Bioactivity and enzyme inhibition properties of Stevia rebaudiana

Current Enzyme Inhibition

Volumn 12, Issue 2, 2016, Pages 188-194

  Can, Zehra ^a   Baltas, Nimet ^b  

^a GIRESUN UNIVERSITY   (Turkey)

^b RECEP TAYYIP ERDOGAN UNIVERSITY   (Turkey)

Author keywords

Antioxidant; Phenolics compound; Radical; Urease; Xanthine oxidase

Indexed keywords

FLAVONOID; GALLIC ACID; PHENOL DERIVATIVE; PLANT EXTRACT; QUERCETIN; STEVIA REBAUDIANA EXTRACT; TANNIN; TROLOX C; UNCLASSIFIED DRUG; UREASE; XANTHINE OXIDASE;

ABTS RADICAL SCAVENGING ASSAY; ANTIOXIDANT ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CARBOHYDRATE ANALYSIS; CONTROLLED STUDY; DPPH RADICAL SCAVENGING ASSAY; ENZYME INHIBITION; EXTRACTION; FERRIC REDUCING ANTIOXIDANT POWER ASSAY; FLOWER; FREE RADICAL SCAVENGING ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; STEVIA REBAUDIANA;

EID: 84981714747     PISSN: 15734080     EISSN: 18756662     Source Type: Journal    
DOI: 10.2174/1573408012666160402001925     Document Type: Article

References (42)

