Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: Effects on sexual function, body composition, muscle performance and physical function in a randomized trial

Menopause

Volumn 21, Issue 6, 2014, Pages 612-623

  Huang, Grace ^a   Basaria, Shehzad ^a   Travison, Thomas G ^a,b   Ho, Matthew H ^c,d   Davda, Maithili ^a,b   Mazer, Norman A ^a   Miciek, Renee ^a   Knapp, Philip E ^a   Zhang, Anqi ^a   Collins, Lauren ^a   Ursino, Monica ^a   Appleman, Erica ^a   Dzekov, Connie ^c   Stroh, Helene ^a   Ouellette, Miranda ^a   Rundell, Tyler ^a   Baby, Merilyn ^a   Bhatia, Narender N ^d   Khorram, Omid ^d   Friedman, Theodore ^c   Storer, Thomas W ^a   Bhasin, Shalender ^a   more..

^a BOSTON MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY   (United States)

^c CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^d HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Body composition; Hysterectomy; Menopause; Muscle performance; Oophorectomy; Physical function.; Sexual function; Testosterone

Indexed keywords

ESTRADIOL; PLACEBO; TESTOSTERONE; TESTOSTERONE ENANTATE; ANDROGEN;

ADULT; ARTICLE; BODY COMPOSITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; EQUILIBRIUM DIALYSIS; FEMALE; HUMAN; HYSTERECTOMY; LEAN BODY WEIGHT; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MULTICENTER STUDY; MUSCLE FUNCTION; OVARIECTOMY; PHYSICAL PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; SEXUAL BEHAVIOR; SEXUAL FUNCTION; TANDEM MASS SPECTROMETRY; TESTOSTERONE BLOOD LEVEL; ANALOGS AND DERIVATIVES; AROUSAL; BLOOD; DRUG EFFECTS; MIDDLE AGED; MUSCLE STRENGTH; PHYSIOLOGY; POSTMENOPAUSE; SEXUALITY; SKELETAL MUSCLE;

ANDROGENS; AROUSAL; BODY COMPOSITION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; HYSTERECTOMY; MIDDLE AGED; MUSCLE STRENGTH; MUSCLE, SKELETAL; OVARIECTOMY; POSTMENOPAUSE; SEXUAL BEHAVIOR; SEXUALITY; TESTOSTERONE;

EID: 84901619466     PISSN: 10723714     EISSN: 15300374     Source Type: Journal    
DOI: 10.1097/GME.0000000000000093     Document Type: Article

References (52)

