메뉴 건너뛰기




Volumn 64, Issue 4, 2016, Pages 831-840

Immunomodulatory effects of mesenchymal stromal cells-derived exosome

Author keywords

Exosome; Immunomodulation; Mesenchymal stem cells; Peripheral blood mononuclear cells

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 1BETA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; CYTOKINE;

EID: 84983042904     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-016-8798-6     Document Type: Article
Times cited : (276)

References (41)
  • 1
    • 84922503485 scopus 로고    scopus 로고
    • Immunosuppressive capabilities of mesenchymal stromal cells are maintained under hypoxic growth conditions and after gamma irradiation
    • COI: 1:CAS:528:DC%2BC2cXhvFWgsLbJ, PID: 25453724
    • Nold P, et al. Immunosuppressive capabilities of mesenchymal stromal cells are maintained under hypoxic growth conditions and after gamma irradiation. Cytotherapy. 2015;17(2):152–62.
    • (2015) Cytotherapy , vol.17 , Issue.2 , pp. 152-162
    • Nold, P.1
  • 2
    • 84876086426 scopus 로고    scopus 로고
    • Human mesenchymal stem cells suppress donor CD4(+) T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease
    • COI: 1:CAS:528:DC%2BC3sXlvVels78%3D, PID: 23574329
    • Tobin LM, et al. Human mesenchymal stem cells suppress donor CD4(+) T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease. Clin Exp Immunol. 2013;172(2):333–48.
    • (2013) Clin Exp Immunol , vol.172 , Issue.2 , pp. 333-348
    • Tobin, L.M.1
  • 3
    • 84922568930 scopus 로고    scopus 로고
    • Standardization of good manufacturing practice–compliant production of bone marrow–derived human mesenchymal stromal cells for immunotherapeutic applications
    • COI: 1:CAS:528:DC%2BC2cXosFals7w%3D, PID: 24856898
    • Wuchter P, et al. Standardization of good manufacturing practice–compliant production of bone marrow–derived human mesenchymal stromal cells for immunotherapeutic applications. Cytotherapy. 2015;17(2):128–39.
    • (2015) Cytotherapy , vol.17 , Issue.2 , pp. 128-139
    • Wuchter, P.1
  • 4
    • 84897455739 scopus 로고    scopus 로고
    • Contribution of human adipose tissue-derived stem cells and the secretome to the skin allograft survival in mice
    • COI: 1:CAS:528:DC%2BC2cXivFCrt74%3D, PID: 24560349
    • Lee SM, Lee SC, Kim SJ. Contribution of human adipose tissue-derived stem cells and the secretome to the skin allograft survival in mice. J Surg Res. 2014;188(1):280–9.
    • (2014) J Surg Res , vol.188 , Issue.1 , pp. 280-289
    • Lee, S.M.1    Lee, S.C.2    Kim, S.J.3
  • 5
    • 84875971568 scopus 로고    scopus 로고
    • Mesenchymal stem cells and kidney repair
    • COI: 1:CAS:528:DC%2BC3sXlsV2qs7Y%3D, PID: 23258756
    • Morigi M, Benigni A. Mesenchymal stem cells and kidney repair. Nephrol Dial Transplant. 2013;28(4):788–93.
    • (2013) Nephrol Dial Transplant , vol.28 , Issue.4 , pp. 788-793
    • Morigi, M.1    Benigni, A.2
  • 6
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • COI: 1:CAS:528:DC%2BD2MXhsVGjt7Y%3D, PID: 15494428
    • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005;105(4):1815–22.
    • (2005) Blood , vol.105 , Issue.4 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 7
    • 33746898242 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells
    • COI: 1:CAS:528:DC%2BD28Xns1Kht7o%3D, PID: 16887966
    • Nauta AJ, et al. Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells. J Immunol. 2006;177(4):2080–7.
    • (2006) J Immunol , vol.177 , Issue.4 , pp. 2080-2087
    • Nauta, A.J.1
  • 8
    • 84929503110 scopus 로고    scopus 로고
    • Assessment of anti-donor T cell proliferation and cytotoxic T lymphocyte-mediated lympholysis in living donor kidney transplant patients
    • COI: 1:CAS:528:DC%2BC2MXotlOntb4%3D, PID: 25173397
    • Rakha A, Todeschini M, Casiraghi F. Assessment of anti-donor T cell proliferation and cytotoxic T lymphocyte-mediated lympholysis in living donor kidney transplant patients. Methods Mol Biol. 2014;1213:355–64.
