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Volumn 3, Issue 8, 2015, Pages

Potentiation of cGMP signaling increases oxygen delivery and oxidative metabolism in contracting skeletal muscle of older but not young humans

Author keywords

Blood flow; Exercise; Sildenafil

Indexed keywords

CYCLIC GMP; SILDENAFIL;

EID: 84980356180     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.12508     Document Type: Article
Times cited : (17)

References (47)
  • 1
    • 0022270890 scopus 로고
    • Maximal perfusion of skeletal muscle in man
    • Andersen P. Saltin B. Maximal perfusion of skeletal muscle in man. J. Physiol. 1985;366:233-249.
    • (1985) J. Physiol , vol.366 , pp. 233-249
    • Andersen, P.1    Saltin, B.2
  • 2
    • 39849090160 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibition reverses impaired forearm exercise-induced vasodilatation in hypertensive patients
    • Attina TM, Malatino LS, Maxwell SR, Padfield PL. Webb DJ. Phosphodiesterase type 5 inhibition reverses impaired forearm exercise-induced vasodilatation in hypertensive patients. J. Hypertens. 2008;26:501-507.
    • (2008) J. Hypertens , vol.26 , pp. 501-507
    • Attina, T.M.1    Malatino, L.S.2    Maxwell, S.R.3    Padfield, P.L.4    Webb, D.J.5
  • 3
    • 0032445219 scopus 로고    scopus 로고
    • Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes
    • Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME., Naylor AM. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J. Urol. 1998;159:2164-2171.
    • (1998) J. Urol , vol.159 , pp. 2164-2171
    • Ballard, S.A.1    Gingell, C.J.2    Tang, K.3    Turner, L.A.4    Price, M.E.5    Naylor, A.M.6
  • 4
    • 0033533528 scopus 로고    scopus 로고
    • Aerobic exercise training can reverse age-related peripheral circulatory changes in healthy older men
    • Beere PA, Russell SD, Morey MC, Kitzman DW. Higginbotham MB. Aerobic exercise training can reverse age-related peripheral circulatory changes in healthy older men. Circulation. 1999;100:1085-1094.
    • (1999) Circulation , vol.100 , pp. 1085-1094
    • Beere, P.A.1    Russell, S.D.2    Morey, M.C.3    Kitzman, D.W.4    Higginbotham, M.B.5
  • 5
    • 71249103087 scopus 로고    scopus 로고
    • Cell-cell and intracellular lactate shuttles
    • Brooks GA. Cell-cell and intracellular lactate shuttles. J. Physiol. 2009;587:5591-5600.
    • (2009) J. Physiol , vol.587 , pp. 5591-5600
    • Brooks, G.A.1
  • 6
    • 70449837103 scopus 로고    scopus 로고
    • Physical activity and prevention of cardiovascular disease in older adults
    • viii
    • Buchner DM. Physical activity and prevention of cardiovascular disease in older adults. Clin. Geriatr. Med. 2009;25:661-675. viii.
    • (2009) Clin. Geriatr. Med , vol.25 , pp. 661-675
    • Buchner, D.M.1
  • 7
    • 84874105434 scopus 로고    scopus 로고
    • Exercise efficiency is reduced by mitochondrial uncoupling in the elderly
    • Conley KE, Jubrias SA, Cress ME. Esselman P. Exercise efficiency is reduced by mitochondrial uncoupling in the elderly. Exp. Physiol. 2013;98:768-777.
    • (2013) Exp. Physiol , vol.98 , pp. 768-777
    • Conley, K.E.1    Jubrias, S.A.2    Cress, M.E.3    Esselman, P.4
  • 8
    • 0038024614 scopus 로고    scopus 로고
    • [3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP
    • Corbin JD, Blount MA, Weeks JL, Beasley A, Kuhn KP, Ho YS, et al. [3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP. Mol. Pharmacol. 2003;63:1364-1372.
    • (2003) Mol. Pharmacol , vol.63 , pp. 1364-1372
    • Corbin, J.D.1    Blount, M.A.2    Weeks, J.L.3    Beasley, A.4    Kuhn, K.P.5    Ho, Y.S.6
  • 10
    • 0141566914 scopus 로고    scopus 로고
    • Invited review: Aging and sarcopenia
