메뉴 건너뛰기




Volumn 113, Issue 15, 2016, Pages E2180-E2188

Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism

Author keywords

Alpha synuclein; Dopamine; Parkinson's disease; Substantia nigra; Ventral tegmental area

Indexed keywords

DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE RECEPTOR; ALPHA SYNUCLEIN;

EID: 84980436600     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1515941113     Document Type: Article
Times cited : (127)

References (51)
  • 1
    • 0029981543 scopus 로고    scopus 로고
    • A framework for mesencephalic dopamine systems based on predictive hebbian learning
    • Montague PR, Dayan P, Sejnowski TJ (1996) A framework for mesencephalic dopamine systems based on predictive Hebbian learning. J Neurosci 16(5):1936-1947.
    • (1996) J Neurosci , vol.16 , Issue.5 , pp. 1936-1947
    • Montague, P.R.1    Dayan, P.2    Sejnowski, T.J.3
  • 2
    • 0030896968 scopus 로고    scopus 로고
    • A neural substrate of prediction and reward
    • Schultz W, Dayan P, Montague PR (1997) A neural substrate of prediction and reward. Science 275(5306):1593-1599.
    • (1997) Science , vol.275 , Issue.5306 , pp. 1593-1599
    • Schultz, W.1    Dayan, P.2    Montague, P.R.3
  • 3
    • 34247523368 scopus 로고    scopus 로고
    • Behavioral dopamine signals
    • Schultz W (2007) Behavioral dopamine signals. Trends Neurosci 30(5):203-210.
    • (2007) Trends Neurosci , vol.30 , Issue.5 , pp. 203-210
    • Schultz, W.1
  • 4
    • 67349098495 scopus 로고    scopus 로고
    • Two types of dopamine neuron distinctly convey positive and negative motivational signals
    • Matsumoto M, Hikosaka O (2009) Two types of dopamine neuron distinctly convey positive and negative motivational signals. Nature 459(7248):837-841.
    • (2009) Nature , vol.459 , Issue.7248 , pp. 837-841
    • Matsumoto, M.1    Hikosaka, O.2
  • 5
    • 84887114618 scopus 로고    scopus 로고
    • Reward and aversion in a heterogeneous midbrain dopamine system
    • Lammel S, Lim BK, Malenka RC (2014) Reward and aversion in a heterogeneous midbrain dopamine system. Neuropharmacology 76(Pt B):351-9.
    • (2014) Neuropharmacology , vol.76 , pp. 351-359
    • Lammel, S.1    Lim, B.K.2    Malenka, R.C.3
  • 6
    • 78649966665 scopus 로고    scopus 로고
    • Dopamine in motivational control: Rewarding, aversive, and alerting
    • Bromberg-Martin ES, Matsumoto M, Hikosaka O (2010) Dopamine in motivational control: Rewarding, aversive, and alerting. Neuron 68(5):815-834.
    • (2010) Neuron , vol.68 , Issue.5 , pp. 815-834
    • Bromberg-Martin, E.S.1    Matsumoto, M.2    Hikosaka, O.3
  • 7
    • 84878572201 scopus 로고    scopus 로고
    • Dissecting the diversity of midbrain dopamine neurons
    • Roeper J (2013) Dissecting the diversity of midbrain dopamine neurons. Trends Neurosci 36(6):336-342.
    • (2013) Trends Neurosci , vol.36 , Issue.6 , pp. 336-342
    • Roeper, J.1
  • 8
    • 84884190234 scopus 로고    scopus 로고
    • Distinct representations of cognitive and motivational signals in midbrain dopamine neurons
    • Matsumoto M, Takada M (2013) Distinct representations of cognitive and motivational signals in midbrain dopamine neurons. Neuron 79(5):1011-1024.
    • (2013) Neuron , vol.79 , Issue.5 , pp. 1011-1024
    • Matsumoto, M.1    Takada, M.2
  • 9
    • 0034061668 scopus 로고    scopus 로고
    • Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
    • Horvitz JC (2000) Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events. Neuroscience 96(4):651-656.
