A systematic reviewandmeta-analysis of randomized controlled trials investigating the effects of supplementationwith Nigella sativa (black seed) on blood pressure

Journal of Hypertension

Volumn 34, Issue 11, 2016, Pages 2127-2135

  Sahebkar, Amirhossein ^a,b   Soranna, Davide ^c,d   Liu, Xiaoqiu ^c,d   Thomopoulos, Costas ^e   Simental Mendia, Luis E ^f   Derosa, Giuseppe ^g   Maffioli, Pamela ^g   Parati, Gianfranco ^c,d  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^e HELENA VENIZELOU HOSPITAL   (Greece)

^f INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^g UNIVERSITY OF PAVIA   (Italy)

Author keywords

Arterial hypertension; Meta analysis; Nigella sativa; Nutraceuticals

Indexed keywords

ANTIHYPERTENSIVE AGENT; BLACK CUMIN EXTRACT; PLACEBO; PLANT EXTRACT; UNCLASSIFIED DRUG; POWDER; VEGETABLE OIL;

ANTIHYPERTENSIVE ACTIVITY; BLACK CUMIN; BLOOD PRESSURE; COCHRANE LIBRARY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HYPERTENSION; INFORMATION RETRIEVAL; MEDLINE; META ANALYSIS; POWDER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SCOPUS; SUPPLEMENTATION; SYSTEMATIC REVIEW; TREATMENT DURATION; ADMINISTRATION AND DOSAGE; DIETARY SUPPLEMENT; DRUG EFFECTS; PHYTOTHERAPY; THERAPEUTIC USE;

BLOOD PRESSURE; DIETARY SUPPLEMENTS; HUMANS; HYPERTENSION; NIGELLA SATIVA; PHYTOTHERAPY; PLANT OILS; POWDERS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84981508363     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0000000000001049     Document Type: Review

References (35)

1. Taylor J. 2013 ESH/ESC Guidelines for the management of arterial hypertension. Eur Heart J 2013; 34:2108-2109.
2. Mashour NH, Lin GI, Frishman WH. Herbal medicine for the treatment of cardiovascular disease: clinical considerations. Arch Intern Med 1998; 158:2225-2234.
3. Meddah B, Ducroc R, El Abbes Faouzi M, Eto B, Mahraoui L, Benhaddou-Andaloussi A, et al. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J Ethnopharmacol 2009; 121:419-424.
4. Nagi MN, Almakki HA. Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity. Phytother Res 2009; 23:1295-1298.
5. Sahebkar A, Beccuti G, Simental-Mendía LE, Nobili V, Bo S. Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials. Pharmacol Res 2016; 106:37-50.
6. Ibrahim RM, Hamdan NS, Ismail M, Saini SM, Rashid SN, Latiff LA, et al. Protective effects of Nigella sativa on metabolic syndrome in menopausal women. Adv Pharm Bull 2014; 4:29-33.
7. Ghannadi A, Hajhashemi V, Jafarabadi H. An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols. J Med Food 2005; 8:488-493.
8. Jaarin K, Foong W, Yeoh M, Kamarul Z, Qodriyah H, Azman A, et al. Mechanisms of the antihypertensive effects of Nigella sativa oil in LNAME-induced hypertensive rats. Clinics 2015; 70:751-757.
9. Ahmed OG, El-Mottaleb NA. Renal function and arterial blood pressure alterations after exposure to acetaminophen with a potential role of Nigella sativa oil in adult male rats. J Physiol Biochem 2013; 69:1-13.
10. Latiff LA, Parhizkar S, Dollah MA, Hassan ST. Alternative supplement for enhancement of reproductive health and metabolic profile among perimenopausal women: a novel role of Nigella sativa. Iran J Basic Med Sci 2014; 17:980-985.
11. Bin Sayeed MS, Asaduzzaman M, Morshed H, Hossain MM, Kadir MF, Rahman MR. The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers. J Ethnopharmacol 2013; 148:780-786.
12. Bin Sayeed MS, Shams T, Fahim Hossain S, Rahman MR, Mostofa A, Fahim Kadir M, et al. Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males. J Ethnopharmacol 2014; 152:156-162.
13. Amin F, Islam N, Anila N, Gilani AH. Clinical efficacy of the coadministration of turmeric and black seeds (kalongi) in metabolic syndrome: a double blind randomized controlled trial: TAK-MetS trial. Complement Ther Med 2015; 23:165-174.
14. Datau EA, Wardhana. Surachmanto EE, Pandelaki K, Langi JA, Fias. Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Med Indones 2010; 42:130-134.
15. Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol 2008; 22:447-452.
16. Huseini HF, Amini M, Mohtashami R, Ghamarchehre ME, Sadeqhi Z, Kianbakht S, et al. Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebocontrolled clinical trial. Phytother Res 2013; 1853:1849-1853.
17. Najmi A, Nasiruddin M, Khan RA, Haque SF. Indigenous herbal product Nigella sativa proved effective as an antihypertensive in metabolic syndrome. Asian J Pharm Clin Res 2013; 6:61-64.
18. Mahdavi R, Namazi N, Alizadeh M, Farajnia S. Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: a randomized controlled clinical trial. Food Funct 2015; 6:2041-2048.
19. Qidwai W, Hamza HB, Qureshi R, Gilani A. Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. J Altern Complement Med 2009; 15:639-644.
20. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 2015; 4:1.
21. Der Simonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7:177-188.
22. Parati G, Ochoa JE, Lombardi C, Salvi P, Bilo G. Assessment and interpretation of blood pressure variability in a clinical setting. Blood Press 2013;345-354.
23. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003; 327:557-560.
24. Sutton AJ, Higgins JP. Recent developments in meta-analysis. Stat Med 2008; 27:625-650.
25. Higgins JPT, Green S (eds). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from http://handbook.cochrane. org.
26. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315:629-634.
27. Shabana A, El-Menyar A, Asim M, Al-Azzeh H, Al Thani H. Cardiovascular benefits of black cumin (Nigella sativa). Cardiovasc Toxicol 2013; 13:9-21.
28. Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phyther Res 2003; 17:299-305.
29. Leong X, Mustafa MR, Jaarin K. Nigella sativa and its protective role in oxidative stress and hypertension. Evid Based Complement Alternat Med 2013; 2013:120732.
30. Sandhu KS, Rana AC. A review of plant Nigella sativa: a brief consideration of its pharmaconostic characters, chemical constituents and therapeutic benefits. An Int J Pharm Sci 2013; 4:323-343.
31. Domenech M, Roman P, Lapetra J, Garcia De La Corte FJ, Sala-Vila A, De La Torre R, et al. Mediterranean diet reduces 24-h ambulatory blood pressure, blood glucose, and lipids: one-year randomized, clinical trial. Hypertension 2014; 64:69-76.
32. el Tahir KE, Ashour MM, Al-Harbi MM. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 1993; 24:1123-1131.
33. el Tahir KE, Ageel AM. Effect of volatile oil of Nigella sativa on the arterial blood pressure and heart rate of the guinea pig. Saudi Med J 1994; 2:163-168.
34. Peixoto-Neves D, Silva-Alves KS, Gomes MD, Lima FC, Lahlou S, Magalhaes PJ, et al. Vasorelaxant effects of the monoterpenic phenol isomers, carvacrol and thymol, on rat isolated aorta. Fundam Clin Pharmacol 2010; 24:341-350.
35. Zaoui A, Cherrah Y, Lacaille-Dubois MA, Settaf A, Amarouch H, Hassar M. [Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat]. Therapie 2000; 55:379-382.