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Volumn 68, Issue 6, 2015, Pages 1023-1030

Is Hypospadias Associated with Prenatal Exposure to Endocrine Disruptors? A French Collaborative Controlled Study of a Cohort of 300 Consecutive Children Without Genetic Defect

(24)  Kalfa, Nicolas a   Paris, Françoise a,b   Philibert, Pascal a   Orsini, Mattea c   Broussous, Sylvie a   Fauconnet Servant, Nadège a   Audran, Françoise a   Gaspari, Laura a   Lehors, Hélène d   Haddad, Myriam d   Guys, Jean Michel d   Reynaud, Rachel d   Alessandrini, Pierre e   Merrot, Thierry e   Wagner, Kathy f   Kurzenne, Jean Yves g   Bastiani, Florence g   Bréaud, Jean g   Valla, Jean Stéphane g   Lacombe, Gérard Morisson h   more..


Author keywords

Birth defect; Disorder of sex determination; Endocrine disrupting chemicals; Environment; Hypospadias; Occupation; Pesticides

Indexed keywords

ADHESIVE AGENT; COSMETIC; DETERGENT; ENDOCRINE DISRUPTOR; PAINT; PESTICIDE; SOLVENT;

EID: 84983119862     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2015.05.008     Document Type: Article
Times cited : (101)

