메뉴 건너뛰기




Volumn 7, Issue 26, 2016, Pages 39497-39510

Paeonol protects endotoxin-induced acute kidney injury: Potential mechanism of inhibiting TLR4-NF-κB signal pathway

Author keywords

Acute kidney injury; NF B signal pathway; Paeono; Sepsis; TLR4

Indexed keywords

CREATININE; I KAPPA B ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITROGEN; PEONOL; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; UREA; ACETOPHENONE DERIVATIVE; CYTOKINE; ENDOTOXIN; LIPOPOLYSACCHARIDE; RELA PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

EID: 84982921018     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.8347     Document Type: Article
Times cited : (56)

References (42)
  • 1
    • 84892384818 scopus 로고    scopus 로고
    • The definition and detection of acute kidney injury
    • Pickering JW, Endre ZH. The definition and detection of acute kidney injury. J Renal Inj Prev. 2014; 3: 21-25.
    • (2014) J Renal Inj Prev , vol.3 , pp. 21-25
    • Pickering, J.W.1    Endre, Z.H.2
  • 4
    • 34247188442 scopus 로고    scopus 로고
    • The incidence and prognostic significance of acute kidney injury
    • Waikar SS, Liu KD, Chertow GM. The incidence and prognostic significance of acute kidney injury. Curr Opin Nephrol Hypertens. 2007; 16:227-236.
    • (2007) Curr Opin Nephrol Hypertens , vol.16 , pp. 227-236
    • Waikar, S.S.1    Liu, K.D.2    Chertow, G.M.3
  • 5
    • 84896660351 scopus 로고    scopus 로고
    • The association between renal replacement therapy modality and long-term outcomes among critically ill adults with acute kidney injury: a retrospective cohort study*
    • Wald R, Shariff SZ, Adhikari NK, Bagshaw SM, Burns KE, Friedrich JO, Garg AX, Harel Z, Kitchlu A, Ray JG. The association between renal replacement therapy modality and long-term outcomes among critically ill adults with acute kidney injury: a retrospective cohort study*. Crit Care Med. 2014; 42:868-877.
    • (2014) Crit Care Med , vol.42 , pp. 868-877
    • Wald, R.1    Shariff, S.Z.2    Adhikari, N.K.3    Bagshaw, S.M.4    Burns, K.E.5    Friedrich, J.O.6    Garg, A.X.7    Harel, Z.8    Kitchlu, A.9    Ray, J.G.10
  • 8
    • 0037378947 scopus 로고    scopus 로고
    • Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome
    • Hoste EA, Lameire NH, Vanholder RC, Benoit DD, Decruyenaere JM, Colardyn FA. Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome. J Am Soc Nephrol. 2003; 14:1022-1030.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1022-1030
    • Hoste, E.A.1    Lameire, N.H.2    Vanholder, R.C.3    Benoit, D.D.4    Decruyenaere, J.M.5    Colardyn, F.A.6
  • 10
    • 34249290789 scopus 로고    scopus 로고
    • Sepsis in the 21st century: recent definitions and therapeutic advances
    • Nguyen HB, Smith D. Sepsis in the 21st century: recent definitions and therapeutic advances. Am J Emerg Med. 2007; 25:564-571.
    • (2007) Am J Emerg Med , vol.25 , pp. 564-571
    • Nguyen, H.B.1    Smith, D.2
  • 11
    • 84862884363 scopus 로고    scopus 로고
    • Endotoxin-induced basal respiration alterations of renal HK-2 cells: a sign of pathologic metabolism down-regulation
    • Quoilin C, Mouithys-Mickalad A, Duranteau J, Gallez B, Hoebeke M. Endotoxin-induced basal respiration alterations of renal HK-2 cells: a sign of pathologic metabolism down-regulation. Biochem Biophys Res Commun. 2012; 423:350-354.
    • (2012) Biochem Biophys Res Commun , vol.423 , pp. 350-354
    • Quoilin, C.1    Mouithys-Mickalad, A.2    Duranteau, J.3    Gallez, B.4    Hoebeke, M.5
  • 12
    • 84902590318 scopus 로고    scopus 로고
    • Pioglitazone reduces inflammation through inhibition of NF-kappaB in polymicrobial sepsis
