Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease

Clinical and Experimental Immunology

Volumn 155, Issue 3, 2009, Pages 559-566

  Fortunati, E ^a   Kazemier, K M ^a   Grutters, J C ^b   Koenderman, L ^a   Van Den Bosch, Van J M M ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ST ANTONIUS HOSPITAL   (Netherlands)

Author keywords

Immunophenotype; Lungs; Neutrophils; Sarcoidosis; Surface receptors

Indexed keywords

ANTIBODY; CD11B ANTIGEN; CD16 ANTIGEN; CD32 ANTIGEN; CD45 ANTIGEN; CD66B ANTIGEN; CHEMOKINE; COMPLEMENT COMPONENT C5A RECEPTOR; FC RECEPTOR; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HOMEOSTASIS; HUMAN; LUNG; LUNG LAVAGE; MALE; NEUTROPHIL; PHENOTYPE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOIDOSIS;

ADULT; ANTIGENS, CD; ANTIGENS, CD11B; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; CELL ADHESION MOLECULES; FEMALE; HUMANS; IMMUNOPHENOTYPING; INTERCELLULAR ADHESION MOLECULE-1; L-SELECTIN; LUNG; MALE; MIDDLE AGED; NEUTROPHIL ACTIVATION; NEUTROPHILS; RECEPTORS, COMPLEMENT; SARCOIDOSIS;

EID: 59249091523     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2008.03791.x     Document Type: Article

References (32)