References (47)
  • 3
    • 82155166314 scopus 로고    scopus 로고
    • Polymorphisms of MAMLD1 gene in hypospadias
    • N. Kalfa, F. Cassorla, F. Audran, and et al. Polymorphisms of MAMLD1 gene in hypospadias J Pediatr Urol 7 2011 585 591
    • (2011) J Pediatr Urol , vol.7 , pp. 585-591
    • Kalfa, N.1    Cassorla, F.2    Audran, F.3
  • 4
    • 84859127320 scopus 로고    scopus 로고
    • Screening of MAMLD1 mutations in 70 children with 46,XY DSD: Identification and functional analysis of two new mutations
    • N. Kalfa, M. Fukami, P. Philibert, and et al. Screening of MAMLD1 mutations in 70 children with 46,XY DSD: identification and functional analysis of two new mutations PLoS One 7 2012 e32505
    • (2012) PLoS One , vol.7 , pp. e32505
    • Kalfa, N.1    Fukami, M.2    Philibert, P.3
  • 5
    • 84876972707 scopus 로고    scopus 로고
    • Minor hypospadias: The "tip of the iceberg" of the partial androgen insensitivity syndrome
    • N. Kalfa, P. Philibert, R. Werner, and et al. Minor hypospadias: the "tip of the iceberg" of the partial androgen insensitivity syndrome PLoS One 8 2013 e61824
    • (2013) PLoS One , vol.8 , pp. e61824
    • Kalfa, N.1    Philibert, P.2    Werner, R.3
  • 7
    • 84880944302 scopus 로고    scopus 로고
    • Trends in reproductive health in Israel: Implications for environmental health policy
    • T. Berman, H. Levine, R. Gamzu, and I. Grotto Trends in reproductive health in Israel: implications for environmental health policy Isr J Health Policy Res 1 2012 34
    • (2012) Isr J Health Policy Res , vol.1 , pp. 34
    • Berman, T.1    Levine, H.2    Gamzu, R.3    Grotto, I.4
  • 8
    • 62649116391 scopus 로고    scopus 로고
    • Prevalence of hypospadias in Danish boys: A longitudinal study, 1977-2005
    • Corrigendum. Eur Urol 2009;56:e41
    • L. Lund, M.C. Engebjerg, L. Pedersen, V. Ehrenstein, M. Nørgaard, and H.T. Sørensen Prevalence of hypospadias in Danish boys: a longitudinal study, 1977-2005 Eur Urol 55 2009 1022 1026 Corrigendum. Eur Urol 2009;56:e41
    • (2009) Eur Urol , vol.55 , pp. 1022-1026
    • Lund, L.1    Engebjerg, M.C.2    Pedersen, L.3    Ehrenstein, V.4    Nørgaard, M.5    Sørensen, H.T.6
  • 9
    • 64049113333 scopus 로고    scopus 로고
    • Hypospadias rates in New York state are not increasing
    • H. Fisch, S.M. Lambert, T.W. Hensle, and G. Hyun Hypospadias rates in New York state are not increasing J Urol 181 2009 2291 2294
    • (2009) J Urol , vol.181 , pp. 2291-2294
    • Fisch, H.1    Lambert, S.M.2    Hensle, T.W.3    Hyun, G.4
  • 10
    • 41749092093 scopus 로고    scopus 로고
    • Testicular dysgenesis syndrome: Mechanistic insights and potential new downstream effects
    • R.M. Sharpe, and N.E. Skakkebaek Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects Fertil Steril 89 2 Suppl 2008 e33 e38
    • (2008) Fertil Steril , vol.89 , Issue.2 , pp. e33-e38
    • Sharpe, R.M.1    Skakkebaek, N.E.2
  • 12
    • 33645215636 scopus 로고    scopus 로고
    • Reproductive dysgenesis in wildlife: A comparative view
    • T.M. Edwards, B.C. Moore, and L.J. Guillette Jr. Reproductive dysgenesis in wildlife: a comparative view Int J Androl 29 2006 109 121
    • (2006) Int J Androl , vol.29 , pp. 109-121
    • Edwards, T.M.1    Moore, B.C.2    Guillette, L.J.3
  • 13
    • 1842309752 scopus 로고    scopus 로고
    • Male reproductive health and environmental xenoestrogens
    • J. Toppari, J.C. Larsen, P. Christiansen, and et al. Male reproductive health and environmental xenoestrogens Environ Health Perspect 104 Suppl 4 1996 741 803
    • (1996) Environ Health Perspect , vol.104 , pp. 741-803
    • Toppari, J.1    Larsen, J.C.2    Christiansen, P.3
  • 14
    • 43149089371 scopus 로고    scopus 로고
    • Screening of 397 chemicals and development of a quantitative structure-activity relationship model for androgen receptor antagonism
    • A.M. Vinggaard, J. Niemela, E.B. Wedebye, and G.E. Jensen Screening of 397 chemicals and development of a quantitative structure-activity relationship model for androgen receptor antagonism Chem Res Toxicol 21 2008 813 823
    • (2008) Chem Res Toxicol , vol.21 , pp. 813-823
    • Vinggaard, A.M.1    Niemela, J.2    Wedebye, E.B.3    Jensen, G.E.4
  • 15
    • 1842434975 scopus 로고    scopus 로고
    • Environmental anti-androgens and male reproductive health: Focus on phthalates and testicular dysgenesis syndrome
