-
1
-
-
79952441758
-
Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis
-
Aanaes, K., Rickelt, L. F., Johansen, H. K., von Buchwald, C., Pressler, T., Høiby, N. & Jensen, P. Ø. (2011). Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis. J Cyst Fibros 10, 114–120
-
(2011)
J Cyst Fibros
, vol.10
, pp. 114-120
-
-
Aanaes, K.1
Rickelt, L.F.2
Johansen, H.K.3
Von Buchwald, C.4
Pressler, T.5
Høiby, N.6
Jensen, P.7
-
2
-
-
84870745042
-
Secretory IgA as a diagnostic tool for Pseudomonas aeruginosa respiratory colonization
-
Aanaes, K., Johansen, H. K., Poulsen, S. S., Pressler, T., Buchwald, C. & Høiby, N. (2013a). Secretory IgA as a diagnostic tool for Pseudomonas aeruginosa respiratory colonization. J Cyst Fibros 12, 81–87
-
(2013)
J Cyst Fibros
, vol.12
, pp. 81-87
-
-
Aanaes, K.1
Johansen, H.K.2
Poulsen, S.S.3
Pressler, T.4
Buchwald, C.5
Høiby, N.6
-
3
-
-
84876026223
-
The effect of sinus surgery with intensive follow-up on pathogenic sinus bacteria in patients with cystic fibrosis
-
Aanaes, K., von Buchwald, C., Hjuler, T., Skov, M., Alanin, M. & Johansen, H. K. (2013b). The effect of sinus surgery with intensive follow-up on pathogenic sinus bacteria in patients with cystic fibrosis. Am J Rhinol Allergy 27, e1–e4
-
(2013)
Am J Rhinol Allergy
, vol.27
, pp. e1-e4
-
-
Aanaes, K.1
Von Buchwald, C.2
Hjuler, T.3
Skov, M.4
Alanin, M.5
Johansen, H.K.6
-
4
-
-
0028961174
-
Auxotrophic variants of Pseudomonas aeruginosa are selected from prototrophic wild-type strains in respiratory infections in patients with cystic fibrosis
-
Barth, A. L. & Pitt, T. L. (1995). Auxotrophic variants of Pseudomonas aeruginosa are selected from prototrophic wild-type strains in respiratory infections in patients with cystic fibrosis. J Clin Microbiol 33, 37–40
-
(1995)
J Clin Microbiol
, vol.33
, pp. 37-40
-
-
Barth, A.L.1
Pitt, T.L.2
-
5
-
-
0029760688
-
The high amino-acid content of sputum from cystic fibrosis patients promotes growth of auxotrophic Pseudomonas aeruginosa
-
Barth, A. L. & Pitt, T. L. (1996). The high amino-acid content of sputum from cystic fibrosis patients promotes growth of auxotrophic Pseudomonas aeruginosa. J Med Microbiol 45, 110–119
-
(1996)
J Med Microbiol
, vol.45
, pp. 110-119
-
-
Barth, A.L.1
Pitt, T.L.2
-
6
-
-
84873101916
-
Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis chronic lung infections
-
Behrends, V., Ryall, B., Zlosnik, J. E. A., Speert, D. P., Bundy, J. G. & Williams, H. D. (2013). Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis chronic lung infections. Environ Microbiol 15, 398–408
-
(2013)
Environ Microbiol
, vol.15
, pp. 398-408
-
-
Behrends, V.1
Ryall, B.2
Zlosnik, J.3
Speert, D.P.4
Bundy, J.G.5
Williams, H.D.6
-
7
-
-
67249099362
-
Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients
-
Bjarnsholt, T., Jensen, P. Ø., Fiandaca, M. J., Pedersen, J., Hansen, C. R., Andersen, C. B., Pressler, T., Givskov, M. & Høiby, N. (2009). Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients. Pediatr Pulmonol 44, 547–558
-
(2009)
Pediatr Pulmonol
, vol.44
, pp. 547-558
-
-
Bjarnsholt, T.1
Jensen, P.2
Fiandaca, M.J.3
Pedersen, J.4
Hansen, C.R.5
Ersen, C.B.6
Pressler, T.7
Givskov, M.8
Høiby, N.9
-
8
-
-
57649123534
-
Global phenotypic characterization of bacteria
