Chemistry and pharmacology of Gynostemma pentaphyllum

Phytochemistry Reviews

Volumn 4, Issue 2-3, 2005, Pages 197-219

  Razmovski Naumovski, Valentina ^a   Huang, Tom Hsun Wei ^a   Tran, Van Hoan ^a   Li, George Qian ^a   Duke, Colin C ^a   Roufogalis, Basil D ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Dammarane; Gynosaponin; Gynoside; Gynostemma pentaphyllum; Gypenoside; Herbal medicine; Saponin; Sterol

Indexed keywords

ALPHA SPINASTEROL; CAROTENOID; CHOLESTANOL; CHONDRILLASTEROL; CYCLOPHOSPHAMIDE; ERGOSTANOL; FLAVONOID; GINSENOSIDE; GLYCOSIDE; GYPENOSIDE; GYPENOSIDE I; GYPENOSIDE II; GYPENOSIDE III; GYPENOSIDE IV; GYPENOSIDE IX; GYPENOSIDE LV; GYPENOSIDE LXII; GYPENOSIDE LXIII; GYPENOSIDE V; GYPENOSIDE VIII; GYPENOSIDE XVII; GYPENOSIDE XVIII; GYPENOSIDE XXXVII; PHANOSIDE; RUTOSIDE; SAPONIN DERIVATIVE; SITOSTEROL; STEROL DERIVATIVE; STIGMASTEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ABDOMINAL PRESSURE; ADRENAL CORTEX ATROPHY; ANOXIA; ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ATHEROSCLEROSIS; BIOLOGICAL ACTIVITY; BRAIN ISCHEMIA; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; CEREBROVASCULAR DISEASE; CHEMISTRY; CHRONIC BRONCHITIS; CHRONIC GASTRITIS; CLINICAL TRIAL; CONFERENCE PAPER; CONSTIPATION; CORONARY ARTERY SPASM; DEMENTIA; DIARRHEA; DIZZINESS; DRUG ACTIVITY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG METABOLISM; DRUG STRUCTURE; ESOPHAGUS CANCER; FATIGUE; GINSENG; GYNOSTEMMA PENTAPHYLLUM; HEART ARRHYTHMIA; HEART INFARCTION; HEART MUSCLE INJURY; HEPATITIS B; HERBAL MEDICINE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERLIPIDEMIA; HYPERTHERMIA; IMMUNE SYSTEM; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LEUKOPENIA; LEUKOPLAKIA; LIPID METABOLISM; LIVER DISEASE; LIVER INJURY; LIVER PROTECTION; MEDICINAL PLANT; MIGRAINE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; SARCOMA; SPECIES CULTIVATION; SPLEEN DISEASE; STOMACH ULCER; THROMBOCYTE AGGREGATION; THYMUS ATROPHY; TINNITUS; ULCER; VISUAL IMPAIRMENT; VOMITING;

GYNOSTEMMA PENTAPHYLLUM; PANAX GINSENG;

EID: 28644433854     PISSN: 15687767     EISSN: 1572980X     Source Type: Journal    
DOI: 10.1007/s11101-005-3754-4     Document Type: Conference Paper

References (156)

1. 7-sterols from Gynostemma pentaphyllum Lipids 21 8 515 517
2. T Akihisa T Tamura T Matsumoto 1987 14α-Methyl-5α-ergosta- 9(11),24(28)-dien -3β-ol, a sterol from Gynostemma pentaphyllum Phytochemistry 26 8 2412 2413
3. T Akihisa H Mihara T Fujikawa T Tamura T Matsumoto 1988 24,24-Dimethyl-5-α-cholestan-3-β-ol, a sterol from Gynostemma pentaphyllum Phytochemistry 27 9 2931 2933
4. T Akihisa M Kanari T Tamura T Matsumoto 1989a 24(R)- and 24(S)-14-α-methyl-5α-ergost-9(11)-en-3-β-ols from Gynostemma pentaphyllum Phytochemistry 28 4 1271 1273
5. T Akihisa T Tamura T Matsumoto WCMC Kokke T Yokota 1989b Isolation of acetylenic sterols from a higher plant. Further evidence that marine sterols are not unique J. Organic Chem. 54 3 606 610
6. T Akihisa WCMC Kokke T Yokota T Tamura T Matsumoto 1990 4-α,14-α-dimethyl-5-α-ergosta-7,9(11), 24(28)-trien-3-β- ol from Phaseolus vulgaris and Gynostemma pentaphyllum Phytochemistry 29 5 1647 1651
7. F Aktan S Henness BD Roufogalis AJ Ammit 2003 Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-κB-mediated iNOS protein expression Nitric Oxide 8 235 242
8. Ankang Pharmaceutical Institution of Beijing Medical University, promotional material, 1999.
9. D Arbain JR Cannon K Afriastini Kartawinata R Djamal A Bustari A Dharma H Rosmawaty Rivai D Zaherman Basir M Sjafar R Sjaiful Nawfa S Kosela 1989 Survey of some West Sumatran plants for alkaloids Econ. Bot. 43 1 73 78
10. Arichi S, Takemoto T & Uchida Y (1985a) Saponins of Gynostemma pentaphyllum as neoplasm inhibitors, Patent-Japan Kokai Tokkyo Koho-60 105, 627.
