A gene signature of inhibitory MHC receptors identifies a BDCA3+ subset of IL-10-induced dendritic cells with reduced allostimulatory capacity in vitro

European Journal of Immunology

Volumn 34, Issue 10, 2004, Pages 2800-2811

  Velten, Florian W ^a   Duperrier, Karine ^a   Bohlender, Johannes ^a   Metharom, Patraporn ^a   Goerdt, Sergij ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Dendritic cells; Gene profiling; Immunoreceptors; Interleukin 10

Indexed keywords

CD123 ANTIGEN; CD14 ANTIGEN; CD150 ANTIGEN; CD209 ANTIGEN; CD3 ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; DNA; FC RECEPTOR; INTERLEUKIN 10; LYMPHOCYTE SURFACE MARKER; RECEPTOR PROTEIN; TOLL LIKE RECEPTOR 2; TRANSCRIPTION FACTOR; TYROSINE;

ALLOIMMUNITY; ARTICLE; BONE MARROW CELL; CELL MATURATION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREGULATION; IMMUNOSTIMULATION; IN VITRO STUDY; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR DYNAMICS; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

CYTOKINES; DENDRITIC CELLS; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTES;

EID: 7244260415     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324732     Document Type: Article

References (42)

1. Goerdt, S. and Orfanos, C. E., Other functions, other genes: alternative activation of antigen-presenting cells. Immunity 1999. 10: 137-142.
2. Heath, W. R. and Carbone, F. R., Cross-presentation, dendritic cells, tolerance and immunity. Annu. Rev. Immunol. 2001. 19: 47-64.
3. Hartmann, G. and Krieg, A. M., CpG DNA and LPS induce distinct patterns of activation in human monocytes. Gene Ther. 1999. 6: 893-903.
4. Kato, K., Takaue, Y. and Wakasugi, H., T-cell-conditioned medium efficiently induces the maturation and function of human dendritic cells. J. Leukoc. Biol. 2001. 70: 941-949.
5. Liu, Y. J., Kanzler, H., Soumelis, V. and Gilliet, M., Dendritic cell lineage, plasticity and cross-regulation. Nat. Immunol. 2001. 2: 585-589.
6. Gilliet, M. and Liu, Y. J., Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells. Hum. Immunol. 2002. 63: 1149-1155.
7. Steinman, R. M., Turley, S., Mellman, I. and Inaba, K., The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 2000. 191: 411-416.
8. Lutz, M. B. and Schuler, G., Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 2002. 23: 445-449.
9. Jonuleit, H., Schmitt, E., Steinbrink, K. and Enk, A. H., Dendritic cells as a tool to induce anergic and regulatory T cells. Trends Immunol. 2001. 22: 394-400.
10. Steinbrink, K., Wolfl, M., Jonuleit, H., Knop, J. and Enk, A. H., Induction of tolerance by IL-10-treated dendritic cells. J. Immunol. 1997. 159: 4772-4780.
11. Enk, A. H., Jonuleit, H., Saloga, J. and Knop, J., Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma. Int. J. Cancer 1997. 73: 309-316.
12. Stein, M., Keshav, S., Harris, N. and Gordon, S., Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J. Exp. Med. 1992. 176: 287-292.
13. Kodelja, V., Muller, C., Politz, O., Hakij, N., Orfanos, C. E. and Goerdt, S., Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. J. Immunol. 1998. 160: 1411-1418.
14. Goerdt, S., Birk, R., Dippel, E. and Orfanos, C. E., Beyond inflammation: tolerance, immunotherapy and more. Eur. J. Dermatol. 1999. 9: 507-513.
15. Politz, O., Gratchev, A., McCourt, P. A., Schledzewski, K., Guillot, P., Johansson, S., Svineng, G., Franke, P., Kannicht, C., Kzhyshkowska, J., Longati, P., Velten, F. W. and Goerdt, S., Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochem. J. 2002. 362: 155-164.
16. Jonuleit, H., Kuhn, U., Muller, G., Steinbrink, K., Paragnik, L., Schmitt, E., Knop, J. and Enk, A. H., Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur. J. Immunol. 1997. 27: 3135-3142.
17. Chang, C. C., Ciubotariu, R., Manavalan, J. S., Yuan, J., Colovai, A. I., Piazza, F., Lederman, S., Colonna, M., Cortesini, R., Dalla-Favera, R. and Suciu-Foca, N., Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat. Immunol. 2002. 3: 237-243.
18. Buelens, C., Verhasselt, V., De Groote, D., Thielemans, K., Goldman, M. and Willems, F., Interleukin-10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin-4 and granulocyte/macrophage-colony-stimulating factor. Eur J. Immunol. 1997. 27: 756-762.
19. Allavena, P., Piemonti, L., Longoni, D., Bernasconi, S., Stoppacciaro, A., Ruco, L. and Mantovani, A., IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur. J. Immunol. 1998. 28: 359-369.