-
Bochner, B. R. (2009). Global phenotypic characterization of bacteria. FEMS Microbiol Rev 33, 191–205
-
(2009)
FEMS Microbiol Rev
, vol.33
, pp. 191-205
-
-
Bochner, B.R.1
-
9
-
-
70350452738
-
Characterization of alanine catabolism in Pseudomonas aeruginosa and its importance for proliferation in vivo
-
Boulette, M. L., Baynham, P. J., Jorth, P. A., Kukavica-Ibrulj, I., Longoria, A., Barrera, K., Levesque, R. C. & Whiteley, M. (2009). Characterization of alanine catabolism in Pseudomonas aeruginosa and its importance for proliferation in vivo. J Bacteriol 191, 6329–6334
-
(2009)
J Bacteriol
, vol.191
, pp. 6329-6334
-
-
Boulette, M.L.1
Baynham, P.J.2
Jorth, P.A.3
Kukavica-Ibrulj, I.4
Longoria, A.5
Barrera, K.6
Levesque, R.C.7
Whiteley, M.8
-
10
-
-
33947118871
-
Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis
-
Brennan, A. L., Gyi, K. M., Wood, D. M., Johnson, J., Holliman, R., Baines, D. L., Philips, B. J., Geddes, D. M., Hodson, M. E. & Baker, E. H. (2007). Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis. J Cyst Fibros 6, 101–109
-
(2007)
J Cyst Fibros
, vol.6
, pp. 101-109
-
-
Brennan, A.L.1
Gyi, K.M.2
Wood, D.M.3
Johnson, J.4
Holliman, R.5
Baines, D.L.6
Philips, B.J.7
Geddes, D.M.8
Hodson, M.E.9
Baker, E.H.10
-
11
-
-
70349303073
-
Role of CFTR, Pseudomonas aeruginosa and Toll-like receptors in cystic fibrosis lung inflammation
-
Buchanan, P. J., Ernst, R. K., Elborn, J. S. & Schock, B. (2009). Role of CFTR, Pseudomonas aeruginosa and Toll-like receptors in cystic fibrosis lung inflammation. Biochem Soc Trans 37, 863–867
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 863-867
-
-
Buchanan, P.J.1
Ernst, R.K.2
Elborn, J.S.3
Schock, B.4
-
12
-
-
0035253464
-
Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis
-
Burns, J. L., Gibson, R. L., McNamara, S., Yim, D., Emerson, J., Rosenfeld, M., Hiatt, P., McCoy, K., Castile, R. & other authors (2001). Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis. J Infect Dis 183, 444–452
-
(2001)
J Infect Dis
, vol.183
, pp. 444-452
-
-
Burns, J.L.1
Gibson, R.L.2
McNamara, S.3
Yim, D.4
Emerson, J.5
Rosenfeld, M.6
Hiatt, P.7
McCoy, K.8
Castile, R.9
-
13
-
-
19544386997
-
Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation
-
Ciofu, O., Riis, B., Pressler, T., Poulsen, H. E. & Høiby, N. (2005). Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation. Antimicrob Agents Chemother 49, 2276–2282
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 2276-2282
-
-
Ciofu, O.1
Riis, B.2
Pressler, T.3
Poulsen, H.E.4
Høiby, N.5
-
14
-
-
38849136576
-
Investigation of the algT operon sequence in mucoid and non-mucoid Pseudomonas aeruginosa isolates from 115 Scandinavian patients with cystic fibrosis and in 88 in vitro nonmucoid revertants
-
Scandinavian Cystic Fibrosis Study Consortium
-
Ciofu, O., Lee, B., Johannesson, M., Hermansen, N. O., Meyer, P., Høiby, N. & Scandinavian Cystic Fibrosis Study Consortium (2008). Investigation of the algT operon sequence in mucoid and non-mucoid Pseudomonas aeruginosa isolates from 115 Scandinavian patients with cystic fibrosis and in 88 in vitro nonmucoid revertants. Microbiology 154, 103–113
-
(2008)
Microbiology
, vol.154
, pp. 103-113
-
-
Ciofu, O.1
Lee, B.2
Johannesson, M.3