11. Arichi S, Takemoto T & Uchida Y (1985b) Prevention of glucocorticoid side effects by saponins of Gynostemma pentaphyllum, Patent-Japan Kokai Tokkyo Koho-60 105, 625.
12. Arichi S, Takemoto T & Uchida Y (1985c) Saponins of Gynostemma pentaphyllum as tonics, Patent-Japan Kokai Tokkyo Koho-60 105, 626.
13. A Attawish S Chivapat S Phadungpat J Bansiddhi Y Techadamrongsin O Mitrijit B Chaorai P Chavalittumrong 2004 Chronic toxicity of Gynostemma pentaphyllum Fitoterapia 75 539 551
14. M Blumert JL Liu 1999 Jiaogulan China's "Immortality" Herb Torchlight Publishing Inc. Badger, USA
15. C Bogdan 2001 Nitric oxide and the immune response Nat. Immunol. 2 10 907 916
16. 1) in mice Acta Chin. Pharmacol. 4 6 358 361
17. CK Chang KS Chang YC Lin SY Liu CY Chen 2005 Hairy root cultures of Gynostemma pentaphyllum (Thunb.) Makino: a promising approach for the production of gypenosides as an alternative of Ginseng saponins Biotechnol. Lett. 27 16 1165 1169
18. JC Chen JG Chung LD Chen 1999 Gypenoside induces apoptosis in human Hep3B and HA22T tumour cells Cytobios 100 37 48
19. JC Chen CC Tsai LD Chen HH Chen WC Wang 2000 Therapeutic effect of gypenoside on chronic liver injury and fibrosis induced by CCl4 in rats Am. J. Chin. Med. 28 2 175 185
20. WC Chen DM Hau KT Chen MI Wang IH Lin 1996 Protective effects of Gynostemma pentaphyllum in gamma-irradiated mice Am. J. Chin. Med. 24 1 83 92
21. JG Cheng 1990 Investigation of the plant Jiaogulan and its analogous herb.. Wulianmei Zhong Cao Yao 21 9 424
22. China Pharmaceutical University 1996 Y-Q Yan Encyclopedia of Chinese Herbs Vol. 2, 1st ed China Medicine, Science and Technology Publisher China 1878 1882
23. TH Chiu JC Chen JG Chung 2003 N-acetyltransferase is involved in gypenosides-induced N-acetylation of 2-aminofluorene and DNA adduct formation in human cervix epidermoid carcinoma cells (Ca Ski) In Vivo 17 3 281 288
24. C Circosta R De Pasquale F Occhiuto 2005 Cardiovascular effects of the aqueous extract of Gynostemma pentaphyllum Makino Phytomedicine 12 638 643
25. JF Cui P Eneroth JG Bruhn S Arihara K Yoshikawa 1998 Alkaline cleavage of gypenosides and characterization of dammarane-type aglycones by gas chromatography-mass spectrometry Phytochem. Anal. 9 3 128 133
26. JF Cui P Eneroth JG Bruhn 1999 Gynostemma pentaphyllum: identification of major sapogenins and differentiation from Panax species Eur. J. Pharmaceut. Sci. 8 187 191
27. S Deng X Li B Chen F Deng X Zhou 1994 Analysis of amino acids, vitamins, and chemical elements in Gynostemma pentaphyllum (Thunb) Makino Hunan Yike Daxue Xuebao (Bulletin of Hunan Medical University) 19 6 487 490
28. S Ding Z Zhu 1992 Resources of genus Gynostemma and determination of their total saponins contents Zhongcaoyao 23 12 627 629
29. ZP Fang XY Zeng 1989 Isolation and identification of flavonoids and organic acid from Gynostemma pentaphyllum Makino Zhongguo Zhongyao Zazhi 14 11 676 678
30. ZP Fang XY Zeng 1996 Structure of Gypentonoside A from Gynostemma pentaphyllum Makino Acta Pharmaceut. Sin. 31 680 683
31. Y Gao B Yu 1993 Wuxi Inst. Light Ind., Wuxi Inst. Ind., Wuxi, Peop. Rep. China. Preparation of Gynostemma pentaphyllum wine Wuxi Qinggongye Xueyuan Xuebao 12 3 183 186
32. S Guo Q Wang G Wang Y Ma 1987 Advances in the researchs on fiveleaf gynostemma (Gynostemma pentaphyllum) Zhongcaoyao 18 7 325 328
33. Guo WY & Wang WX (1993) Cultivation and utilisation of Gynostemma pentaphyllum. Publishing House of Electronics, Science and Technology University, pp. 1-261.
