Testosterone injection stimulates net protein synthesis but not tissue amino acid transport

American Journal of Physiology - Endocrinology and Metabolism

Volumn 275, Issue 5 38-5, 1998, Pages

  Ferrando, Arny A ^a,b   Tipton, Kevin D ^a   Doyle, David ^a   Phillips, Stuart M ^a   Cortiella, Joaquin ^a   Wolfe, Robert R ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b Metabolism   (United States)

Author keywords

Amino nitrogen uptake; Fractional breakdown rate

Indexed keywords

AMINO ACID; MUSCLE PROTEIN; NITROGEN; PROTEIN; TESTOSTERONE; TESTOSTERONE ENANTATE;

AMINO ACID TRANSPORT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; DIET RESTRICTION; DRUG EFFECT; HORMONAL THERAPY; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; LEAN BODY WEIGHT; MALE; MUSCLE BIOPSY; MUSCLE METABOLISM; NITROGEN BALANCE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; TESTOSTERONE BLOOD LEVEL; VASTUS LATERALIS MUSCLE;

EID: 0031730933     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.275.5.e864     Document Type: Article

References (22)

1. Bergström, J., P. Fürst, L.-O. Norée, and E. Vinnars. Intracellular free amino acid concentration in human muscle tissue. J. Appl. Physiol. 36: 693-697, 1974.
2. Bhasin, S., T. W. Storer, N. Berman, C. Callegari, B. Clevenger, J. Phillips, T. J. Bunnell, R. Tricker, A. Shirazi, and R. Casaburi. The effects of supraphysiological doses of testosterone on muscle size and strength in normal men. N. Eng. J. Med. 335: 1-7, 1996.
3. Bhasin, S., T. W. Storer, N. Berman, K. E. Yarasheski, B. Clevenger, J. Phillips, W. P. Lee, J. Bunnell, and R. Casaburi. Testosterone replacement increases fat-free mass and muscle size in hypogonadal men. J. Clin. Endocrinol. Metab. 82: 407-413, 1997.
4. Biolo, G., D. Chinkes, X. Zhang, and R. R. Wolfe. A new model to determine in vivo the relationship between amino acid transmembrane transport and protein kinetics in muscle. J. Parenter. Enteral Nutr. 16: 305-315, 1992.
5. Biolo, G., R. Y. D. Fleming, S. P. Maggi, and R. R. Wolfe. Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E75-E84, 1995.
6. Biolo, G., R. Y. D. Fleming, and R. R. Wolfe. Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. J. Clin. Invest. 95: 811-819, 1995.
7. Biolo, G., K. D. Tipton, S. Klein, and R. R. Wolfe. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E122-E129, 1997.
8. Brodsky, I. G., P. Balagopal, and K. S. Nair. Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men - a clinical research center study. J. Clin. Endocrinol. Metab. 81: 3469-3475, 1996.
9. Dempster, W. T., and G. R. L. Gaughran. Properties of body segment based on size and weight. Am. J. Anat. 120: 33-54, 1965.
10. Ferrando, A. A., H. W. Lane, C. A. Stuart, J. Davis-Street, and R. R. Wolfe. Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E627-E633, 1996.
11. Fryburg, D. A. Insulin-like growth factor I exerts growth hormone- and insulin-like actions on human muscle protein metabolism. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E331-E336, 1994.
12. Fryburg, D. A., R. A. Gelfand, and E. J. Barrett. Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans. Am. J. Physiol. 260 (Endocrinol. Metab. 23): E499-E504, 1991.
13. Fryburg, D. A., L. A. Jahn, S. A. Hill, D. M. Oliveras, and E. J. Barrett. Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J. Clin. Invest. 96: 1722-1729, 1995.
14. Griggs, R. C., W. Kingston, R. F. Jozefowicz, B. E. Herr, G. Forbes, and D. Halliday. Effect of testosterone on muscle mass and muscle protein synthesis. J. Appl. Physiol. 66: 498-503, 1989.
15. Haupt, H. A., and G. D. Rovere. Anabolic steroids: a review of the literature. Am. J. Sports Med. 12: 469-484, 1984.
16. Hobbs, C. J., S. R. Plymate, C. J. Rosen, and R. A. Adler. Testosterone adminitration increases insulin-like growth factor-I levels in normal men. J. Endocrinol. Metab. 77: 776-779, 1993.
17. Katznelson, L., J. S. Finkelstein, D. A. Schoenfeld, D. I. Rosenthal, E. J. Anderson, and A. Klibanski. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J. Clin. Endocrinol. Metab. 81: 4358-4365, 1996.
18. Tenover, J. S. Effects of testosterone supplementation in the aging male. J. Clin. Endocrinol. Metab. 75: 1092-1098, 1992.
19. Urban, R. J., Y. H. Bodenburg, C. Gilkison, J. Foxworth, A. R. Coggan, R. R. Wolfe, and A. Ferrando. Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E820-E826, 1995.
20. Welle, S., R. Jozefowicz, G. Forbes, and R. Griggs. Effect of testosterone on metabolic rate and body composition in normal men and men with muscular dystrophy. J. Clin. Endocrinol. Metab. 74: 332-335, 1992.
21. Wolfe, R. R. Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. New York: Wiley-Liss, 1992.
22. Zhang, X.-J., D. L. Chinkes, Y. Sakurai, and R. R. Wolfe. An isotopic method for measurement of muscle protein fractional breakdown rate in vivo. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E759-E767, 1996.