    • Doherty TJ. Invited review: aging and sarcopenia. J. Appl. Physiol. (1985) 2003;95:1717-1727.
    • (2003) J. Appl. Physiol. (1985) , vol.95 , pp. 1717-1727
    • Doherty, T.J.1
  • 12
    • 38649099116 scopus 로고    scopus 로고
    • Sildenafil citrate concentrations not affecting oxidative phosphorylation depress H2O2 generation by rat heart mitochondria
    • Fernandes MA, Marques RJ, Vicente JA, Santos MS, Monteiro P, Moreno AJ, et al. Sildenafil citrate concentrations not affecting oxidative phosphorylation depress H2O2 generation by rat heart mitochondria. Mol. Cell. Biochem. 2008;309:77-85.
    • (2008) Mol. Cell. Biochem , vol.309 , pp. 77-85
    • Fernandes, M.A.1    Marques, R.J.2    Vicente, J.A.3    Santos, M.S.4    Monteiro, P.5    Moreno, A.J.6
  • 13
    • 0035862195 scopus 로고    scopus 로고
    • Exercising skeletal muscle blood flow in humans responds to reduction in arterial oxyhaemoglobin, but not to altered free oxygen
    • Gonzalez-Alonso J, Richardson RS. Saltin B. Exercising skeletal muscle blood flow in humans responds to reduction in arterial oxyhaemoglobin, but not to altered free oxygen. J. Physiol. 2001;530:331-341.
    • (2001) J. Physiol , vol.530 , pp. 331-341
    • Gonzalez-Alonso, J.1    Richardson, R.S.2    Saltin, B.3
  • 15
    • 84871077211 scopus 로고    scopus 로고
    • Vasodilator interactions in skeletal muscle blood flow regulation
    • Hellsten Y, Nyberg M, Jensen LG. Mortensen SP. Vasodilator interactions in skeletal muscle blood flow regulation. J. Physiol. 2012;590:6297-6305.
    • (2012) J. Physiol , vol.590 , pp. 6297-6305
    • Hellsten, Y.1    Nyberg, M.2    Jensen, L.G.3    Mortensen, S.P.4
  • 16
    • 0344086180 scopus 로고    scopus 로고
    • Lactate transport in skeletal muscle - Role and regulation of the monocarboxylate transporter
    • Juel C., Halestrap AP. Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter. J. Physiol. 1999;517(Pt 3):633-642.
    • (1999) J. Physiol , vol.517 , pp. 633-642
    • Juel, C.1    Halestrap, A.P.2
  • 17
    • 84863723701 scopus 로고    scopus 로고
    • Impaired skeletal muscle blood flow control with advancing age in humans: Attenuated ATP release and local vasodilation during erythrocyte deoxygenation
    • Kirby BS, Crecelius AR, Voyles WF. Dinenno FA. Impaired skeletal muscle blood flow control with advancing age in humans: attenuated ATP release and local vasodilation during erythrocyte deoxygenation. Circ. Res. 2012;111:220-230.
    • (2012) Circ. Res , vol.111 , pp. 220-230
    • Kirby, B.S.1    Crecelius, A.R.2    Voyles, W.F.3    Dinenno, F.A.4
  • 19
  • 20
    • 77954850266 scopus 로고    scopus 로고
    • Exercise, physiological function, and the selection of participants for aging research
    • Lazarus NR., Harridge SD. Exercise, physiological function, and the selection of participants for aging research. J. Gerontol. A Biol. Sci. Med. Sci. 2010;65:854-857.
    • (2010) J. Gerontol. a Biol. Sci. Med. Sci , vol.65 , pp. 854-857
    • Lazarus, N.R.1    Harridge, S.D.2
  • 21
    • 0035860241 scopus 로고    scopus 로고
    • Age-related decrease of protein kinase G activation in vascular smooth muscle cells. Biochem. Biophys. Res
    • Lin CS, Liu X, Tu R, Chow S. Lue TF. Age-related decrease of protein kinase G activation in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 2001;287:244-248.
    • (2001) Commun , vol.287 , pp. 244-248
    • Lin, C.S.1    Liu, X.2    Tu, R.3    Chow, S.4    Lue, T.F.5
  • 22
    • 62349119843 scopus 로고    scopus 로고
    • Evidence for differential regulation of lactate metabolic properties in aged and unloaded rat skeletal muscle
    • Masuda S, Hayashi T, Egawa T., Taguchi S. Evidence for differential regulation of lactate metabolic properties in aged and unloaded rat skeletal muscle. Exp. Gerontol. 2009;44:280-288.
