메뉴 건너뛰기




Volumn 44, Issue 4, 2016, Pages 2114-2119

Exosomes from adipose-derived stem cells ameliorate phenotype of Huntington's disease in vitro model

Author keywords

adipose derived stem cells; exosomes; Huntington's disease; paracrine effect

Indexed keywords

CELL PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HUNTINGTIN; PGC 1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84982227563     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/ejn.13275     Document Type: Article
Times cited : (114)

References (32)
  • 1
    • 84873919177 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
    • Arslan, F., Lai, R.C., Smeets, M.B., Akeroyd, L., Choo, A., Aguor, E.N., Timmers, L., van Rijen, H.V. et al. (2013) Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res., 10, 301–312.
    • (2013) Stem Cell Res. , vol.10 , pp. 301-312
    • Arslan, F.1    Lai, R.C.2    Smeets, M.B.3    Akeroyd, L.4    Choo, A.5    Aguor, E.N.6    Timmers, L.7    van Rijen, H.V.8
  • 2
    • 36048991451 scopus 로고    scopus 로고
    • Opportunities and challenges for mesenchymal stem cell-mediated heart repair
    • Atsma, D.E., Fibbe, W.E. & Rabelink, T.J. (2007) Opportunities and challenges for mesenchymal stem cell-mediated heart repair. Curr. Opin. Lipidol., 18, 645–649.
    • (2007) Curr. Opin. Lipidol. , vol.18 , pp. 645-649
    • Atsma, D.E.1    Fibbe, W.E.2    Rabelink, T.J.3
  • 3
    • 84901833952 scopus 로고    scopus 로고
    • Surface analysis of Dicrocoelium dendriticum. The molecular characterization of exosomes reveals the presence of miRNAs
    • Bernal, D., Trelis, M., Montaner, S., Cantalapiedra, F., Galiano, A., Hackenberg, M. & Marcilla, A. (2014) Surface analysis of Dicrocoelium dendriticum. The molecular characterization of exosomes reveals the presence of miRNAs. J. Proteomics., 105, 232–241.
    • (2014) J. Proteomics. , vol.105 , pp. 232-241
    • Bernal, D.1    Trelis, M.2    Montaner, S.3    Cantalapiedra, F.4    Galiano, A.5    Hackenberg, M.6    Marcilla, A.7
  • 4
    • 57649187103 scopus 로고    scopus 로고
    • Mitochondria and Huntington's disease pathogenesis: insight from genetic and chemical models
    • Browne, S.E. (2008) Mitochondria and Huntington's disease pathogenesis: insight from genetic and chemical models. Ann. N. Y. Acad. Sci., 1147, 358–382.
    • (2008) Ann. N. Y. Acad. Sci. , vol.1147 , pp. 358-382
    • Browne, S.E.1
  • 5
    • 18544410106 scopus 로고    scopus 로고
    • Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
    • Davies, S.W., Turmaine, M., Cozens, B.A., DiFiglia, M., Sharp, A.H., Ross, C.A., Scherzinger, E., Wanker, E.E. et al. (1997) Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell, 90, 537–548.
    • (1997) Cell , vol.90 , pp. 537-548
    • Davies, S.W.1    Turmaine, M.2    Cozens, B.A.3    DiFiglia, M.4    Sharp, A.H.5    Ross, C.A.6    Scherzinger, E.7    Wanker, E.E.8
  • 7
    • 58149347238 scopus 로고    scopus 로고
    • Paracrine mechanisms in adult stem cell signaling and therapy
    • Gnecchi, M., Zhang, Z., Ni, A. & Dzau, V.J. (2008) Paracrine mechanisms in adult stem cell signaling and therapy. Circ. Res., 103, 1204–1219.
    • (2008) Circ. Res. , vol.103 , pp. 1204-1219
    • Gnecchi, M.1    Zhang, Z.2    Ni, A.3    Dzau, V.J.4
  • 8
    • 84875679090 scopus 로고    scopus 로고
    • Extracts of adipose derived stem cells slows progression in the R6/2 model of Huntington's disease
    • Im, W., Ban, J., Lim, J., Lee, M., Lee, S.T., Chu, K. & Kim, M. (2013) Extracts of adipose derived stem cells slows progression in the R6/2 model of Huntington's disease. PLoS One, 8, e59438.
    • (2013) PLoS One , vol.8
    • Im, W.1    Ban, J.2    Lim, J.3    Lee, M.4    Lee, S.T.5    Chu, K.6    Kim, M.7
  • 9
    • 84947764821 scopus 로고    scopus 로고
    • Multidrug resistance protein 1 reduces the aggregation of mutant huntingtin in neuronal cells derived from the Huntington's disease R6/2 model
    • Im, W., Ban, J.J., Chung, J.Y., Lee, S.T., Chu, K. & Kim, M. (2015) Multidrug resistance protein 1 reduces the aggregation of mutant huntingtin in neuronal cells derived from the Huntington's disease R6/2 model. Sci. Rep., 5, 16887.
