메뉴 건너뛰기




Volumn 154, Issue 6, 2013, Pages 2166-2173

Hypothalamic IGF-I gene therapy prolongs estrous cyclicity and protects ovarian structure in middle-aged female rats

Author keywords

[No Author keywords available]

Indexed keywords

LUTEINIZING HORMONE; RECOMBINANT ADENOASSOCIATED VIRUS; RED FLUORESCENT PROTEIN; SOMATOMEDIN C; UNCLASSIFIED DRUG;

EID: 84878426010     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1069     Document Type: Article
Times cited : (16)

References (54)
  • 2
    • 67651151321 scopus 로고    scopus 로고
    • The excitatory peptide kisspeptin restores the luteinizing hormone surge and modulates amino acid neurotransmission in the medial preoptic area of middle-aged rats
    • Neal-Perry G, Lebesgue D, Lederman M, Shu J, Zeevalk GD, Etgen AM. The excitatory peptide kisspeptin restores the luteinizing hormone surge and modulates amino acid neurotransmission in the medial preoptic area of middle-aged rats. Endocrinology. 2009;150:3699-3708.
    • (2009) Endocrinology , vol.150 , pp. 3699-3708
    • Neal-Perry, G.1    Lebesgue, D.2    Lederman, M.3    Shu, J.4    Zeevalk, G.D.5    Etgen, A.M.6
  • 3
    • 77149173162 scopus 로고    scopus 로고
    • Hypothalamic insulin-like growth factor-I receptors are necessary for hormone-dependent luteinizing hormone surges: Implications for female reproductive aging
    • Todd BJ, Merhi ZO, Shu J, Etgen AM, Neal-Perry GS. Hypothalamic insulin-like growth factor-I receptors are necessary for hormone-dependent luteinizing hormone surges: implications for female reproductive aging. Endocrinology. 2010;151:1356-1366.
    • (2010) Endocrinology , vol.151 , pp. 1356-1366
    • Todd, B.J.1    Merhi, Z.O.2    Shu, J.3    Etgen, A.M.4    Neal-Perry, G.S.5
  • 4
    • 0142126332 scopus 로고    scopus 로고
    • Stereologic Analysis of Estrogen Receptor Alpha (ERα) Expression in Rat Hypothalamus and Its Regulation by Aging and Estrogen
    • DOI 10.1002/cne.10906
    • Chakraborty TR, Hof PR, Ng L, Gore AC. Stereologic analysis of estrogen receptor α (ERα) expression in rat hypothalamus and its regulation by aging and estrogen. J Comp Neurol. 2003;466:409-421. (Pubitemid 37296648)
    • (2003) Journal of Comparative Neurology , vol.466 , Issue.3 , pp. 409-421
    • Chakraborty, T.R.1    Hof, P.R.2    Ng, L.3    Gore, A.C.4
  • 5
    • 0028694395 scopus 로고
    • Effects of estrogen and estrogen receptor messenger RNA levels in young and middle-aged female rats: Comparison of medial preoptic area and mediobasal hypothalamus
    • Funabashi T, Kimura F. Effects of estrogen and estrogen receptor messenger RNA levels in young and middle-aged female rats: comparison of medial preoptic area and mediobasal hypothalamus. Acta Biol Hung. 1994;45:223-231.
    • (1994) Acta Biol Hung , vol.45 , pp. 223-231
    • Funabashi, T.1    Kimura, F.2
  • 6
    • 0034281988 scopus 로고    scopus 로고
    • Changes in estrogenic regulation of estrogen receptor α mRNA and progesterone receptor mRNA in the female rat hypothalamus during aging: an in situ hybridization study
    • Funabashi T, Kleopoulos SP, Brooks PJ, et al. Changes in estrogenic regulation of estrogen receptor α mRNA and progesterone receptor mRNA in the female rat hypothalamus during aging: an in situ hybridization study. Neurosci Res. 2000;38:85-92.