1. Padero MC, Bhasin S, Friedman TC. Androgen supplementation in older women: too much hype, not enough data. J Am Geriatr Soc 2002;50: 1131-1140.
2. Basaria S, Dobs AS. Clinical review: Controversies regarding transdermal androgen therapy in postmenopausal women. J Clin Endocrinol Metab 2006;91:4743-4752.
3. Laughlin GA, Barrett-Connor E, Kritz-Silverstein D, von Muhlen D. Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernardo Study. J Clin Endocrinol Metab 2000;85:645-651.
4. Maserejian NN, Shifren J, Parish SJ, Segraves RT, Huang L, Rosen RC. Sexual arousal and lubrication problems in women with clinically diagnosed hypoactive sexual desire disorder: preliminary findings from the hypoactive sexual desire disorder registry for women. J Sex Marital Ther 2012;38:41-62.
5. Zussman L, Zussman S, Sunley R, Bjornson E. Sexual response after hysterectomy-oophorectomy: recent studies and reconsideration of psychogenesis. Am J Obstet Gynecol 1981;140:725-729.
6. Nathorst-Boos J, von Schoultz B. Psychological reactions and sexual life after hysterectomy with and without oophorectomy. Gynecol Obstet Investig 1992;34:97-101.
7. Celik H, Gurates B, Yavuz A, Nurkalem C, Hanay F, Kavak B. The effect of hysterectomy and bilaterally salpingo-oophorectomy on sexual function in post-menopausal women. Maturitas 2008;61:358-363.
8. Nathorst-Boos J, von Schoultz B, Carlstrom K. Elective ovarian removal and estrogen replacement therapyVeffects on sexual life, psychological well-being and androgen status. J Psychosom Obstet Gynaecol 1993;14: 283-293.
9. Shifren JL, Braunstein GD, Simon JA, et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000;343:682-688.
10. Davis SR, Moreau M, Kroll R, et al. Testosterone for low libido in postmenopausal women not taking estrogen. N Engl J Med 2008;359: 2005-2017.
11. Buster JE, Kingsberg SA, Aguirre O, et al. Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 2005;105(PART. 1):944-952.
12. Braunstein GD, Sundwall DA, Katz M, et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Arch Intern Med 2005;165:1582-1589.
13. Simon J, Braunstein G, Nachtigall L, et al. Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 2005;90: 5226-5233.
14. Panay N, Al-Azzawi F, Bouchard C, et al. Testosterone treatment of HSDD in naturally menopausal women: the ADORE study. Climacteric 2010;13:121-131.
15. Shifren JL, Davis SR, Moreau M, et al. Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 Study. Menopause 2006;13:770-779.
16. Douchi T, Yamamoto S, Nakamura S, et al. The effect of menopause on regional and total body lean mass. Maturitas 1998;29:247-252.
17. Aloia JF, McGowan DM, Vaswani AN, Ross P, Cohn SH. Relationship of menopause to skeletal and muscle mass. Am J Clin Nutr 1991;53: 1378-1383.
18. Sowers M, Zheng H, Tomey K, et al. Changes in body composition in women over six years at midlife: ovarian and chronological aging. J Clin Endocrinol Metab 2007;92:895-901.
19. Cappola AR, Xue QL, Fried LP. Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the Women's Health and Aging studies. J Gerontol A Biol Sci Med Sci 2009;64:243-248.
20. Dobs AS, Nguyen T, Pace C, Roberts CP. Differential effects of oral estrogen versus oral estrogen-androgen replacement therapy on body composition in postmenopausal women. J Clin EndocrinolMetab 2002;87: 1509-1516.
21. Miller KK, Grieco KA, Klibanski A. Testosterone administration in women with anorexia nervosa. J Clin Endocrinol Metab 2005;90:1428-1433.
22. Davis SR, McCloud P, Strauss BJ, Burger H. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995;21:227-236.
23. Gruber DM, Sator MO, Kirchengast S, Joura EA, Huber JC. Effect of percutaneous androgen replacement therapy on body composition and body weight in postmenopausal women. Maturitas 1998;29:253-259.
24. Sinha-Hikim I, Arver S, Beall G, et al. The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virusYinfected women. J Clin Endocrinol Metab 1998;83:1312-1318.
25. Mazer NA, Leiblum SR, Rosen RC. The Brief Index of Sexual Functioning for Women (BISF-W): a new scoring algorithm and comparison of normative and surgically menopausal populations. Menopause 2000;7: 350-363.
26. Grossi E, Groth N, Mosconi P, et al. Development and validation of the short version of the Psychological General Well-Being Index (PGWB-S). Health Qual Life Outcomes 2006;4:88.