    • (2014) Methods Mol Biol , vol.1213 , pp. 355-364
    • Rakha, A.1    Todeschini, M.2    Casiraghi, F.3
  • 9
    • 50849088328 scopus 로고    scopus 로고
    • The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes
    • COI: 1:CAS:528:DC%2BD1cXhtl2gtbfE, PID: 18641017
    • Tabera S, et al. The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes. Haematologica. 2008;93(9):1301–9.
    • (2008) Haematologica , vol.93 , Issue.9 , pp. 1301-1309
    • Tabera, S.1
  • 10
    • 84925654860 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy in proteoglycan induced arthritis
    • COI: 1:CAS:528:DC%2BC2MXmsFygurY%3D, PID: 24395558
    • Swart J, et al. Mesenchymal stem cell therapy in proteoglycan induced arthritis. Ann Rheum Dis. 2015;74(4):769–77.
    • (2015) Ann Rheum Dis , vol.74 , Issue.4 , pp. 769-777
    • Swart, J.1
  • 11
    • 84904966024 scopus 로고    scopus 로고
    • Safety and feasibility of umbilical cord mesenchymal stem cells in treatment-refractory systemic lupus erythematosus nephritis: time for a double-blind placebo-controlled trial to determine efficacy
    • PID: 25166210
    • Woodworth TG, Furst DE. Safety and feasibility of umbilical cord mesenchymal stem cells in treatment-refractory systemic lupus erythematosus nephritis: time for a double-blind placebo-controlled trial to determine efficacy. Arthritis Res Ther. 2014;16(4):113.
    • (2014) Arthritis Res Ther , vol.16 , Issue.4 , pp. 113
    • Woodworth, T.G.1    Furst, D.E.2
  • 12
    • 84886675301 scopus 로고    scopus 로고
    • Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells for severe aplastic anemia: successful engraftment and mild GVHD
    • COI: 1:CAS:528:DC%2BC2cXltVWntw%3D%3D, PID: 24185180
    • Wu Y, et al. Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells for severe aplastic anemia: successful engraftment and mild GVHD. Stem Cell Res. 2014;12(1):132–8.
    • (2014) Stem Cell Res , vol.12 , Issue.1 , pp. 132-138
    • Wu, Y.1
  • 13
    • 84934434339 scopus 로고    scopus 로고
    • Mesenchymal stromal cells derived from Crohn’s patients deploy indoleamine 2, 3-dioxygenase-mediated immune suppression, independent of autophagy
    • COI: 1:CAS:528:DC%2BC2MXht1ygsb3I, PID: 25899824
    • Chinnadurai R, et al. Mesenchymal stromal cells derived from Crohn’s patients deploy indoleamine 2, 3-dioxygenase-mediated immune suppression, independent of autophagy. Mol Ther. 2015;23(7):1248–61.
    • (2015) Mol Ther , vol.23 , Issue.7 , pp. 1248-1261
    • Chinnadurai, R.1
  • 14
    • 84930448863 scopus 로고    scopus 로고
    • Human graft-derived mesenchymal stromal cells potently suppress alloreactive T-cell responses
    • PID: 25744002
    • de Mare-Bredemeijer EL, et al. Human graft-derived mesenchymal stromal cells potently suppress alloreactive T-cell responses. Stem Cells Dev. 2015;24(12):1436–47.
    • (2015) Stem Cells Dev , vol.24 , Issue.12 , pp. 1436-1447
    • de Mare-Bredemeijer, E.L.1
  • 15
    • 84928713603 scopus 로고    scopus 로고
    • Effect of human bone marrow mesenchymal stromal cells on cytokine production by peripheral blood naive, memory, and effector T cells
    • PID: 25559824
    • Laranjeira P, et al. Effect of human bone marrow mesenchymal stromal cells on cytokine production by peripheral blood naive, memory, and effector T cells. Stem Cell Res Ther. 2015;6(1):3.
