Genomic instability en route to and from cancer stem cells

Cell Cycle

Volumn 8, Issue 7, 2009, Pages 1000-1002

  Li, Linda ^a   Borodyansky, Laura ^a   Yang, Youxin ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cancer stem cells; CSC; Genomic instability; GIN; hES; mES

Indexed keywords

MYC PROTEIN;

CANCER RESISTANCE; CANCER STEM CELL; CARCINOGENESIS; CELL HETEROGENEITY; CELL POPULATION; CHROMOSOME ABERRATION; EMBRYONIC STEM CELL; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; METASTASIS; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SEVERE COMBINED IMMUNODEFICIENCY; TUMOR GROWTH;

EID: 65949106349     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.7.8041     Document Type: Review

References (28)

1. Aguilera A, Gómez-González B. Genome instability: a mechanistic view of its causes and consequences. Nat Rev Genet 2008; 9:204-217
2. Jallepalli PV, Lengauer C. Chromosome segregation and cancer: cutting through the mystery. Nat Rev Cancer 2001; 1:109-117 (Pubitemid 33741886)
3. Venkitaraman AR. Chromosomal instability in cancer: causality and interdependence. Cell Cycle 2007; 6:2341-2343 (Pubitemid 350058684)
4. Dick JE. Stem cell concepts renew cancer research. Blood 2008; 112:4793-4807
5. Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea - a paradigm shift. Cancer Res 2006; 66:1883-1890 (Pubitemid 43294892)
6. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, et al. Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006; 66:9339-9344
7. Ailles LE, Weissman IL. Cancer stem cells in solid tumors. Curr Opin Biotechnol 2007; 18:460-466 (Pubitemid 350116595)
8. Blagosklonny MV. Cancer stem cell and cancer stemloids: from biology to therapy. Cancer Biol Ther 2007; 6:1684-1690
9. Miura M, Miura Y, Padilla-Nash HM, Molinolo AA, Fu B, Patel V, et al. Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells 2006; 24:1095-1103
10. Shiras A, Chettiar ST, Shepal V, Rajendran G, Prasad GR, Shastry P. Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma. Stem Cells 2007; 25:1478-1489
11. Lagasse E. Cancer stem cells with genetic instability: the best vehicle with the best engine for cancer. Gene Ther 2008; 15:136-142
12. Conway AE, Lindgren A, Galic Z, Pyle AD, Wu H, Zack JA, et al. A pluripotency and self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors. Stem Cells 2008; doi:10.1634/stemcells.2008-0529.
13. Blagosklonny MV. Oncogenic resistance to growth-limiting conditions. Nat Rev Cancer 2002; 2:221-225 (Pubitemid 37328791)
14. Bodnar MS, Meneses JJ, Rodriguez RT, Firpo MT. Propagation and maintenance of undifferentiated human embryonic stem cells. Stem Cells Dev 2004; 13:243-253 (Pubitemid 38738366)
15. Draper JS, Smith K, Gokhale P, Moore HD, Maltby E, Johnson J, et al. Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol 2004; 22:53-54
16. Imreh MP, Gertow K, Cedervall J, Unger C, Holmberg K, Szöke K, et al. In vitro culture conditions favoring selection of chromosomal abnormalities in human ES cells. J Cell Biochem 2006; 99:508-516
17. Spits C, Mateizel I, Geens M, Mertzanidou A, Staessen C, Vandeskelde Y, et al. Recurrent chromosomal abnormalities in human embryonic stem cells. Nat Biotechnol 2008; 26:1361-1363
18. Lefort N, Feyeux M, Bas C, Féraud O, Bennaceur-Griscelli A, Tachdjian G, et al. Human embryonic stem cells reveal recurrent genomic instability at 20q11.21. Nat Biotechnol 2008; 26:1364-1366
19. Gerson SL, Reese J, Kenyon J. DNA repair in stem cell maintenance and conversion to cancer stem cells. Ernst Schering Found Symp Proc 2006; 5:231-244
20. Mantel C, Guo Y, Lee MR, Kim MK, Han MK, Shibayama H, et al. Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotypic instability. Blood 2007; 109:4518-4527
21. Aoki K, Aoki M, Sugai M, Harada N, Miyoshi H, Tsukamoto T, et al. Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells. Oncogene 2007; 26:3511-3520
22. Wong DJ, Segal E, Chang HY. Stemness, cancer and cancer stem cells. Cell Cycle 2008; 7:3622-3624
23. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444:756-760
24. Ju Z, Rudolph KL. Telomeres and telomerase in cancer stem cells. Eur J Cancer 2006; 42:1197-1203 (Pubitemid 43810142)
25. Solé RV, Rodríguez-Caso C, Deisboeck TS, Saldaña J. Cancer stem cells as the engine of unstable tumor progression. J Theor Biol 2008; 253:629-637
26. Grichnik JM. Genomic instability and tumor stem cells. J Invest Dermatol 2006; 126:1214-1216 (Pubitemid 43997898)
27. Wang E, Voiculescu S, Le Poole IC, El-Gamil M, Li X, Sabatino M, et al. Clonal persistence and evolution during a decade of recurrent melanoma. J Invest Dermatol 2006; 126:1372-1377
28. Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008; 321:1801-1806.