    • (2000) Neurosci Res , vol.38 , pp. 85-92
    • Funabashi, T.1    Kleopoulos, S.P.2    Brooks, P.J.3
  • 7
    • 0023017695 scopus 로고
    • Estrogen binding in nuclear and cytosolic extracts from brain and pituitary of middle-aged female rats
    • DOI 10.1016/0006-8993(86)90008-9
    • Rubin BS, Fox TO, Bridges RS. Estrogen binding in nuclear and cytosolic extracts from brain and pituitary of middle-aged female rats. Brain Res. 1986;383:60-67. (Pubitemid 17179965)
    • (1986) Brain Research , vol.383 , Issue.1-2 , pp. 60-67
    • Rubin, B.S.1    Fox, T.O.2    Bridges, R.S.3
  • 8
    • 34249660014 scopus 로고    scopus 로고
    • Anterior pituitary gene expression with reproductive aging in the female rat
    • DOI 10.1095/biolreprod.106.057877
    • Zheng W, Jimenez-Linan M, Rubin BS, Halvorson LM. Anterior pituitary gene expression with reproductive aging in the female rat. Biol Reprod. 2007;76:1091-1102. (Pubitemid 46835018)
    • (2007) Biology of Reproduction , vol.76 , Issue.6 , pp. 1091-1102
    • Zheng, W.1    Jimenez-Linan, M.2    Rubin, B.S.3    Halvorson, L.M.4
  • 9
    • 24944487970 scopus 로고    scopus 로고
    • Attenuation of preoptic area glutamate release correlates with reduced luteinizing hormone secretion in middle-aged female rats
    • DOI 10.1210/en.2005-0575
    • Neal-Perry GS, Zeevalk GD, Santoro NF, Etgen AM. Attenuation of preoptic area glutamate release correlates with reduced luteinizing hormone secretion in middle-aged female rats. Endocrinology. 2005;146:4331-4339. (Pubitemid 41324029)
    • (2005) Endocrinology , vol.146 , Issue.10 , pp. 4331-4339
    • Neal-Perry, G.S.1    Zeevalk, G.D.2    Santoro, N.F.3    Etgen, A.M.4
  • 10
    • 0017197539 scopus 로고
    • Capacity of old versus young female rats to secrete LH, FSH and prolactin
    • Huang HH, Marshall S, Meites J. Capacity of old versus young female rats to secrete LH, FSH and prolactin. Biol Reprod. 1976;14:538-543.
    • (1976) Biol Reprod , vol.14 , pp. 538-543
    • Huang, H.H.1    Marshall, S.2    Meites, J.3
  • 11
    • 77955921961 scopus 로고    scopus 로고
    • The neuroendocrine physiology of female reproductive aging: An update
    • Neal-Perry G, Nejat E, Dicken C. The neuroendocrine physiology of female reproductive aging: an update. Maturitas. 2010;67:34-38.
    • (2010) Maturitas , vol.67 , pp. 34-38
    • Neal-Perry, G.1    Nejat, E.2    Dicken, C.3
  • 12
    • 0028097227 scopus 로고
    • A reduced proportion of luteinizing hormone (LH)-releasing hormone neurons express fos protein during the preovulatory or steroid-induced LH surge in middle-aged rats
    • DOI 10.1095/biolreprod51.6.1264
    • Rubin BS, Lee CE, King JC. A reduced proportion of luteinizing hormone (LH)-releasing hormone neurons express Fos protein during the preovulatory or steroid-induced LH surge in middle-aged rats. Biol Reprod. 1994;51:1264-1272. (Pubitemid 24354287)
    • (1994) Biology of Reproduction , vol.51 , Issue.6 , pp. 1264-1272
    • Rubin, B.S.1    Lee, C.E.2    King, J.C.3
  • 13
    • 0022576614 scopus 로고
    • LHRH neurons in the female C57BL/6J mouse brain during reproductive aging: No loss up to middle age
    • DOI 10.1016/0197-4580(86)90026-6
    • Hoffman GE, Finch CE. LHRH neurons in the female C57BL/6J mouse brain during reproductive aging: no loss up to middle age. Neurobiol Aging. 1986;7:45-48. (Pubitemid 16153130)
    • (1986) Neurobiology of Aging , vol.7 , Issue.1 , pp. 45-48
    • Hoffman, G.E.1    Finch, C.E.2
  • 14
    • 0035081715 scopus 로고    scopus 로고
    • Fos-induction in gonadotropin-releasing hormone neurons receiving vasoactive intestinal polypeptide innervation is reduced in middle-aged female rats
