Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor

ACS Chemical Biology

Volumn 11, Issue 8, 2016, Pages 2275-2284

  Yeh, Hsu Hua ^a   Ahuja, Manmeet ^b   Chiang, Yi Ming ^a,c   Oakley, C Elizabeth ^b   Moore, Shauna ^b   Yoon, Olivia ^b   Hajovsky, Heather ^b   Bok, Jin Woo ^d   Keller, Nancy P ^d   Wang, Clay C C ^a   Oakley, Berl R ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FELLUTAMIDE B; INPE PROTEIN; PROTEASOME; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; LIPOPEPTIDE;

ANTIFUNGAL RESISTANCE; ARTICLE; ASPERGILLUS NIDULANS; CONTROLLED STUDY; DATA MINING; DRUG PROTEIN BINDING; DRUG SYNTHESIS; FUNGAL GENE; FUNGAL GENETICS; FUNGAL GENOME; FUNGAL STRAIN; GENE CLUSTER; GENE DELETION; GENE TARGETING; HETEROLOGOUS EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; BIOSYNTHESIS; DRUG EFFECTS; ELECTROSPRAY MASS SPECTROMETRY; GENETICS; MULTIGENE FAMILY; PROTON NUCLEAR MAGNETIC RESONANCE;

ASPERGILLUS NIDULANS; ENZYME INHIBITORS; GENOME, FUNGAL; LIPOPEPTIDES; MULTIGENE FAMILY; PROMOTER REGIONS, GENETIC; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTON MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84983287438     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.6b00213     Document Type: Article

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