Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats

European Journal of Neuroscience

Volumn 44, Issue 4, 2016, Pages 2120-2128

  Pardo, Joaquín ^a,b   Uriarte, Maia ^a,b   Cónsole, Gloria M ^b   Reggiani, Paula C ^a,b   Outeiro, Tiago F ^c   Morel, Gustavo R ^a,b   Goya, Rodolfo G ^a,b  

^a INSTITUTO DE INVESTIGACIONES BIOQUÍMICAS DE LA PLATA INIBIOLP   (Argentina)

^b FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

aging; Barnes maze; gene therapy; hippocampal morphology; IGF I; spatial memory

Indexed keywords

ADENOVIRUS VECTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; SOMATOMEDIN C;

ACCURACY; AGING; AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE BRANCHING; BARNES MAZE; CELL BODY; CEREBROSPINAL FLUID ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DENTATE GYRUS; DENTATE HILUS; DORSAL HIPPOCAMPUS; DRUG CEREBROSPINAL FLUID LEVEL; EPENDYMA CELL; FEMALE; GENE EXPRESSION; GENE THERAPY; HIPPOCAMPAL MORPHOLOGY; HIPPOCAMPUS; LATENT PERIOD; MAZE TEST; MEMORY ACCURACY; MORPHOLOGY; NERVE CELL CHARACTERISTICS AND FUNCTIONS; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; SPATIAL MEMORY; STRATUM RADIATUM; TRANSGENE; TREATMENT DURATION;

EID: 84982198660     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/ejn.13278     Document Type: Article

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