Bisphenol A Exposure May Induce Hepatic Lipid Accumulation via Reprogramming the DNA Methylation Patterns of Genes Involved in Lipid Metabolism

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Ke, Zhang Hong ^a   Pan, Jie Xue ^a,b   Jin, Lu Yang ^a,c   Xu, Hai Yan ^a   Yu, Tian Tian ^a   Ullah, Kamran ^a,c   Rahman, Tanzil Ur ^a,c   Ren, Jun ^a,c   Cheng, Yi ^a,c   Dong, Xin Yan ^a,c   Sheng, Jian Zhong ^a,c   Huang, He Feng ^a,d  

^a ZHEJIANG UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; BENZHYDRYL DERIVATIVE; CHOLESTEROL; DNA (CYTOSINE 5) METHYLTRANSFERASE 1; DNMT1 PROTEIN, MOUSE; PHENOL DERIVATIVE; SMALL INTERFERING RNA; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ANALYSIS; ANIMAL; CELL LINE; CPG ISLAND; CYTOLOGY; DNA METHYLATION; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; LIPID METABOLISM; LIVER; LIVER CELL; MALE; METABOLISM; MOUSE; OBESITY;

ADIPOSE TISSUE; ANIMALS; BENZHYDRYL COMPOUNDS; BLOOD GLUCOSE; CELL LINE; CHOLESTEROL; CPG ISLANDS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; DNA METHYLATION; FEMALE; HEPATOCYTES; LIPID METABOLISM; LIVER; MALE; MICE; OBESITY; PHENOLS; RNA, SMALL INTERFERING; TRIGLYCERIDES;

EID: 84981206918     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep31331     Document Type: Article

References (30)