Hermansen, N.O.4
Meyer, P.5
Høiby, N.6
-
15
-
-
77950648700
-
Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: Strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants
-
Ciofu, O., Mandsberg, L. F., Bjarnsholt, T., Wassermann, T. & Høiby, N. (2010). Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants. Microbiology 156, 1108–1119
-
(2010)
Microbiology
, vol.156
, pp. 1108-1119
-
-
Ciofu, O.1
Mandsberg, L.F.2
Bjarnsholt, T.3
Wassermann, T.4
Høiby, N.5
-
16
-
-
84878113691
-
Respiratory bacterial infections in cystic fibrosis
-
Ciofu, O., Hansen, C. R. & Høiby, N. (2013). Respiratory bacterial infections in cystic fibrosis. Curr Opin Pulm Med 19, 251–258
-
(2013)
Curr Opin Pulm Med
, vol.19
, pp. 251-258
-
-
Ciofu, O.1
Hansen, C.R.2
Høiby, N.3
-
17
-
-
60549100505
-
Neutrophil recruitment to the lungs during bacterial pneumonia
-
Craig, A., Mai, J., Cai, S. & Jeyaseelan, S. (2009). Neutrophil recruitment to the lungs during bacterial pneumonia. Infect Immun 77, 568–575
-
(2009)
Infect Immun
, vol.77
, pp. 568-575
-
-
Craig, A.1
Mai, J.2
Cai, S.3
Jeyaseelan, S.4
-
18
-
-
34247333058
-
Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients
-
D’Argenio, D. A., Wu, M., Hoffman, L. R., Kulasekara, H. D., Déziel, E., Smith, E. E., Nguyen, H., Ernst, R. K., Larson Freeman, T. J. & other authors (2007). Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients. Mol Microbiol 64, 512–533
-
(2007)
Mol Microbiol
, vol.64
, pp. 512-533
-
-
D’Argenio, D.A.1
Wu, M.2
Hoffman, L.R.3
Kulasekara, H.D.4
Déziel, E.5
Smith, E.E.6
Nguyen, H.7
Ernst, R.K.8
Larson Freeman, T.J.9
-
19
-
-
84877339385
-
Evolutionary remodeling of global regulatory networks during long-term bacterial adaptation to human hosts
-
Damkiær, S., Yang, L., Molin, S. & Jelsbak, L. (2013). Evolutionary remodeling of global regulatory networks during long-term bacterial adaptation to human hosts. Proc Natl Acad Sci USA 110, 7766–7771
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 7766-7771
-
-
Damkiær, S.1
Yang, L.2
Molin, S.3
Jelsbak, L.4
-
20
-
-
84926631053
-
Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection
-
Darch, S. E., McNally, A., Harrison, F., Corander, J., Barr, H. L., Paszkiewicz, K., Holden, S., Fogarty, A., Crusz, S. A. & Diggle, S. P. (2015). Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection. Sci Rep 5, 7649
-
(2015)
Sci Rep
, vol.5
-
-
Darch, S.E.1
McNally, A.2
Harrison, F.3
Corander, J.4
Barr, H.L.5
Paszkiewicz, K.6
Holden, S.7
Fogarty, A.8
Crusz, S.A.9
Diggle, S.P.10
-
21
-
-
84869120178
-
Treatment of lung infection in patients with cystic fibrosis: Current and future strategies
-
Döring, G., Flume, P., Heijerman, H. & Elborn, J. S. (2012). Treatment of lung infection in patients with cystic fibrosis: current and future strategies. J Cyst Fibros 11, 461–479
-
(2012)
J Cyst Fibros
, vol.11
, pp. 461-479
-
-
Döring, G.1
Flume, P.2
Heijerman, H.3
Elborn, J.S.4
-
22
-
-
58349104978
-
Neutrophils in cystic fibrosis
-
Downey, D. G., Bell, S. C. & Elborn, J. S. (2009). Neutrophils in cystic fibrosis. Thorax 64, 81–88
-
(2009)
Thorax
, vol.64
, pp. 81-88
-
-
Downey, D.G.1
Bell, S.C.2
Elborn, J.S.3
-
23
-
-
84908338190
-
