Endotoxin-induced basal respiration alterations of renal HK-2 cells: A sign of pathologic metabolism down-regulation

Biochemical and Biophysical Research Communications

Volumn 423, Issue 2, 2012, Pages 350-354

  Quoilin, C ^a   Mouithys Mickalad, A ^a   Duranteau, J ^b   Gallez, B ^c   Hoebeke, M ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b BICÊTRE HOSPITAL   (France)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Acute kidney injury (AKI); Endotoxin; Inflammation; Metabolism; Oxygen consumption; Sepsis

Indexed keywords

ENDOTOXIN; LIPOPOLYSACCHARIDE;

ACUTE KIDNEY FAILURE; ARTICLE; CELL RESPIRATION; CELL STRAIN HK 2; CELL STRESS; CONTROLLED STUDY; DOWN REGULATION; ELECTRON SPIN RESONANCE; EPITHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; KIDNEY TUBULE CELL; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIROMETRY;

ACUTE KIDNEY INJURY; CELL LINE; CELL RESPIRATION; DOWN-REGULATION; HUMANS; KIDNEY; LIPOPOLYSACCHARIDES; OXIMETRY; OXYGEN CONSUMPTION; SEPSIS;

BACTERIA (MICROORGANISMS);

EID: 84862884363     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.05.128     Document Type: Article

References (28)

1. Nguyen H.B., Smith D. Sepsis in the 21st century: recent definitions and therapeutic advances. Am. J. Emerg. Med. 2007, 25:564-571.
2. Bone R.C., Sprung C.L., Sibbald W.J. Definitions for sepsis and organ failure. Crit. Care Med. 1992, 20:724-726.
3. Adib-Conquy M., Cavaillon J.-M. Stress molecules in sepsis and systemic inflammatory response syndrome. FEBS Lett. 2007, 581:3723-3733.
4. Bone R.C. Gram-negative sepsis: a dilemma of modern medicine. Clin. Microbiol. Rev. 1993, 6:57-68.
5. Papasian C., Morrison D.C. The pathogenesis of Gram-negative sepsis. The Sepsis Text 2002, 97-115. Kluwer Academic Publishers, Boston (Massachusetts). J.-L. Vincent, J. Carlet, S.M. Opal (Eds.).
6. Rangel-Frausto M.S. The epidemiology of bacterial sepsis. Infect. Dis. Clin. North Am. 1999, 13:299-312.
7. Morrison D.C., Ryan J.L. Endotoxins and disease mechanism. Annu. Rev. Med. 1987, 38:417-432.
8. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice. mutations in Tlr4 gene. Science 1998, 282:2085-2088.
9. Dickson S. Sepsis and multiple organ failure. Anaesth. Intensive Care Med. 2009, 10:165-168.
10. Schrier R.W., Wang W. Acute renal failure and sepsis. N. Engl. J. Med. 2004, 351:159-169.
11. Wan L., Bagshaw S.M., Langenberg C., Saotome T., May C., Bellomo R. Pathophysiology of septic acute kidney injury: what do we really know?. Crit. Care Med. 2008, 36:S198-S203.
12. Langenberg C., Bellomo R., May C., Wan L., Egi M., Morgera S. Renal blood flow in sepsis. Crit. Care 2005, 9:R363-R374.
13. Regueira T., Andresen M., Mercado M., Downey P. Physiopathology of acute renal failure during sepsis. Med. Intensiva (English Edition) 2011, 35:424-432.
14. Harrois A., Huet O., Duranteau J. Alterations of mitochondrial function in sepsis and critical illness. Curr. Opin. Anesthesiol. 2009, 22:143-149.
15. Carré J.E., Singer M. Cellular energetic metabolism in sepsis: the need for a systems approach. Biochim. Biophys. Acta 2008, 1777:763-771.
16. Ryan M.J., Johnson G., Kirk J., Fuerstenberg S.M., Zager R.A., Torok-Storb B. HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int. 1994, 45:48-57.
17. Hütter E., Unterluggauer H., Garedew A., Jansen-Durr P., Gnaiger E. High-resolution respirometry-a modern tool in aging research. Exp. Gerontol. 2006, 41:103-109.
18. Gnaigner E. Polarographic oxygen sensors, the oxygraph and high resolution respirometry to assess mitochondrial function. Drug-Induced Mitochondrial Dysfunction 2008, 327-352. John Wiley & Sons, New Jersey. J. Dykens, Y. Will (Eds.).
19. Schneider N., Mouithys-Mickalad A.L., Lejeune J.-P., Deby-Dupont G.P., Hoebeke M., Serteyn D.A. Synoviocytes, not chondrocytes, release free radicals after cycles of anoxia/re-oxygenation. Biochem. Biophys. Res. Commun. 2005, 334:669-673.
20. James P.E., Jackson S.K., Grinberg O.Y., Swartz H.M. The effects of endotoxin on oxygen consumption of various cell types in vitro: an EPR oximetry study. Free Radic. Biol. Med. 1995, 18:641-647.
21. Diepart C., Verrax J., Calderon P.B., Feron O., Jordan B.F., Gallez B. Comparison of methods for measuring oxygen consumption in tumor cells in vitro. Anal. Biochem. 2010, 396:250-256.
22. Jordan B.F., Gregoire V., Demeure R.J., Sonveaux P., Feron O., O'Hara J., Vanhulle V.P., Delzenne N., Gallez B. Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption. Cancer Res. 2002, 62:3555-3561.
23. 2, measured by in vivo electron paramagnetic resonance oximetry and magnetic resonance imaging. Free Radic. Biol. Med. 1996, 21:25-34.
24. Hu H., Sosnovsky G., Swartz H.M. Simultaneous measurements of the intra- and extra-cellular oxygen concentration in viable cells. Biochim. Biophys. Acta 1992, 1112:161-166.
25. Singer M. Mitochondrial function in sepsis: acute phase versus multiple organ failure. Crit. Care Med. 2007, 35:S441-S448.
26. Levy R.J. Mitochondrial dysfunction, bioenergetic impairment, and metabolic down-regulation in sepsis. Shock 2007, 28:24-28.
27. 2 sensor. J. Biol. Chem. 1998, 273:3320-3326.
28. Leverve X.M. Mitochondrial function and substrate availability. Crit. Care Med. 2007, 35:S454-S460.