34. K Hostettmann A Marston 1995 Chemistry and Pharmacology of Natural Products: Saponins Cambridge University Press New York
35. MQ Han JX Liu H Gao 1995 Effects of 24 Chinese medicinal herbs on nucleic acid, protein and cell cycle of human lung adenocarcinoma cell Zhongguo Zhong Xi Yi Jie He Za Zhi 15 3 147 149
36. X Han H Wei Y Wang C Luo 1996 Inhibitory effects of gypenoside on rat heart and brain Na+, K+(-)ATPase activity Zhongguo Zhong Yao Za Zhi 21 299
37. J Hou S Liu Z Ma X Lang J Wang J Wang Z Liang 1991 Effects of Gynostemma pentaphyllum on the immunological function of cancer patients J. Traditional Chin. Med. 11 1 47 52
38. LH Hu ZL Chen YY Xie 1996 New triterpenoid saponins from Gynostemma pentaphyllum J. Nat. Prod. 59 12 1143 1145
39. LH Hu ZL Chen YY Xie 1997 Dammarane-type glycosides from Gynostemma pentaphyllum Phytochemistry 44 4 667 670
40. C Huang Z Wu Y Yao X Xu 2004 Photosynthetic characteristics of Gynostemma pentaphyllum under shade Ying Yong Sheng Tai Xue Bao 15 2099 2103
41. TH-W Huang V Razmovski-Naumovski NK Salam RK Duke VH Tran CC Duke BD Roufogalis 2005 A novel LXR-α activator identified from the natural product Gynostemma pentaphyllum Biochem. Pharmacol 70 9 1298 1308 (DOI:10.1016)
42. YJ Jang JK Kim MS Lee IH Ham WK Whang KH Kim HJ Kim 2001 Hypoglycemic and hypolipidemic effects of crude saponin fractions from Panax ginseng and Gynostemma pentaphyllum Yakhak Hoechi 45 5 545 556
43. Jian Su New Medical College 1986 The Dictionary of Chinese Medicine (Zhong Yao Da Ci Dian) Shanghai Science and Technology Press Shanghai, China
44. Jork H, Funk W, Fischer W & Wimmer H (1990) Thin-Layer Chromatography. Reagent and Detection Methods. Volume 1a. Physical and Chemical Detection Methods: Fundamentals, Reagents I. (pp. 412). VCH Verlagsgesellschaft mbH, Weinheim, Germany.
45. Juchi S (1986) Preparation of a tea-like beverage containing Gynostemma pentaphyllum saponins. Osaka Yakuhin Kenkyusho K. K. Patent-Japan Kokai Tokkyo Koho-61 104, 772.
46. M Karikura T Miyase H Tanizawa T Taniyama Y Takino 1991 Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats Chem. Pharmaceut. Bull. (Tokyo) 39 9 2357 2361
47. Y Kimura H Okuda S Arichi T Takemoto 1983 Effects of crude saponins of Gynostemma pentaphyllum on lipid metabolism Shoyakugaku Zasshi 37 272 275
48. M Kuwahara F Kawanishi T Komiya H Oshio 1989 Dammarane saponins of Gynostemma pentaphyllum Makino and isolation of malonylginsenosides-Rb1, -Rd, and malonylgypenoside V Chem. Pharmaceut. Bull. 37 1 135 139
49. B La Cour P Molgaard Z Yi 1995 Traditional Chinese medicine in treatment of hyperlipidaemia J. Ethnopharmacol. 46 2 125 129
50. FC Lee 1992 Facts about Ginseng, the elixir of life. Hollym Corporation Seoul, Korea 69 75
51. SZ Li 1985 Ben Chao Gangu Mu (Compendium of Materia Medica). vol. 2 (pp. 1326) People's Health Publisher Beijing, China 1326
52. L Li B Lau 1993 Protection of vascular endothelial cells from hydrogen peroxide-induced oxidant injury by gypenosides, saponins of Gynostemma pentaphyllum Phytother. Res. 7 4 299 304
53. L Li LP Jiao BHS Lau 1993 Protective effects of gypenosides against oxidative stress in phagocytes, vascular endothelial cells and liver microsomes Cancer Biother. 8 3 263 272
54. SX Liang HW Sun 2002 Determination of six nutritional elements in Chinese herbal medicines by graphite furnace atomic absorption spectrometry Guang Pu Xue Yu Guang Pu Fen Xi 22 5 847 849
