Safety and feasibility of umbilical cord mesenchymal stem cells in treatment-refractory systemic lupus erythematosus nephritis: Time for a double-blind placebo-controlled trial to determine efficacy

Arthritis Research and Therapy

Volumn 16, Issue 4, 2014, Pages

  Woodworth, Thasia G ^a   Furst, Daniel E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; HUMAN; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; PROCEDURES;

CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION;

EID: 84904966024     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4677     Document Type: Editorial

References (7)

1. Wang D, Li J, Zhang Y, Zhang M, Chen J, Li X, Hu X, Jiang S, Shi S, Sun L. Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study. Arthritis Res Ther 2014, 16:R79. 10.1186/ar4520, 4060570, 24661633.
2. Sun L, Wang D, Liang J, Zhang H, Feng X, Wang H, Hua B, Liu B, Ye S, Hu X, Xu W, Zeng X, Hou Y, Gilkeson GS, Silver RM, Lu L, Shi S. Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum 2010, 62:2467-2475. 10.1002/art.27548, 20506343.
3. Liang J, Zhang H, Hua B, Wang H, Lu L, Shi S, Hou Y, Zeng X, Gilkeson GS, Sun L. Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis 2010, 69:1423-1429. 10.1136/ard.2009.123463, 20650877.
4. Wang D, Akiyama K, Zhang H, Yamaza T, Li X, Feng X, Wang H, Hua B, Liu B, Xu H, Chen W, Shi S, Sun L. Double allogenic mesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus. Clin Dev Immunol 2012, 2012:273291. 3399403, 22829849.
5. Wang D, Zhang H, Liang J, Li X, Feng X, Wang H, Hua B, Liu B, Lu L, Gilkeson GS, Silver RM, Chen W, Shi S, Sun L. Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience. Cell Transplant 2013, 22:2267-2277.
6. Tyndall A, Houssiau FA. Mesenchymal stem cells in the treatment of autoimmune diseases. Ann Rheum Dis 2010, 69:1413-1414. 10.1136/ard.2010.132639, 20650875.
7. Collins E, Gilkeson G. Hematopoetic and mesenchymal stem cell transplantation in the treatment of refractory systemic lupus erythematosus - where are we now?. Clin Immunol 2013, 148:328-334. 10.1016/j.clim.2013.01.009, 23411031.