Genetic and environmental effects on body mass index from infancy to the onset of adulthood: An individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

American Journal of Clinical Nutrition

Volumn 104, Issue 2, 2016, Pages 371-379

  Silventoinen, Karri ^a,c   Jelenkovic, Aline ^a,d   Sund, Reijo ^a   Hur, Yoon Mi ^e   Yokoyama, Yoshie ^f   Honda, Chika ^c   Hjelmborg, Jacob B ^g   Moller, Soren ^g   Ooki, Syuichi ⁱ   Aaltonen, Sari ^a,b   Ji, Fuling ^j   Ning, Feng ^j   Pang, Zengchang ^j   Rebato, Esther ^d   Busjahn, Andreas ^k   Kandler, Christian ^l   Saudino, Kimberly J ^m   Jang, Kerry L ⁿ   Cozen, Wendy ^o,q   Hwang, Amie E ^o   MacK, Thomas M ^o,q   Gao, Wenjing ^r   Yu, Canqing ^r   Li, Liming ^r   Corley, Robin P ^s   Huibregtse, Brooke M ^s   Christensen, Kaare ^g,t   Skytthe, Axel ^g   Kyvik, Kirsten O ^h,u   Derom, Catherine A ^x,y   Vlietinck, Robert F ^x   Loos, Ruth J ^z   Heikkila, Kauko ^b   Wardle, Jane ^aa   Llewellyn, Clare H ^aa   Fisher, Abigail ^aa   McAdams, Tom A ^aa,ab   Eley, Thalia C ^ab   Gregory, Alice M ^ac   He, Mingguang ^ad,ae   Ding, Xiaohu ^ad   Bjerregaard Andersen, Morten ^v,af,ag   Beck Nielsen, Henning ^v   Sodemann, Morten ^v,w   Tarnoki, Adam D ^ah,ai   Tarnoki, David L ^ah,ai   Stazi, Maria A ^aj   Fagnani, Corrado ^aj   D'Ippolito, Cristina ^aj   Knafo Noam, Ariel ^ak   Mankuta, David ^ak   Abramson, Lior ^ak   Burt, S Alexandra ^al   Klump, Kelly L ^al   Silberg, Judy L ^am   Eaves, Lindon J ^am   Maes, Hermine H ^am,ao   Krueger, Robert F ^ap   McGue, Matt ^ap   Pahlen, Shandell ^ap   Gatz, Margaret ^p,aq   Butler, David A ^as   Bartels, Meike ^at   Van Beijsterveldt, T C E M ^at   Craig, Jeffrey M ^ae,au   Saffery, Richard ^ae,au   Freitas, Duarte L ^av   Maia, José Antonio ^aw   Dubois, Lise ^ax   Boivin, Michel ^ay,az   Brendgen, Mara ^ba   Dionne, Ginette ^ay   Vitaro, Frank ^bb   Martin, Nicholas G ^bc   Medland, Sarah E ^bc   Montgomery, Grant W ^bd   Chong, Youngsook ^be   Swan, Gary E ^bf   Krasnow, Ruth ^bg   Magnusson, Patrik K E ^aq   Pedersen, Nancy L ^aq   Tynelius, Per ^ba   Lichtenstein, Paul ^aq   Haworth, Claire M A ^bh   Plomin, Robert ^ab   Bayasgalan, Gombojav ^bi   Narandalai, Danshiitsoodol ^bi,bj   Harden, K Paige ^bk   Tucker Drob, Elliot M ^bk   Oncel, Sevgi Y ^bl   Aliev, Fazil ^am,an   Spector, Timothy ^ab   Mangino, Massimo ^ab   Lachance, Genevieve ^ab   Baker, Laura A ^p   Tuvblad, Catherine ^p,bm   Duncan, Glen E ^bn   Buchwald, Dedra ^bo   Willemsen, Gonneke ^at   Rasmussen, Finn ^ar   Jack, H Goldberg ^bp   Sørensen, Thorkild I ^bh,bq,br   Boomsma, Dorret I ^au   Kaprio, Jaakko ^b,bs   more..