1. Schymeinsky J, Mocsai A, Walzog B. Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications. Thromb Haemost 2007 98 : 262 73.
2. Warringa RA, Mengelers HJ, Raaijmakers JA, Bruijnzeel PL, Koenderman L. Upregulation of formyl-peptide and interleukin-8-induced eosinophil chemotaxis in patients with allergic asthma. J Allergy Clin Immunol 1993 91 : 1198 205.
3. Yamagata T, Sugiura H, Yokoyama T et al. Overexpression of CD-11b and CXCR1 on circulating neutrophils: its possible role in COPD. Chest 2007 132 : 890 9.
4. Hietbrink F, Oudijk EJ, Braams R, Koenderman L, Leenen L. Aberrant regulation of polymorphonuclear phagocyte responsiveness in multitrauma patients. Shock 2006 26 : 558 64.
5. Mann BS, Chung KF. Blood neutrophil activation markers in severe asthma: lack of inhibition by prednisolone therapy. Respir Res 2006 7 : 59.
6. Pignatti P, Moscato G, Casarini S et al. Downmodulation of CXCL8/IL-8 receptors on neutrophils after recruitment in the airways. J Allergy Clin Immunol 2005 115 : 88 94.
7. Soejima K, Fujishima S, Nakamura H et al. Downmodulation of IL-8 receptors, type A and type B, on human lung neutrophils in vivo. Am J Physiol Lung Cell Mol Physiol 1997 273 : L618 25.
8. Warringa RA, Mengelers HJ, Raaijmakers JA, Bruijnzeel PL, Koenderman L. Upregulation of formyl-peptide and interleukin-8-induced eosinophil chemotaxis in patients with allergic asthma. J Allergy Clin Immunol 1993 91 : 1198 205.
9. In't Veen JCCM, Grootendorst DC, Bel EH et al. CD11b and L-selectin expression on eosinophils and neutrophils in blood and induced sputum of patients with asthma compared with normal subjects. Clin Exp Allergy 1998 28 : 606 15.
10. Georas SN, Liu MC, Newman W, Beall LD, Stealey BA, Bochner BS. Altered adhesion molecule expression and endothelial-cell activation accompany the recruitment of human granulocytes to the lung after segmental antigen challenge. Am J Respir Cell Mol Biol 1992 7 : 261 9.
11. Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl Med J 2007 357 : 2153 65.
12. Drent M, Jacobs JA, de Vries J, Lamers RJ, Liem IH, Wouters EF. Does the cellular bronchoalveolar lavage fluid profile reflect the severity of sarcoidosis? Eur Respir J 1999 13 : 1338 44.
13. Ziegenhagen MW, Rothe ME, Schlaak M, Muller-Quernheim J. Bronchoalveolar and serological parameters reflecting the severity of sarcoidosis. Eur Respir J 2003 21 : 407 13.
14. Tutor-Ureta P, Citores MJ, Castejon R et al. Prognostic value of neutrophils and NK cells in bronchoalveolar lavage of sarcoidosis. Cytometry B Clin Cytom 2006 70 : 416 22.
15. Takizawa H, Satoh M, Okazaki H et al. Increased IL-6 and IL-8 in bronchoalveolar lavage fluids (BALF) from patients with sarcoidosis: correlation with the clinical parameters. Clin Exp Immunol 1997 107 : 175 81.
16. Car BD, Meloni F, Luisetti M, Semenzato G, Gialdroni-Grassi G, Walz A. Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Respir Crit Care Med 1994 149 : 655 9.
17. Peros-Golubicic T, Ivicevic A, Bekic A, Alilovic M, Tekavec-Trkanjec J, Smojver-Jezek S. Lung lavage neutrophils, neutrophil elastase and albumin in the prognosis of pulmonary sarcoidosis. Coll Antropol 2001 25 : 349 55.
18. Kanters D, ten HW, Luijk B et al. Expression of activated Fc gamma RII discriminates between multiple granulocyte-priming phenotypes in peripheral blood of allergic asthmatic subjects. J Allergy Clin Immunol 2007 120 : 1073 81.
19. Drent M, Mansour K, Linssen C. Bronchoalveolar lavage in sarcoidosis. Semin Respir Crit Care Med 2007 28 : 486 95.
20. Takizawa H, Satoh M, Okazaki H et al. Increased IL-6 and IL-8 in bronchoalveolar lavage fluids (BALF) from patients with sarcoidosis: correlation with the clinical parameters. Clin Exp Immunol 1997 107 : 175 81.
21. Yoon J, Terada A, Kita H. CD66b regulates adhesion and activation of human eosinophils. J Immunol 2007 179 : 8454 62.
22. Buckley CD, Ross EA, McGettrick HM et al. Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration. J Leukoc Biol 2006 79 : 303 11.
23. Roebuck KA, Finnegan A. Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J Leukoc Biol 1999 66 : 876 88.
24. Ryder MI, Fujitaki R, Lebus S et al. Alterations of neutrophil L-selectin and CD18 expression by tobacco smoke: implications for periodontal diseases. J Periodont Res 1998 33 : 359 68.
25. Halvorsen B, Lund SE, Ueland T, Aukrust P, Tonstad S. Effect of smoking cessation on markers of inflammation and endothelial cell activation among individuals with high risk for cardiovascular disease. Scand J Clin Lab Invest 2007 67 : 604 11.
26. Kaseda M, Kadota J, Mukae H et al. Possible role of L-selectin in T lymphocyte alveolitis in patients with active pulmonary sarcoidosis. Clin Exp Immunol 2000 121 : 146 50.
27. Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 2007 7 : 678 89.
28. von Andrian UH, Chambers JD, McEvoy LM, Bargatze RF, Arfors KE, Butcher EC. Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo. Proc Natl Acad Sci USA 1991 88 : 7538 42.
29. Smalley DM, Ley K. L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med 2005 9 : 255 66.
30. Unkeless JC, Shen Z, Lin CW, DeBeus E. Function of human Fc gamma RIIA and Fc gamma RIIIB. Semin Immunol 1995 7 : 37 44.
31. Takabayshi K, Corr M, Hayashi T et al. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 2006 24 : 475 87.
32. Kim DS, Paik SH, Lim CM et al. Value of ICAM-1 expression and soluble ICAM-1 level as a marker of activity in sarcoidosis. Chest 1999 115 : 1059 65.