    • (2015) Sci. Rep. , vol.5 , pp. 16887
    • Im, W.1    Ban, J.J.2    Chung, J.Y.3    Lee, S.T.4    Chu, K.5    Kim, M.6
  • 10
    • 84949513875 scopus 로고    scopus 로고
    • Neuroprotective effect of human adipose stem cell-derived extract in amyotrophic lateral sclerosis
    • Jeon, G.S., Im, W., Shim, Y.M., Lee, M., Kim, M.J., Hong, Y.H., Seong, S.Y., Kim, M. et al. (2016) Neuroprotective effect of human adipose stem cell-derived extract in amyotrophic lateral sclerosis. Neurochem. Res., 41, 913–923.
    • (2016) Neurochem. Res. , vol.41 , pp. 913-923
    • Jeon, G.S.1    Im, W.2    Shim, Y.M.3    Lee, M.4    Kim, M.J.5    Hong, Y.H.6    Seong, S.Y.7    Kim, M.8
  • 11
    • 84865187620 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in neurodegenerative diseases
    • Johri, A. & Beal, M.F. (2012) Mitochondrial dysfunction in neurodegenerative diseases. J. Pharmacol. Exp. Ther., 342, 619–630.
    • (2012) J. Pharmacol. Exp. Ther. , vol.342 , pp. 619-630
    • Johri, A.1    Beal, M.F.2
  • 12
    • 33751199883 scopus 로고    scopus 로고
    • Exosomes: from biogenesis and secretion to biological function
    • Keller, S., Sanderson, M.P., Stoeck, A. & Altevogt, P. (2006) Exosomes: from biogenesis and secretion to biological function. Immunol. Lett., 107, 102–108.
    • (2006) Immunol. Lett. , vol.107 , pp. 102-108
    • Keller, S.1    Sanderson, M.P.2    Stoeck, A.3    Altevogt, P.4
  • 13
    • 84922271592 scopus 로고    scopus 로고
    • Autocrine stimulation of IL-10 is critical to the enrichment of IL-10-producing CD40(hi)CD5(+) regulatory B cells in vitro and in vivo
    • Kim, H.S., Lee, J.H., Han, H.D., Kim, A.R., Nam, S.T., Kim, H.W., Park, Y.H., Lee, D. et al. (2015) Autocrine stimulation of IL-10 is critical to the enrichment of IL-10-producing CD40(hi)CD5(+) regulatory B cells in vitro and in vivo. BMB Rep., 48, 54–59.
    • (2015) BMB Rep. , vol.48 , pp. 54-59
    • Kim, H.S.1    Lee, J.H.2    Han, H.D.3    Kim, A.R.4    Nam, S.T.5    Kim, H.W.6    Park, Y.H.7    Lee, D.8
  • 14
    • 72949093579 scopus 로고    scopus 로고
    • Slowed progression in models of Huntington disease by adipose stem cell transplantation
    • Lee, S.T., Chu, K., Jung, K.H., Im, W.S., Park, J.E., Lim, H.C., Won, C.H., Shin, S.H. et al. (2009) Slowed progression in models of Huntington disease by adipose stem cell transplantation. Ann. Neurol., 66, 671–681.
    • (2009) Ann. Neurol. , vol.66 , pp. 671-681
    • Lee, S.T.1    Chu, K.2    Jung, K.H.3    Im, W.S.4    Park, J.E.5    Lim, H.C.6    Won, C.H.7    Shin, S.H.8
  • 15
    • 79957619269 scopus 로고    scopus 로고
    • Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors
    • Lee, J.W., Fang, X., Krasnodembskaya, A., Howard, J.P. & Matthay, M.A. (2011) Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors. Stem Cells, 29, 913–919.
    • (2011) Stem Cells , vol.29 , pp. 913-919
    • Lee, J.W.1    Fang, X.2    Krasnodembskaya, A.3    Howard, J.P.4    Matthay, M.A.5
  • 16
    • 84930914287 scopus 로고    scopus 로고
    • The ADAM15 ectodomain is shed from secretory exosomes
    • Lee, H.D., Kim, Y.H., Koo, B.H. & Kim, D.S. (2015) The ADAM15 ectodomain is shed from secretory exosomes. BMB Rep., 48, 277–282.
    • (2015) BMB Rep. , vol.48 , pp. 277-282
    • Lee, H.D.1    Kim, Y.H.2    Koo, B.H.3    Kim, D.S.4
  • 18
    • 84898771564 scopus 로고    scopus 로고
    • Isolation and quantification of microRNAs from urinary exosomes/microvesicles for biomarker discovery
    • Lv, L.L., Cao, Y., Liu, D., Xu, M., Liu, H., Tang, R.N., Ma, K.L. & Liu, B.C. (2013) Isolation and quantification of microRNAs from urinary exosomes/microvesicles for biomarker discovery. Int. J. Biol. Sci., 9, 1021–1031.
    • (2013) Int. J. Biol. Sci. , vol.9 , pp. 1021-1031
    • Lv, L.L.1    Cao, Y.2    Liu, D.3    Xu, M.4    Liu, H.5    Tang, R.N.6    Ma, K.L.7    Liu, B.C.8
  • 19
    • 77956404647 scopus 로고    scopus 로고
    • Exosomes: extracellular organelles important in intercellular communication
    • Mathivanan, S., Ji, H. & Simpson, R.J. (2010) Exosomes: extracellular organelles important in intercellular communication. J. Proteomics., 73, 1907–1920.
