Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats

American Journal of Physiology - Endocrinology and Metabolism

Volumn 310, Issue 6, 2016, Pages E405-E417

  Shankaran, Mahalakshmi ^a   Shearer, Todd W ^b   Stimpson, Stephen A ^b   Turner, Scott M ^a   King, Chelsea ^a   Wong, Po Yin Anne ^a   Shen, Ying ^b   Turnbull, Philip S ^b   Kramer, Fritz ^b   Clifton, Lisa ^b   Russell, Alan ^b   Hellerstein, Marc K ^a,c   Evans, William J ^a,b  

^a KINEMED INC   (United States)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anabolism; Biomarkers of muscle anabolism; Dynamic proteomics; Fractional synthesis rate; Protein synthesis; Selective androgen receptor modulator; Skeletal muscle; Stable isotope

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATASE (CALCIUM); ALPHA ACTININ 2; ALPHA ACTININ 3; ALPHA TROPOMYOSIN; BISPHOSPHOGLYCERATE MUTASE; CALCIUM ION; CARBONATE DEHYDRATASE III; CREATINE KINASE; CREATINE KINASE M TYPE; DJ 1 PROTEIN; FRUCTOSE BISPHOSPHATE ALDOLASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOGEN PHOSPHORYLASE; GSK 212A; HISTONE H2B; LUMICAN; MALATE DEHYDROGENASE; MUSCLE PROTEIN; MYOGLOBIN; MYOSIN BINDING PROTEIN C; MYOSIN III; MYOSIN IV; MYOSIN LIGHT CHAIN; PEROXIREDOXIN 1; PEROXIREDOXIN 6; PHOSPHOGLUCOMUTASE; PHOSPHOGLYCERATE KINASE; SELECTIVE ANDROGEN RECEPTOR MODULATOR; TRIOSEPHOSPHATE ISOMERASE; UNCLASSIFIED DRUG; ANDROGEN; ANDROGEN RECEPTOR; CREATINE KINASE MM; DEUTERIUM; PROTEOME;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; DOSE RESPONSE; EXTENSOR DIGITORUM LONGUS MUSCLE; FEMALE; FRACTIONAL SYNTHESIS RATE; IN VIVO STUDY; LEAN BODY WEIGHT; MUSCLE MASS; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEOMICS; RAT; SOLEUS MUSCLE; WEIGHT GAIN; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; ORGAN SIZE; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT;

ANDROGENS; ANIMALS; BODY COMPOSITION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; CREATINE KINASE, MM FORM; DEUTERIUM; FEMALE; MASS SPECTROMETRY; MUSCLE PROTEINS; MUSCLE, SKELETAL; ORGAN SIZE; OVARIECTOMY; PROTEIN BIOSYNTHESIS; PROTEOME; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN;

EID: 84982845824     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00257.2015     Document Type: Article

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