27. Derogatis LR. The Derogatis Interview for Sexual Functioning (DISF/DISF-SR): an introductory report. J Sex Marital Ther 1997;23:291-304.
28. Derogatis L, Clayton A, Lewis-D'Agostino D, Wunderlich G, Fu Y. Validation of the Female Sexual Distress ScaleVRevised for assessing distress in women with hypoactive sexual desire disorder. J Sex Med 2008;5:357-364.
29. Kim J, Wang Z, Heymsfield SB, Baumgartner RN, Gallagher D. Totalbody skeletal muscle mass: estimation by a new dual-energy X-ray absorPART.iometry method. Am J Clin Nutr 2002;76:378-383.
30. Storer TW,Magliano L, Woodhouse L, et al. Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. J Clin Endocrinol Metab 2003;88: 1478-1485.
31. Krasnoff JB, Basaria S, Pencina MJ, et al. Free testosterone levels are associated with mobility limitation and physical performance in communitydwelling men: the Framingham Offspring Study. J Clin Endocrinol Metab 2010;95:2790-2799.
32. LeBrasseur NK, Lajevardi N, Miciek R, Mazer N, Storer TW, Bhasin S. Effects of testosterone therapy on muscle performance and physical function in older men with mobility limitations (The TOM Trial): design and methods. Contemp Clin Trials 2009;30:133-140.
33. Travison TG, Basaria S, Storer TW, et al. Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation. J Gerontol A Biol Sci Med Sci 2011;66:1090-1099.
34. Basaria S, Coviello AD, Travison TG, et al. Adverse events associated with testosterone administration. N Engl J Med 2010;363:109-122.
35. LeBrasseur NK, Bhasin S, Miciek R, Storer TW. Tests of muscle strength and physical function: reliability and discrimination of performance in younger and older men and older men with mobility limitations. J Am Geriatr Soc 2008;56:2118-2123.
36. Pierard G, Pierard-Franchimont C. The Sebutape technique for monitoring androgen dependent disorders. Eur J Med 1992;1:109-112.
37. Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961;21:1440-1447.
38. Palatsi R, Hirvensalo E, Liukko P, et al. Serum total and unbound testosterone and sex hormone binding globulin (SHBG) in female acne patients treated with two different oral contracePART.ives. Acta Derm Venereol 1984;64:517-523.
39. Bhasin S, Pencina M, Jasuja GK, et al. Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts. J Clin Endocrinol Metab 2011;96:2430-2439.
40. Choi HH, Gray PB, Storer TW, et al. Effects of testosterone replacement in human immunodeficiency virusYinfected women with weight loss. J Clin Endocrinol Metab 2005;90:1531-1541.
41. Bhasin S, Woodhouse L, Casaburi R, et al. Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab 2001;281:E1172-E1181.
42. van Buuren S. Multiple imputation of discrete and continuous data by fully conditional specification. Stat Methods Med Res 2007;16:219-242.
43. van Buuren S, Groothuis-Oudshoorn K. MICE: Multivariate Imputation by Chained Equations in R. J Stat Softw 2011;45:1-67.
44. White IR, Royston P, Wood AM. Multiple imputation using chained equations: issues and guidance for practice. Stat Med 2011;30:377-399.
45. Li KH, Meng XL, Raghunathan TE, Rubin DB. Significance levels from repeated p-values with multiply-imputed data. Stat Sin 1991;1:65-92.
46. Wood SN. Generalized Additive Models: An Introduction With R. Boca Raton, FL: Chapman and Hall/CRC, 2006.
47. Coviello AD, Nelson KP, Bhasin S. Reference ranges for circulating testosterone in the follicular and luteal phases of the menstrual cycle in a healthy, community-based sample of women in the Framingham Heart Study [Abstract]. Endocr Rev 2012;33.
48. Bhasin S. Female androgen deficiency syndromeVan unproven hypothesis. J Clin Endocrinol Metab 2005;90:4970-4972.
49. Bachmann G, Bancroft J, Braunstein G, et al. Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. Fertil Steril 2002;77:660-665.
50. Miller KK, Biller BM, Beauregard C, et al. Effects of testosterone replacement in androgen-deficient women with hypopituitarism: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2006;91:1683-1690.
51. Herbst KL, Calof OM, Hsia SH, et al. Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virusYinfected women with mild to moderate weight loss. Fertil Steril 2006;85:1794-1802.
52. Brand JS, van der Schouw YT. Testosterone, SHBG and cardiovascular health in postmenopausal women. Int J Impotence Res 2010;22:91-104.