55. CC Lin PC Huang JM Lin 2000 Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum Am. J. Chin. Med. 28 1 87 96
56. JM Lin CC Lin HF Chiu JJ Yang SG Lee 1993 Evaluation of the anti-inflammatory and liver-protective effects of Anoectochilus formosanus, Ganoderma lucidum and Gynostemma pentaphyllum in rats Am. J. Chin. Med. 21 1 59 69
57. JD Liu S Wang HT Lau LP Yang GZ Nang 1994 Effects of saponins from Chinese medicinal herbs on immune functions of lymphocytes in the elderly Chin. J. Pharmacol. (Zhongguo Yaoxue Zazhi) 29 12 717 721
58. X Liu WC Ye HWW Hsaio CT Che SX Zhao 2003 Studies on chemical constituents of Gynostemma pentaphyllum Zhongguo Yaoke Daxue Xuebao 34 21 24
59. X Liu W Ye Z Mo B Yu S Zhao H Wu C Che R Jiang TCW Mak WLW Hsaio 2004 Five new ocotillone-type saponins from Gynostemma pentaphyllum J. Nat. Prod. 67 1147 1151
60. YP Liu LL Gao ZM Fan ZW Guan 1996 Studies on dissolution and stability of micropills of total glycosides of Gynostemma pentaphylla Chin. J. Pharmaceut. Zhonogguo Yiyao Gongye Zazhi 27 8 349 352
61. G Liu D Guo R Zhong Z Yao H Wen W He W Hu 1997 Determination on the glycosyl sequence of gypenoside A by TLC-FABMS Zhong Yao Cai 20 8 398 400
62. YC Ma J Zhu L Benkrima M Luo LH Sun S Sain K Kont YJ Plaut-Carcasson 1995 A comparative evaluation of ginsenosides in commercial ginseng products and tissue culture samples using HPLC J. Herbs, Spices, Med. Plants 3 4 41 50
63. 2- and OH Zhong Yao Cai 22 6 303 306
64. M Mackay JX Wei YG Chen 1991 Structure of a new dammarane-type triterpene from Gynostemma pentaphyllum (Thurb.) Makino Acta Crystallogr. Sec. C: Crystal Struct. Commun. C47 790 793
65. A Marino GM Elbert A Cataldo 1989 Sterols from Gynostemma pentaphyllum Bolletino della Societa Italiana di Biologia Sperimentale 65 4 317 319
66. S Megalli BD Roufogalis 2005 Cholesterol lowering for healthy hearts: a herbal approach Aust. J. Pharm. 86 326 330
67. S Megalli F Aktan NM Davies BD Roufogalis 2005 Phytopreventative anti-hyperlipidemic effects of Gynostemma pentaphyllum in rats J. Pharm. Pharmaceut. Sci. 8 3 507 515
68. YY Mo SQ Luo JP Dong Y Yang 1997 The new progress of the anti-cancer function researches of Gynostemma pentaphyllum Northwestern J. Pharmacol. (Xi Bei Yao Xue Za Zhi) 12 4 177 178
69. M Nagai K Izawa S Nagumo N Sakurai T Inoue 1981 Two glycosides of a novel dammarane alcohol from Gynostemma pentaphyllum Chem. Pharmaceut. Bull. 29 779 783
70. Nippon Shoji Co., Ltd. (1983) Gypenosides. Jpn. Kokai Tokkyo Koho, JKXXAF JP 58208300 A2 19831203 Showa. JP 82-91793 19820528. CAN 14: 206696 AN 1984: 206696, Japan.
71. Nippon Shoji Co., Ltd. (1985) Gypenosides. Patent-Japan Kokai Tokkyo Koho-58, 208, 34: 10 pp. Chemical Abstract 14: 206696y.
72. Nippon Shoji Co., Ltd and Takemoto T (1983) Saponins from Gynostemma pentaphyllum Jpn. Kokai Tokkyo Koho, JKXXAF JP 58057398 A2 19830405 Showa. CAN 99:76853 AN 1983: 476853.
73. A Norberg NK Hoa E Liepinsh D Van Phan ND Thuan H Jornvall R Sillard CG Ostenson 2004 A novel insulin-releasing substance, phanoside, from the plant Gynostemma pentaphyllum J. Biol. Chem. 279 40 41361 41367
74. Osaka Yakuhin Kenkyusho KK (1985a) Saponins from Gynostemma pentaphyllum as health food supplements. Patent-Japan Kokai Tokkyo Koho-60 43, 358.
75. Osaka Yakuhin Kenkyusho KK (1985b) Rice vinegar containing saponins as health food supplement. Patent-Japan Kokai Tokkyo Koho-60 37, 960.
76. Oshio H, Kuwahara M & Komiya T (1987) Ginsenoside - Rd. Takeda Chemical Industries Ltd. Patent-Brit UK Pat-2, 179, 042.