Coexistence and within-host evolution of diversified lineages of hypermutable Pseudomonas aeruginosa in long-term cystic fibrosis infections
-
Feliziani, S., Marvig, R. L., Luján, A. M., Moyano, A. J., Di Rienzo, J. A., Krogh Johansen, H., Molin, S. & Smania, A. M. (2014). Coexistence and within-host evolution of diversified lineages of hypermutable Pseudomonas aeruginosa in long-term cystic fibrosis infections. PLoS Genet 10, e1004651
-
(2014)
Plos Genet
-
-
Feliziani, S.1
Marvig, R.L.2
Luján, A.M.3
Moyano, A.J.4
Di Rienzo, J.A.5
Krogh Johansen, H.6
Molin, S.7
Smania, A.M.8
-
24
-
-
84869219279
-
Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: An evolutionary perspective
-
Folkesson, A., Jelsbak, L., Yang, L., Johansen, H. K., Ciofu, O., Høiby, N. & Molin, S. (2012). Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective. Nat Rev Microbiol 10, 841–851
-
(2012)
Nat Rev Microbiol
, vol.10
, pp. 841-851
-
-
Folkesson, A.1
Jelsbak, L.2
Yang, L.3
Johansen, H.K.4
Ciofu, O.5
Høiby, N.6
Molin, S.7
-
25
-
-
84907351159
-
Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs
-
Fothergill, J. L., Neill, D. R., Loman, N., Winstanley, C. & Kadioglu, A. (2014). Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs. Nat Commun 5, 4780
-
(2014)
Nat Commun
, vol.5
-
-
Fothergill, J.L.1
Neill, D.R.2
Loman, N.3
Winstanley, C.4
Kadioglu, A.5
-
26
-
-
0030995361
-
Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis
-
Frederiksen, B., Koch, C. & Høiby, N. (1997). Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis. Pediatr Pulmonol 23, 330–335
-
(1997)
Pediatr Pulmonol
, vol.23
, pp. 330-335
-
-
Frederiksen, B.1
Koch, C.2
Høiby, N.3
-
27
-
-
0032695668
-
Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis
-
Garred, P., Pressler, T., Madsen, H. O., Frederiksen, B., Svejgaard, A., Høiby, N., Schwartz, M. & Koch, C. (1999). Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. J Clin Invest 104, 431–437
-
(1999)
J Clin Invest
, vol.104
, pp. 431-437
-
-
Garred, P.1
Pressler, T.2
Madsen, H.O.3
Frederiksen, B.4
Svejgaard, A.5
Høiby, N.6
Schwartz, M.7
Koch, C.8
-
28
-
-
55549102981
-
Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experience
-
Hansen, C. R., Pressler, T. & Høiby, N. (2008). Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experience. J Cyst Fibros 7, 523–530
-
(2008)
J Cyst Fibros
, vol.7
, pp. 523-530
-
-
Hansen, C.R.1
Pressler, T.2
Høiby, N.3
-
29
-
-
84355161775
-
Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection
-
Hansen, S. K., Rau, M. H., Johansen, H. K., Ciofu, O., Jelsbak, L., Yang, L., Folkesson, A., Jarmer, H. O., Aanæs, K. & other authors (2012). Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection. ISME J 6, 31–45
-
(2012)
ISME J
, vol.6
, pp. 31-45
-
-
Hansen, S.K.1
Rau, M.H.2
Johansen, H.K.3
Ciofu, O.4
Jelsbak, L.5
Yang, L.6
Folkesson, A.7
Jarmer, H.O.8
Aanæs, K.9
-
30
-
-
2642572004
-
Biofilm formation by the small colony variant phenotype of Pseudomonas aeruginosa
-
Häussler, S. (2004). Biofilm formation by the small colony variant phenotype of Pseudomonas aeruginosa. Environ Microbiol 6, 546–551
-
(2004)
Environ Microbiol
, vol.6
, pp. 546-551
-
-
Häussler, S.1
-
31
-
-
67650685860
-
Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis
-
