Glioma stem cells but not bulk glioma cells upregulate IL-6 secretion in microglia/brain macrophages via toll-like receptor 4 signaling

Journal of Neuropathology and Experimental Neurology

Volumn 75, Issue 5, 2016, Pages 429-440

  Dzaye, Omar Dildar A ^a   Hu, Feng ^a,b   Derkow, Katja ^c   Haage, Verena ^a   Euskirchen, Philipp ^c,d   Harms, Christoph ^d   Lehnardt, Seija ^e   Synowitz, Michael ^f   Wolf, Susanne A ^a   Kettenmann, Helmut ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c Center for Stroke Research Berlin   (Germany)

^d Center for Anatomy   (United Kingdom)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Glioma; Glioma stem cells; Glioma associated microglia brain macrophages; IL 6; Toll like receptor 4

Indexed keywords

CD133 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 6; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR; IL6 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE LOCUS; GLIOMA STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MACROPHAGE; MICROGLIA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR MODEL; TUMOR VOLUME; UPREGULATION; ANIMAL; BIOSYNTHESIS; BRAIN; BRAIN TUMOR; C57BL MOUSE; CANCER STEM CELL; CHICKEN; GLIOMA; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SECRETION (PROCESS); TUMOR CELL CULTURE; TUMOR CELL LINE;

ANIMALS; BRAIN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CHICKENS; GLIOMA; HUMANS; INTERLEUKIN-6; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NEOPLASTIC STEM CELLS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 84982149390     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1093/jnen/nlw016     Document Type: Article

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