    • Kaplan J, Nowell M, Chima R, Zingarelli B. Pioglitazone reduces inflammation through inhibition of NF-kappaB in polymicrobial sepsis. Innate Immun. 2013; 20:519-528.
    • (2013) Innate Immun , vol.20 , pp. 519-528
    • Kaplan, J.1    Nowell, M.2    Chima, R.3    Zingarelli, B.4
  • 14
    • 82255180232 scopus 로고    scopus 로고
    • Anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional chinese herbal medicine
    • He DY, Dai SM. Anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional chinese herbal medicine. Front Pharmacol. 2011; 2:10.
    • (2011) Front Pharmacol , vol.2 , pp. 10
    • He, D.Y.1    Dai, S.M.2
  • 15
    • 84857565714 scopus 로고    scopus 로고
    • Paeonol attenuates microglia-mediated inflammation and oxidative stress-induced neurotoxicity in rat primary microglia and cortical neurons
    • Tseng YT, Hsu YY, Shih YT, Lo YC. Paeonol attenuates microglia-mediated inflammation and oxidative stress-induced neurotoxicity in rat primary microglia and cortical neurons. Shock. 2012, 37:312-318.
    • (2012) Shock , vol.37 , pp. 312-318
    • Tseng, Y.T.1    Hsu, Y.Y.2    Shih, Y.T.3    Lo, Y.C.4
  • 16
    • 44249098462 scopus 로고    scopus 로고
    • Paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting ERK, p38 and NF-kappaB pathway
    • Tsai HY, Lin HY, Fong YC, Wu JB, Chen YF, Tsuzuki M, Tang CH. Paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting ERK, p38 and NF-kappaB pathway. Eur J Pharmacol. 2008; 588:124-133.
    • (2008) Eur J Pharmacol , vol.588 , pp. 124-133
    • Tsai, H.Y.1    Lin, H.Y.2    Fong, Y.C.3    Wu, J.B.4    Chen, Y.F.5    Tsuzuki, M.6    Tang, C.H.7
  • 17
    • 70349781839 scopus 로고    scopus 로고
    • Paeonol from Paeonia suffruticosa prevents TNF-alpha-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression
    • Pan LL, Dai M. Paeonol from Paeonia suffruticosa prevents TNF-alpha-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression. Phytomedicine. 2009; 16:1027-1032.
    • (2009) Phytomedicine , vol.16 , pp. 1027-1032
    • Pan, L.L.1    Dai, M.2
  • 18
    • 84861212441 scopus 로고    scopus 로고
    • Paeonol inhibits oxidized low density lipoprotein-induced monocyte adhesion to vascular endothelial cells by inhibiting the mitogen activated protein kinase pathway
    • Wang YQ, Dai M, Zhong JC, Yin DK. Paeonol inhibits oxidized low density lipoprotein-induced monocyte adhesion to vascular endothelial cells by inhibiting the mitogen activated protein kinase pathway. Biol Pharm Bull. 2012; 35:767-772.
    • (2012) Biol Pharm Bull , vol.35 , pp. 767-772
    • Wang, Y.Q.1    Dai, M.2    Zhong, J.C.3    Yin, D.K.4
  • 19
    • 33846649645 scopus 로고    scopus 로고
    • Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways
    • Nizamutdinova IT, Oh HM, Min YN, Park SH, Lee MJ, Kim JS, Yean MH, Kang SS, Kim YS, Chang KC, Kim HJ. Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways. Int Immunopharmacol. 2007; 7:343-350.
    • (2007) Int Immunopharmacol , vol.7 , pp. 343-350
    • Nizamutdinova, I.T.1    Oh, H.M.2    Min, Y.N.3    Park, S.H.4    Lee, M.J.5    Kim, J.S.6    Yean, M.H.7    Kang, S.S.8    Kim, Y.S.9    Chang, K.C.10    Kim, H.J.11
  • 20
    • 33646819692 scopus 로고    scopus 로고
    • Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats
    • Hsieh CL, Cheng CY, Tsai TH, Lin IH, Liu CH, Chiang SY, Lin JG, Lao CJ, Tang NY. Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. J Ethnopharmacol. 2006; 106:208-215.
    • (2006) J Ethnopharmacol , vol.106 , pp. 208-215
    • Hsieh, C.L.1    Cheng, C.Y.2    Tsai, T.H.3    Lin, I.H.4    Liu, C.H.5    Chiang, S.Y.6    Lin, J.G.7    Lao, C.J.8    Tang, N.Y.9
  • 21