Hoboth, C., Hoffmann, R., Eichner, A., Henke, C., Schmoldt, S., Imhof, A., Heesemann, J. & Hogardt, M. (2009). Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis. J Infect Dis 200, 118–130
-
(2009)
J Infect Dis
, vol.200
, pp. 118-130
-
-
Hoboth, C.1
Hoffmann, R.2
Eichner, A.3
Henke, C.4
Schmoldt, S.5
Imhof, A.6
Heesemann, J.7
Hogardt, M.8
-
32
-
-
77649212763
-
Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway
-
Hoffman, L. R., Richardson, A. R., Houston, L. S., Kulasekara, H. D., Martens-Habbena, W., Klausen, M., Burns, J. L., Stahl, D. A., Hassett, D. J. & other authors (2010). Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway. PLoS Pathog 6, e1000712
-
(2010)
Plos Pathog
-
-
Hoffman, L.R.1
Richardson, A.R.2
Houston, L.S.3
Kulasekara, H.D.4
Martens-Habbena, W.5
Klausen, M.6
Burns, J.L.7
Stahl, D.A.8
Hassett, D.J.9
-
33
-
-
20144388608
-
Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis
-
Hoffmann, N., Rasmussen, T. B., Jensen, P. Ø., Stub, C., Hentzer, M., Molin, S., Ciofu, O., Givskov, M., Johansen, H. K. & Høiby, N. (2005). Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis. Infect Immun 73, 2504–2514
-
(2005)
Infect Immun
, vol.73
, pp. 2504-2514
-
-
Hoffmann, N.1
Rasmussen, T.B.2
Jensen, P.3
Stub, C.4
Hentzer, M.5
Molin, S.6
Ciofu, O.7
Givskov, M.8
Johansen, H.K.9
Høiby, N.10
-
34
-
-
78549263685
-
Adaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lung
-
Hogardt, M. & Heesemann, J. (2010). Adaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lung. Int J Med Microbiol 300, 557–562
-
(2010)
Int J Med Microbiol
, vol.300
, pp. 557-562
-
-
Hogardt, M.1
Heesemann, J.2
-
35
-
-
0016158866
-
Epidemiological investigations of the respiratory tract bacteriology in patients with cystic fibrosis
-
Høiby, N. (1974). Epidemiological investigations of the respiratory tract bacteriology in patients with cystic fibrosis. Acta Pathol Microbiol Scand B Microbiol Immunol 82, 541–550
-
(1974)
Acta Pathol Microbiol Scand B Microbiol Immunol
, vol.82
, pp. 541-550
-
-
Høiby, N.1
-
36
-
-
77049122482
-
Antibiotic resistance of bacterial biofilms
-
Høiby, N., Bjarnsholt, T., Givskov, M., Molin, S. & Ciofu, O. (2010a). Antibiotic resistance of bacterial biofilms. Int J Antimicrob Agents 35, 322–332
-
(2010)
Int J Antimicrob Agents
, vol.35
, pp. 322-332
-
-
Høiby, N.1
Bjarnsholt, T.2
Givskov, M.3
Molin, S.4
Ciofu, O.5
-
37
-
-
78650181025
-
Pseudomonas aeruginosa biofilms in cystic fibrosis
-
Høiby, N., Ciofu, O. & Bjarnsholt, T. (2010b). Pseudomonas aeruginosa biofilms in cystic fibrosis. Future Microbiol 5, 1663–1674
-
(2010)
Future Microbiol
, vol.5
, pp. 1663-1674
-
-
Høiby, N.1
Ciofu, O.2
Bjarnsholt, T.3
-
38
-
-
0000271704
-
Genetic recombination in Pseudomonas aeruginosa
-
Holloway, B. W. (1955). Genetic recombination in Pseudomonas aeruginosa. J Gen Microbiol 13, 572–581
-
(1955)
J Gen Microbiol
, vol.13
, pp. 572-581
-
-
Holloway, B.W.1
-
39
-
-
34248402460
-
Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients
-
Jelsbak, L., Johansen, H. K., Frost, A. L., Thøgersen, R., Thomsen, L. E., Ciofu, O., Yang, L., Haagensen, J. A. J., Høiby, N. & Molin, S. (2007). Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients. Infect Immun 75, 2214–2224
-
(2007)
Infect Immun
, vol.75
, pp. 2214-2224
-
-
Jelsbak, L.1
Johansen, H.K.2