1. Kinghorn, A.; Soejarto, D. In: Economics and medicinal plant research, Current status of stevioside as a sweetening agent for human use; H. Wagner, H. Hikino, & N. Farnsworth, Eds.; London, UK Academic Press, 1985, Vol. 1, pp. 1-52.
2. Mogra, R.; Dashora, V. Exploring the use of Stevia rebaudiana as a sweetener in comparison with other sweeteners. J. Human Ecolog., 2009, 25, 117-120.
3. Tadhani, M.B.; Patel, V.H.; Subhash, R. In vitro antioxidant activities of Stevia rebaudiana leaves and callus. J. Food Comp. Anal., 2007, 20, 323-329.
4. Criado, M.N.; Civera, M.; Martínez, A.; Rodrigo, D. Use of Weibull distribution to quantify the antioxidant effect of Stevia rebaudiana on oxidative enzymes. LWT-Food Sci. Technol., 2015, 60, 985-989.
5. Jayaraman, S.; Manoharan, M.S.; Illanchezian, S. In-vitro antimicrobial and antitumor activities of Stevia rebaudiana (asteraceae) leaf extracts. Tropical J. Pharm. Res., 2008, 7(4), 1143-1149.
6. Shivanna, N.; Naika, M.; Khanum, F.; Kaul, K.V. Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana. J. Diabetes Its Complicat., 2003, 27, 103-113.
7. Lespade, L.; Bercion, S. Theoretical study of the mechanism of inhibition of xanthine oxydase by flavonoids and gallic acid derivatives. J. Phys. Chem., 2010, 114, 921-928.
8. Hille, R.; Nishino, T. Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase. Faseb J., 1995, 9, 995-1003.
9. Virsaladze, D.K.; Tetradze, L.O.; Dzhavashvili, L.V.; Esaliia, N.G.; Tananashvili, D.E. Levels of uric acid in serum in patients with metabolic syndrome. Georgian Medic. News., 2007, 146, 35-37.
10. Kong, L.D.; Cai, Y.; Huang, W.W.; Cheng, C.H.K.; Tan, R.X. Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout. J. Ethnopharm., 2000, 73(1-2), 199-220.
11. Kim, S.C.; Newcomb, C.; Margolis, D.; Roy, J.; Hennessy S.Severe cutaneous reactions requiring hospitalization in allopurinol initiators: A Population-Based Cohort Study. Arthrit. Care & Res., 2013, 65, 493-524.
12. Holm, L.; Sander, C. An evolutionary treasure: unification of a broad set of amidohydrolases related to urease. Proteins, 1997, 28(1), 72-82.
13. Karplus, P.A.; Pearson, M.A.; Hausinger, R.P. 70 years of crystalline urease: what have we learned?. Accounts of Chem. Res., 1997, 30(8), 330-337.
14. Mobley, H.L.T.; Island, M.D.; Hausinger, R.P. Molecular-Biology of Microbial Ureases. Microbiol. Rev., 1995, 59(3), 451-480.
15. Kolaylı, S.; Sahin, H.; Can, Z.; Yildiz, O.; Sahin, K. Honey shows potent inhibitory activity against the bovine testes hyaluronidase. J. Enzyme Inhib. Med. Chem., 2015, DOI: 10.3109/14756366.1054819.
16. Singleton, V.L.; Rossi, J.L. Colorimetry of total phenolics with phosphomolybdic phosphotungstic acid reagents. Am. Soci. for Enol. Viticult., 1965, 16, 144-158.
17. Fukumoto, L.R.; Mazza, G. Assessing antioxidant and prooxidantactivities of phenolic compounds. J. Agr. Food Chem., 2000, 48, 3597-3604.
18. Julkunen-Tıtto, R. Phenolic constituents in the leaves of northernwillows: methods for the analysis of certain phenolics. J. Agr. Food Chem., 1985, 33, 213-217.
19. Benzie, I.F.F.; Strain, J.J. Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods in Enzymol., 1999, 299, 15-27.
20. Molyneux, P. The use of the stable free radical diphenylpicrylhyrazyl (DPPH) for estimating antioxidant activity. Songklanakarin J. Sci. Technol., 2004, 26, 211-219.
21. Re, R.; Pellegrini, N.; Proteggente, A.; Pannala, A.; Yang, M.; Rıce-Evans, C. Antioxidant activity applying animproved ABTS radical cation decolourization assay. Free Radical Bio. Med., 1999, 26(9, 10), 1231-1237.
22. Can, Z.; Yildiz, O.; Sahin, H.; Turumtay, E.A.; Silici, S.; Kolayli, S. An investigation of Turkish honeys: their physico-chemical properties, antioxidant capacites and phenolic profiles. Food Chem., 2015, 180, 133-141.
23. Hayashi, T.; Sawa, K.; Kawasaki, M.; Arisawa, M.; Shimizu, M.; Morita, N. Inhibition of cow’s milk xanthine-oxidase by flavonoids. J. Nat. Prod., 1988, 51, 345-348.
24. Weatherburn, M.W. Phenol-hypochlorite reaction for determination of Ammonia. Anal. Chem., 1967, 39, 971-974.
25. Sahin, H.; Akyuz-Turumtay, E.; Yildiz, O.; Kolayli, S. Grayanotoxin-IIIdetection and antioxidant activity of mad honey. Int. J. Food Proper., 2015, 18(12), 2665-2674.
26. Tavarini, S.; Angelini, L.G. Stevia rebaudiana Bertoni as a source of bioactive compounds: the effect of harvest time, experimental site and crop age on steviol glycoside content and antioxidant properties. J. Sci. Food Agr., 2013, 93, 2121-2129.
27. Barba, F.J.; Grimi, N.; Vorobiev, E. Evaluating the potential of cell disruption technologies for green selective extraction of antioxidant compounds from Stevia rebaudianabertoni leaves. J. Food Eng., 2015, 149, 222-228.
28. Cai, Y.Z.; Sun, M.; Xing, J.; Luo, Q.; Corke, H. Structure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants. Life Scie., 2006, 78, 2872-2888.
29. Gao, X.; Ohlander, M.; Jeppsson, N.; Bjork, L.; Trajkovski, V. Changes in antioxidant effects and their relationship to phytonutrients in fruits of sea buckthorn (Hippophae rhamnoides L.) during maturation. J. Agr. Food Chem., 2000, 48, 1485-1490.
30. Amira, E.A.; Behija, S.E.; Beligh, M.; Lamia, L.; Manel, I.; Mohamed, H.; Lotf, A. Effects of the ripening stage on phenolic profile, phytochemical composition and antioxidant activity of date palm fruit. J. Agric. Food Chem., 2012, 60(44), 10896-10902.
31. Lin, Y.; Shi, R.; Wang, X.; Shen, H.M. Luteolin a flavonoid with potential for cancer prevention and therapy. Curr. Cancer Drug Targets, 2008, 8(7), 634-646.
32. Gullo, V.P.; Mcalpine, J.; Kam, K.S.; Baker, D.; Peterson, F. Drug discovery from natural products. J. Ind. Microbiol., 2006, 33, 523-531.
33. Umamaheswari, M.; Asokkumar, K.; Sivashanmugam, A.T.; Remyaraju, A.; Subhadradevi, V.; Ravi, T.K. In vitro xanthine oxidase inhibitory activity of the fractions of Erythrina strictaroxb. J. Ethnopharmacol., 2009, 124, 646-648.
34. Hudaib, M.M.; Tawaha, K.A.; Mohammad, K.M.; Assaf, A.M.; Issa, A.Y.; Alali, F.Q.; Aburjai, T.A.; Bustanji, Y.K. Xanthine oxidase inhibitory activity of the methanolic extracts of selected Jordanian medicinal plants Pharmacogn. Mag., 2011, 7(28), 320-324.
35. Sowndhararajan, K.; Joseph, J.M.; Rajendrakumaran, D. In vitro xanthine oxidase inhibitory activity of methanol extracts of Erythrina indicalam. leaves and stem barkAsian. Pac. J. Trop. Biomed., 2012, 2(3), 1415-1417.
36. Baltas, N.; Yildiz, O.; Kolayli, S. Inhibition properties of Propolis extracts to some clinically important enzymes. J. Enz. Inhib. Med. Chem., 2016, DOI: 10.3109/14756366.2016.1167049.
37. Lespade, L.; Bercion, S. Theoretical study of the mechanism of inhibition of xanthine oxydase by flavonoids and gallic acid derivatives. J. Phys. Chem., 2010, 114, 921-928.
38. Modolo, L.V.; Souza, A.X.; Hort, L.P.; Araujo, D.P.; Fátıma Â. An overview on the potential of natural products as ureases inhibitors: A review. J. Advan. Materials Res., 2015, 6, 35-44.
39. Amin, M.; Anwar, F.; Naz, F.; Mehmood, T.; Saari, N. Anti Helicobacter pylori and urease inhibition activities of some traditional medicinal plants. Molecules, 2013, 18, 2135-2149.
40. Demirci, S.; Demirbas, A.; Alpay-Karaoglu, S.; Demirbas, N. Synthesis of some heterofunctionalized penicillanic acid derivatives and investigation of their biological activities. Arch. Pharm. Chem. Life Scie., 2014, 347, 200-220.
41. Baltas, N. Investigation of a wild pear species (Pyrus elaeagnifolia subsp. elaeagnifolia Pallas) from Antalya, Turkey: polyphenol oxidase properties and anti-xanthine oxidase, anti-urease and antioxidant activity. Int. J. Food Prop., 2016, DOI: 10.1080/10942912.2016.1171777.
42. Lemus-Mondaca, R.; Vega-Gálveza, A.; Zura-Bravoa, L.; Ah-Hend, K. Stevia rebaudianabertoni source of a high-potency natural sweetener: a comprehensive review on the biochemical nutritional and functional aspects. Food Chem., 2012, 132, 1121-1132.