1. Calafat, A. M., Ye, X. Y., Wong, L. Y., Reidy, J. A. & Needham, L. L. Exposure of the US population to bisphenol A and 4-Tertiaryoctylphenol: 2003-2004. Environmental health perspectives 116, 39-44, doi: 10.1289/ehp.10753 (2008).
2. Jenkins, S., Wang, J., Eltoum, I., Desmond, R. & Lamartiniere, C. A. Chronic Oral Exposure to Bisphenol A Results in a Nonmonotonic Dose Response in Mammary Carcinogenesis and Metastasis in MMTV-erbB2 Mice. Environmental health perspectives 119, 1604-1609, doi: 10.1289/ehp.1103850 (2011).
3. Vandenberg, L. N., Maffini, M. V., Sonnenschein, C., Rubin, B. S. & Soto, A. M. Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption. Endocrine reviews 30, 75-95, doi: 10.1210/er.2008-0021 (2009).
4. Marmugi, A. et al. Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver. Hepatology 55, 395-407, doi: 10.1002/hep.24685 (2012).
5. Hugo, E. R. et al. Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes. Environmental health perspectives 116, 1642-1647, doi: 10.1289/ehp.11537 (2008).
6. Nadal, A., Alonso-Magdalena, P., Soriano, S., Quesada, I. & Ropero, A. B. The pancreatic beta-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes. Molecular and cellular endocrinology 304, 63-68, doi: 10.1016/j.mce.2009.02.016 (2009).
7. Marmugi, A. et al. Low doses of bisphenol a induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver. Hepatology 55, 395-407, doi: 10.1002/hep.24685 (2012).
8. Cabaton, N. J. et al. Effects of Low Doses of Bisphenol A on the Metabolome of Perinatally Exposed CD-1 Mice. Environmental health perspectives 121, 586-593, doi: 10.1289/ehp.1205588 (2013).
9. Marmugi, A. et al. Adverse effects of long-Term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice. Toxicology 325, 133-143, doi: 10.1016/j.tox.2014.08.006 (2014).
10. Jiang, Y. et al. Mitochondrial dysfunction in early life resulted from perinatal bisphenol A exposure contributes to hepatic steatosis in rat offspring. Toxicology Letters 228, 85-92, doi: 10.1016/j.toxlet.2014.04.013 (2014).
11. Gluckman, P. D., Hanson, M. A., Buklijas, T., Low, F. M. & Beedle, A. S. Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nat. Rev. Endocrinol. 5, 401-408, doi: 10.1038/nrendo.2009.102 (2009).
12. Murphy, S. K. et al. Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology 145, 1076-1087, doi: 10.1053/j.gastro.2013.07.047 (2013).
13. Pirola, C. J. et al. Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease. Gut 62, 1356-1363, doi: 10.1136/gutjnl-2012-302962 (2013).
14. Ahrens, M. et al. DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery. Cell Metabolism 18, 296-302, doi: 10.1016/j.cmet.2013.07.004 (2013).
15. Chang, X. X. et al. Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats. Journal of lipid research 51, 2504-2515, doi: 10.1194/jlr.M001958 (2010).
16. Pooya, S. et al. Methyl donor deficiency impairs fatty acid oxidation through PGC-1 alpha hypomethylation and decreased ERalpha, ERR-Alpha, and HNF-4 alpha in the rat liver. J. Hepatol. 57, 344-351, doi: 10.1016/j.jhep.2012.03.028 (2012).
17. Sakakura, Y. et al. Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis. Biochemical and biophysical research communications 286, 176-183, doi: 10.1006/bbrc.2001.5375 (2001).
18. Hayhurst, G. P., Lee, Y. H., Lambert, G., Ward, J. M. & Gonzalez, F. J. Hepatocyte nuclear factor 4 alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 21, 1393-1403, doi: 10.1128/mcb.21.4.1393-1403.2001 (2001).
19. Jurkowska, R. Z., Jurkowski, T. P. & Jeltsch, A. Structure and Function of Mammalian DNA Methyltransferases. ChemBioChem 12, 206-222, doi: 10.1002/cbic.201000195 (2011).
20. Neuschwander-Tetri, B. A. Hepatic Lipotoxicity and the Pathogenesis of Nonalcoholic Steatohepatitis: The Central Role of Nontriglyceride Fatty Acid Metabolites. Hepatology 52, 774-788, doi: 10.1002/hep.23719 (2010).
21. Horton, J. D., Goldstein, J. L. & Brown, M. S. SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109, 1125-1131, doi: 10.1172/jci200215593 (2002).
22. Xie, X. et al. Down-Regulation of Hepatic HNF4 alpha Gene Expression during Hyperinsulinemia via SREBPs. Mol. Endocrinol. 23, 434-443, doi: 10.1210/me.2007-0531 (2009).
23. Raghow, R., Yellaturu, C., Deng, X., Park, E. A. & Elam, M. B. SREBPs: The crossroads of physiological and pathological lipid homeostasis. Trends Endocrinol. Metab. 19, 65-73, doi: 10.1016/j.tem.2007.10.009 (2008).
24. Jaenisch, R. & Bird, A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nature Genet. 33, 245-254, doi: 10.1038/ng1089 (2003).
25. Dolinoy, D. C., Huang, D. & Jirtle, R. L. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proceedings of the National Academy of Sciences of the United States of America 104, 13056-13061, doi: 10.1073/pnas.0703739104 (2007).
26. Ma, Y. et al. Hepatic DNA methylation modifications in early development of rats resulting from perinatal BPA exposure contribute to insulin resistance in adulthood. Diabetologia 56, 2059-2067, doi: 10.1007/s00125-013-2944-7 (2013).
27. Kim, J. H. et al. Perinatal bisphenol A exposure promotes dose-dependent alterations of the mouse methylome. BMC Genomics 15, doi: 10.1186/1471-2164-15-30 (2014).
28. Susiarjo, M., Sasson, I., Mesaros, C. & Bartolomei, M. S. Bisphenol A Exposure Disrupts Genomic Imprinting in the Mouse. PLoS Genet. 9, doi: 10.1371/journal.pgen.1003401 (2013).
29. Elbashir, S. M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498, doi: 10.1038/35078107 (2001).
30. Suzuki, M. et al. RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells. Cancer research 64, 3137-3143, doi: 10.1158/0008-5472.can-03-3046 (2004).