Frost, A.L.3
Thøgersen, R.4
Thomsen, L.E.5
Ciofu, O.6
Yang, L.7
Haagensen, J.8
Høiby, N.9
Molin, S.10
-
40
-
-
2442467027
-
Antibody response to Pseudomonas aeruginosa in cystic fibrosis patients: A marker of therapeutic success?—A 30-year cohort study of survival in Danish CF patients after onset of chronic P. Aeruginosa lung infection
-
Johansen, H. K., Nørregaard, L., Gøtzsche, P. C., Pressler, T., Koch, C. & Høiby, N. (2004). Antibody response to Pseudomonas aeruginosa in cystic fibrosis patients: a marker of therapeutic success?—A 30-year cohort study of survival in Danish CF patients after onset of chronic P. aeruginosa lung infection. Pediatr Pulmonol 37, 427–432
-
(2004)
Pediatr Pulmonol
, vol.37
, pp. 427-432
-
-
Johansen, H.K.1
Nørregaard, L.2
Gøtzsche, P.C.3
Pressler, T.4
Koch, C.5
Høiby, N.6
-
41
-
-
51549106318
-
Spread of colistin resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients
-
Johansen, H. K., Moskowitz, S. M., Ciofu, O., Pressler, T. & Høiby, N. (2008). Spread of colistin resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients. J Cyst Fibros 7, 391–397
-
(2008)
J Cyst Fibros
, vol.7
, pp. 391-397
-
-
Johansen, H.K.1
Moskowitz, S.M.2
Ciofu, O.3
Pressler, T.4
Høiby, N.5
-
42
-
-
84869082881
-
Colonisation and infection of the paranasal sinuses in cystic fibrosis patients is accompanied by a reduced PMN response
-
Johansen, H. K., Aanaes, K., Pressler, T., Nielsen, K. G., Fisker, J., Skov, M., Høiby, N. & von Buchwald, C. (2012). Colonisation and infection of the paranasal sinuses in cystic fibrosis patients is accompanied by a reduced PMN response. J Cyst Fibros 11, 525–531
-
(2012)
J Cyst Fibros
, vol.11
, pp. 525-531
-
-
Johansen, H.K.1
Aanaes, K.2
Pressler, T.3
Nielsen, K.G.4
Fisker, J.5
Skov, M.6
Høiby, N.7
Von Buchwald, C.8
-
43
-
-
0038375994
-
Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants
-
Klausen, M., Heydorn, A., Ragas, P., Lambertsen, L., Aaes- Jørgensen, A., Molin, S. & Tolker-Nielsen, T. (2003). Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants. Mol Microbiol 48, 1511–1524
-
(2003)
Mol Microbiol
, vol.48
, pp. 1511-1524
-
-
Klausen, M.1
Heydorn, A.2
Ragas, P.3
Lambertsen, L.4
Aaes-Jørgensen, A.5
Molin, S.6
Tolker-Nielsen, T.7
-
44
-
-
60449108922
-
Differences in prevalence and treatment of Pseudomonas aeruginosa in cystic fibrosis centres in Denmark, Norway and Sweden
-
Scandinavian CF Study Consortium (SCFSC)
-
Knudsen, P. K., Olesen, H. V., Høiby, N., Johannesson, M., Karpati, F., Laerum, B. N., Meyer, P., Pressler, T., Lindblad, A. & Scandinavian CF Study Consortium (SCFSC) (2009). Differences in prevalence and treatment of Pseudomonas aeruginosa in cystic fibrosis centres in Denmark, Norway and Sweden. J Cyst Fibros 8, 135–142
-
(2009)
J Cyst Fibros
, vol.8
, pp. 135-142
-
-
Knudsen, P.K.1
Olesen, H.V.2
Høiby, N.3
Johannesson, M.4
Karpati, F.5
Laerum, B.N.6
Meyer, P.7
Pressler, T.8
Lindblad, A.9
-
45
-
-
0027404779
-
Pathogenesis of cystic fibrosis
-
Koch, C. & Høiby, N. (1993). Pathogenesis of cystic fibrosis. Lancet 341, 1065–1069
-
(1993)
Lancet
, vol.341
, pp. 1065-1069
-
-
Koch, C.1
Høiby, N.2
-
46
-
-
73449143182
-
Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis
-