    • Krajnak K, Rosewell KL, Wise PM. Fos-induction in gonadotropin-releasing hormone neurons receiving vasoactive intestinal polypeptide innervation is reduced in middle-aged female rats. Biol Reprod. 2001;64:1160-1164. (Pubitemid 32239187)
    • (2001) Biology of Reproduction , vol.64 , Issue.4 , pp. 1160-1164
    • Krajnak, K.1    Rosewell, K.L.2    Wise, P.M.3
  • 15
    • 0030813102 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone gene expression differs in young and middle-aged females on the day of a steroid-induced LH surge
    • DOI 10.1016/S0006-8993(97)00879-2, PII S0006899397008792
    • Rubin BS, Lee CE, Ohtomo M, King JC. Luteinizing hormone-releasing hormone gene expression differs in young and middle-aged females on the day of a steroid-induced LH surge. Brain Res. 1997;770:267-276. (Pubitemid 27468077)
    • (1997) Brain Research , vol.770 , Issue.1-2 , pp. 267-276
    • Rubin, B.S.1    Lee, C.E.2    Ohtomo, M.3    King, J.C.4
  • 16
    • 0024580290 scopus 로고
    • Alterations in luteinizing hormone-releasing hormone release from the mediobasal hypothalamus of ovariectomized, steroid-primed middle-aged rats as measured by push-pull perfusion
    • Rubin BS, Bridges RS. Alterations in luteinizing hormone-releasing hormone release from the mediobasal hypothalamus of ovariectomized, steroid-primed middle-aged rats as measured by push-pull perfusion. Neuroendocrinology. 1989;49:225-232. (Pubitemid 19095260)
    • (1989) Neuroendocrinology , vol.49 , Issue.3 , pp. 225-232
    • Rubin, B.S.1    Bridges, R.S.2
  • 17
    • 0034898523 scopus 로고    scopus 로고
    • Alterations in hypothalamic insulin-like growth factor-I and its associations with gonadotropin releasing hormone neurones during reproductive development and ageing
    • DOI 10.1046/j.1365-2826.2001.00686.x
    • Miller BH, Gore AC. Alterations in hypothalamic insulin-like growth factor-I and its associations with gonadotropin releasing hormone neurones during reproductive development and ageing. J Neuroendocrinol. 2001;13:728-736. (Pubitemid 32725581)
    • (2001) Journal of Neuroendocrinology , vol.13 , Issue.8 , pp. 728-736
    • Miller, B.H.1    Gore, A.C.2
  • 18
    • 0034751111 scopus 로고    scopus 로고
    • Parallel declines in Fos activation of the medial anteroventral periventricular nucleus and LHRH neurons in middle-aged rats
    • DOI 10.1210/en.142.11.4976
    • Le WW, Wise PM, Murphy AZ, Coolen LM, Hoffman GE. Parallel declines in Fos activation of the medial anteroventral periventricular nucleus and LHRH neurons in middle-aged rats. Endocrinology. 2001;142:4976-4982. (Pubitemid 33022374)
    • (2001) Endocrinology , vol.142 , Issue.11 , pp. 4976-4982
    • Le, W.-W.1    Wise, P.M.2    Murphy, A.Z.3    Coolen, L.M.4    Hoffman, G.E.5
  • 19
    • 0036364349 scopus 로고    scopus 로고
    • Neuroendocrine modulation and repercussions of female reproductive aging
    • Wise PM, Smith MJ, Dubal DB, et al. Neuroendocrine modulation and repercussions of female reproductive aging. Recent Prog Horm Res. 2002;57:235-256.
    • (2002) Recent Prog Horm Res , vol.57 , pp. 235-256
    • Wise, P.M.1    Smith, M.J.2    Dubal, D.B.3
  • 20
    • 55549126867 scopus 로고    scopus 로고
    • Restoration of the luteinizing hormone surge in middle-aged female rats by altering the balance of GABA and glutamate transmission in the medial preoptic area
    • Neal-Perry GS, Zeevalk GD, Shu J, Etgen AM. Restoration of the luteinizing hormone surge in middle-aged female rats by altering the balance of GABA and glutamate transmission in the medial preoptic area. Biol Reprod. 2008;79:878-888.
