Enhanced skin delivery of aceclofenac via hydrogel-based solid lipid nanoparticles

Artificial Cells, Nanomedicine and Biotechnology

Volumn 44, Issue 6, 2016, Pages 1434-1439

  Raj, Rakesh ^a   Mongia, Pooja ^a   Ram, Alpana ^a   Jain, N K ^b  

^a GURU GHASIDAS UNIVERSITY   (India)

^b DR H S GOUR UNIVERSITY   (India)

Author keywords

hydrogels; skin targeting; solid lipid nanoparticles; topical application

Indexed keywords

DIFFERENTIAL SCANNING CALORIMETRY; EMULSIFICATION; NANOPARTICLES; PARTICLE SIZE; POLYDISPERSITY; X RAY DIFFRACTION;

ENTRAPMENT EFFICIENCY; LIPID CONTENT; POLYDISPERSITY INDICES; SOLID LIPID NANOPARTICLE (SLN); STIRRING SPEED; TOPICAL APPLICATION; TOPICAL DELIVERY; ULTRASONIC EMULSIFICATION;

HYDROGELS;

ACECLOFENAC; CARBOPOL 934; GLYCEROL STEARATE; LIPID; PHOSPHATIDYLCHOLINE; POLYSORBATE 80; SOLID LIPID NANOPARTICLE; DICLOFENAC; DRUG CARRIER; HYDROGEL; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARRAGEENAN-INDUCED PAW EDEMA; CHEMICAL STRUCTURE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG FORMULATION; DRUG PENETRATION; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; MALE; NANOEMULSION; NANOPHARMACEUTICS; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; RAT; SKIN PENETRATION; SURFACE PROPERTY; TOPICAL TREATMENT; TRANSDERMAL DRUG DELIVERY SYSTEM; ULTRASOUND; X RAY DIFFRACTION; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG EFFECTS; METABOLISM; PHARMACOKINETICS; PHARMACOLOGY; SKIN; SKIN ABSORPTION; SPRAGUE DAWLEY RAT; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; DICLOFENAC; DRUG CARRIERS; HYDROGELS; LIPIDS; NANOPARTICLES; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION;

EID: 84982984181     PISSN: 21691401     EISSN: 2169141X     Source Type: Journal    
DOI: 10.3109/21691401.2015.1036997     Document Type: Article

References (32)