    • (2015) Stem Cell Res Ther , vol.6 , Issue.1 , pp. 3
    • Laranjeira, P.1
  • 16
    • 84930376817 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stromal cells induce proliferative, cytokinic and molecular changes during the t cell response: the importance of the IL-10/CD210 axis
    • COI: 1:CAS:528:DC%2BC2cXhvVGisL3I
    • Najar M, et al. Bone marrow mesenchymal stromal cells induce proliferative, cytokinic and molecular changes during the t cell response: the importance of the IL-10/CD210 axis. Stem Cell Rev Rep. 2015;11(3):442–52.
    • (2015) Stem Cell Rev Rep , vol.11 , Issue.3 , pp. 442-452
    • Najar, M.1
  • 17
    • 84939893615 scopus 로고    scopus 로고
    • A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles
    • Akyurekli C, et al. A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles. Stem Cell Reviews and Reports. 2014;11(1):150–60.
    • (2014) Stem Cell Reviews and Reports , vol.11 , Issue.1 , pp. 150-160
    • Akyurekli, C.1
  • 18
    • 84896818399 scopus 로고    scopus 로고
    • Regulation of immune responses by extracellular vesicles
    • COI: 1:CAS:528:DC%2BC2cXivFyhtbg%3D, PID: 24566916
    • Robbins PD, Morelli AE. Regulation of immune responses by extracellular vesicles. Nat Rev Immunol. 2014;14(3):195–208.
    • (2014) Nat Rev Immunol , vol.14 , Issue.3 , pp. 195-208
    • Robbins, P.D.1    Morelli, A.E.2
  • 19
    • 84927558911 scopus 로고    scopus 로고
    • Camussi G. Exploring mesenchymal stem cell-derived extracellular vesicles in acute kidney injury. In: Animal models for stem cell therapy
    • Bruno S, Camussi G. Exploring mesenchymal stem cell-derived extracellular vesicles in acute kidney injury. In: Animal models for stem cell therapy. Springer; 2014. p. 139–45.
    • Springer , vol.2014 , pp. 139-145
    • Bruno, S.1
  • 20
    • 84929574438 scopus 로고    scopus 로고
    • Extracellular vesicles secreted by bone marrow-and adipose tissue-derived mesenchymal stromal cells fail to suppress lymphocyte proliferation
    • COI: 1:CAS:528:DC%2BC2MXos1Ojt70%3D, PID: 25779336
    • Gouveia de Andrade AV, et al. Extracellular vesicles secreted by bone marrow-and adipose tissue-derived mesenchymal stromal cells fail to suppress lymphocyte proliferation. Stem Cells Dev. 2015;24(11):1374–6.
    • (2015) Stem Cells Dev , vol.24 , Issue.11 , pp. 1374-1376
    • Gouveia de Andrade, A.V.1
  • 21
    • 84878665716 scopus 로고    scopus 로고
    • The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
    • COI: 1:CAS:528:DC%2BC3sXivFymtbo%3D, PID: 23335344
    • Katsuda T, et al. The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Proteomics. 2013;13(10–11):1637–53.
    • (2013) Proteomics , vol.13 , Issue.10-11 , pp. 1637-1653
    • Katsuda, T.1
  • 22
    • 84898039042 scopus 로고    scopus 로고
    • MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease
    • COI: 1:CAS:528:DC%2BC2cXmtFWiurY%3D, PID: 24445866
    • Kordelas L, et al. MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease. Leukemia. 2014;28(4):970.
    • (2014) Leukemia , vol.28 , Issue.4 , pp. 970
    • Kordelas, L.1
  • 23
    • 84949749008 scopus 로고    scopus 로고
    • Immunoregulatory effects of mesenchymal stem cell-derived extracellular vesicles on T lymphocytes
    • PID: 25695896
    • Del Fattore A, et al. Immunoregulatory effects of mesenchymal stem cell-derived extracellular vesicles on T lymphocytes. Cell Transplant. 2015;24(12):2615–27.
    • (2015) Cell Transplant , vol.24 , Issue.12 , pp. 2615-2627
    • Del Fattore, A.1
  • 24
    • 22044446912 scopus 로고    scopus 로고
    • Exosomal-like vesicles are present in human blood plasma
    • COI: 1:CAS:528:DC%2BD2MXmt1eku78%3D, PID: 15908444
    • Caby MP, et al. Exosomal-like vesicles are present in human blood plasma. Int Immunol. 2005;17(7):879–87.