^a Departments of Social Research   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

^c OSAKA UNIVERSITY   (Japan)

^d UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^e Mokpo National University   (South Korea)

^f Osaka Prefecture University   (Japan)

^g Danish Twin Registry   (Denmark)

^h UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

ⁱ ISHIKAWA PREFECTURAL NURSING UNIVERSITY   (Japan)

^j Qingdao Center for Disease Control and Prevention   (China)

^k HealthTwist GmbH   (Germany)

^l BIELEFELD UNIVERSITY   (Germany)

^m BOSTON UNIVERSITY   (United States)

ⁿ UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^o UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^p UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^q UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^r PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^s UNIVERSITY OF COLORADO   (United States)

^t Departments of Clinical Biochemistry and Pharmacology Clinical Genetics   (United States)

^u Odense Patient Data Explorative Network (OPEN)   (United States)

^v Diabetes and Metabolism   (United States)

^w ODENSE UNIVERSITY HOSPITAL   (Denmark)

^x UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^y GHENT UNIVERSITY   (Belgium)

^z MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^aa UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ab KING'S COLLEGE LONDON   (United Kingdom)

^ac UNIVERSITY OF LONDON   (United Kingdom)

^ad SUN YAT SEN UNIVERSITY   (China)

^ae UNIVERSITY OF MELBOURNE   (Australia)

^af Studies of the Epidemiology of Epilepsy in Demographic Surveillance Systems   (Guinea)

^ag STATENS SERUM INSTITUT   (Denmark)

^ah SEMMELWEIS UNIVERSITY   (Hungary)

^ai Hungarian Twin Registry   (Hungary)

^aj ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^ak HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^al MICHIGAN STATE UNIVERSITY   (United States)

^am Medical School ^*  (United States)

^an Departments of Psychiatry and Psychology   (United States)

^ao VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^ap UNIVERSITY OF MINNESOTA   (United States)

^aq Epidemiology and Biostatistics   (United States)

^ar KAROLINSKA INSTITUTE   (Sweden)

^as NATIONAL ACADEMY OF SCIENCES   (United States)

^at VU UNIVERSITY AMSTERDAM   (Netherlands)

^au ROYAL CHILDREN'S HOSPITAL   (Australia)

^av UNIVERSITY OF MADEIRA   (Portugal)

^aw UNIVERSITY OF PORTO   (Portugal)

^ax UNIVERSITY OF OTTAWA   (Canada)

^ay UNIVERSITÉ LAVAL   (Canada)

^az TOMSK STATE UNIVERSITY   (Russian Federation)

^ba UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^bb UNIVERSITÉ DE MONTRÉAL   (Canada)

^bc Genetic Epidemiology Department   (Canada)

^bd QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^be Pusan National University   (South Korea)

^bf STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bg SRI INTERNATIONAL   (United States)

^bh MEDICAL RESEARCH COUNCIL   (United Kingdom)

^bi Healthy Twin Association of Mongolia   (Mongolia)

^bj HIROSHIMA UNIVERSITY   (Japan)

^bk UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^bl KIRIKKALE UNIVERSITY   (Turkey)

^bm Örebro University   (Sweden)

^bn WASHINGTON STATE UNIVERSITY   (United States)

^bo WASHINGTON STATE UNIVERSITY   (United States)

^bp UNIVERSITY OF WASHINGTON   (United States)

^bq UNIVERSITY OF COPENHAGEN   (Denmark)

^br The Capital Region   (Denmark)

^bs NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

more..

Author keywords

BMI; Children; Genetics; International comparisons; Twins

Indexed keywords

ADOLESCENT; ADULT; ADULTHOOD; ANTHROPOMETRY; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHILD; COHORT ANALYSIS; DIZYGOTIC TWINS; DNA SEQUENCE; ENVIRONMENTAL FACTOR; FEMALE; GENETIC CORRELATION; GENETIC VARIATION; GEOGRAPHIC DISTRIBUTION; HEREDITY; HERITABILITY; HUMAN; INFANCY; MALE; MONOZYGOTIC TWINS; NORMAL HUMAN; PRESCHOOL CHILD; RACE DIFFERENCE; SCHOOL CHILD; SEX DIFFERENCE; STRUCTURAL EQUATION MODELING; TWINS; AGE; AUSTRALIA; ENVIRONMENT; ETHNOLOGY; EUROPE; FAR EAST; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; INFANT; NORTH AMERICA; OBESITY; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; AUSTRALIA; BODY MASS INDEX; CHILD; CHILD, PRESCHOOL; ENVIRONMENT; EUROPE; FAR EAST; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC VARIATION; HUMANS; INFANT; MALE; NORTH AMERICA; OBESITY; SEX FACTORS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; YOUNG ADULT;