Kolpen, M., Hansen, C. R., Bjarnsholt, T., Moser, C., Christensen, L. D., van Gennip, M., Ciofu, O., Mandsberg, L., Kharazmi, A. & other authors (2010). Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis. Thorax 65, 57–62
-
(2010)
Thorax
, vol.65
, pp. 57-62
-
-
Kolpen, M.1
Hansen, C.R.2
Bjarnsholt, T.3
Moser, C.4
Christensen, L.D.5
Van Gennip, M.6
Ciofu, O.7
Mandsberg, L.8
Kharazmi, A.9
-
47
-
-
0016273208
-
Phage typing of Pseudomonas aeruginosa: Clinical and epidemiologic considerations
-
Lindberg, R. B. & Latta, R. L. (1974). Phage typing of Pseudomonas aeruginosa: clinical and epidemiologic considerations. J Infect Dis 130, S33–S42
-
(1974)
J Infect Dis
, vol.130
, pp. S33-S42
-
-
Lindberg, R.B.1
Latta, R.L.2
-
48
-
-
33947157567
-
Divergence and redundancy of transport and metabolic rate-yield strategies in a single Escherichia coli population
-
Maharjan, R. P., Seeto, S. & Ferenci, T. (2007). Divergence and redundancy of transport and metabolic rate-yield strategies in a single Escherichia coli population. J Bacteriol 189, 2350–2358
-
(2007)
J Bacteriol
, vol.189
, pp. 2350-2358
-
-
Maharjan, R.P.1
Seeto, S.2
Ferenci, T.3
-
49
-
-
77950405367
-
YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosa
-
Malone, J. G., Jaeger, T., Spangler, C., Ritz, D., Spang, A., Arrieumerlou, C., Kaever, V., Landmann, R. & Jenal, U. (2010). YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosa. PLoS Pathog 6, e1000804
-
(2010)
Plos Pathog
, vol.804
, pp. 6
-
-
Malone, J.G.1
Jaeger, T.2
Spangler, C.3
Ritz, D.4
Spang, A.5
Arrieumerlou, C.6
Kaever, V.7
Landmann, R.8
Jenal, U.9
-
50
-
-
84908425385
-
Environmental heterogeneity drives within-host diversification and evolution of Pseudomonas aeruginosa
-
Markussen, T., Marvig, R. L., Gόmez-Lozano, M., Aanæs, K., Burleigh, A. E., Høiby, N., Johansen, H. K., Molin, S. & Jelsbak, L. (2014). Environmental heterogeneity drives within-host diversification and evolution of Pseudomonas aeruginosa. MBio 5, e01592–e01e14
-
(2014)
Mbio
, vol.5
-
-
Markussen, T.1
Marvig, R.L.2
Gόmez-Lozano, M.3
Aanæs, K.4
Burleigh, A.E.5
Høiby, N.6
Johansen, H.K.7
Molin, S.8
Jelsbak, L.9
-
51
-
-
85028139131
-
Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis
-
Marvig, R. L., Sommer, L. M., Molin, S. & Johansen, H. K. (2015). Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis. Nat Genet 47, 57–64
-
(2015)
Nat Genet
, vol.47
, pp. 57-64
-
-
Marvig, R.L.1
Sommer, L.M.2
Molin, S.3
Johansen, H.K.4
-
52
-
-
0033056054
-
Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: A mechanism for virulence activation in the cystic fibrosis lung
-
Mathee, K., Ciofu, O., Sternberg, C., Lindum, P. W., Campbell, J. I., Jensen, P., Johnsen, A. H., Givskov, M., Ohman, D. E. & other authors (1999). Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung. Microbiology 145, 1349–1357
-
(1999)
Microbiology
, vol.145
, pp. 1349-1357
-
-
Mathee, K.1
Ciofu, O.2
Sternberg, C.3
Lindum, P.W.4
Campbell, J.I.5
Jensen, P.6
Johnsen, A.H.7
Givskov, M.8
Ohman, D.E.9
-
53
-
-
72849116639
-
Ventilation and aerosolized drug delivery to the paranasal sinuses using pulsating airflow - a preliminary study
-
Moeller, W., Schuschnig, U., Meyer, G., Hüussinger, K., Keller, M., Junge-Hülsing, B. & Mentzel, H. (2009). Ventilation and aerosolized drug delivery to the paranasal sinuses using pulsating airflow - a preliminary study. Rhinology 47, 405–412