1. R.Alvarez-Roman, A.Naik, Y.N.Kalia, S.Fessi, R.H.Guy. 2004. Visualisation of skin penetration using confocal laser scanning microscopy. Eur J Pharm Biopharm. 58:301–306.
2. A.D.Beaulieu, P.M.Peloso, B.Haraoui, W.Bensen, G.Thomson, J.Wade,. 2008. Once-daily, controlled-release tramadol and sustained-release diclofenac relieve chronic pain due to osteoarthritis:A randomized controlled trial. Pain Res Manage. 13:103–110.
3. H.Bunjes, K.Westensen, M.H.J.Koch. 1996. Crystallization tendency and polymorphic transition in triglyceride nanoparticles. Int J Pharm. 129:159–173.
4. F.Castelli, C.Puglia, M.G.Sarpietro, L.Rizza, F.Bonina. 2005. Characterization of indomethacin-loaded lipid nanoparticles by differential scanning calorimetry. Int J Pharm. 304:231–238.
5. S.Chakraborty, M.Khandai, A.Sharma, N.Khanam, C.N.Patra, S.C.Dinda, K.K.Sen. 2010. Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres:an investigation of the effects of polymers using multiple comparison analysis. Acta Pharm. 60:255.
6. V.Chawla, S.A.Saraf. 2012. Rheological studies on solid lipid nanoparticle based carbopol gels of aceclofenac. Coll Sur B:Biointerfaces. 92:293–298.
7. H.Chen, X.Chang, D.Du, W.Liu, J.Liu, T.Weng,. 2006. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting. J Control Rel. 110:296–306.
8. T.de Vringer, H.A.G.de Ronde. 1995. Preparation and structure of water in oil cream containing lipid nanoparticles. J Pharm Sci. 84:466–472.
9. K.Dua, K.Pabreja, M.V.Ramana. 2010. Aceclofenac topical dosage forms:in vitro and in vivo characterization. Acta Pharm. 60:467.
10. V.Dubey, D.Mishra, A.Asthana, N.K.Jain. 2006. Transdermal delivery of a pineal hormone:melatonin via elastic liposomes. Biomaterials. 27:3491–3496.
11. Z.Hou, C.Xie, K.Haung, C.Zha. 2003. The production and characteristics of solid lipid nanoparticles (SLNs). Biomaterials. 24:1781–1785.
12. C.S.Jayaraman, C.Ramachandran, N.Weiner. 1996. Topical delivery of erythromycin from various formulations:an in vivo hairless mouse skin. J Pharm Sci. 85:1082–1085.
13. V.Jenning, S.Gohla. 2001. Encapsulation of retinoids in solid lipid nanoparticles. J. Microencap.18:149–158.
14. V.Jenning, A.Gysler, M.Schafer-Korting, S.H.Gohla. 2000. Vitamin A loaded solid lipid nanoparticles for topical use:occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm. 49:211–218.
15. J.Liu, W.Hu, H.Chen, Q.Ni, H.Xu, X.Yang. 2007. Isotretinoin-loaded solid lipid nanoparticle with skin targeting for topical delivery. Int J Pharm. 328:191–195.
16. L.B.Lopes, D.A.Ferreira, D.Poula, M.J.Garcia, J.A.Thiomazini, M.A.Fantini, M.B.Bentley. 2006. Reverse hexagonal nanodispersion of monoolean and oleic acid for topical delivery of triptolide:in vitro and in vivo skin penetration of cyclosporine A. Pharm Res. 23:1332–1342.
17. Y.Luo, D.Chen, L.Ren, X.Zhao, J.Qin. 2006. Solid lipid nanoparticles for enhancing vinpocetine’s oral bioavailability. J Control Rel. 114:53–59.
18. C.S.Mai, W.Mehnert, M.Schäfer-Korting. 2000. Solid lipid nanoparticles as drug carriers for topical glucocorticoids. Int J Pharm. 196:165–167.
19. Z.Mei, Q.Wu, S.Hu, X.Li, X.Yang. 2005. Triptolide loaded solid lipid nanoparticle hydrogel for topical application. Drug Develop Ind Pharm. 31:161–168.
20. R.H.Muller, W.Mehnert, J.S.Lucks, C.Schuwarz, Z.A.Muhlen, H.Weyners,. 1995. Solid lipid nanoparticles (SLN) an alternative colloidal carrier system for controlled drug delivery. Eur J Pharm Biopharm. 41:62–69.
21. R.H.Muller, M.Radtke, S.A.Wissing. 2002. Solid lipid nanoparticles (SLN) and nanostructured lipid carrier (NLC) in cosmectic and dermatological preparation. Adv Drug Deliv Rev. 54:S131–135.
22. P.Musmade, G.Subramanian, K.K.Srinivasan. 2007. High performance thin layer chromatography and pharmacokinetic of aceclofenac in rats. Analytica Chem Acta. 585:1082–1085.
23. A.Pareek, N.Chandurkar, A.Gupta, A.Sirsikar, B.Dalal, B.Jesalpura,. 2011. Efficacy and Safety of Aceclofenac-CR and Aceclofenac in the Treatment of Knee Osteoarthritis:A 6-Week, Comparative, Randomized, Multicentric, Double-Blind Study. The J Pain.12:546–553.
24. C.Puglia, F.Bonina, L.Rizza, P.Blasi, A.Schoubben, R.Perrotta,. 2012. Lipid nanoparticles as carrier for octyl-methoxycinnamate:in vitro percutaneous absorption and photostability studies. J Pharma Sciences. 101:301–311.
25. R.C.Rowe, P.J.Shesky, P.J.Weller. 2002. Glyceryl monostearate. In:R.C.Rowe, P.J.Sheskey, W.G.Cook,. Handbook of Pharmaceutical Excipient, 4th Ed. New York:Pharmaceutical Press, pp. 264–265.
26. A.Schatzlein G.Leve. 1998. Non uniform cellular packing of the stratum corneun and permeability barrier fuction of the intact skin, high resolution confocal scanning microscopy study using highly deformable vesicles (tranferosome). British J Dermat. 138:583–592.
27. A.K.Shah, A.A.Date, M.D.Joshi, V.B.Patravale. 2007. Solid lipid nanoparticles (SLN) of tretinoin:potential in topical delivery. Int J Pharm. 345:163–171.
28. F.Shakeel, S.Baboota, A.Ahuja, J.Ali, M.Aquil, S.Shafiq. 2007. Nanoemulsion as vehicles for transdermal delivery of acelofenac. AAPS Pharm SciTech. 8:E1–9.
29. E.B.Souto, S.A.Wissing, C.M.Barbosa, R.H.Muller. 2004a. Development of controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int J Pharm. 278:71–78.
30. E.B.Souto, S.A.Wissing, C.M.Barbosa, R.H.Muller. 2004b. Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations. Eur J Pharm Biopharm. 58:83–90.
31. C.A.Winter. 1965. Anti-inflammatory testing methods:comparative evaluation of indomethacin and other agents. Nonsteroidal Anti-inflmmat Drug. 52:190–202.
32. A.Wissing, R.H.Muller. 2002. Solid lipid nanoparticles as carrier for sunscreens:in vitro release and in vivo skin penetration. J Control Rel. 81:225–233.