Vasodilator interactions in skeletal muscle blood flow regulation

Journal of Physiology

Volumn 590, Issue 24, 2012, Pages 6297-6305

  Hellsten, Y ^a   Nyberg, M ^a   Jensen, L G ^a   Mortensen, S P ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOSINE; ADENOSINE TRIPHOSPHATE; BRADYKININ; CYCLIC AMP; CYCLIC GMP; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; NITRIC OXIDE; PROSTACYCLIN; PROSTANOID; VASODILATOR AGENT;

ARTICLE; ENDOTHELIUM CELL; FLOW RATE; FOREARM BLOOD FLOW; HUMAN; HYPEREMIA; LIMB BLOOD FLOW; MOLECULAR DYNAMICS; MUSCLE BLOOD FLOW; MUSCLE EXERCISE; MUSCLE FUNCTION; MUSCLE RELAXATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SMOOTH MUSCLE FIBER;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL FACTORS; CYCLIC AMP; CYCLIC GMP; ENDOTHELIUM, VASCULAR; EPOPROSTENOL; EXERCISE; HOMEOSTASIS; HUMANS; HYPEREMIA; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; OXYGEN CONSUMPTION; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; VASODILATION;

EID: 84871077211     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.240762     Document Type: Article

References (75)

1. Andersen P & Saltin B (1985). Maximal perfusion of skeletal-muscle in man. J Physiol 366, 233-249.
2. Baenziger NL, Force LE & Becherer PR (1980). Histamine stimulate prostacyclin synthesis in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun 92, 1435-1440.
3. Bauersachs J, Popp R, Hecker M, Sauer E, Fleming I & Busse R (1996). Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation 94, 3341-3347.
4. Bevegård S & Orö L (1969). Effect of prostaglandin E1 on forearm blood flow. Scand J Clin Lab Inevest 23, 347-353.
5. Bina S, Hart JL & Muldoon SM (1994). Comparative effects of exogenous nitrovasodilators on cGMP levels in different canine blood vessels. Life Sci 56, 33-38.
6. Bolz SS & Pohl U (1997). Indomethacin enhances endothelial NO release - evidence for a role of PGI2 in the autocrine control of calcium-dependent autacoid production. Cardiovasc Res 36, 437-444.
7. 2+ changes and dilation in isolated resistance arteries. FASEB J 14, 255-260.
8. 2 during exercise. Am J Physiol Regul Integr Comp Physiol 303, R94-R100.
9. Boushel R, Langberg H, Gemmer C, Olesen J, Crameri R, Scheede C, Sander M & Kjaer M (2002). Combined inhibition of nitric oxide and prostaglandins reduces human skeletal muscle blood flow during exercise. J Physiol 543, 691-698.
10. Bradley SJ, Kingwell BA & McConell GK (1999). Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans. Diabetes 48, 1815-1821.
11. Busse R, Edwards G, Félétou M & Fleming I (2002). EDHF: bringing the concepts together. Trends Pharmacol Sci 23, 374-380.
12. Casey DP, Curry TB & Joyner MJ. Measuring muscle blood flow: a key link between systemic and regional metabolism. Curr Opin Clin Nutr Metab Care. (2008). 11(5):580-586.
13. Carter TD, Hallam TJ, Cusack NJ & Pearson JD (1988). Regulation of P2y-purinoceptor-mediated prostacyclin release from human endothelial cells by cytoplasmic calcium concentration. Br J Pharmacol 95, 1181-1190.
14. Carvajal JA, Germain AM, Huidobro-Toro JP & Weiner CP (2000). Molecular mechanism of cGMP-mediated smooth muscle relaxation. J Cell Physiol 184, 409-420.
15. Crecelius AR, Kirby BS, Voyles WF & Dinenno FA (2011). Augmented skeletal muscle hyperaemia during hypoxic exercise in humans is blunted by combined inhibition of nitric oxide and vasodilating prostaglandins. J Physiol 589, 3671-3683.
16. Clifford PS & Hellsten Y (2004). Vasodilatory mechanisms in contracting skeletal muscle. J Appl Physiol 97, 393-403.
17. da Silva CG, Specht A, Wegiel B, Ferran C & Kaczmarek E (2009). Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. Circulation 119, 871-879.
18. de Wit C, von Bismarck P & Pohl U (1994). Synergistic action of vasodilators that increase cGMP and cAMP in the hamster cremaster microcirculation. Cardiovasc Res 28, 1513-1518.
19. de Wit C, Schäfer C, von Bismarck P, Bolz SS & Pohl U (1997). Elevation of plasma viscosity induces sustained NO-mediated dilation in the hamster cremaster microcirculation in vivo. Pflugers Arch 434, 354-361.
20. Domeier TL & Segal SS (2007). Electromechanical and pharmacomechanical signalling pathways for conducted vasodilatation along endothelium of hamster feed arteries. J Physiol 579, 175-186.
21. Dudzinski D & Michel T (2007). Life history of eNOS: partners and pathways. Cardiovasc Res 75, 247-260.
