Increasing genetic variance of body mass index during the swedish obesity epidemic

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Rokholm, Benjamin ^a   Silventoinen, Karri ^b   Tynelius, Per ^c   Gamborg, Michael ^a   Sørensen, Thorkild I A ^a   Rasmussen, Finn ^c  

^a The Capital Region   (Denmark)

^b UNIVERSITY OF HELSINKI   (Finland)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BODY MASS; CHROMOSOME PAIRING; CONTROLLED STUDY; DIZYGOTIC TWINS; ENVIRONMENTAL FACTOR; GENETIC EPIDEMIOLOGY; GENETIC RISK; GENETIC VARIABILITY; HUMAN; MALE; MONOZYGOTIC TWINS; OBESITY; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SWEDEN; ADOLESCENT; ENVIRONMENT; FAMILY; GENETICS; REGISTER; TWINS;

ADOLESCENT; BODY MASS INDEX; ENVIRONMENT; FAMILY; GENETIC VARIATION; HUMANS; OBESITY; REGISTRIES; RISK FACTORS; SWEDEN; TWINS;

EID: 80455131337     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027135     Document Type: Article

References (33)

1. Neovius M, Teixeira-Pinto A, Rasmussen F, (2008) Shift in the composition of obesity in young adult men in Sweden over a third of a century. Int J Obes (Lond) 32: 832-6.
2. Sundquist J, Johansson SE, Sundquist K, (2010) Levelling off of prevalence of obesity in the adult population of Sweden between 2000/01 and 2004/05. BMC Public Health 10: 119.
3. Ford ES, Mokdad AH, (2008) Epidemiology of obesity in the Western Hemisphere. J Clin Endocrinol Metab 93: S1-S8.
4. Ogden CL, Yanovski SZ, Carroll MD, Flegal KM, (2007) The epidemiology of obesity. Gastroenterology 132: 2087-102.
5. Schousboe K, Willemsen G, Kyvik KO, Mortensen J, Boomsma DI, et al. (2003) Sex differences in heritability of BMI: a comparative study of results from twin studies in eight countries. Twin Res 6: 409-21.
6. Silventoinen K, Rokholm B, Kaprio J, Sørensen TIA, (2009) The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies. Int J Obes (Lond).
7. Wardle J, Carnell S, Haworth CM, Plomin R, (2008) Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am J Clin Nutr 87: 398-404.
8. Staub K, Ruhli FJ, Woitek U, Pfister C, (2010) BMI distribution/social stratification in Swiss conscripts from 1875 to present. Eur J Clin Nutr 64: 335-40.
9. Silventoinen K, Hasselbalch AL, Lallukka T, Bogl L, Pietilainen KH, et al. (2009) Modification effects of physical activity and protein intake on heritability of body size and composition. Am J Clin Nutr 90: 1096-103.
10. Karnehed N, Tynelius P, Heitmann BL, Rasmussen F, (2006) Physical activity, diet and gene-environment interactions in relation to body mass index and waist circumference: the Swedish young male twins study. Public Health Nutr 9: 851-8.
11. Heitmann BL, Kaprio J, Harris JR, Rissanen A, Korkeila M, et al. (1997) Are genetic determinants of weight gain modified by leisure-time physical activity? A prospective study of Finnish twins. Am J Clin Nutr 66: 672-8.
12. Vimaleswaran KS, Li S, Zhao JH, Luan J, Bingham SA, et al. (2009) Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. Am J Clin Nutr 90: 425-8.
13. Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, et al. (2008) Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 57: 95-101.
14. Rampersaud E, Mitchell BD, Pollin TI, Fu M, Shen H, et al. (2008) Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Intern Med 168: 1791-7.
15. Li S, Zhao JH, Luan J, Ekelund U, Luben RN, et al. (2010) Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. PLoS Med 7.
16. Sonestedt E, Roos C, Gullberg B, Ericson U, Wirfalt E, et al. (2009) Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr 90: 1418-25.
17. Rokholm B, Silventoinen K, Angquist L, Skytthe A, Kyvik KO, et al. (2011) Increased genetic variance of BMI with a higher prevalence of obesity. PLoS One 6: e20816.
18. Lichtenstein P, De Faire U, Floderus B, Svartengren M, Svedberg P, et al. (2002) The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies. J Intern Med 252: 184-205.
19. Rasmussen F, Kark M, Tholin S, Karnehed N, Tynelius P, (2006) The Swedish Young Male Twins Study: a resource for longitudinal research on risk factors for obesity and cardiovascular diseases. Twin Res Hum Genet 9: 883-9.
20. Neale MC, Maes HHM, (2006) Methodology for Genetic Studies of Twins and Families Kluwer Academic Publishers B.V. Dordrecht, The Netherlands.
21. Neale MC, (2003) Mx: Statistical modeling Richmond, VA Department of Psychiatry.
22. WHO (2000) World Health Organization. Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Consultation on Obesity Geneva WHO Technical Report Series no. 894, 2000.
23. Silventoinen K, Magnusson PK, Tynelius P, Kaprio J, Rasmussen F, (2008) Heritability of body size and muscle strength in young adulthood: a study of one million Swedish men. Genet Epidemiol 32: 341-9.
24. Clément K, Sørensen TIA, (2008) Obesity, Genomics and Postgenomics Informa Healthcare USA, Inc.
25. Prentice AM, Jebb SA, (1995) Obesity in Britain: gluttony or sloth? BMJ 311: 437-9.
26. Purcell S, (2002) Variance components models for gene-environment interaction in twin analysis. Twin Res 5: 554-71.
27. Beyerlein A, Toschke AM, von Kries R, (2010) Risk factors for childhood overweight: shift of the mean body mass index and shift of the upper percentiles: results from a cross-sectional study. Int J Obes (Lond) 34: 642-8.
28. Johnson W, Kyvik KO, Skytthe A, Deary IJ, Sorensen TI, (2011) Education modifies genetic and environmental influences on BMI. PLoS One 6: e16290.
29. Freathy RM, Kazeem GR, Morris RW, Johnson PC, Paternoster L, et al. (2011) Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. Int J Epidemiol.
30. Hebebrand J, Wulftange H, Goerg T, Ziegler A, Hinney A, et al. (2000) Epidemic obesity: are genetic factors involved via increased rates of assortative mating? Int J Obes Relat Metab Disord 24: 345-53.
31. Richardson K, Norgate S, (2005) The equal environments assumption of classical twin studies may not hold. Br J Educ Psychol 75: 339-50.
32. Kaminsky ZA, Tang T, Wang SC, Ptak C, Oh GH, et al. (2009) DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet 41: 240-5.
33. Christiansen L, Frederiksen H, Schousboe K, Skytthe A, von Wurmb-Schwark N, et al. (2003) Age- and sex-differences in the validity of questionnaire-based zygosity in twins. Twin Res 6: 275-8.