The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Carreras Torres, Robert ^a   Haycock, Philip C ^b   Relton, Caroline L ^b   Martin, Richard M ^b,c   Smith, George Davey ^b   Kraft, Peter ^d   Gao, Chi ^d   Tworoger, Shelley ^d,e   Le Marchand, Loïc ^f   Wilkens, Lynne R ^f   Park, Sungshim L ^g   Haiman, Christopher ^g   Field, John K ^h   Davies, Michael ^h   Marcus, Michael ^h   Liu, Geoffrey ⁱ   Caporaso, Neil E ^j   Christiani, David C ^k   Wei, Yongyue ^k   Chen, Chu ^l   Doherty, Jennifer A ^m   Severi, Gianluca ⁿ   Goodman, Gary E ^l   Hung, Rayjean J ^o   Amos, Christopher I ^m   McKay, James ^a   Johansson, Mattias ^a   Brennan, Paul ^a   more..

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^g UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^h UNIVERSITY OF LIVERPOOL   (United Kingdom)

ⁱ PRINCESS MARGARET HOSPITAL   (Canada)

^j NATIONAL CANCER INSTITUTE   (United States)

^k MASSACHUSETTS GENERAL HOSPITAL   (United States)

^l USA   (United States)

^m DARTMOUTH MEDICAL SCHOOL   (United States)

ⁿ Human Genetics Foundation (HuGeF)   (Italy)

^o MOUNT SINAI HOSPITAL   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BODY MASS; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; HUMAN; LUNG TUMOR; MALE; MENDELIAN RANDOMIZATION ANALYSIS; PATHOLOGY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SMOKING;

BODY MASS INDEX; CASE-CONTROL STUDIES; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MENDELIAN RANDOMIZATION ANALYSIS; RISK FACTORS; SMOKING;

EID: 84982735799     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep31121     Document Type: Article

References (25)

1. Kaidar-Person, O., Bar-Sela, G. & Person, B. The Two Major Epidemics of the Twenty-First Century: Obesity and Cancer. Obes. Surg. 21, 1792-1797 (2011).
2. Bhaskaran, K. et al. Body-mass index and risk of 22 specifc cancers: a population-based cohort study of 5·24 million UK adults. Lancet 755-765, doi: 10.1016/S0140-6736(14)60892-8 (2014).
3. Duan, P. et al. Body mass index and risk of lung cancer: Systematic review and dose-response meta-analysis. Sci. Rep. 5, 16938 (2015).
4. Kabat, G. C., Kim, M., Hunt, J. R., Chlebowski, R. T. & Rohan, T. E. Body mass index and waist circumference in relation to lung cancer risk in the women's health initiative. Am. J. Epidemiol. 168, 158-169 (2008).
5. Lam, T. K. et al. Anthropometric Measures and Physical Activity and the Risk of Lung Cancer in Never-Smokers: A Prospective Cohort Study. PLoS One 8 (2013).
6. Li, X. et al. Association of Body Mass Index with Chromosome Damage Levels and Lung Cancer Risk among Males. Sci. Rep. 5, 9458 (2015).
7. Smith, L. et al. Body mass index and risk of lung cancer among never, former, and current smokers. J. Natl. Cancer Inst. 104, 778-789 (2012).
8. Yang, Y. et al. Obesity and incidence of lung cancer: A meta-analysis. Int. J. Cancer 132, 1162-1169 (2013).
9. Freathy, R. M. et al. Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to infuence body mass index. Int. J. Epidemiol. 40, 1617-1628 (2011).
10. Taylor, A. E. et al. Stratifcation by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers. PLoS Genet. 10, e1004799 (2014).
11. Winslow, U. C., Rode, L. & Nordestgaard, B. G. High tobacco consumption lowers body weight: a Mendelian randomization study of the Copenhagen General Population Study. Int. J. Epidemiol. 540-550, doi: 10.1093/ije/dyu276 (2015).
12. Davey Smith, G. & Ebrahim, S. Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int. J. Epidemiol. 1-22, doi: 10.1093/ije/dyg070 (2003).
13. Davey Smith, G. & Hemani, G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum. Mol. Genet. 23, 1-10 (2014).
14. Locke, A. E. et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197-206 (2015).
15. Giant Consortiums data fles. at http://www.broadinstitute.org/collaboration/giant/index.php/GIANT-consortium-data-fles.
16. Wang, Y. et al. Rare variants of large efect in BRCA2 and CHEK2 afect risk of lung cancer. Nat. Genet. 46, 736-741 (2014).
17. Johansson, M. et al. Serum B Vitamin Levels and Risk of Lung Cancer. JAMA 303, 2377-2385 (2010).
18. Consortium launches genotyping efort. Cancer Discov. 3, 1321-1322 (2013).
19. Kachuri, L. et al. Fine-mapping of chromosome 5p15. 33 based on a targeted deep sequencing identifies novel lung cancer susceptibility loci. Carcinogenesis bgv165 (2015).
20. Burgess, S. Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome. Int. J. Epidemiol. 43, 922-929 (2014).
21. Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efcient meta-analysis of genomewide association scans. Bioinformatics 26, 2190-2191 (2010).
22. Burgess, S., Butterworth, A. & Tompson, S. G. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet. Epidemiol. 37, 658-665 (2013).
23. Bowden, J., Smith, G. D., Haycock, P. C. & Burgess, S. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol 40, 304-314 (2016).
24. Bowden, J., Davey Smith, G. & Burgess, S. Mendelian randomization with invalid instruments: efect estimation and bias detection through Egger regression. Int. J. Epidemiol. 512-525, doi: 10.1093/ije/dyv080 (2015).
25. Renehan, A. G., Zwahlen, M. & Egger, M. Adiposity and cancer risk: new mechanistic insights from epidemiology. Nat. Rev. Cancer 15, 484-498 (2015).