Quantifying biased signaling in GPCRs using BRET-based biosensors

Methods

Volumn 92, Issue , 2016, Pages 5-10

  Namkung, Yoon ^a   Radresa, Olivier ^a   Armando, Sylvain ^a   Devost, Dominic ^b   Beautrait, Alexandre ^c   Le Gouill, Christian ^c   Laporte, Stephane A ^a,b  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

Angiotensin II type 1 receptor; Biased signaling; BRET; G proteins; Operational model; Arrestin

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; AGTR1 PROTEIN, HUMAN; ANGIOTENSIN II; LIGAND;

AMINO ACID SEQUENCE; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; BIOSENSOR; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; HEK293 CELL LINE; HIGH THROUGHPUT SCREENING; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; DOSE RESPONSE; GENETIC PROCEDURES; HUMAN; METABOLISM; PHYSIOLOGY; PROCEDURES;

ANGIOTENSIN II; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER TECHNIQUES; BIOSENSING TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; LIGANDS; RECEPTOR, ANGIOTENSIN, TYPE 1; SIGNAL TRANSDUCTION;

EID: 84983142534     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2015.04.010     Document Type: Article

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