Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Nature Chemical Biology

Volumn 12, Issue 10, 2016, Pages 779-786

  Boudreau, Aaron ^a   Purkey, Hans E ^a   Hitz, Anna ^a   Robarge, Kirk ^a   Peterson, David ^a   Labadie, Sharada ^a   Kwong, Mandy ^a   Hong, Rebecca ^a   Gao, Min ^a   Del Nagro, Christopher ^a   Pusapati, Raju ^a   Ma, Shuguang ^a   Salphati, Laurent ^a   Pang, Jodie ^a   Zhou, Aihe ^a   Lai, Tommy ^b   Li, Yingjie ^b   Chen, Zhongguo ^b   Wei, Binqing ^a   Yen, Ivana ^a   Sideris, Steve ^a   McCleland, Mark ^a   Firestein, Ron ^a   Corson, Laura ^a   Vanderbilt, Alex ^a   Williams, Simon ^a   Daemen, Anneleen ^a   Belvin, Marcia ^a   Eigenbrot, Charles ^a   Jackson, Peter K ^a,c   Malek, Shiva ^a   Hatzivassiliou, Georgia ^a   Sampath, Deepak ^a   Evangelista, Marie ^a   O'Brien, Thomas ^a   more..

^a GENENTECH INC   (United States)

^b WUXI APPTEC   (China)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; ENZYME INHIBITOR; GNE 140; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; PHENFORMIN; S6 KINASE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; GNE-140; PYRIDONE DERIVATIVE; THIOPHENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; METABOLIC REGULATION; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR GROWTH; ANTAGONISTS AND INHIBITORS; CELL PLASTICITY; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

CELL DEATH; CELL LINE, TUMOR; CELL PLASTICITY; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; L-LACTATE DEHYDROGENASE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84980413785     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2143     Document Type: Article

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