Chronic Stress Aggravates Cognitive Impairment and Suppresses Insulin Associated Signaling Pathway in APP/PS1 Mice

Journal of Alzheimer's Disease

Volumn 53, Issue 4, 2016, Pages 1539-1552

  Han, Bing ^a   Yu, Lulu ^a   Geng, Yuan ^b   Shen, Li ^a   Wang, Hualong ^a   Wang, Yanyong ^a   Wang, Jinhua ^a   Wang, Mingwei ^a,b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province   (China)

Author keywords

Alzheimer's disease; Cognitive function; Hippocampus; Insulin sensitivity; Stress; Transgenic animals

Indexed keywords

CORTICOSTERONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, MOUSE; PRESENILIN 1; PSEN1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHRONIC STRESS; CHRONIC UNPREDICTABLE MILD STRESS; COGNITIVE DEFECT; CONTROLLED STUDY; GENE MUTATION; GLUCOSE BLOOD LEVEL; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; MALE; MOUSE; NERVE INJURY; NONHUMAN; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; SENILE PLAQUE; SIGNAL TRANSDUCTION; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL; C57BL MOUSE; CHRONIC DISEASE; DISEASE MODEL; GENETICS; HUMAN; MENTAL STRESS; METABOLISM; NERVE CELL; PATHOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CHRONIC DISEASE; COGNITIVE DYSFUNCTION; DISEASE MODELS, ANIMAL; GLUCOCORTICOIDS; HIPPOCAMPUS; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; PLAQUE, AMYLOID; PRESENILIN-1; RECEPTOR, INSULIN; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL;

EID: 84981719335     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-160189     Document Type: Article

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