77. S Piacente C Pizza N De Tommasi F De Simone 1995 New dammarane-type glycosides from Gynostemma pentaphyllum J. Nat. Prod. 58 4 512 519
78. J Purmova L Opletal 1995 Phytotherapeutic aspects of diseases of the cardiovascular system. 5. Saponins and possibilities of their use in prevention and therapy Ceska Slov Farm. 44 5 246 251
79. XW Qian 2001 Repairing function of Gynostemma pentaphyllum on damaged DNA induced by potassium aluminium sulfate or cyclophosphamide Zhongguo Gonggong Weisheng 17 11 1009 1010
80. Z Qin L Zhao S Bi L You 1992 Saponin constituents and resource of Gynostemma pentaphyllum Tianran Chanwu Yanjiu Yu Kaifa 4 1 83 98
81. G Qi L Zhang C Li 1996 Influence of gypenoside on serum lipoprotein and atherosclerosis in hyperlipidemia animals Zhongguo Zhongyao Zazhi 21 562 564
82. G Qi L Zhang WL Xie XY Chen JS Li 2000 Protective effect of gypenosides on DNA and RNA of rat neurons in cerebral ischemia-reperfusion injury Acta Pharmacol. Sin. 21 12 1193 1196
83. H Qian S Fu G Jiang L Wang X Fu M Ye S Zhao 1995 Protective effect of Jiaogulan on cellular immunity of the patients with primary lung cancer treated by radiotherapy plus chemotherapy Acta Acad. Med. Shanghai 22 5 363 366
84. Razmovski-Naumovski V, Li GQ & Duke CC (2005a) Gynostemma pentaphyllum and its cultivation in Sydney, Australia. J. Appl. Hort. (in press).
85. V Razmovski-Naumovski RK Duke P Turner CC Duke 2005b (20S), 2α, 3β, 12β- Trihydroxydammar-24-ene 20-O-β-d-glucopyranoside (Gynosaponin TN1) as the 2,5-methanol solvate Acta Crystallogr. Sec. E 61 5 o1239 o1241
86. C Rujjanawate D Kanjanapothi D Amornlerdpison 2004 The anti-gastric ulcer effect of Gynostemma pentaphyllum Makino Phytomedicine 11 5 431 435
87. Scifinder Scholar, Version 2004 copyright© 2003 American Chemical Society.
88. CZ Song 1996 Practical Chinese Herbal Preparations Handbook People's Army Medical Press Beijing, China
89. J Takagi T Imada T Kikuchi Y Saito Y Inada 1985 A new platelet aggregation factor from Gynostemma pentaphyllum Makino Chem. Pharmaceut. Bull. 33 12 5568 5571
90. Takemoto T & Nippon Shoji Co., Ltd (1984a) Gynosaponin E extraction from Gynostemma pentaphyllum. Jpn. Kokai Tokkyo Koho, JKXXAF JP 59080698 A2 19840510 Showa. JP 83-170424 19830914, CAN 101: 235568, AN 1984: 635568.
91. Takemoto T & Nippon Shoji Co., Ltd (1984b) Gynosaponins G, K, and progynosaponin A2 extraction from Gynostemma pentaphyllum. Japan Kokai Tokkyo Koho, JKXXAF JP 59080697 A2 19840510 Showa. JP 83-170423 19830914, CAN 101: 216398, AN 1984: 616398.
92. Takemoto T & Nippon Shoji Co., Ltd (1984c) Gynosaponins extraction from Gynostemma pentaphyllum. Japan Kokai Tokkyo Koho, JKXXAF JP 59080696 A2 19840510 Showa. JP 83-170422 19830914, CAN 101: 216399, AN 1984: 616399.
93. Takemoto T & Nippon Shoji Co., Ltd (1984d) Gynosaponins M, N, and O extraction from Gynostemma pentaphyllum. Japan Kokai Tokkyo Koho JKXXAF JP 59080699 A2 19840510 Showa. JP 83-170425 19830914, CAN 101: 235567, AN 1984: 635567.
94. Takemoto T, Arichi S, Arihara S, Nakajima T, Okuhira M & Uchida Y (1981) Gynosaponins and drug preparations containing these compounds. Ger. Offen. DE 80-3042117 19801107. CAN 96: 24789. AN 1982: 24789.
95. Takemoto T, Arichi S, Arihara S, Nakajima T, Okuhira M & Yoshihiro U (1982) Gynosaponins, their use and a process for preparing the same. Patent 4339422, SN: 205377, INTL: A01N 031/00, US: 424/182.