    • (2009) Exp. Gerontol , vol.44 , pp. 280-288
    • Masuda, S.1    Hayashi, T.2    Egawa, T.3    Taguchi, S.4
  • 23
    • 0035908973 scopus 로고    scopus 로고
    • A 30-year follow-up of the Dallas Bedrest and Training Study: I. Effect of age on the cardiovascular response to exercise
    • McGuire DK, Levine BD, Williamson JW, Snell PG, Blomqvist CG, Saltin B, et al. A 30-year follow-up of the Dallas Bedrest and Training Study: I. Effect of age on the cardiovascular response to exercise. Circulation. 2001;104:1350-1357.
    • (2001) Circulation , vol.104 , pp. 1350-1357
    • McGuire, D.K.1    Levine, B.D.2    Williamson, J.W.3    Snell, P.G.4    Blomqvist, C.G.5    Saltin, B.6
  • 24
    • 84856224116 scopus 로고    scopus 로고
    • Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle
    • Morgado M, Cairrao E, Santos-Silva AJ. Verde I. Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle. Cell. Mol. Life Sci. 2012;69:247-266.
    • (2012) Cell. Mol. Life Sci , vol.69 , pp. 247-266
    • Morgado, M.1    Cairrao, E.2    Santos-Silva, A.J.3    Verde, I.4
  • 25
    • 34249745856 scopus 로고    scopus 로고
    • Inhibition of nitric oxide and prostaglandins, but not endothelial-derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human leg
    • Mortensen SP, Gonzalez-Alonso J, Damsgaard R, Saltin B. Hellsten Y. Inhibition of nitric oxide and prostaglandins, but not endothelial-derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human leg. J. Physiol. 2007;581:853-861.
    • (2007) J. Physiol , vol.581 , pp. 853-861
    • Mortensen, S.P.1    Gonzalez-Alonso, J.2    Damsgaard, R.3    Saltin, B.4    Hellsten, Y.5
  • 26
    • 84868105599 scopus 로고    scopus 로고
    • Lifelong physical activity preserves functional sympatholysis and purinergic signalling in the ageing human leg
    • Mortensen SP, Nyberg M, Winding K., Saltin B. Lifelong physical activity preserves functional sympatholysis and purinergic signalling in the ageing human leg. J. Physiol. 2012;590:6227-6236.
    • (2012) J. Physiol , vol.590 , pp. 6227-6236
    • Mortensen, S.P.1    Nyberg, M.2    Winding, K.3    Saltin, B.4
  • 27
    • 84868104223 scopus 로고    scopus 로고
    • Lifelong physical activity prevents an age-related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans
    • Nyberg M, Blackwell JR, Damsgaard R, Jones AM, Hellsten Y., Mortensen SP. Lifelong physical activity prevents an age-related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans. J. Physiol. 2012;590:5361-5370.
    • (2012) J. Physiol , vol.590 , pp. 5361-5370
    • Nyberg, M.1    Blackwell, J.R.2    Damsgaard, R.3    Jones, A.M.4    Hellsten, Y.5    Mortensen, S.P.6
  • 28
    • 84908377301 scopus 로고    scopus 로고
    • Infusion of ATP increases leg oxygen delivery but not oxygen uptake in the initial phase of intense knee-extensor exercise in humans
    • Nyberg M, Christensen PM, Mortensen SP, Hellsten Y. Bangsbo J. Infusion of ATP increases leg oxygen delivery but not oxygen uptake in the initial phase of intense knee-extensor exercise in humans. Exp. Physiol. 2014;99:1399-1408.
    • (2014) Exp. Physiol , vol.99 , pp. 1399-1408
    • Nyberg, M.1    Christensen, P.M.2    Mortensen, S.P.3    Hellsten, Y.4    Bangsbo, J.5
  • 29
    • 0037052454 scopus 로고    scopus 로고
    • Demography. Broken limits to life expectancy
    • Oeppen J. Vaupel JW. Demography. Broken limits to life expectancy. Science. 2002;296:1029-1031.
    • (2002) Science , vol.296 , pp. 1029-1031
    • Oeppen, J.1    Vaupel, J.W.2
  • 31
    • 84870354153 scopus 로고    scopus 로고
    • Lifelong physical activity and blood flow to active muscles: Sufficient supply to meet the demand