22. 2+. Am J Physiol Heart Circ Physiol 285, H26-H37.
23. Dyke CK, Proctor DN, Dietz NM & Joyner MJ (1995). Role of nitric oxide in exercise hyperaemia during prolonged rhythmic handgripping in humans. J Physiol 488, 259-265.
24. Félétou M, Huang Y & Vanhoutte PM (2010). Vasoconstrictor prostanoids. Pflugers Arch 459, 941-950.
25. Félétou M, Huang Y & Vanhoutte PM (2011). Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol 164, 894-912.
26. Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I & Busse R (1999). Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature 401, 493-497.
27. Fleming I & Busse R (2003). Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 284, R1-R12.
28. G-monomethyl- L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle. J Vasc Res 37, 297-302.
29. G-nitro-L-arginine methyl ester in humans. J Physiol 531, 257-264.
30. Gilligan DM, Panza JA, Kilcoyne CM, Waclawiw MA, Casino PR & Quyyumi AA (1994). Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation 90, 2853-2858.
31. Gordon JL (1986). Extracellular ATP: effects, sources and fate. Biochem J 233, 309-319.
32. Grabowski EF, Jaffe EA & Weksler BB (1985). Prostacyclin production by cultured endothelial cell monolayers exposed to step increases in shear stress. J Lab Clin Med 105, 36-43.
33. Halcox JP, Narayanan S, Cramer-Joyce L, Mincemoyer R & Quyyumi AA (2001). Characterization of endothelium-derived hyperpolarizing factor in the human forearm microcirculation. Am J Physiol Heart Circ Physiol 280, H2470-H2477.
34. Hammer LW, Ligon AL & Hester RL (2001). ATP-mediated release of arachidonic acid metabolites from venular endothelium causes arteriolar dilation. Am J Physiol Heart Circ Physiol 280, H2616-H2622.
35. Heinonen I, Bengt S, Jukka K, Sipilä HT, Vesa O, Pirjo N, Juhani K, Kari K & Ylva H (2011). Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a pet study with nitric oxide and cyclooxygenase inhibition. Am J Physiol Heart Circ Physiol 300, 1510-1517.
36. Hellsten Y, Nyberg M & Mortensen SP (2012). Contribution of intravascular versus interstitial purines and nitric oxide in the regulation of exercise hyperaemia in humans. J Physiol 590, 5015-5023.
37. Hillig T, Krustrup P, Fleming I, Osada T, Saltin B & Hellsten Y (2003). Cytochrome P450 2C9 plays an important role in the regulation of exercise-induced skeletal muscle blood flow and oxygen uptake in humans. J Physiol (lond) 546, 307-314.
38. Karamouzis M, Langberg H, Skovgaard D, Bülow J, Kjaer M & Saltin B (2001). In situ microdialysis of intramuscular prostaglandin and thromboxane in contracting skeletal muscle in humans. Acta Physiol Scand 171, 71-76.
39. Kingwell BA, Formosa M, Muhlmann M, Bradley SJ & McConell GK (2002). Nitric oxide synthase inhibition reduces glucose uptake during exercise in individuals with type 2 diabetes more than in control subjects. Diabetes 51, 2572-2580.
40. Kirby BS, Crecelius AR, Voyles WF & Dinenno FA (2010). Vasodilatory responsiveness to adenosine triphosphate in ageing humans. J Physiol (Lond) 588, 4017-4027.
41. Koller A, Sun D, Huang A & Kaley G (1994). Corelease of nitric oxide and prostaglandins mediates flow-dependent dilation of rat gracilis muscle arterioles. Am J Physiol Heart Circ Physiol 267, H326-H332.
42. Martin EA, Nicholson WT, Eisenach JH, Charkoudian N & Joyner MJ (2006). Influences of adenosine receptor antagonism on vasodilator responses to adenosine and exercise in adenosine responders and nonresponders. J Appl Physiol 101, 1678-1684.
43. Maurice DH & Haslam RJ (1990). Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol Pharmacol 37, 671-681.
44. McCullough W, Collins D & Ellsworth M (1997). Arteriolar responses to extracellular ATP in striated muscle. Am J Physiol Heart Circ Physiol 272, H1886-H1891.
45. Mortensen SP, Askew CD, Walker M, Nyberg M & Hellsten Y (2012). The hyperaemic response to passive leg movement is dependent on nitric oxide; a new tool to evaluate endothelial nitric oxide function. J Physiol 590, 4391-4404.
46. Mortensen SP, Gonzalez-Alonso J, Damsgaard R, Saltin B & Hellsten Y (2007). Inhibition of nitric oxide and prostaglandins, but not endothelial-derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human leg. J Physiol 581, 853-861.
47. Mortensen SP, González-Alonso J, Bune LT, Saltin B, Pilegaard H & Hellsten Y (2009a). ATP-induced vasodilation and purinergic receptors in the human leg: roles of nitric oxide, prostaglandins, and adenosine. Am J Physiol Regul Integr Comp Physiol 296, R1140-R1148.