    • (2008) Biol Reprod , vol.79 , pp. 878-888
    • Neal-Perry, G.S.1    Zeevalk, G.D.2    Shu, J.3    Etgen, A.M.4
  • 22
    • 15244350751 scopus 로고    scopus 로고
    • The aging reproductive neuroendocrine axis
    • DOI 10.1016/j.steroids.2004.12.008
    • Brann DW, Mahesh VB. The aging reproductive neuroendocrine axis. Steroids. 2005;70:273-283. (Pubitemid 40387382)
    • (2005) Steroids , vol.70 , Issue.4 , pp. 273-283
    • Brann, D.W.1    Mahesh, V.B.2
  • 23
    • 0032526420 scopus 로고    scopus 로고
    • Aging alters the rhythmic expression of vasoactive intestinal polypeptide mRNA but not arginine vasopressin mRNA in the suprachiasmatic nuclei of female rats
    • Krajnak K, Kashon ML, Rosewell KL, Wise PM. Aging alters the rhythmic expression of vasoactive intestinal polypeptide mRNA but not arginine vasopressin mRNA in the suprachiasmatic nuclei of female rats. J Neurosci. 1998;18:4767-4774. (Pubitemid 28280184)
    • (1998) Journal of Neuroscience , vol.18 , Issue.12 , pp. 4767-4774
    • Krajnak, K.1    Kashon, M.L.2    Rosewell, K.L.3    Wise, P.M.4
  • 24
    • 17044420428 scopus 로고    scopus 로고
    • Age-related effects of IGF-1 on the NMDA-, GH- and IGF-1-receptor mRNA transcripts in the rat hippocampus
    • Le Grevès M, Le Grevès P, Nyberg F. Age-related effects of IGF-1 on the NMDA-, GH- and IGF-1-receptor mRNA transcripts in the rat hippocampus. Brain Res Bull. 2005;65:369-374.
    • (2005) Brain Res Bull , vol.65 , pp. 369-374
    • Le Grevès, M.1    Le Grevès, P.2    Nyberg, F.3
  • 26
    • 58149473441 scopus 로고    scopus 로고
    • Insulin-like growth factor-I activates KiSS-1 gene expression in the brain of the prepubertal female rat
    • Hiney JK, Srivastava VK, Pine MD, Les Dees W. Insulin-like growth factor-I activates KiSS-1 gene expression in the brain of the prepubertal female rat. Endocrinology. 2009;150:376-384.
    • (2009) Endocrinology , vol.150 , pp. 376-384
    • Hiney, J.K.1    Srivastava, V.K.2    Pine, M.D.3    Les Dees, W.4
  • 27
    • 0028113501 scopus 로고
    • Induction of vasoactive intestinal peptide gene expression and prolactin secretion by insulin-like growth factor I in rat pituitary cells: Evidence for an autoparacrine regulatory system
    • DOI 10.1210/en.135.6.2526
    • Lara JI, Lorenzo MJ, Cacicedo L, et al. Induction of vasoactive intestinal peptide gene expression and prolactin secretion by insulin-like growth factor I in rat pituitary cells: evidence for an autoparacrine regulatory system. Endocrinology. 1994;135:2526-2532. (Pubitemid 24377412)
    • (1994) Endocrinology , vol.135 , Issue.6 , pp. 2526-2532
    • Lara, J.I.1    Lorenzo, M.J.2    Cacicedo, L.3    Tolon, R.M.4    Balsa, J.A.5    Lopez-Fernandez, J.6    Sanchez-Franco, F.7
  • 28
    • 0034913897 scopus 로고    scopus 로고
    • IGF-I as a mediator of VIP/activity-dependent neurotrophic factor-stimulated embryonic growth
    • DOI 10.1210/en.142.8.3348
    • Servoss SJ, Lee SJ, Gibney G, Gozes I, Brenneman DE, Hill JM. IGF-I as a mediator of VIP/activity-dependent neurotrophic factor-stimulated embryonic growth. Endocrinology. 2001;142:3348-3353. (Pubitemid 32681739)
    • (2001) Endocrinology , vol.142 , Issue.8 , pp. 3348-3353