    • (2005) Int Immunol , vol.17 , Issue.7 , pp. 879-887
    • Caby, M.P.1
  • 25
    • 84874283661 scopus 로고    scopus 로고
    • Comparative immunomodulatory properties of adipose-derived mesenchymal stem cells conditioned media from BALB/c, C57BL/6, and DBA mouse strains
    • COI: 1:CAS:528:DC%2BC3sXislSgsLw%3D, PID: 23225199
    • Hashemi SM, et al. Comparative immunomodulatory properties of adipose-derived mesenchymal stem cells conditioned media from BALB/c, C57BL/6, and DBA mouse strains. J Cell Biochem. 2013;114(4):955–65.
    • (2013) J Cell Biochem , vol.114 , Issue.4 , pp. 955-965
    • Hashemi, S.M.1
  • 26
    • 84929353372 scopus 로고    scopus 로고
    • Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications
    • PID: 25961059
    • Castro-Manrreza ME, Montesinos JJ. Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications. J Immunol Res. 2015;2015:394917.
    • (2015) J Immunol Res , vol.2015 , pp. 394917
    • Castro-Manrreza, M.E.1    Montesinos, J.J.2
  • 27
    • 84919782445 scopus 로고    scopus 로고
    • Inhibition of B-cell proliferation and antibody production by mesenchymal stromal cells is mediated by T cells
    • COI: 1:CAS:528:DC%2BC2cXitFaltLvI, PID: 25036865
    • Rosado MM, et al. Inhibition of B-cell proliferation and antibody production by mesenchymal stromal cells is mediated by T cells. Stem Cells Dev. 2015;24(1):93–103.
    • (2015) Stem Cells Dev , vol.24 , Issue.1 , pp. 93-103
    • Rosado, M.M.1
  • 28
    • 34447298069 scopus 로고    scopus 로고
    • Interferon-γ does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BD2sXhtVShs73K, PID: 17521318
    • Ryan J, et al. Interferon-γ does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells. Clin Exp Immunol. 2007;149(2):353–63.
    • (2007) Clin Exp Immunol , vol.149 , Issue.2 , pp. 353-363
    • Ryan, J.1
  • 29
    • 84883212311 scopus 로고    scopus 로고
    • Mesenchymal stromal cells augment CD4+ and CD8+ T-cell proliferation through a CCL2 pathway
    • COI: 1:CAS:528:DC%2BC3sXhs1Whs7%2FK, PID: 23845188
    • Zhou Y, et al. Mesenchymal stromal cells augment CD4+ and CD8+ T-cell proliferation through a CCL2 pathway. Cytotherapy. 2013;15(10):1195–207.
    • (2013) Cytotherapy , vol.15 , Issue.10 , pp. 1195-1207
    • Zhou, Y.1
  • 30
    • 84893577574 scopus 로고    scopus 로고
    • Human mesenchymal stromal cells modulate T-cell responses through TNF-alpha-mediated activation of NF-kappaB
    • COI: 1:CAS:528:DC%2BC3sXhvVOhtr3P, PID: 24307058
    • Dorronsoro A, et al. Human mesenchymal stromal cells modulate T-cell responses through TNF-alpha-mediated activation of NF-kappaB. Eur J Immunol. 2014;44(2):480–8.
    • (2014) Eur J Immunol , vol.44 , Issue.2 , pp. 480-488
    • Dorronsoro, A.1
  • 31
    • 84942038168 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells and their conditioned medium attenuate fibrosis in an irreversible model of unilateral ureteral obstruction
    • PID: 25695732
    • Silva A, et al. Bone marrow-derived mesenchymal stem cells and their conditioned medium attenuate fibrosis in an irreversible model of unilateral ureteral obstruction. Cell Transplant. 2015;24(12):2657–66.
    • (2015) Cell Transplant , vol.24 , Issue.12 , pp. 2657-2666
    • Silva, A.1
  • 32
    • 84899645318 scopus 로고    scopus 로고
    • Cancer gene therapy using mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BC2cXjslKlsbc%3D, PID: 24578184
    • Uchibori R, et al. Cancer gene therapy using mesenchymal stem cells. Int J Hematol. 2014;99(4):377–82.