    • J.S. Fisher Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome Reproduction 127 2004 305 315
    • (2004) Reproduction , vol.127 , pp. 305-315
    • Fisher, J.S.1
  • 16
    • 84861455815 scopus 로고    scopus 로고
    • High prevalence of micropenis in 2710 male newborns from an intensive-use pesticide area of Northeastern Brazil
    • L. Gaspari, D.R. Sampaio, F. Paris, and et al. High prevalence of micropenis in 2710 male newborns from an intensive-use pesticide area of Northeastern Brazil Int J Androl 35 2012 253 264
    • (2012) Int J Androl , vol.35 , pp. 253-264
    • Gaspari, L.1    Sampaio, D.R.2    Paris, F.3
  • 17
    • 80054886955 scopus 로고    scopus 로고
    • Prenatal environmental risk factors for genital malformations in a population of 1442 French male newborns: A nested case-control study
    • L. Gaspari, F. Paris, C. Jandel, and et al. Prenatal environmental risk factors for genital malformations in a population of 1442 French male newborns: a nested case-control study Hum Reprod 26 2011 3155 3162
    • (2011) Hum Reprod , vol.26 , pp. 3155-3162
    • Gaspari, L.1    Paris, F.2    Jandel, C.3
  • 18
    • 84879899370 scopus 로고    scopus 로고
    • Increased serum estrogenic bioactivity in girls with premature thelarche: A marker of environmental pollutant exposure?
    • F. Paris, L. Gaspari, N. Servant, P. Philibert, and C. Sultan Increased serum estrogenic bioactivity in girls with premature thelarche: a marker of environmental pollutant exposure? Gynecol Endocrinol 29 2013 788 792
    • (2013) Gynecol Endocrinol , vol.29 , pp. 788-792
    • Paris, F.1    Gaspari, L.2    Servant, N.3    Philibert, P.4    Sultan, C.5
  • 19
    • 80053555736 scopus 로고    scopus 로고
    • "idiopathic" partial androgen insensitivity syndrome in 28 newborn and infant males: Impact of prenatal exposure to environmental endocrine disruptor chemicals?
    • L. Gaspari, F. Paris, P. Philibert, and et al. "Idiopathic" partial androgen insensitivity syndrome in 28 newborn and infant males: impact of prenatal exposure to environmental endocrine disruptor chemicals? Eur J Endocrinol 165 2011 579 587
    • (2011) Eur J Endocrinol , vol.165 , pp. 579-587
    • Gaspari, L.1    Paris, F.2    Philibert, P.3
  • 20
    • 80051505707 scopus 로고    scopus 로고
    • Peripheral precocious puberty in a 4-month-old girl: Role of pesticides?
    • L. Gaspari, F. Paris, C. Jeandel, and C. Sultan Peripheral precocious puberty in a 4-month-old girl: role of pesticides? Gynecol Endocrinol 27 2011 721 724
    • (2011) Gynecol Endocrinol , vol.27 , pp. 721-724
    • Gaspari, L.1    Paris, F.2    Jeandel, C.3    Sultan, C.4
  • 21
    • 79959689357 scopus 로고    scopus 로고
    • Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: A multigenerational national cohort study
    • N. Kalfa, F. Paris, M.O. Soyer-Gobillard, J.P. Daures, and C. Sultan Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study Fertil Steril 95 2011 2574 2577
    • (2011) Fertil Steril , vol.95 , pp. 2574-2577
    • Kalfa, N.1    Paris, F.2    Soyer-Gobillard, M.O.3    Daures, J.P.4    Sultan, C.5
  • 22
    • 84859495274 scopus 로고    scopus 로고
    • Regional differences and temporal trends in male reproductive health disorders: Semen quality may be a sensitive marker of environmental exposures
    • L. Nordkap, U.N. Joensen, M. Blomberg Jensen, and N. Jorgensen Regional differences and temporal trends in male reproductive health disorders: semen quality may be a sensitive marker of environmental exposures Mol Cell Endocrinol 355 2012 221 230
    • (2012) Mol Cell Endocrinol , vol.355 , pp. 221-230
    • Nordkap, L.1    Joensen, U.N.2    Blomberg Jensen, M.3    Jorgensen, N.4
  • 23
    • 84869096282 scopus 로고    scopus 로고
    • Exploration of gene-environment interactions, maternal effects and parent of origin effects in the etiology of hypospadias
    • L.F. van der Zanden, T.E. Galesloot, W.F. Feitz, and et al. Exploration of gene-environment interactions, maternal effects and parent of origin effects in the etiology of hypospadias J Urol 188 2012 2354 2360
    • (2012) J Urol , vol.188 , pp. 2354-2360
    • Van Der Zanden, L.F.1    Galesloot, T.E.2    Feitz, W.F.3
  • 26
    • 77950814705 scopus 로고    scopus 로고