    • (2000) Neuroscience , vol.96 , Issue.4 , pp. 651-656
    • Horvitz, J.C.1
  • 10
    • 33747585633 scopus 로고    scopus 로고
    • Midbrain dopamine neurons encode decisions for future action
    • Morris G, Nevet A, Arkadir D, Vaadia E, Bergman H (2006) Midbrain dopamine neurons encode decisions for future action. Nat Neurosci 9(8):1057-1063.
    • (2006) Nat Neurosci , vol.9 , Issue.8 , pp. 1057-1063
    • Morris, G.1    Nevet, A.2    Arkadir, D.3    Vaadia, E.4    Bergman, H.5
  • 11
    • 0020957435 scopus 로고
    • Relations between movement and single cell discharge in the Substantia nigra of the behaving monkey
    • DeLong MR, Crutcher MD, Georgopoulos AP (1983) Relations between movement and single cell discharge in the substantia nigra of the behaving monkey. J Neurosci 3(8):1599-1606.
    • (1983) J Neurosci , vol.3 , Issue.8 , pp. 1599-1606
    • DeLong, M.R.1    Crutcher, M.D.2    Georgopoulos, A.P.3
  • 12
    • 77954925944 scopus 로고    scopus 로고
    • Start/stop signals emerge in nigrostriatal circuits during sequence learning
    • Jin X, Costa RM (2010) Start/stop signals emerge in nigrostriatal circuits during sequence learning. Nature 466(7305):457-462.
    • (2010) Nature , vol.466 , Issue.7305 , pp. 457-462
    • Jin, X.1    Costa, R.M.2
  • 14
    • 84859778306 scopus 로고    scopus 로고
    • Mechanisms of action selection and timing in Substantia nigra neurons
    • Fan D, Rossi MA, Yin HH (2012) Mechanisms of action selection and timing in substantia nigra neurons. J Neurosci 32(16):5534-5548.
    • (2012) J Neurosci , vol.32 , Issue.16 , pp. 5534-5548
    • Fan, D.1    Rossi, M.A.2    Yin, H.H.3
  • 15
    • 0020639433 scopus 로고
    • The activity of pars compacta neurons of the monkey Substantia nigra in relation to motor activation
    • Schultz W, Ruffieux A, Aebischer P (1983) The activity of pars compacta neurons of the monkey substantia nigra in relation to motor activation. Exp Brain Res 51:377-387.
    • (1983) Exp Brain Res , vol.51 , pp. 377-387
    • Schultz, W.1    Ruffieux, A.2    Aebischer, P.3
  • 16
    • 84930204365 scopus 로고    scopus 로고
    • Beyond reward prediction errors: The role of dopamine in movement kinematics
    • (May)
    • Barter JW, et al. (2015) Beyond reward prediction errors: The role of dopamine in movement kinematics. Front Integr Nuerosci 9(May):39.
    • (2015) Front Integr Nuerosci , vol.9 , pp. 39
    • Barter, J.W.1
  • 17
    • 84929292843 scopus 로고    scopus 로고
    • Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus
    • Dodson PD, et al. (2015) Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus. Neuron 86(2):501-513.
    • (2015) Neuron , vol.86 , Issue.2 , pp. 501-513
    • Dodson, P.D.1
  • 18
    • 34247469020 scopus 로고    scopus 로고
    • Dopamine neuron systems in the brain: An update
    • Björklund A, Dunnett SB (2007) Dopamine neuron systems in the brain: An update. Trends Neurosci 30(5):194-202.
    • (2007) Trends Neurosci , vol.30 , Issue.5 , pp. 194-202
    • Björklund, A.1    Dunnett, S.B.2
  • 19
    • 77958521455 scopus 로고    scopus 로고
    • Influence of phasic and tonic dopamine release on receptor activation
    • Dreyer JK, Herrik KF, Berg RW, Hounsgaard JD (2010) Influence of phasic and tonic dopamine release on receptor activation. J Neurosci 30(42):14273-14283.
    • (2010) J Neurosci , vol.30 , Issue.42 , pp. 14273-14283
    • Dreyer, J.K.1    Herrik, K.F.2    Berg, R.W.3    Hounsgaard, J.D.4
  • 20
    • 84871909089 scopus 로고    scopus 로고
    • Mathematical model of dopamine autoreceptors and uptake inhibitors and their influence on tonic and phasic dopamine signaling
    • Dreyer JK, Hounsgaard J (2013) Mathematical model of dopamine autoreceptors and uptake inhibitors and their influence on tonic and phasic dopamine signaling. J Neurophysiol 109(1):171-182.
