Li, G.; Duke, C.; Roufogalis, B. Chemistry and pharmacology of Gynostemma pentaphyllum. Phytochem. Rev. 2005, 4, 197-219.
18. Yan, W.; Niu, Y.G.; Lv, J.L.; Xie, Z.H.; Jin, L.; Yao, W.B.; Gao, X.D.; Yu, L.L. Characterization of a heteropolysaccharide isolated from diploid Gynostemma pentaphyllum Makino. Carbohydr. Polym. 2013, 92, 2111-2117.
19. Niu, Y.G.; Shang, P.P.; Chen, L.; Zhang, H.; Gong, L.; Zhang, X.W.; Yu, W.J.; Xu, Y.H.; Wang, Q.; Yu, L.L. Characterization of a novel alkali-soluble heteropolysaccharide from tetraploid Gynostemma pentaphyllum Makino and its potential anti-inflammatory and antioxidant properties. J. Agric. Food Chem. 2014, 62, 3783-3790.
20. Li, B.; Zhang, X.Y.; Wang, M.Z.; Jiao, L.L. Characterization and antioxidant activities of acidic polysaccharides from Gynostemma pentaphyllum (Thunb.) Markino. Carbohydr. Polym. 2015, 127, 209-214.
21. 22 tumor-bearing mice. Int. J. Biol. Macromol. 2014, 69, 1-4.
22. Shang, X.Y.; Zhang, Y.; Bai, Y.L.; Xu, C.L.; Niu, W.N.; Qin, C.G. Extraction and antioxidant activities of polysaccharides from Gynostemma pentaphyllum Makino. Asian J. Chem. 2013, 25, 9092-9096.
23. Xie, J.H.; Xie, M.Y.; Nie, S.P.; Shen, M.Y.; Wang, Y.X.; Li, C. Isolation, chemical composition and antioxidant activities of a water-soluble polysaccharide from Cyclocarya paliurus (Batal.) lljinskaja. Food Chem. 2010, 119, 1626-1632.
24. Sun, X.; Liu, N.; Wu, Z.; Feng, Y.; Meng, X. Anti-tumor activity of a polysaccharide from blueberry. Molecules 2015, 20, 3841-3853.
25. Sun, H.X.; Chen, L.Q.; Zhang, J.; Chen, F.Y. Anti-tumor and immunomodulatory activity of peptide fraction from the larvae of Musca domestica. J. Ethnopharmacol. 2014, 153, 831-839.
26. Yang, L.C.; Hsieh, C.C.; Lin, W.C. Characterization and immunomodulatory activity of rice hull polysaccharides. Carbohydr. Polym. 2015, 124, 150-156.
27. Yang, X.B.; Lv, Y.; Tian, L.M.; Zhao, Y. Composition and systemic immune activity of the polysaccharides from an herbal tea (Lysopus iucidus Trucz). J. Agric. Food Chem. 2010, 58, 6075-6080.
28. Vivier, E.; Raulet, D.H.; Moretta, A.; Caligiuri, M.A.; Zitvogel, L.; Lanier, L.L.; Yokoyama, W.M.; Ugolini, S. Innate or adaptive immunity? The example of natural killer cells. Science 2011, 331, 44-49.
29. Suciu-Foca, N.; Manavalan, J.S.; Cortesini, R. Generation and function of antigen-specific suppressor and regulatory T cells. Transplant. Immunol. 2003, 11, 235-244.
30. Steensberg, A.; Toft, A.D.; Bruunsgaard, H.; Sandmand, M.; Halkjær-Kristensen, J.; Pedersen, B.K. Strenuous exercise decreases the percentage of type 1 T cells in the circulation. J. Appl. Physiol. 2001, 91, 1708-1712.
31. Wong, K.H.; Lai, C.K.M.; Cheung, P.C.K. Immunomodulatory activities of mushroom sclerotial polysaccharides. Food Hydrocoll. 2011, 25, 150-158.
32. Ding, X.; Zhu, F.S.; Gao, S.G. Purification, antitumour and immunomodulatory activity of water-extractable and alkali-extractable polysaccharides from Solanum nigrum L. Food Chem. 2012, 131, 677-684.
33. Lovrić, J.; Mesić, M.; Macan, M.; Koprivanac, M.; Kelava, M.; Bradamante, V. Measurement of malondialdehyde (MDA) level in rat plasma after simvastatin treatment using two different analytical methods. Period. Biol. 2008, 110, 63-67.
34. Carillon, J.; Rouanet, J.M.; Cristol, J.P.; Brion, R. Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: Several routes of supplementation and proposal of an original mechanism of action. Pharm. Res. 2013, 30, 2718-2728.
35. Cichoski, A.J.; Rotta, R.B.; Scheuermann, G.; Cunha Junior, A.; Barin, J.S. Investigation of glutathione peroxidase activity in chicken meat under different experimental conditions. Ciênc. Tecnol. Aliment. 2012, 32, 661-667.
36. Rees, M.D.; Kennett, E.C.; Whitelock, J.M.; Davies, M.J. Oxidative damage to extracellular matrix and its role in human pathologies. Free Radic. Biol. Med. 2008, 44, 1973-2001.
37. Rahman, K. Studies on free radicals, antioxidants and co-factors. Clin. Interv. Aging 2007, 2, 219-236.
38. Xu, R.; Shang, N.; Li, P. In vitro and in vivo antioxidant activity of exopolysaccharide fractions from Bifidobacterium animalis RH. Anaerobe 2011, 17, 226-231.
39. Hua, Y.L.; Gao, Q.; Wen, L.R.; Yang, B.; Tang, J.; You, L.J.; Zhao, M.M. Structural characterization of acid- and alkali-soluble polysaccharides in the fruiting body of Dictyophora indusiata and their immunomodulatory activities. Food Chem. 2012, 132, 739-743.
40. Dai, Z.Q.; Su, D.; Zhang, Y.; Sun, Y.; Hu, B.; Ye, H.; Jabbar, S.; Zeng, X.X. Immunomodulatory activity in vitro and in vivo of verbascose from mung beans (Phaseolus aureus). J. Agric. Food Chem. 2014, 62, 10727-10735.
41. Chalamaiah, M.; Hemalatha, R.; Jyothirmayi, T.; Diwan, P.V.; Bhaskarachary, K.; Vajreswari, A.; Kumar, R.R.; Kumar, B.D. Chemical composition and immunomodulatory effects of enzymatic protein hydrolysates from common carp (Cyprinus carpio) egg. Nutrition 2015, 31, 388-398.