    • Servoss, S.J.1    Lee, S.J.2    Gibney, G.3    Gozes, I.4    Brenneman, D.E.5    Hill, J.M.6
  • 29
    • 33745888080 scopus 로고    scopus 로고
    • Serum insulin-like growth factor I in brain function
    • DOI 10.2302/kjm.55.59
    • Carro E, Torres-Aleman I. Serum insulin growth factor I in brain function. IKeio J Med. 2006;55:59-63. (Pubitemid 44049646)
    • (2006) Keio Journal of Medicine , vol.55 , Issue.2 , pp. 59-63
    • Carro, E.1    Torres-Aleman, I.2
  • 30
    • 33846523620 scopus 로고    scopus 로고
    • Restorative effect of insulin-like growth factor-I gene therapy in the hypothalamus of senile rats with dopaminergic dysfunction
    • DOI 10.1038/sj.gt.3302870, PII 3302870
    • Hereñú CB, Cristina C, Rimoldi OJ, et al. Restorative effect of insulin-like growth factor-I gene therapy in the hypothalamus of senile rats with dopaminergic dysfunction. Gene Therapy. 2007;14:237-245. (Pubitemid 46152627)
    • (2007) Gene Therapy , vol.14 , Issue.3 , pp. 237-245
    • Herenu, C.B.1    Cristina, C.2    Rimoldi, O.J.3    Becu-Villalobos, D.4    Cambiaggi, V.5    Portiansky, E.L.6    Goya, R.G.7
  • 32
    • 79952002363 scopus 로고    scopus 로고
    • Restorative effect of intracerebroventricular insulin-like growth factor-I gene therapy on motor performance in aging rats
    • Nishida F, Morel GR, Hereñú CB, Schwerdt JI, Goya RG, Portiansky EL. Restorative effect of intracerebroventricular insulin-like growth factor-I gene therapy on motor performance in aging rats. Neuroscience. 2011;177:195-206.
    • (2011) Neuroscience , vol.177 , pp. 195-206
    • Nishida, F.1    Morel, G.R.2    Hereñú, C.B.3    Schwerdt, J.I.4    Goya, R.G.5    Portiansky, E.L.6
  • 34
    • 0032506752 scopus 로고    scopus 로고
    • Novel tools for production and purification of recombinant adenoassociated virus vectors
    • Grimm D, Kern A, Rittner K, Kleinschmidt JA. Novel tools for production and purification of recombinant adenoassociated virus vectors. Hum Gene Ther. 1998;9:2745-2760. (Pubitemid 29027018)
    • (1998) Human Gene Therapy , vol.9 , Issue.18 , pp. 2745-2760
    • Grimm, D.1    Kern, A.2    Rittner, K.3    Kleinschmidt, J.A.4
  • 36
    • 0003255738 scopus 로고    scopus 로고
    • Determination of the estrous cycle phases of rats: Some helpful considerations
    • Marcondes FK, Bianchi FJ, Tanno AP. Determination of the estrous cycle phases of rats: some helpful considerations. Braz J Biol. 2002;62:609-614.
    • (2002) Braz J Biol , vol.62 , pp. 609-614
    • Marcondes, F.K.1    Bianchi, F.J.2    Tanno, A.P.3
  • 37
    • 0001116593 scopus 로고
    • Changes in the weight and water content of the uterus of the normal adult rat
    • Astwood EB. Changes in the weight and water content of the uterus of the normal adult rat. Am J Physiol. 1939;126:162-170.
    • (1939) Am J Physiol , vol.126 , pp. 162-170
    • Astwood, E.B.1
  • 38
    • 64949134616 scopus 로고    scopus 로고
    • Morphological characterization of the ovary under normal cycling in rats and its viewpoints of ovarian toxicity detection
    • Yoshida M, Sanbuissyo A, Hisada S, Takahashi M, Ohno Y, Nishikawa A. Morphological characterization of the ovary under normal cycling in rats and its viewpoints of ovarian toxicity detection. J Toxicol Sci. 2009;34(suppl 1):189-197.