EID: 84980329049     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.116.130252     Document Type: Article

References (35)

1. Ogden CL, CarrollMD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 2014;311:806-14.
2. Gupta N, Goel K, Shah P, Misra A. Childhood obesity in developing countries: epidemiology, determinants, and prevention. Endocr Rev 2012;33:48-70.
3. Davenport CB. Body-build and its inheritance. Washington (DC): Carnegie Institution of Washington; 1923.
4. Elks CE, den Hoed M, Zhao JH, Sharp SJ, Wareham NJ, Loos RJ, Ong KK. Variability in the heritability of body mass index: a systematic review and meta-regression. Front Endocrinol (Lausanne) 2012;3.
5. Silventoinen K, Rokholm B, Kaprio J, Sørensen TIA. The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies. Int J Obes (Lond) 2010;34:29-40.
6. Dubois L, Ohm Kyvik K, Girard M, Tatone-Tokuda F, Perusse D, Hjelmborg J, Skytthe A, Rasmussen F, Wright MJ, Lichtenstein P, et al. Genetic and environmental contributions to weight, height, and BMI from birth to 19 years of age: an international study of over 12,000 twin pairs. PLoS One 2012;7:e30153.
7. Lajunen HR, Kaprio J, Keski-Rahkonen A, Rose RJ, Pulkkinen L, Rissanen A, Silventoinen K. Genetic and environmental effects on body mass index during adolescence: a prospective study among Finnish twins. Int J Obes (Lond) 2009;33:559-67.
8. Hur YM, Kaprio J, Iacono WG, Boomsma DI, McGue M, Silventoinen K, Martin NG, Luciano M, Visscher PM, Rose RJ, et al. Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins. Int J Obes (Lond) 2008;32:1455-67.
9. Silventoinen K, Jelenkovic A, Sund R, Honda C, Aaltonen S, Yokoyama Y, Tarnoki AD, Tarnoki DL, Ning F, Ji F, et al. The CODATwins Project: The cohort description of collaborative project of development of anthropometrical measures in twins to study macro-environmental variation in genetic and environmental effects on anthropometric traits. Twin Res Hum Genet 2015;18:348-60.
10. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, Mullany EC, Biryukov S, Abbafati C, Abera SF, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014;384:766-81.
11. Liu Q, Yu C, Gao W, Cao W, Lyu J, Wang S, Pang Z, Cong L, Dong Z, Wu F, et al. Genetic and environmental effects on weight, height, and bmi under 18 years in a Chinese population-based twin sample. Twin Res Hum Genet 2015;18:571-80.
12. Posthuma D, Beem AL, de Geus EJ, van Baal GC, von Hjelmborg JB, Iachine I, Boomsma DI. Theory and practice in quantitative genetics. Twin Res 2003;6:361-76.
13. Boker S, Neale M, Maes H, Wilde M, Spiegel M, Brick T, Spies J, Estabrook R, Kenny S, Bates T, et al. OpenMx: an open source extended structural equation modeling framework. Psychometrika 2011;76:306-17.
14. Jelenkovic A, Yokoyama Y, Sund R, Honda C, Bogl LH, Aaltonen S, Ji F, Ning F, Pang Z, Ordonanã JR, et al. Zygosity differences in height and body mass index of twins from infancy to old age: a study of the CODATwins project. Twin Res Hum Genet 2015;18:557-70.
15. Loos RJ, Yeo GS. The bigger picture of FTO: the first GWAS-identified obesity gene. Nat Rev Endocrinol 2014;10:51-61.
16. Rzehak P, Scherag A, Grallert H, Sausenthaler S, Koletzko S, Bauer CP, Schaaf B, von Berg A, Berdel D, Borte M, et al. Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years. Obes Facts 2010;3:173-80.
17. Elks CE, Loos RJ, Sharp SJ, Langenberg C, Ring SM, Timpson NJ, Ness AR, Davey Smith G, Dunger DB, Wareham NJ, et al. Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. PLoS Med 2010;7:e1000284.