    • 70349781839 scopus 로고    scopus 로고
    • Paeonol from Paeonia suffruticosa prevents TNF-alpha-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression
    • Pan LL, Dai M. Paeonol from Paeonia suffruticosa prevents TNF-alpha-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression. Phytomedicine. 2009; 16:1027-1032.
    • (2009) Phytomedicine , vol.16 , pp. 1027-1032
    • Pan, L.L.1    Dai, M.2
  • 22
    • 65449182356 scopus 로고    scopus 로고
    • Inhibition of LPS-induced iNOS, COX-2 and inflammatory mediator expression by paeonol through the MAPKs inactivation in RAW 264.7 cells
    • Chae HS, Kang OH, Lee YS, Choi JG, Oh YC, Jang HJ, Kim MS, Kim JH, Jeong SI, Kwon DY. Inhibition of LPS-induced iNOS, COX-2 and inflammatory mediator expression by paeonol through the MAPKs inactivation in RAW 264.7 cells. Am J Chin Med. 2009; 37:181-194.
    • (2009) Am J Chin Med , vol.37 , pp. 181-194
    • Chae, H.S.1    Kang, O.H.2    Lee, Y.S.3    Choi, J.G.4    Oh, Y.C.5    Jang, H.J.6    Kim, M.S.7    Kim, J.H.8    Jeong, S.I.9    Kwon, D.Y.10
  • 23
    • 0041667974 scopus 로고    scopus 로고
    • Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia
    • Chou TC. Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia. Br J Pharmacol. 2003; 139:1146-1152.
    • (2003) Br J Pharmacol , vol.139 , pp. 1146-1152
    • Chou, T.C.1
  • 24
    • 3142634845 scopus 로고    scopus 로고
    • Acute renal failure and sepsis
    • Schrier RW, Wang W. Acute renal failure and sepsis. N Engl J Med. 2004; 351:159-169.
    • (2004) N Engl J Med , vol.351 , pp. 159-169
    • Schrier, R.W.1    Wang, W.2
  • 25
    • 84862884363 scopus 로고    scopus 로고
    • Endotoxin-induced basal respiration alterations of renal HK-2 cells: a sign of pathologic metabolism down-regulation
    • Quoilin C, Mouithys-Mickalad A, Duranteau J, Gallez B, Hoebeke M. Endotoxin-induced basal respiration alterations of renal HK-2 cells: a sign of pathologic metabolism down-regulation. Biochem Biophys Res Commun. 2012; 423:350-354.
    • (2012) Biochem Biophys Res Commun , vol.423 , pp. 350-354
    • Quoilin, C.1    Mouithys-Mickalad, A.2    Duranteau, J.3    Gallez, B.4    Hoebeke, M.5
  • 26
    • 0036948953 scopus 로고    scopus 로고
    • Animal and human models for sepsis
    • Schultz MJ, van der Poll T. Animal and human models for sepsis. Ann Med. 2002; 34:573-581.
    • (2002) Ann Med , vol.34 , pp. 573-581
    • Schultz, M.J.1    van der Poll, T.2
  • 27
    • 70349705711 scopus 로고    scopus 로고
    • Animal models of sepsis and sepsis-induced kidney injury
    • Doi K, Leelahavanichkul A, Yuen PS, Star RA. Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest. 2009; 119:2868-2878.
    • (2009) J Clin Invest , vol.119 , pp. 2868-2878
    • Doi, K.1    Leelahavanichkul, A.2    Yuen, P.S.3    Star, R.A.4
  • 28
    • 84890861186 scopus 로고    scopus 로고
    • Animal models of sepsis
    • Fink MP. Animal models of sepsis. Virulence. 2014; 5:143-153.
    • (2014) Virulence , vol.5 , pp. 143-153
    • Fink, M.P.1
  • 29
    • 27944440153 scopus 로고    scopus 로고
    • Disruption of renal peritubular blood flow in lipopolysaccharide-induced renal failure: role of nitric oxide and caspases
    • Tiwari MM, Brock RW, Megyesi JK, Kaushal GP, Mayeux PR. Disruption of renal peritubular blood flow in lipopolysaccharide-induced renal failure: role of nitric oxide and caspases. Am J Physiol Renal Physiol. 2005; 289:F1324-F1332.
    • (2005) Am J Physiol Renal Physiol , vol.289 , pp. F1324-F1332
    • Tiwari, M.M.1    Brock, R.W.2    Megyesi, J.K.3    Kaushal, G.P.4    Mayeux, P.R.5
  • 30
    • 84903270910 scopus 로고    scopus 로고