    • (2013) J Neurophysiol , vol.109 , Issue.1 , pp. 171-182
    • Dreyer, J.K.1    Hounsgaard, J.2
  • 21
    • 84907015840 scopus 로고    scopus 로고
    • Three mechanisms by which striatal denervation causes breakdown of dopamine signaling
    • Dreyer JK (2014) Three mechanisms by which striatal denervation causes breakdown of dopamine signaling. J Neurosci 34(37):12444-12456.
    • (2014) J Neurosci , vol.34 , Issue.37 , pp. 12444-12456
    • Dreyer, J.K.1
  • 22
    • 84870056096 scopus 로고    scopus 로고
    • Conserved dorsal-ventral gradient of dopamine release and uptake rate in mice, rats and rhesus macaques
    • Calipari ES, Huggins KN, Mathews TA, Jones SR (2012) Conserved dorsal-ventral gradient of dopamine release and uptake rate in mice, rats and rhesus macaques. Neurochem Int 61(7):986-991.
    • (2012) Neurochem Int , vol.61 , Issue.7 , pp. 986-991
    • Calipari, E.S.1    Huggins, K.N.2    Mathews, T.A.3    Jones, S.R.4
  • 23
    • 79959869606 scopus 로고    scopus 로고
    • Modulation of striatal projection systems by dopamine
    • Gerfen CR, Surmeier DJ (2011) Modulation of striatal projection systems by dopamine. Annu Rev Neurosci 34:441-466.
    • (2011) Annu Rev Neurosci , vol.34 , pp. 441-466
    • Gerfen, C.R.1    Surmeier, D.J.2
  • 24
    • 79952032110 scopus 로고    scopus 로고
    • The physiology, signaling, and pharmacology of dopamine receptors
    • Beaulieu J-M, Gainetdinov RR (2011) The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev 63(1):182-217.
    • (2011) Pharmacol Rev , vol.63 , Issue.1 , pp. 182-217
    • Beaulieu, J.-M.1    Gainetdinov, R.R.2
  • 25
    • 45949098156 scopus 로고    scopus 로고
    • Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol
    • Bertran-Gonzalez J, et al. (2008) Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol. J Neurosci 28(22):5671-5685.
    • (2008) J Neurosci , vol.28 , Issue.22 , pp. 5671-5685
    • Bertran-Gonzalez, J.1
  • 26
    • 0034652091 scopus 로고    scopus 로고
    • Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors
    • Svenningsson P, et al. (2000) Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors. Proc Natl Acad Sci USA 97(4):1856-1860.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.4 , pp. 1856-1860
    • Svenningsson, P.1
  • 27
    • 84907970035 scopus 로고    scopus 로고
    • Phasic dopamine release drives rapid activation of striatal D2-receptors
    • Marcott PF, Mamaligas AA, Ford CP (2014) Phasic dopamine release drives rapid activation of striatal D2-receptors. Neuron 84(1):164-176.
    • (2014) Neuron , vol.84 , Issue.1 , pp. 164-176
    • Marcott, P.F.1    Mamaligas, A.A.2    Ford, C.P.3
  • 28
    • 84885743813 scopus 로고    scopus 로고
    • Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model
    • Janezic S, et al. (2013) Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model. Proc Natl Acad Sci USA 110(42): E4016-E4025.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.42 , pp. E4016-E4025
    • Janezic, S.1
  • 29
    • 84906246805 scopus 로고    scopus 로고
    • Heterogeneity of dopamine neuron activity across traits and states
    • Marinelli M, McCutcheon JE (2014) Heterogeneity of dopamine neuron activity across traits and states. Neuroscience 282C:176-197.
    • (2014) Neuroscience , vol.282 C , pp. 176-197
    • Marinelli, M.1    McCutcheon, J.E.2
  • 30
    • 40249097514 scopus 로고    scopus 로고
    • Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
    • Lammel S, et al. (2008) Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron 57(5):760-773.