    • (2009) J Toxicol Sci , vol.34 , Issue.SUPPL. 1 , pp. 189-197
    • Yoshida, M.1    Sanbuissyo, A.2    Hisada, S.3    Takahashi, M.4    Ohno, Y.5    Nishikawa, A.6
  • 40
    • 0016832464 scopus 로고
    • Reproductive capacity of aging female rats
    • Huang HH, Meites J. Reproductive capacity of aging female rats. Neuroendocrinology. 1975;17:289-295.
    • (1975) Neuroendocrinology , vol.17 , pp. 289-295
    • Huang, H.H.1    Meites, J.2
  • 41
    • 0018650096 scopus 로고
    • Chronological changes in sex steroid, gonadotropin and prolactin secretion in aging female rats displaying different reproductive states
    • DOI 10.1095/biolreprod21.1.193
    • Lu KH, Hopper BR, Vargo TM, Yen SSC. Chronological changes in sex steroid, gonadotropin and prolactin secretions in aging female rats displaying different reproductive states. Biol Reprod. 1979;21:193-203. (Pubitemid 9249743)
    • (1979) Biology of Reproduction , vol.21 , Issue.1 , pp. 193-203
    • Lu, K.H.1    Hopper, B.R.2    Vargo, T.M.3    Yen, S.S.C.4
  • 42
    • 84878451545 scopus 로고
    • Repetitive pseudopregnancy in senile rats
    • [in French] CR
    • Aschheim P. Repetitive pseudopregnancy in senile rats [in French] CR. Acad Sci. 1961;253:1988-1990.
    • (1961) Acad Sci , vol.253 , pp. 1988-1990
    • Aschheim, P.1
  • 43
    • 0018182449 scopus 로고
    • Patterns of sex steroid and gonadotropin secretion in aging female rats
    • Huang HH, Steger RW, Bruni JF, Meites J. Patterns of sex steroid and gonadotropin secretion in aging female rats. Endocrinology. 1978;103:1855-1859. (Pubitemid 9052643)
    • (1978) Endocrinology , vol.103 , Issue.5 , pp. 1855-1859
    • Huang, H.H.1    Steger, R.W.2    Bruni, J.F.3    Meites, J.4
  • 44
    • 84878448438 scopus 로고
    • Chronological changes in ovarian function and morphology in aging rats and their relation to neuroendocrine responses
    • Schwartz NB, Hunzicker-Dunn M, eds. New York, New York: Raven Press
    • Lu JKH, Kledzik GS. Chronological changes in ovarian function and morphology in aging rats and their relation to neuroendocrine responses. In: Schwartz NB, Hunzicker-Dunn M, eds. Dynamics of Ovarian Function. New York, New York: Raven Press; 1981:291-296.
    • (1981) Dynamics of Ovarian Function , pp. 291-296
    • Lu, J.K.H.1    Kledzik, G.S.2
  • 45
    • 0003147718 scopus 로고
    • Changes in ovarian function and gonadotropin and prolactin secretion in aging female rats
    • Meites J, ed. New York, New York: Plenum Press
    • Lu, JKH. Changes in ovarian function and gonadotropin and prolactin secretion in aging female rats. In: Meites J, ed. Neuroendocrinology of Aging. New York, New York: Plenum Press; 1983:103-122.