96. T Takemoto S Arihara T Nakajima M Okuhira 1983a Studies on the constituents of Gynostemma pentaphyllum MAKINO. I. Structures of Gypenoside I-XIV Yakugaku Zasshi 103 2 173 185
97. T Takemoto S Arihara T Nakajima M Okuhira 1983b Studies on the constituents of Gynostemma pentaphyllum MAKINO. II. Structures of Gypenoside XV-XXI Yakugaku Zasshi 103 10 1015 1023
98. Takemoto T & Odashima T (1983) Antitumor saponins from Gynostemma pentaphyllum. Rhoto Pharmaceuticals Ltd. Japan Kokai Tokkyo Koho, JKXXAF JP 58059921 A2 19830409 Showa. JP 81-157925 19811002. CAN 99: 47915 AN 1983: 447915.
99. T Takemoto S Arihara K Yoshikawa T Nakajima M Okuhira 1984a Studies on the constituents of Cucurbitaceae Plants. VIII. On the saponin constituents of Gynostemma pentaphyllum MAKINO.(4) Yakugaku Zasshi 104 4 332 339
100. T Takemoto S Arihara K Yoshikawa T Nakajima M Okuhira 1984b Studies on the constituents of Cucurbitaceae plants. IX. On the saponin constituents of Gynostemma pentaphyllum MAKINO.(5) Yakugaku Zasshi 104 724 730
101. T Takemoto S Arihara K Yoshikawa T Nakajima M Okuhira 1984c Studies on the constituents of Cucurbitaceae plants. VII. On the saponin constituents of Gynostemma pentaphyllum MAKINO. (3) Yakugaku Zasshi 104 4 325 331
102. T Takemoto S Arihara K Yoshikawa T Nakajima M Okuhira 1984d Studies on the constituents of Cucurbitaceae plants. X. On the saponin constituents of Gynostemma pentaphyllum MAKINO. (6) Yakugaku Zasshi 104 9 939 945
103. T Takemoto S Arihara K Yoshikawa J Kawasaki T Nakajima M Okuhira 1984e Studies on the constituents of Cucurbitaceae plants. XI. On the saponin constituents of Gynostemma pentaphyllum MAKINO. (7) Yakugaku Zasshi 104 10 1043 1049
104. T Takemoto S Arihara K Yoshikawa K Hino T Nakajima M Okuhira 1984f Studies on the constituents of Cucurbitaceae plants. XII. On the saponin constituents of Gynostemma pentaphyllum MAKINO. (8) Yakugaku Zasshi 104 1115 1162
105. T Takemoto S Arihara K Yoshikawa 1986b Studies on the constituents of Cucurbitaceae plants. XIV. On the saponin constituents of Gynostemma pentaphyllum Makino Yakugaku Zasshi 106 8 664 670
106. Takemoto T, Hayashi S & Nishimoto K (1986a) Gypenoside-containing extracts of Gynostemma pentaphyllum for the control of underarm odour. Patent-Japan Kokai Tokkyo Koho-61 76, 412: 10 pp. Chemical Abstract 105: 30100m (Rohto Pharmaceutical Co., Ltd.).
107. H Tan ZL Liu MJ Liu 1993 Antithrombotic effect of Gynostemma pentaphyllum Chung-Kuo Chung His i Chieh Ho Tsa Chih (Chin. J. Integr. Traditional Western Med.) 13 5 278 280
108. MA Tanner X Bu JA Steimle PR Myers 1999 The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum Nitric Oxide 3 5 359 365
109. BQ Wang 1994 Research on the Quality of Chinese Preparative Medicines and Reference Substances China Medical and Phamaceutical Science and Technology Press Beijing, China
110. C Wang X Wang Y Li S Deng Y Jiang L Yue 1995 A preliminary observation of the preventative and blocking effect of Gynostemma pentaphyllum (Thunb) Makino on esophageal cancer in rats Hua-Hsi i Ko Ta Hsueh Hsueh Pao (J. West China Univ. Med. Sci.) 26 4 430 432
111. J Wang X Li 1997 Leaves and stems of Panax quinquefolium L. (I) Isolation and identification of eleven triterpenoid saponins Zhongguo Yaowu Huaxue Zazhi 7 2 130 132
112. J Wang Z Lu J Chi W Wang M Su W Kou P Yu J Yu L Chen JS Zhu J Chang 1997b Multicenter clinical trial of the serum lipid-lowering effects of a Monascus purpureus (red yeast) rice preparation from traditional Chinese medicine Curr. Ther. Res. 58 12 964 978
113. M Wang Y Wu T Chen 1997a Extract of gynosaponin by column chromatography Guizhou Gongye Daxue Xuebao 26 3 60 63