    • (2008) Neuron , vol.57 , Issue.5 , pp. 760-773
    • Lammel, S.1
  • 31
    • 79958055503 scopus 로고    scopus 로고
    • Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli
    • Lammel S, Ion DI, Roeper J, Malenka RC (2011) Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron 70(5):855-862.
    • (2011) Neuron , vol.70 , Issue.5 , pp. 855-862
    • Lammel, S.1    Ion, D.I.2    Roeper, J.3    Malenka, R.C.4
  • 32
    • 84938263574 scopus 로고    scopus 로고
    • Circuit architecture of VTA dopamine neurons revealed by systematic input-output mapping
    • Beier KT, et al. (2015) Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping. Cell 162(3):622-634.
    • (2015) Cell , vol.162 , Issue.3 , pp. 622-634
    • Beier, K.T.1
  • 33
    • 84938243334 scopus 로고    scopus 로고
    • Intact-brain analyses reveal distinct information carried by SNc dopamine subcircuits
    • Lerner TN, et al. (2015) Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits. Cell 162(3):635-647.
    • (2015) Cell , vol.162 , Issue.3 , pp. 635-647
    • Lerner, T.N.1
  • 35
    • 84856431209 scopus 로고    scopus 로고
    • Neuron-type-specific signals for reward and punishment in the ventral tegmental area
    • Cohen JY, Haesler S, Vong L, Lowell BB, Uchida N (2012) Neuron-type-specific signals for reward and punishment in the ventral tegmental area. Nature 482(7383):85-88.
    • (2012) Nature , vol.482 , Issue.7383 , pp. 85-88
    • Cohen, J.Y.1    Haesler, S.2    Vong, L.3    Lowell, B.B.4    Uchida, N.5
  • 36
    • 1642404961 scopus 로고    scopus 로고
    • Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli
    • Ungless MA, Magill PJ, Bolam JP (2004) Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. Science 303(5666):2040-2042.
    • (2004) Science , vol.303 , Issue.5666 , pp. 2040-2042
    • Ungless, M.A.1    Magill, P.J.2    Bolam, J.P.3
  • 37
    • 63849221600 scopus 로고    scopus 로고
    • Activity of neurochemically heterogeneous dopaminergic neurons in the Substantia nigra during spontaneous and driven changes in brain state
    • Brown MTC, Henny P, Bolam JP, Magill PJ (2009) Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. J Neurosci 29(9):2915-2925.
    • (2009) J Neurosci , vol.29 , Issue.9 , pp. 2915-2925
    • Brown, M.T.C.1    Henny, P.2    Bolam, J.P.3    Magill, P.J.4
  • 38
    • 58149236469 scopus 로고    scopus 로고
    • Midbrain dopaminergic neurons and striatal cholinergic interneurons encode the difference between reward and aversive events at different epochs of probabilistic classical conditioning trials
    • Joshua M, Adler A, Mitelman R, Vaadia E, Bergman H (2008) Midbrain dopaminergic neurons and striatal cholinergic interneurons encode the difference between reward and aversive events at different epochs of probabilistic classical conditioning trials. J Neurosci 28(45):11673-11684.
    • (2008) J Neurosci , vol.28 , Issue.45 , pp. 11673-11684
    • Joshua, M.1    Adler, A.2    Mitelman, R.3    Vaadia, E.4    Bergman, H.5
  • 39
    • 21544435722 scopus 로고    scopus 로고
    • Midbrain dopamine neurons encode a quantitative reward prediction error signal
    • Bayer HM, Glimcher PW (2005) Midbrain dopamine neurons encode a quantitative reward prediction error signal. Neuron 47(1):129-141.
    • (2005) Neuron , vol.47 , Issue.1 , pp. 129-141
    • Bayer, H.M.1    Glimcher, P.W.2
  • 40
    • 77954439717 scopus 로고    scopus 로고
    • A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons
    • Lobb CJ, Wilson CJ, Paladini CA (2010) A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol 104(1): 403-413.
    • (2010) J Neurophysiol , vol.104 , Issue.1 , pp. 403-413
    • Lobb, C.J.1    Wilson, C.J.2    Paladini, C.A.3
  • 41
    • 84863393406 scopus 로고    scopus 로고
    • Structural correlates of heterogeneous in vivo activity of midbrain dopaminergic neurons
    • Henny P, et al. (2012) Structural correlates of heterogeneous in vivo activity of midbrain dopaminergic neurons. Nat Neurosci 15(4):613-619.