    • (1983) Neuroendocrinology of Aging , pp. 103-122
    • Lu, J.K.H.1
  • 46
    • 0025187494 scopus 로고
    • Gonadal function in aging rats and its relation to pituitary and mammary pathology
    • DOI 10.1016/0047-6374(90)90116-W
    • Goya RG, Lu JKH, Meites J. Gonadal functionin aging rats and its relation to pituitary and mammary pathology. Mech Age Dev. 1990;56:77-88. (Pubitemid 20349656)
    • (1990) Mechanisms of Ageing and Development , vol.56 , Issue.1 , pp. 77-88
    • Goya, R.G.1    Lu, J.K.H.2    Meites, J.3
  • 47
    • 34347377175 scopus 로고    scopus 로고
    • Distribution and localization patterns of estrogen receptor-β and insulin-like growth factor-1 receptors in neurons and glial cells of the female rat substantia nigra: Localization of ERβ and IGF-1R in substantia nigra
    • DOI 10.1002/cne.21358
    • Quesada A, Romeo HE, Micevych P. Distribution and localization patterns of estrogen receptor-β and insulin-like growth factor-1 receptors in neurons and glial cells of the female rat substantia nigra: localization of ERβ and IGF-1R in substantia nigra. J Comp Neurol. 2007;503:198-208. (Pubitemid 47024427)
    • (2007) Journal of Comparative Neurology , vol.503 , Issue.1 , pp. 198-208
    • Quesada, A.1    Romeo, H.E.2    Micevych, P.3
  • 48
    • 0343825861 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptors and estrogen receptors colocalize in female rat brain
    • Cardona-Gómez GP, DonCarlos L, Garcia-Segura LM. Insulin-like growth factor I receptors and estrogen receptors colocalize in female rat brain. Neuroscience. 2000;99:751-760.
    • (2000) Neuroscience , vol.99 , pp. 751-760
    • Cardona-Gómez, G.P.1    DonCarlos, L.2    Garcia-Segura, L.M.3
  • 49
    • 33750939778 scopus 로고    scopus 로고
    • Cross-talk between estrogen receptors and insulin-like growth factor-I receptor in the brain: Cellular and molecular mechanisms
    • DOI 10.1016/j.yfrne.2006.09.001, PII S0091302206003748, Estrogen, Growth Factors and Brain Function
    • Méndez P, Wandosell F, Garcia-Segura LM. Cross-talk between estrogen receptors and insulin-like growth factor-I receptor in the brain: cellular and molecular mechanisms. Front. Neuroendocr. 2006;27:391-403 (Pubitemid 44738015)
    • (2006) Frontiers in Neuroendocrinology , vol.27 , Issue.4 , pp. 391-403
    • Mendez, P.1    Wandosell, F.2    Garcia-Segura, L.M.3
  • 50
    • 0021359368 scopus 로고
    • Alterations in ovarian steroid and gonadotrophin secretion preceding the cessation of regular oestrous cycles in ageing female rats
    • Nass TE, LaPolt PS, Judd HL, Lu JK. Alterations in ovarian steroid and gonadotrophin secretion preceding the cessation of regular oestrous cycles in ageing female rats. J Endocrinol. 1984;100:43-50. (Pubitemid 14198694)
    • (1984) Journal of Endocrinology , vol.100 , Issue.1 , pp. 43-50
    • Nass, T.E.1    LaPolt, P.S.2    Judd, H.L.3    Lu, J.K.H.4
  • 52
    • 0019482778 scopus 로고
    • Relationship between circulating estrogens and the central mechanisms by which ovarian steroids stimulate luteinizing hormone secretion in aged and young female rats
    • Lu KH, Gilman DP, Meldrum DR, Judd HL, Sawyer CH. Relationship between circulating estrogens and the central mechanisms by which ovarian steroids stimulate luteinizing hormone secretion in aged and young female rats. Endocrinology. 1981;108:836-841. (Pubitemid 11142264)
    • (1981) Endocrinology , vol.108 , Issue.3 , pp. 836-841
    • Lu, J.K.H.1    Gilman, D.P.2    Meldrum, D.R.3
  • 53
    • 0015383576 scopus 로고
    • Aging of hypothalamic-pituitary-ovarian function in the rat
    • Peng MT, Huang HH. Aging of hypothalamic-pituitary-ovarian function in the rat. Fertil Steril. 1972;23:535-542.
    • (1972) Fertil Steril , vol.23 , pp. 535-542
    • Peng, M.T.1    Huang, H.H.2
  • 54
    • 33645230428 scopus 로고    scopus 로고
    • Neuroendocrine control of reproductive aging: Roles of GnRH neurons
    • Yin W, Gore AC. Neuroendocrine control of reproductive aging: roles of GnRH neurons. Reproduction. 2006;131:403-414.
    • (2006) Reproduction , vol.131 , pp. 403-414
    • Yin, W.1    Gore, A.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.