18. Sovio U, Mook-Kanamori DO, Warrington NM, Lawrence R, Briollais L, Palmer CN, Cecil J, Sandling JK, Syvanen AC, Kaakinen M, et al. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLoS Genet 2011;7:e1001307.
19. Warrington NM, Howe LD, Paternoster L, Kaakinen M, Herrala S, Huikari V, Wu YY, Kemp JP, Timpson NJ, St Pourcain B, et al. A genome-wide association study of body mass index across early life and childhood. Int J Epidemiol 2015;44:700-12.
20. Llewellyn CH, Trzaskowski M, Plomin R, Wardle J. From modeling to measurement: developmental trends in genetic influence on adiposity in childhood. Obesity (Silver Spring) 2014;22:1756-61.
21. Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, et al. Obesityassociated variants within FTO form long-range functional connections with IRX3. Nature 2014;507:371-5.
22. Faith MS, Carnell S, Kral TV. Genetics of food intake self-regulation in childhood: literature review and research opportunities. Hum Hered 2013, 4;75:80-9.
23. Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015;518: 197-206.
24. Breen FM, Plomin R, Wardle J. Heritability of food preferences in young children. Physiol Behav 2006;88:443-7.
25. Hasselbalch AL, Heitmann BL, Kyvik KO, Sørensen TIA. Studies of twins indicate that genetics influence dietary intake. J Nutr 2008;138: 2406-12.
26. Keskitalo K, Silventoinen K, Tuorila H, Perola M, Pietilainen KH, Rissanen A, Kaprio J. Genetic and environmental contributions to food use patterns of young adult twins. Physiol Behav 2008;93:235-42.
27. Sørensen TIA. Challenges in understanding development of obesity. In: Nobrega R, Redriguez-Lopez R, editors. Molecular mechanisms underpinning the development of obesity.New York: Springer; 2014. p. 1-7.
28. Pietilainen KH, Ismail K, Jarvinen E, Heinonen S, Tummers M, Bollepalli S, Lyle R, Muniandy M, Moilanen E, Hakkarainen A, Lundbom J, Lundbom N, Rissanen A, Kaprio J, Ollikainen M. DNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs. Int J Obes 2016;40:654-61.
29. van Dongen J, Ehli EA, Slieker RC, Bartels M, Weber ZM, Davies GE, Slagboom PE, Heijmans BT, Boomsma DI. Epigenetic variation in monozygotic twins: a genome-wide analysis of DNA methylation in buccal cells. Genes (Basel) 2014;5:347-65.
30. Malina RM, Bouchard C, Bar-Or O. Growth, maturation, and physical activity. 2nd ed. Champaign (IL): Human Kinetics; 2004.
31. Schousboe K, Willemsen G, Kyvik KO, Mortensen J, Boomsma DI, Cornes BK, Davis CJ, Fagnani C, Hjelmborg J, Kaprio J, et al. Sex differences in heritability of BMI: a comparative study of results from twin studies in eight countries. Twin Res 2003;6:409-21.
32. Rokholm B, Silventoinen K, Angquist L, Skytthe A, Kyvik KO, Sørensen TIA. Increased genetic variance of BMI with a higher prevalence of obesity. PLoS One 2011;6:e20816.
33. Rokholm B, Silventoinen K, Tynelius P, Gamborg M, Sørensen TIA, Rasmussen F. Increasing genetic variance of body mass index during the Swedish obesity epidemic. PLoS One 2011;6:e27135.
34. Robinson MR, Hemani G, Medina-Gomez C, Mezzavilla M, Esko T, Shakhbazov K, Powell JE, Vinkhuyzen A, Berndt SI, Gustafsson S, et al. Population genetic differentiation of height and body mass index across Europe. Nat Genet 2015;47:1357-62.
35. Kirk SF, Penney TL, McHugh TL. Characterizing the obesogenic environment: the state of the evidence with directions for future research. Obes Rev 2010;11:109-17.