    • (2012) Nat Neurosci , vol.15 , Issue.4 , pp. 613-619
    • Henny, P.1
  • 42
    • 84861936797 scopus 로고    scopus 로고
    • Whole-brain mapping of direct inputs to midbrain dopamine neurons
    • Watabe-Uchida M, Zhu L, Ogawa SK, Vamanrao A, Uchida N (2012) Whole-brain mapping of direct inputs to midbrain dopamine neurons. Neuron 74(5):858-873.
    • (2012) Neuron , vol.74 , Issue.5 , pp. 858-873
    • Watabe-Uchida, M.1    Zhu, L.2    Ogawa, S.K.3    Vamanrao, A.4    Uchida, N.5
  • 44
    • 0037107131 scopus 로고    scopus 로고
    • Altered dopamine release and uptake kinetics in mice lacking D2 receptors
    • Schmitz Y, Schmauss C, Sulzer D (2002) Altered dopamine release and uptake kinetics in mice lacking D2 receptors. J Neurosci 22(18):8002-8009.
    • (2002) J Neurosci , vol.22 , Issue.18 , pp. 8002-8009
    • Schmitz, Y.1    Schmauss, C.2    Sulzer, D.3
  • 45
    • 0032973437 scopus 로고    scopus 로고
    • The basal ganglia: A vertebrate solution to the selection problem?
    • Redgrave P, Prescott TJ, Gurney K (1999) The basal ganglia: A vertebrate solution to the selection problem? Neuroscience 89(4):1009-1023.
    • (1999) Neuroscience , vol.89 , Issue.4 , pp. 1009-1023
    • Redgrave, P.1    Prescott, T.J.2    Gurney, K.3
  • 46
    • 0030294556 scopus 로고    scopus 로고
    • The basal ganglia: Focused selection and inhibition of competing motor programs
    • Mink JW (1996) The basal ganglia: Focused selection and inhibition of competing motor programs. Prog Neurobiol 50(4):381-425.
    • (1996) Prog Neurobiol , vol.50 , Issue.4 , pp. 381-425
    • Mink, J.W.1
  • 47
    • 84940460509 scopus 로고    scopus 로고
    • Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
    • Kupchik YM, et al. (2015) Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections. Nat Neurosci 18(9):1230-1232.
    • (2015) Nat Neurosci , vol.18 , Issue.9 , pp. 1230-1232
    • Kupchik, Y.M.1
  • 48
    • 84867291438 scopus 로고    scopus 로고
    • Dopaminergic neurons inhibit striatal output through non-canonical release of GABA
    • Tritsch NX, Ding JB, Sabatini BL (2012) Dopaminergic neurons inhibit striatal output through non-canonical release of GABA. Nature 490(7419):262-266.
    • (2012) Nature , vol.490 , Issue.7419 , pp. 262-266
    • Tritsch, N.X.1    Ding, J.B.2    Sabatini, B.L.3
  • 49
    • 84862889904 scopus 로고    scopus 로고
    • A cytoarchitectonic and chemoarchitectonic analysis of the dopamine cell groups in the Substantia nigra, ventral tegmental area, and retrorubral field in the mouse
    • Fu Y, et al. (2012) A cytoarchitectonic and chemoarchitectonic analysis of the dopamine cell groups in the substantia nigra, ventral tegmental area, and retrorubral field in the mouse. Brain Struct Funct 217(2):591-612.
    • (2012) Brain Struct Funct , vol.217 , Issue.2 , pp. 591-612
    • Fu, Y.1
  • 51
    • 0029894898 scopus 로고    scopus 로고
    • Comparison of discharge variability in vitro and in vivo in cat visual cortex neurons
    • Holt GR, Softky WR, Koch C, Douglas RJ (1996) Comparison of discharge variability in vitro and in vivo in cat visual cortex neurons. J Neurophysiol 75(5):1806-1814.
    • (1996) J Neurophysiol , vol.75 , Issue.5 , pp. 1806-1814
    • Holt, G.R.1    Softky, W.R.2    Koch, C.3    Douglas, R.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.