114. QG Wang SL Hu LY He CE Jiang YN Lei YS Lin 1997c Inhibitory effect of Gynostemma pentaphyllum against ischemia reperfusion damage of hippocampal structure in rat Zhongguo Bingli Shengli Zazhi 13 5 513 516
115. YQ Wang 1988 Antitumor effect of gypenoside Zhong Xi Yi Jie He Za Zhi 8 286 262
116. QF Wang JC Chen SJ Hsieh CC Cheng SL Hsu 2002 Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells Cancer Lett. 183 2 169 178
117. WX Wang Y Yang M Deng W Ke MQ Ding WP Dai 1996 Effect of ecological factor on the total gynosaponin content of Gynostemma pentaphyllum (Thunb.) Makino J. Chin. Traditional Herbal Drugs 27 9 559 561
118. YG Wang RR Bai 1994 Effects of gypenosides (GP) on mutagenesis induced by cyclophosphamide (CP) in mice. Zhongguo Yaolixue Tongbao 10 6 457 459
119. ZY Wang P Qui 1992 Protective effect of gypenosides on acute incomplete cerebral ischemia in rabbits Zhongguo Yaolixue Yu Dulixue Zazhi 6 3 204 206
120. QY Wang QS Guo JY Sun SD Zhang YH Li 2004 Studies on sex identification and variation of endogenous hormones in female and male plants of Gynostemma pentaphyllum Zhongguo Zhong Yao Za Zhi 29 9 837 840
121. J Wei Y Chen S Cao 1992 Saponins in the fruit pedicels of Panax notoginseng (Burk.) Zhongguo Zhongyao Zazhi 17 10 611 613
122. J Wu P Qui J Liu Q Mu D Xin 1990 Effects of gypenosides on platelet aggregation release and cAMP level in rabbits Zhongguo Yaolixue Yu Dulixue Zazhi 4 1 54 57
123. QJ Wu 1957 Zi Wu Ming Shi Tu Kau (Textual Investigation of Herbal Plants) 2 Shang Wu Publishing House China 559
124. YG Wu 1998 Dictionary of Chinese Materia Medica, Vol. 2, 1st ed. Shanghai Science and Technological Publishing House Shanghai, China 1088
125. PS Xie YZ Yan 1987 HPTLC fingerprint identification of commercial ginseng drugs-reinvestigation of HPTLC of ginsenosides J. High Resolu. Chromatogr. Chromatogr. Commun. 10 11 607 613
126. S Xu H Xiang J Zhou 1994 Pharmacological effect of gypenosides J. Sun Yatsen Univ. 6 Suppl. 64 68
127. Xu S, Yao L & Wang Y (1994a) Prepararation of Gulanpenisong capsules and tablets containing Gynostemma pentaphyllum saponin and prednisone. Ankang Medicinal Plant Development Institute. Patent-Faming Zhuanli Shenqing Gongkai Shuomingshu-1,088,783.
128. Xu S, Yao L & Wang Y (1994b) Pharmaceutical tablets containing dexamethasone and Gynostemma pentaphyllum saponins. Patent-Faming Zhuanli Shenqing Gongkai Shuomingshu-1,089,139.
129. Xu SM & Wang YQ (1999) Testing of the stability of Gynostemma gypenosides extract capsules. Ankang Pharmaceutical Institution of Beijing Medical University (2 page report).
130. YP Yao GQ Liu HH Wen WD He SK Zhao WM Hu 1994 Determination of the glycosyl sequence of glycosides by enzymic hydrolysis followed by TLC-FABMS J. Chromatogr. - Modern TLC 7 5 410 412
131. F Yin L Hu R Pan 2004a Novel dammarane-type glycosides from Gynostemma pentaphyllum Chem. Pharmaceut. Bull. 52 12 1440 1444
132. F Yin L Hu F Lou R Pan 2004b Dammarane-type glycosides from Gynostemma pentaphyllum J. Nat. Prod. 67 6 942 952
133. K Yoshikawa T Takemoto S Arihara 1986 Studies on the constituents of Cucurbitaceae Plants. XV. On the saponin constituents of Gynostemma pentaphyllum MAKINO. (10) Yakugaku Zasshi 106 9 758 763
134. K Yoshikawa M Mitake T Takemoto S Arihara 1987a Studies on the constituents of Cucurbitaceae Plants. XVII. On the saponin constituents of Gynostemma pentaphyllum MAKINO. (12) Yakugaku Zasshi 107 355 360
135. K Yoshikawa T Takemoto S Arihara 1987b Studies on the constituents of Cucurbitaceae plants. XVI. On the saponin constituents of Gynostemma pentaphyllum Makino. (II) Yakugaku Zasshi 107 4 262 267