    • (2010) J. Proteomics. , vol.73 , pp. 1907-1920
    • Mathivanan, S.1    Ji, H.2    Simpson, R.J.3
  • 20
    • 33750462349 scopus 로고    scopus 로고
    • PGC-1alpha, a new therapeutic target in Huntington's disease?
    • McGill, J.K. & Beal, M.F. (2006) PGC-1alpha, a new therapeutic target in Huntington's disease? Cell, 127, 465–468.
    • (2006) Cell , vol.127 , pp. 465-468
    • McGill, J.K.1    Beal, M.F.2
  • 22
    • 77955360645 scopus 로고    scopus 로고
    • Adipose-derived stem and stromal cells for cell-based therapy: current status of preclinical studies and clinical trials
    • Mizuno, H. (2010) Adipose-derived stem and stromal cells for cell-based therapy: current status of preclinical studies and clinical trials. Curr. Opin. Mol. Ther., 12, 442–449.
    • (2010) Curr. Opin. Mol. Ther. , vol.12 , pp. 442-449
    • Mizuno, H.1
  • 23
    • 84871923602 scopus 로고    scopus 로고
    • Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells
    • Ohno, S., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T. et al. (2013) Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol. Ther., 21, 185–191.
    • (2013) Mol. Ther. , vol.21 , pp. 185-191
    • Ohno, S.1    Takanashi, M.2    Sudo, K.3    Ueda, S.4    Ishikawa, A.5    Matsuyama, N.6    Fujita, K.7    Mizutani, T.8
  • 24
    • 77953302472 scopus 로고    scopus 로고
    • Nature and cause of mitochondrial dysfunction in Huntington's disease: focusing on huntingtin and the striatum
    • Oliveira, J.M. (2010) Nature and cause of mitochondrial dysfunction in Huntington's disease: focusing on huntingtin and the striatum. J. Neurochem., 114, 1–12.
    • (2010) J. Neurochem. , vol.114 , pp. 1-12
    • Oliveira, J.M.1
  • 26
    • 84922292046 scopus 로고    scopus 로고
    • Oxidized LDL induces phosphorylation of non-muscle myosin IIA heavy chain in macrophages
    • Park, Y.M. (2015) Oxidized LDL induces phosphorylation of non-muscle myosin IIA heavy chain in macrophages. BMB Rep., 48, 48–53.
    • (2015) BMB Rep. , vol.48 , pp. 48-53
    • Park, Y.M.1
  • 27
    • 84930483835 scopus 로고    scopus 로고
    • Classification, functions, and clinical relevance of extracellular vesicles
    • van der Pol, E., Boing, A.N., Harrison, P., Sturk, A. & Nieuwland, R. (2012) Classification, functions, and clinical relevance of extracellular vesicles. Pharmacol. Rev., 64, 676–705.
    • (2012) Pharmacol. Rev. , vol.64 , pp. 676-705
    • van der Pol, E.1    Boing, A.N.2    Harrison, P.3    Sturk, A.4    Nieuwland, R.5
  • 28
    • 67349204472 scopus 로고    scopus 로고
    • Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms
    • Prockop, D.J. (2009) Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms. Mol. Ther., 17, 939–946.
    • (2009) Mol. Ther. , vol.17 , pp. 939-946
    • Prockop, D.J.1
  • 30
    • 34147107634 scopus 로고    scopus 로고
    • Concise review: adipose tissue-derived stromal cells–basic and clinical implications for novel cell-based therapies
    • Schaffler, A. & Buchler, C. (2007) Concise review: adipose tissue-derived stromal cells–basic and clinical implications for novel cell-based therapies. Stem Cells, 25, 818–827.
    • (2007) Stem Cells , vol.25 , pp. 818-827
    • Schaffler, A.1    Buchler, C.2
  • 31
    • 33749999530 scopus 로고    scopus 로고
    • Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    • St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J.M., Rhee, J., Jager, S., Handschin, C., Zheng, K. et al. (2006) Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell, 127, 397–408.
    • (2006) Cell , vol.127 , pp. 397-408
    • St-Pierre, J.1    Drori, S.2    Uldry, M.3    Silvaggi, J.M.4    Rhee, J.5    Jager, S.6    Handschin, C.7    Zheng, K.8
  • 32
    • 84860858416 scopus 로고    scopus 로고
    • Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials
    • Vlassov, A.V., Magdaleno, S., Setterquist, R. & Conrad, R. (2012) Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim. Biophys. Acta, 1820, 940–948.
    • (2012) Biochim. Biophys. Acta , vol.1820 , pp. 940-948
    • Vlassov, A.V.1    Magdaleno, S.2    Setterquist, R.3    Conrad, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.