48. Mortensen SP, Nyberg M, Thaning P, Saltin B & Hellsten Y (2009b). Adenosine contributes to blood flow regulation in the exercising human leg by increasing prostaglandin and nitric oxide formation. Hypertension 53, 993-999.
49. Mount PF, Kemp BE & Power DA (2007). Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol 42, 271-279.
50. Nathan C & Xie QW (1994). Nitric oxide synthases: roles, tolls, and controls. Cell 78, 915-918.
51. Newcomer SC, Leuenberger UA, Hogeman CS, Handly BD & Proctor DN (2004). Different vasodilator responses of human arms and legs. J Physiol 556, 1001-1011.
52. Nyberg M, Jensen LG, Thaning P, Hellsten Y & Mortensen SP (2012). Role of nitric oxide and prostanoids in the regulation of leg blood flow and blood pressure in humans with essential hypertension: effect of high-intensity aerobic training. J Physiol 590, 1481-1494.
53. Nyberg M, Mortensen SP, Thaning P, Saltin B & Hellsten Y (2010). Interstitial and plasma adenosine stimulate nitric oxide and prostacyclin formation in human skeletal muscle. Hypertension 56, 1102-1108.
54. Panza JA, Casino PR, Badar DM & Quyyumi AA (1993). Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation 87, 1475-1481.
55. Pawelczyk JA & Levine BD (2002). Heterogeneous responses of human limbs to infused adrenergic agonists: a gravitational effect J Appl Physiol 92, 2105-2113.
56. Ralevic V, Burnstock G. (1998). Receptors for purines and pyrimidines. Pharmacol Rev. 50(3):413-492. Review.
57. 2+ mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells. Cell Calcium 49, 240-248.
58. Ray C & Marshall J (2006). The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium. J Physiol 570, 85-96.
59. Ray CJ, Abbas MR, Coney AM & Marshall JM (2002). Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies. J Physiol 544, 195-209.
60. Rådegran G & Saltin B (1999). Nitric oxide in the regulation of vasomotor tone in human skeletal muscle. Am J Physiol Heart Circ Physiol 276, H1951-H1960.
61. Rongen GA, Smits P & Thien T (1994). Characterization of ATP-induced vasodilation in the human forearm vascular bed. Circulation 90, 1891-1898.
62. Rowell LB (1993). Human Cardiovascular Control. Oxford University Press, New York.
63. Sarelius I & Pohl U (2010). Control of muscle blood flow during exercise: local factors and integrative mechanisms. Acta Physiologica 199, 349-365.
64. Schrage WG (2004). Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humans. J Physiol 557, 599-611.
65. Schrage WG, Wilkins BW, Johnson CP, Eisenach JH, Limberg JK, Dietz NM, Curry TB & Joyner MJ (2010). Roles of nitric oxide synthase and cyclooxygenase in leg vasodilation and oxygen consumption during prolonged low-intensity exercise in untrained humans. J Appl Physiol 109, 768-777.
66. Shoemaker JK, Naylor HL, Pozeg ZI & Hughson RL (1996). Failure of prostaglandins to modulate the time course of blood flow during dynamic forearm exercise in humans. J Appl Physiol 81, 1516-1521.
67. Thaning P, Bune LT, Zaar M, Saltin B & Rosenmeier JB (2011). Functional sympatholysis during exercise in patients with type 2 diabetes with intact response to acetylcholine. Diabetes Care 34, 1186-1191.
68. Thijssen DHJ, Rowley N, Padilla J, Simmons GH, Laughlin MH, Whyte G, Cable NT & Green DJ (2011). Relationship between upper and lower limb conduit artery vasodilator function in humans. J Appl Physiol 111, 244-250.
69. Vallance P, Collier J & Moncada S (1989). Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 334, 997-1000.
70. Vanhoutte PM & Mombouli JV (1996). Vascular endothelium: vasoactive mediators. Prog Cardiovasc Dis 39, 229-238.
71. Vanhoutte PM, Shimokawa H, Tang EHC & Félétou M (2009). Endothelial dysfunction and vascular disease. Acta Physiologica 196, 193-222.
72. Virdis A, Ghiadoni L & Taddei S (2010). Human endothelial dysfunction: EDCFs. Pflugers Arch 459, 1015-1023.
73. Wahren J (1966). Quantitative aspects of blood flow and oxygen uptake in the human forearm during rhythmic exercise. Acta Physiol Scand Suppl 269, 1-93.
74. Wilson JR & Kapoor SC (1993). Contribution of prostaglandins to exercise-induced vasodilation in humans. Am J Physiol Heart Circ Physiol 265, H171-H175.
75. Yegutkin GG (2008). Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade. Biochim Biophys Acta 1783, 673-694.