20. Mueller, C. G., Rissoan, M. C., Salinas, B., Ait-Yahia, S., Ravel, O., Bridon, J. M., Briere, F., Lebecque, S. and Liu, Y. J., Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. J. Exp. Med. 1997. 186: 655-663.
21. Vandenabeele, S., Hochrein, H., Mavaddat, N., Winkel, K. and Shortman, K., Human thymus contains 2 distinct dendritic cell populations. Blood 2001. 97: 1733-1741.
22. Delneste, Y., Charbonnier, P., Herbault, N., Magistrelli, G., Caron, G., Bonnefoy, J. Y. and Jeannin, P., Interferon-gamma switches monocyte differentiation from dendritic cells to macrophages. Blood 2003. 101: 143-150.
23. - dendritic cell populations in the colonic mucosa of patients with Crohn's disease. Eur J. Immunol. 2003. 33: 143-151.
24. Kammerer, U., Eggert, A. O., Kapp, M., McLellan, A. D., Geijtenbeek, T. B., Dietl, J., Van Kooyk, Y. and Kampgen, E., Unique appearance of proliferating antigen-presenting cells expressing DC-SIGN (CD209) in the decidua of early human pregnancy. Am. J. Pathol. 2003. 162: 887-896.
25. Soilleux, E. J. and Coleman, N., Langerhans cells and the cells of Langerhans cell histiocytosis do not express DC-SIGN. Blood 2001. 98: 1987-1988.
26. Bates, E. E., Fournier, N., Garcia, E., Valladeau, J., Durand, I., Pin, J. J., Zurawski, S. M., Patel, S., Abrams, J. S., Lebecque, S., Garrone, P. and Saeland, S., APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J. Immunol. 1999. 163: 1973-1983.
27. Dzionek, A., Fuchs, A., Schmidt, P., Cremer, S., Zysk, M., Miltenyi, S., Buck, D. W. and Schmitz, J., BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immunol. 2000. 165: 6037-6046.
28. MacDonald, K. P., Munster, D. J., Clark, G. J., Dzionek, A., Schmitz, J. and Hart, D. N., Characterization of human blood dendritic cell subsets. Blood 2002. 100: 4512-4520.
29. De Smedt, T., Van Mechelen, M., De Becker, G., Urbain, J., Leo, O. and Moser, M., Effect of interleukin-10 on dendritic cell maturation and function. Eur. J. Immunol. 1997. 27: 1229-1235.
30. Lebre, C. M., Doctoral dissertation, University of Amsterdam, Netherlands, 2003
31. Daeron, M., Latour, S., Malbec, O., Espinosa, E., Pina, P., Pasmans, S. and Fridman, W. H., The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity 1995. 3: 635-646.
32. Fanger, N. A., Cosman, D., Peterson, L., Braddy, S. C., Maliszewski, C. R. and Borges, L., The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Eur. J. Immunol. 1998. 28: 3423-3434.
33. Bellon, T., Kitzig, F., Sayos, J. and Lopez-Botet, M., Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. J. Immunol. 2002. 168: 3351-3359.
34. Kanazawa, N., Okazaki, T., Nishimura, H., Tashiro, K., Inaba, K. and Miyachi, Y., DCIR acts as an inhibitory receptor depending on its immunoreceptor tyrosine-based inhibitory motif. J. Invest. Dermatol. 2002. 118: 261-266.
35. Allan, D. S., Lepin, E. J., Braud, V. M., O'Callaghan, C. A. and McMichael, A. J., Tetrameric complexes of HLA-E, HLA-F, and HLA-G. J. Immunol. Methods 2002. 268: 43-50.
36. Regnault, A., Lankar, D., Lacabanne, V., Rodriguez, A., Thery, C., Rescigno, M., Saito, T., Verbeek, S., Bonnerot, C., Ricciardi-Castagnoli, P. and Amigorena, S., Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J. Exp. Med. 1999. 189: 371-380.
37. Jiang, Y., Hirose, S., Abe, M., Sanokawa-Akakura, R., Ohtsuji, M., Mi, X., Li, N., Xiu, Y., Zhang, D., Shirai, J., Hamano, Y., Fujii, H. and Shirai, T., Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility. Immunogenetics 2000. 51: 429-435.
38. Cornall, R. J., Cyster, J. G., Hibbs, M. L., Dunn, A. R., Otipoby, K. L., Clark, E. A. and Goodnow, C. C., Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 1998. 8: 497-508.
39. Lu, M., Zhang, M., Kitchens, R. L., Fosmire, S., Takashima, A. and Munford, R. S., Stimulus-dependent deacylation of bacterial lipopolysaccharide by dendritic cells. J. Exp. Med. 2003. 197: 1745-1754.
40. Nestle, F. O., Zheng, X. G., Thompson, C. B., Turka, L. A. and Nickoloff, B. J., Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J. Immunol. 1993. 151: 6535-6545.
41. Geijtenbeek, T. B., Van Vliet, S. J., Koppel, E. A., Sanchez-Hernandez, M., Vandenbroucke-Grauls, C. M., Appelmelk, B. and Van Kooyk, Y., Mycobacteria target DC-SIGN to suppress dendritic cell function. J. Exp. Med. 2003. 197: 7-17.
42. Woltman, A. M., de Fijter, J. W., Kamerling, S. W., Paul, L. C., Daha, M. R. and van Kooten, C., The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells. Eur. J. Immunol. 2000. 30: 1807-1812.