136. K Yoshikawa M Arimitsu K Kuki T Takemoto S Arihara 1987c Studies on the constituents of Cucurbitaceae plants. XVIII. On the saponin constituents of Gynostemma pentaphyllum MAKINO. (13) Yakugaku Zasshi 107 5 361 366
137. K Yoshikawa S Arihara K Matsuura T Miyase 1991 Dammarane saponins from Gymnema sylvestre Phytochemistry 31 1 237 241
138. M Yoshikawa T Murakami T Ueno K Yashiro N Hirokawa N Murakami J Yamahara H Matsuda R Saijoh O Tanaka 1997 Bioactive saponins and glycosides. VIII. Notoginseng (1): New dammarane-type triterpene oligoglycosides, notoginsenosides-A, -B, -C, and -D, from the dried root of Panax notoginseng (Burk.) F. H. Chen Chem. Pharmaceut. Bull. 45 6 1039 1045
139. C Yu 1993 Therapeutic effect of tablet gypenosides on 32 patients with hyperlipaemia. Hu Dei Zhong Yi Za Zhi 15 3 21
140. C Zhang X Yang L Xu 1990 Immunomodulatory action of the total saponin of Gynostemma pentaphylla Zhong Xi Yi Jie He Za Zhi 10 2 69 70 96-98
141. ZH Zhang H Liu LH Zhao XZ Han 1989 Clonal propagation of Gynostemma pentaphyllum (Thumb.) Makino in test tubes Zhongguo Zhong Yao Za Zhi 14 335 336
142. H Zhang Q Wu D Liu 1995 Protoplast culture and plant regeneration from the suspension cells of Gynostemma pentaphyllum (Thumb) Mak Chin. J. Biotechnol. 11 207 211
143. L Zhang GL Wu XY Chen G Qi 2002 Protective effect of gypenosides on cerebral cortex and hippocampus in vascular dementia rat. Zhongcaoyao 33 4 330 331
144. QB Zhang JJ Ma ZX Chao ZB Lin 1999 Therapeutic role and its mechanism of gypenosides on delayed healing of experimental gastric ulcer induced by NCTC11637 strain HP in rats Chin. Pharmacol. Bull. 15 3 225 228
145. Z Zhang SJ Xie SP Huang Q Zhang 1993 Analysis of medicinal and nutritional components in Gynostemma pentaphyllum Shanxi Daxue Xuebao Ziran Kexueban 16 3 307 310
146. Zhao C, Chen H & Zou S (1994) Pharmaceutical granules containing Gynostemma pentaphyllum saponins for cardiovascular or cerebrovascular disease, Patent-Faming Zhuanli Shenqing Gongkai Shuomingshu 1, 089, 140.
147. Z Zhao L Xing Z Ma HI Ren 1995 Modified method for the extraction of total saponins from Gynostemma pentaphyllum Zhongcaoyao 26 11 580 581
148. J Zheng W He 2000 Separation and identification of 2α,3β, 12β,20(S)- tetrahydroxydammar-24-ene-3-O-β-sophoroside-20-O-β- rutinoside from saponins of Gynostemma pentaphyllum (Thumb.) Marko Guangdong Yaoxueyuan Xuebao 16 3 203 204
149. Z Zheng ZH Dong J She 1998 Modern Study of Traditional Chinese Medicine 4 Xue Yuan Press Beijing, China 3519
150. B Zhou X Cheng 1996 Assay of ginsenosides and elements in Gynostemma pentaphylla Mak Guangdong Weiliang Yuansu Kexue 3 3 58 59
151. H Zhou 1988 The saponin constituents and pharmacology of Gynostemma pentaphyllum Mak Yaoxue Tongbao 23 12 720 724
152. Z Zhou Y Wang Y Zhou 1996a The effect of Gynostemma pentaphyllum mak (GP) on carcinogenesis of the golden hamster cheek pouch induced by DMBA Zhonghua Kou Qiang Yi Xue Za Zhi 31 5 267 270
153. ZT Zhou SL Zhang WG Li ZG Jin 1996b Observation of the effectiveness of compound Gynostemma pentaphyllum Mak in golden hamster cheek pouch's premalignancy Shanghai Kou Qiang Yi Xue 5 2 74 76
154. Z Zhou Y Wang Y Zhou S Zhang 1998 Effect of Gynostemma pentaphyllum Mak on carcinomatous conversions of golden hamster cheek pouches induced by dimethylbenzanthracene: a histological study Chin. Med. J. 111 9 847 850
155. Z Zhou G Tang W Zhong 2000 Experimental study on the influence of Gynostemma pentaphyllam Mak upon point mutation of Ha-ras oncogene in blocking leukoplakia from canceration Zhonghua Kou Qiang Yi Xue Za Zhi 35 2 91 94
156. S Zhu C Fang S Zhu F Peng L Zhang C Fan 2001 Inhibitory effects of Gynostemma pentaphyllum on the UV induction of bacteriophage lambda in lysogenic Escherichia coli Curr. Microbiol. 43 4 299 301