    • (2014) Int J Hematol , vol.99 , Issue.4 , pp. 377-382
    • Uchibori, R.1
  • 33
    • 84929353372 scopus 로고    scopus 로고
    • Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications
    • PID: 25961059
    • Castro-Manrreza ME, Montesinos JJ. Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications. J Immunol Res. 2015;2015:394917.
    • (2015) J Immunol Res , vol.2015 , pp. 394917
    • Castro-Manrreza, M.E.1    Montesinos, J.J.2
  • 34
    • 84913605925 scopus 로고    scopus 로고
    • Microvescicles derived from mesenchymal stromal cells are not as effective as their cellular counterpart in the ability to modulate immune responses in vitro
    • COI: 1:CAS:528:DC%2BC2cXhvVWis7nI, PID: 24937591
    • Conforti A, et al. Microvescicles derived from mesenchymal stromal cells are not as effective as their cellular counterpart in the ability to modulate immune responses in vitro. Stem cells and development. 2014;23(21):2591–9.
    • (2014) Stem cells and development , vol.23 , Issue.21 , pp. 2591-2599
    • Conforti, A.1
  • 35
    • 84929275438 scopus 로고    scopus 로고
    • Mesenchymal stem cell exosomes
    • COI: 1:CAS:528:DC%2BC2MXktlOqtbo%3D, PID: 25765629
    • Lai RC, Yeo RW, Lim SK. Mesenchymal stem cell exosomes. Semin Cell Dev Biol. 2015;40:82–8.
    • (2015) Semin Cell Dev Biol , vol.40 , pp. 82-88
    • Lai, R.C.1    Yeo, R.W.2    Lim, S.K.3
  • 36
    • 84905237972 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models
    • PID: 24915963
    • Tan CY, Lai RC, Wong W, Dan YY, Lim S-K, Ho HK. Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models. Stem Cell Res Ther. 2014;5:76.
    • (2014) Stem Cell Res Ther , vol.5 , pp. 76
    • Tan, C.Y.1    Lai, R.C.2    Wong, W.3    Dan, Y.Y.4    Lim, S.-K.5    Ho, H.K.6
  • 37
    • 77955643809 scopus 로고    scopus 로고
    • Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
    • PID: 20668554
    • Collino F, et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One. 2010;5(7):e11803.
    • (2010) PLoS One , vol.5 , Issue.7 , pp. e11803
    • Collino, F.1
  • 38
    • 84924364810 scopus 로고    scopus 로고
    • Extracellular membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning
    • Kilpinen L, et al. Extracellular membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning. J Extracell Vesicles. 2013;2:21927.
    • (2013) J Extracell Vesicles , vol.2 , pp. 21927
    • Kilpinen, L.1
  • 39
    • 84865355844 scopus 로고    scopus 로고
    • Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling
    • COI: 1:CAS:528:DC%2BC38XpsVOltbk%3D, PID: 22705267
    • Mokarizadeh A, et al. Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling. Immunol Lett. 2012;147(1):47–54.
    • (2012) Immunol Lett , vol.147 , Issue.1 , pp. 47-54
    • Mokarizadeh, A.1
  • 40
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+) CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • COI: 1:CAS:528:DC%2BD3cXkvFGiu7c%3D, PID: 10899917
    • Takahashi T, et al. Immunologic self-tolerance maintained by CD25(+) CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2000;192(2):303–10.
    • (2000) J Exp Med , vol.192 , Issue.2 , pp. 303-310
    • Takahashi, T.1
  • 41
    • 84940467141 scopus 로고    scopus 로고
    • Interleukin-17A-induced human mesenchymal stem cells are superior modulators of immunological function
    • COI: 1:CAS:528:DC%2BC2MXhsVahs7nE, PID: 26037953
    • Sivanathan KN, et al. Interleukin-17A-induced human mesenchymal stem cells are superior modulators of immunological function. Stem Cells. 2015;33(9):2850–63.
    • (2015) Stem Cells , vol.33 , Issue.9 , pp. 2850-2863
    • Sivanathan, K.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.