    • Maternal exposures to endocrine disrupting chemicals and hypospadias in offspring
    • F. Giordano, A. Abballe, E. De Felip, and et al. Maternal exposures to endocrine disrupting chemicals and hypospadias in offspring Birth Defects Res A Clin Mol Teratol 88 2010 241 250
    • (2010) Birth Defects Res A Clin Mol Teratol , vol.88 , pp. 241-250
    • Giordano, F.1    Abballe, A.2    De Felip, E.3
  • 27
    • 84887110376 scopus 로고    scopus 로고
    • Hypospadias and residential proximity to pesticide applications
    • S.L. Carmichael, W. Yang, E.M. Roberts, and et al. Hypospadias and residential proximity to pesticide applications Pediatrics 132 2013 e1216 e1226
    • (2013) Pediatrics , vol.132 , pp. e1216-e1226
    • Carmichael, S.L.1    Yang, W.2    Roberts, E.M.3
  • 28
    • 0032497162 scopus 로고    scopus 로고
    • Risk of congenital anomalies near hazardous-waste landfill sites in Europe: The EUROHAZCON study
    • H. Dolk, M. Vrijheid, B. Armstrong, and et al. Risk of congenital anomalies near hazardous-waste landfill sites in Europe: the EUROHAZCON study Lancet 352 1998 423 427
    • (1998) Lancet , vol.352 , pp. 423-427
    • Dolk, H.1    Vrijheid, M.2    Armstrong, B.3
  • 29
    • 33744515044 scopus 로고    scopus 로고
    • A study of risk factors for hypospadias in the Rhone-Alpes region (France)
    • A.M. Morera, A.F. Valmalle, M.J. Asensio, and et al. A study of risk factors for hypospadias in the Rhone-Alpes region (France) J Pediatr Urol 2 2006 169 177
    • (2006) J Pediatr Urol , vol.2 , pp. 169-177
    • Morera, A.M.1    Valmalle, A.F.2    Asensio, M.J.3
  • 30
    • 69949111679 scopus 로고    scopus 로고
    • Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspring
    • K.A. McGlynn, X. Guo, B.I. Graubard, J.W. Brock, M.A. Klebanoff, and M.P. Longnecker Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspring Environ Health Perspect 117 2009 1472 1476
    • (2009) Environ Health Perspect , vol.117 , pp. 1472-1476
    • McGlynn, K.A.1    Guo, X.2    Graubard, B.I.3    Brock, J.W.4    Klebanoff, M.A.5    Longnecker, M.P.6
  • 31
    • 77953807730 scopus 로고    scopus 로고
    • Hypospadias and halogenated organic pollutant levels in maternal mid-pregnancy serum samples
    • S.L. Carmichael, A.H. Herring, A. Sjodin, and et al. Hypospadias and halogenated organic pollutant levels in maternal mid-pregnancy serum samples Chemosphere 80 2010 641 646
    • (2010) Chemosphere , vol.80 , pp. 641-646
    • Carmichael, S.L.1    Herring, A.H.2    Sjodin, A.3
  • 33
    • 69949085069 scopus 로고    scopus 로고
    • Occupational exposure to potential endocrine disruptors: Further development of a job exposure matrix
    • M.M. Brouwers, M. Van Tongeren, A.A. Hirst, R.W. Bretveld, and N. Roeleveld Occupational exposure to potential endocrine disruptors: further development of a job exposure matrix Occup Environ Med 66 2010 607 614
    • (2010) Occup Environ Med , vol.66 , pp. 607-614
    • Brouwers, M.M.1    Van Tongeren, M.2    Hirst, A.A.3    Bretveld, R.W.4    Roeleveld, N.5
  • 34
    • 0036634681 scopus 로고    scopus 로고
    • A job-exposure matrix for potential endocrine-disrupting chemicals developed for a study into the association between maternal occupational exposure and hypospadias
    • M. Van Tongeren, M.J. Nieuwenhuijsen, K. Gardiner, and et al. A job-exposure matrix for potential endocrine-disrupting chemicals developed for a study into the association between maternal occupational exposure and hypospadias Ann Occup Hyg 46 2002 465 477
    • (2002) Ann Occup Hyg , vol.46 , pp. 465-477
    • Van Tongeren, M.1    Nieuwenhuijsen, M.J.2    Gardiner, K.3
  • 35
    • 79960706526 scopus 로고    scopus 로고
    • Phenotypic variation of SF1 gene mutations
    • P. Philibert, F. Paris, F. Audran, and et al. Phenotypic variation of SF1 gene mutations Adv Exp Med Biol 707 2011 67 72
    • (2011) Adv Exp Med Biol , vol.707 , pp. 67-72
    • Philibert, P.1    Paris, F.2    Audran, F.3
  • 36
    • 73149084642 scopus 로고    scopus 로고
    • Rising hypospadias rates: Disproving a myth
    • H. Fisch, G. Hyun, and T.W. Hensle Rising hypospadias rates: disproving a myth J Pediatr Urol 6 2010 37 39
    • (2010) J Pediatr Urol , vol.6 , pp. 37-39
    • Fisch, H.1    Hyun, G.2    Hensle, T.W.3
  • 37
    • 84866987609 scopus 로고    scopus 로고
