Aceclofenac topical dosage forms: In vitro and in vivo characterization

Acta Pharmaceutica

Volumn 60, Issue 4, 2010, Pages 467-478

  Dua, Kamal ^a   Pabreja, Kavita ^a   Ramana, Malipeddi ^b  

^a INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^b VIT UNIVERSITY   (India)

Author keywords

Aceclofenac; In vitro activity; In vivo activity; topical gel

Indexed keywords

ACECLOFENAC; CARBOPOL 940; CARRAGEENAN; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL 4000;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DOSAGE FORM; DRUG PENETRATION; DRUG SOLUBILITY; HYPERALGESIA; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; OINTMENT; PAW EDEMA; PH MEASUREMENT; RAT; SKIN ABSORPTION; SKIN IRRITATION; SKIN PERMEABILITY; VISCOSITY;

EID: 78650579079     PISSN: 13300075     EISSN: 18469558     Source Type: Journal    
DOI: 10.2478/v1007-010-0036-5     Document Type: Article

References (18)

1. Y. G. Bachhav and V. B. Patravale, Formulation and evaluation of meloxicam gels, Acta Pharm. 60 (2010) 153-163; DOI: 10.2478/v10007-010-0020-0.
2. Y. G. Bachhav and V. B. Patravale, Microemulsion based vaginal gel of fluconazole: Formulation, in vitro and in vivo evaluation, Int. J Pharm. 365 (2009) 175-179; DOI: 10.1016/j.ijpharm. 2008.08.021.
3. C. M. Chakole, M. A. Shende and S. N. Khadatkar, Formulation and evaluation of novel combined halobetasol propionate and fusidic acid ointment, Int. J. Chem. Tech. Res. 1 (2009) 103-116.
4. V. Rajni and P. R. P. Verma, Diffusion study of ibuprofen from ointment base, Ind. J. Pharm. Sci. 57 (1995) 1-6.
5. A. Mohammed, S. Yasmin and A. Asgar, Transdermal delivery of b-blockers, Exp. Opin. Drug Del. 3 (2006) 405-418.
6. Acta. Pharm. 53 (2003) 119-125; DOI: 10.1517/17425247.3.3.405.
7. T. Higuchi, Mechanism of sustained action medication, theoretical analysis of rate of release of solid drugs dispersed in solid matrices, J. Pharm. Sci. 52 (1963) 1145-1149; DOI: 10.1002/jps.2600521210.
8. P. Costa and J. M. Sousa Lobo, Modeling and comparison of dissolution profiles, Eur. J. Pharm. Sci. 13 (2001) 123-133; DOI: 10.1016/S0928-0987(01) 00095-1. (Pubitemid 32288781)
9. B. J. Vermeer, Skin irritation and sensitization, J. Control. Rel. 15 (1991) 261-265; DOI: 10.1016/ 0168-3659(91)90117-V.
10. S. Padi, N. K. Jain, S. Singh and S. K. Kulkarni, Effect of selective inhibition of cyclooxygenase-2 on lipopolysaccharide-induced hyperalgesia, Inflammopharmacol. 12 (2004) 57-68; DOI: 10.1163/ 156856004773121374. (Pubitemid 38524362)
11. C. A. Winter, E. A. Risley and G. W. Nuss, Carrageenan-induced oedema in hind paw of the rat as an assay for anti-inflammatory drugs, Proc. Soc. Exp. Biol. Med. 111 (1962) 544-547.
12. J. Aukunuru, C. Bonepally and V. Guduri, Preparation, characterization and optimization of ibuprofen ointment intended for topical and systemic delivery, Trop. J. Pharm. Res. 6 (2007) 855-860.
13. Z. Gürol, S. Hekimo Lu, R. Demirdamar and M. Umnu, Percutaneous absorption of ketoprofen. I. In vitro release and percutaneous absorption of ketoprofen from different ointment bases, Pharm. Acta Helv. 71 (1996) 205-212; DOI: 10.1016/0031-6865(96)00011-8. (Pubitemid 26290619)
14. V. V. Dhavse and P. D. Amin, Formulation and evaluation of topical bases of ketoprofen, East Pharm. 40 (1997) 133-135.
15. Y. Obata, K. Takayama, Y. Maitano, Y. Machida and T. Nagai, Effect of ethanol on the permeation of ionized and non-ionized diclofenac, Int. J. Pharm. 89 (1993) 191-198; DOI: 10.1016/0378- -5173(93)90243-9.
16. W. A. C. Megraban and B. W. Barry, Oestradiol permeation across human skin, silastic and snake skin membrane: the effect of ethanol:water cosolvent system, Int. J. Pharm. 116 (1995) 101-112; DOI: 10.1016/0378-5173(94)00321-U.
17. S. C. Chi and H. W. Jun, Release rate of ketoprofen from poloxamer gel in a membraneless diffusion cell, J. Pharm. Sci. 80 (1991) 280-283; DOI: 10.1002/jps.2600800318.
18. T. M. Rafiee and A. Mehramizi, In vitro release studies of piroxicam from oil-in-water creams and hydroalcoholic gel topical formulations, Drug Dev. Ind. Pharm. 26 (2000) 409-414; DOI: 10.1159/000085864.