    • Leonurine ameliorates LPS-induced acute kidney injury via suppressing ROS-mediated NF-kappaB signaling pathway
    • Xu D, Chen M, Ren X, Ren X, Wu Y. Leonurine ameliorates LPS-induced acute kidney injury via suppressing ROS-mediated NF-kappaB signaling pathway. Fitoterapia. 2014; 97:148-155.
    • (2014) Fitoterapia , vol.97 , pp. 148-155
    • Xu, D.1    Chen, M.2    Ren, X.3    Ren, X.4    Wu, Y.5
  • 33
    • 0036164902 scopus 로고    scopus 로고
    • Interleukin-10: A complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug
    • Oberholzer A, Oberholzer C, Moldawer LL. Interleukin-10: A complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug. Crit Care Med. 2002; 30:S58-S63.
    • (2002) Crit Care Med , vol.30 , pp. S58-S63
    • Oberholzer, A.1    Oberholzer, C.2    Moldawer, L.L.3
  • 34
    • 84925321760 scopus 로고    scopus 로고
    • Alterations of dendritic cells in sepsis: featured role in immunoparalysis
    • Fan X, Liu Z, Jin H, Yan J, Liang HP. Alterations of dendritic cells in sepsis: featured role in immunoparalysis. Biomed Res Int. 2015:903720.
    • (2015) Biomed Res Int , pp. 903720
    • Fan, X.1    Liu, Z.2    Jin, H.3    Yan, J.4    Liang, H.P.5
  • 35
    • 84875619751 scopus 로고    scopus 로고
    • Consequences of direct and indirect activation of dendritic cells on antigen presentation: functional implications and clinical considerations
    • Vega-Ramos J, Villadangos JA. Consequences of direct and indirect activation of dendritic cells on antigen presentation: functional implications and clinical considerations. Mol Immunol. 2013; 55:175-178.
    • (2013) Mol Immunol , vol.55 , pp. 175-178
    • Vega-Ramos, J.1    Villadangos, J.A.2
  • 37
    • 54949147176 scopus 로고    scopus 로고
    • New regulators of NF-kappaB in inflammation
    • Ghosh S, Hayden MS. New regulators of NF-kappaB in inflammation. Nat Rev Immunol. 2008; 8:837-848.
    • (2008) Nat Rev Immunol , vol.8 , pp. 837-848
    • Ghosh, S.1    Hayden, M.S.2
  • 38
    • 74049087979 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo
    • Hocherl K, Schmidt C, Kurt B, Bucher M. Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo. Am J Physiol Renal Physiol. 2010; 298:F196-F204.
    • (2010) Am J Physiol Renal Physiol , vol.298 , pp. F196-F204
    • Hocherl, K.1    Schmidt, C.2    Kurt, B.3    Bucher, M.4
  • 40
    • 84904111409 scopus 로고    scopus 로고
    • Small-molecule inhibitors of IkappaB kinase (IKK) and IKK-related kinases
    • Llona-Minguez S, Baiget J, Mackay SP. Small-molecule inhibitors of IkappaB kinase (IKK) and IKK-related kinases. Pharm Pat Anal. 2013; 2:481-498.
    • (2013) Pharm Pat Anal , vol.2 , pp. 481-498
    • Llona-Minguez, S.1    Baiget, J.2    Mackay, S.P.3
  • 41
    • 84870199424 scopus 로고    scopus 로고
    • NF-kappaB as a target for modulating inflammatory responses
    • Gasparini C, Feldmann M. NF-kappaB as a target for modulating inflammatory responses. Curr Pharm Des. 2012; 18:5735-5745.
    • (2012) Curr Pharm Des , vol.18 , pp. 5735-5745
    • Gasparini, C.1    Feldmann, M.2
  • 42
    • 33751424684 scopus 로고    scopus 로고
    • Discoidin domain receptor 2 is involved in the activation of bone marrow-derived dendritic cells caused by type I collagen
    • Lee JE, Kang CS, Guan XY, Kim BT, Kim SH, Lee YM, Moon WS, Kim DK. Discoidin domain receptor 2 is involved in the activation of bone marrow-derived dendritic cells caused by type I collagen. Biochem Biophys Res Commun. 2007; 352:244-250.
    • (2007) Biochem Biophys Res Commun , vol.352 , pp. 244-250
    • Lee, J.E.1    Kang, C.S.2    Guan, X.Y.3    Kim, B.T.4    Kim, S.H.5    Lee, Y.M.6    Moon, W.S.7    Kim, D.K.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.