    • Endocrine-disrupting chemicals: Associated disorders and mechanisms of action
    • S. De Coster, and N. van Larebeke Endocrine-disrupting chemicals: associated disorders and mechanisms of action J Environ Public Health 2012 2012 713696
    • (2012) J Environ Public Health , vol.2012 , pp. 713696
    • De Coster, S.1    Van Larebeke, N.2
  • 38
    • 67449132400 scopus 로고    scopus 로고
    • Endocrine-disrupting chemicals: An Endocrine Society scientific statement
    • E. Diamanti-Kandarakis, J.P. Bourguignon, L.C. Giudice, and et al. Endocrine-disrupting chemicals: an Endocrine Society scientific statement Endocrine Rev 30 2009 293 342
    • (2009) Endocrine Rev , vol.30 , pp. 293-342
    • Diamanti-Kandarakis, E.1    Bourguignon, J.P.2    Giudice, L.C.3
  • 39
    • 34548528825 scopus 로고    scopus 로고
    • Chapel Hill Bisphenol A Expert Panel Consensus Statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    • F.S. Vom Saal, B.T. Akingbemi, S.M. Belcher, and et al. Chapel Hill Bisphenol A Expert Panel Consensus Statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure Reprod Toxicol 24 2007 131 138
    • (2007) Reprod Toxicol , vol.24 , pp. 131-138
    • Vom Saal, F.S.1    Akingbemi, B.T.2    Belcher, S.M.3
  • 40
    • 40349094571 scopus 로고    scopus 로고
    • Low dose mixture effects of endocrine disrupters: Implications for risk assessment and epidemiology
    • A. Kortenkamp Low dose mixture effects of endocrine disrupters: implications for risk assessment and epidemiology Int J Androl 31 2008 233 240
    • (2008) Int J Androl , vol.31 , pp. 233-240
    • Kortenkamp, A.1
  • 41
    • 40349113152 scopus 로고    scopus 로고
    • Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat
    • S. Christiansen, M. Scholze, M. Axelstad, J. Boberg, A. Kortenkamp, and U. Hass Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat Int J Androl 31 2008 241 248
    • (2008) Int J Androl , vol.31 , pp. 241-248
    • Christiansen, S.1    Scholze, M.2    Axelstad, M.3    Boberg, J.4    Kortenkamp, A.5    Hass, U.6
  • 42
    • 33745771307 scopus 로고    scopus 로고
    • Persistent pesticides in human breast milk and cryptorchidism
    • I.N. Damgaard, N.E. Skakkebaek, J. Toppari, and et al. Persistent pesticides in human breast milk and cryptorchidism Environ Health Perspect 114 2006 1133 1138
    • (2006) Environ Health Perspect , vol.114 , pp. 1133-1138
    • Damgaard, I.N.1    Skakkebaek, N.E.2    Toppari, J.3
  • 43
    • 35448990905 scopus 로고    scopus 로고
    • Flame retardants in placenta and breast milk and cryptorchidism in newborn boys
    • K.M. Main, H. Kiviranta, H.E. Virtanen, and et al. Flame retardants in placenta and breast milk and cryptorchidism in newborn boys Environ Health Perspect 115 2007 1519 1526
    • (2007) Environ Health Perspect , vol.115 , pp. 1519-1526
    • Main, K.M.1    Kiviranta, H.2    Virtanen, H.E.3
  • 44
    • 23744469802 scopus 로고    scopus 로고
    • Decrease in anogenital distance among male infants with prenatal phthalate exposure
    • S.H. Swan, K.M. Main, F. Liu, and et al. Decrease in anogenital distance among male infants with prenatal phthalate exposure Environ Health Perspect. 113 Aug 2005 1056 1061
    • (2005) Environ Health Perspect. , vol.113 , pp. 1056-1061
    • Swan, S.H.1    Main, K.M.2    Liu, F.3
  • 45
    • 0347764770 scopus 로고    scopus 로고
    • Animal models for the study of the effects of mixtures, low doses, and the embryonic environment on the action of endocrine disrupting chemicals
    • D. Crews, O. Putz, P. Thomas, T. Hayes, and K. Howdeshell Animal models for the study of the effects of mixtures, low doses, and the embryonic environment on the action of endocrine disrupting chemicals Pure Appl Chem 75 2003 2305 2320
    • (2003) Pure Appl Chem , vol.75 , pp. 2305-2320
    • Crews, D.1    Putz, O.2    Thomas, P.3    Hayes, T.4    Howdeshell, K.5
  • 47
    • 0029278654 scopus 로고
    • Removal of embryo-toxic ammonium from the culture medium by in situ enzymatic conversion to glutamate
    • M. Lane, and D.K. Gardner Removal of embryo-toxic ammonium from the culture medium by in situ enzymatic conversion to glutamate J Exp Zool 271 1995 356 363
    • (1995) J Exp Zool , vol.271 , pp. 356-363
    • Lane, M.1    Gardner, D.K.2


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