    • Proctor DN. Moore DJ. Lifelong physical activity and blood flow to active muscles: sufficient supply to meet the demand. J. Physiol. 2012;590:5927-5928.
    • (2012) J. Physiol , vol.590 , pp. 5927-5928
    • Proctor, D.N.1    Moore, D.J.2
  • 32
    • 33645837065 scopus 로고    scopus 로고
    • Vasodilation and vascular control in contracting muscle of the aging human
    • Proctor DN. Parker BA. Vasodilation and vascular control in contracting muscle of the aging human. Microcirculation. 2006;13:315-327.
    • (2006) Microcirculation , vol.13 , pp. 315-327
    • Proctor, D.N.1    Parker, B.A.2
  • 35
    • 0344436089 scopus 로고    scopus 로고
    • Nitric oxide in the regulation of vasomotor tone in human skeletal muscle
    • Radegran G. Saltin B. Nitric oxide in the regulation of vasomotor tone in human skeletal muscle. Am. J. Physiol. 1999;276:H1951-H1960.
    • (1999) Am. J. Physiol , vol.276 , pp. H1951-H1960
    • Radegran, G.1    Saltin, B.2
  • 36
    • 0001599370 scopus 로고
    • Role of endothelium-derived nitric oxide in the regulation of blood pressure
    • Rees DD, Palmer RM., Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc. Natl Acad. Sci. USA. 1989;86:3375-3378.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 3375-3378
    • Rees, D.D.1    Palmer, R.M.2    Moncada, S.3
  • 37
    • 0033071461 scopus 로고    scopus 로고
    • Arterial O2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans
    • Roach RC, Koskolou MD, Calbet JA. Saltin B. Arterial O2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans. Am. J. Physiol. 1999;276:H438-H445.
    • (1999) Am. J. Physiol , vol.276 , pp. H438-H445
    • Roach, R.C.1    Koskolou, M.D.2    Calbet, J.A.3    Saltin, B.4
  • 39
    • 0042859823 scopus 로고    scopus 로고
    • Cyclic GMP phosphodiesterases and regulation of smooth muscle function
    • Rybalkin SD, Yan C, Bornfeldt KE., Beavo JA. Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circ. Res. 2003;93:280-291.
    • (2003) Circ. Res , vol.93 , pp. 280-291
    • Rybalkin, S.D.1    Yan, C.2    Bornfeldt, K.E.3    Beavo, J.A.4
  • 41
    • 0031888712 scopus 로고    scopus 로고
    • Skeletal muscle blood flow in humans and its regulation during exercise
    • Saltin B, Radegran G, Koskolou MD., Roach RC. Skeletal muscle blood flow in humans and its regulation during exercise. Acta Physiol. Scand. 1998;162:421-436.
    • (1998) Acta Physiol. Scand , vol.162 , pp. 421-436
    • Saltin, B.1    Radegran, G.2    Koskolou, M.D.3    Roach, R.C.4
  • 42
    • 23644439784 scopus 로고    scopus 로고
    • Vascular complications in diabetes mellitus: The role of endothelial dysfunction
    • Schalkwijk CG. Stehouwer CD. Vascular complications in diabetes mellitus: the role of endothelial dysfunction. Clin. Sci. (Lond.) 2005;109:143-159.
    • (2005) Clin. Sci. (Lond.) , vol.109 , pp. 143-159
    • Schalkwijk, C.G.1    Stehouwer, C.D.2
  • 43
    • 33846979103 scopus 로고    scopus 로고
    • Ageing reduces nitric-oxide-and prostaglandin-mediated vasodilatation in exercising humans
    • Schrage WG, Eisenach JH., Joyner MJ. Ageing reduces nitric-oxide-and prostaglandin-mediated vasodilatation in exercising humans. J. Physiol. 2007;579:227-236.
    • (2007) J. Physiol , vol.579 , pp. 227-236
    • Schrage, W.G.1    Eisenach, J.H.2    Joyner, M.J.3
  • 46
    • 0036242933 scopus 로고    scopus 로고
    • Effects of sildenafil citrate (Viagra) on blood pressure in normotensive and hypertensive men
    • Vardi Y, Klein L, Nassar S, Sprecher E. Gruenwald I. Effects of sildenafil citrate (viagra) on blood pressure in normotensive and hypertensive men. Urology. 2002;59:747-752.
    • (2002) Urology , vol.59 , pp. 747-752
    • Vardi, Y.1    Klein, L.2    Nassar, S.3    Sprecher, E.4    Gruenwald, I.5


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