-
(2009)
Rhinology
, vol.47
, pp. 405-412
-
-
Moeller, W.1
Schuschnig, U.2
Meyer, G.3
Hüussinger, K.4
Keller, M.5
Junge-Hülsing, B.6
Mentzel, H.7
-
54
-
-
80051561535
-
Pseudomonas aeruginosa population diversity and turnover in cystic fibrosis chronic infections
-
Mowat, E., Paterson, S., Fothergill, J. L., Wright, E. A., Ledson, M. J., Walshaw, M. J., Brockhurst, M. A. & Winstanley, C. (2011). Pseudomonas aeruginosa population diversity and turnover in cystic fibrosis chronic infections. Am J Respir Crit Care Med 183, 1674–1679
-
(2011)
Am J Respir Crit Care Med
, vol.183
, pp. 1674-1679
-
-
Mowat, E.1
Paterson, S.2
Fothergill, J.L.3
Wright, E.A.4
Ledson, M.J.5
Walshaw, M.J.6
Brockhurst, M.A.7
Winstanley, C.8
-
55
-
-
0035018558
-
The CbrA-CbrB twocomponent regulatory system controls the utilization of multiple carbon and nitrogen sources in Pseudomonas aeruginosa
-
Nishijyo, T., Haas, D. & Itoh, Y. (2001). The CbrA-CbrB twocomponent regulatory system controls the utilization of multiple carbon and nitrogen sources in Pseudomonas aeruginosa. Mol Microbiol 40, 917–931
-
(2001)
Mol Microbiol
, vol.40
, pp. 917-931
-
-
Nishijyo, T.1
Haas, D.2
Itoh, Y.3
-
56
-
-
41149163825
-
Genome-scale metabolic network analysis of the opportunistic pathogen Pseudomonas aeruginosa
-
Oberhardt, M. A., Puchałka, J., Fryer, K. E., Martins dos Santos, V. A. P. & Papin, J. A. (2008). Genome-scale metabolic network analysis of the opportunistic pathogen Pseudomonas aeruginosa PAO1 J Bacteriol 190, 2790–2803
-
(2008)
PAO1 J Bacteriol
, vol.190
, pp. 2790-2803
-
-
Oberhardt, M.A.1
Puchałka, J.2
Fryer, K.E.3
Dos Martins Santos, V.4
Papin, J.A.5
-
57
-
-
22544455625
-
Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology
-
Palmer, K. L., Mashburn, L. M., Singh, P. K. & Whiteley, M. (2005). Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. J Bacteriol 187, 5267–5277
-
(2005)
J Bacteriol
, vol.187
, pp. 5267-5277
-
-
Palmer, K.L.1
Mashburn, L.M.2
Singh, P.K.3
Whiteley, M.4
-
58
-
-
36549035760
-
Nutritional cues control Pseudomonas aeruginosa multicellular behavior in cystic fibrosis sputum
-
Palmer, K. L., Aye, L. M. & Whiteley, M. (2007). Nutritional cues control Pseudomonas aeruginosa multicellular behavior in cystic fibrosis sputum. J Bacteriol 189, 8079–8087
-
(2007)
J Bacteriol
, vol.189
, pp. 8079-8087
-
-
Palmer, K.L.1
Aye, L.M.2
Whiteley, M.3
-
59
-
-
77952558851
-
Characterization of the Pseudomonas aeruginosa transcriptional response to phenylalanine and tyrosine
-
Palmer, G. C., Palmer, K. L., Jorth, P. A. & Whiteley, M. (2010). Characterization of the Pseudomonas aeruginosa transcriptional response to phenylalanine and tyrosine. J Bacteriol 192, 2722–2728
-
(2010)
J Bacteriol
, vol.192
, pp. 2722-2728
-
-
Palmer, G.C.1
Palmer, K.L.2
Jorth, P.A.3
Whiteley, M.4
-
60
-
-
0026558972
-
Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis
-
Pedersen, S. S., Møller, H., Espersen, F., Sørensen, C. H., Jensen, T. & Høiby, N. (1992). Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis. APMIS 100, 326–334
-
(1992)
APMIS
, vol.100
, pp. 326-334
-
-
Pedersen, S.S.1
Møller, H.2
Espersen, F.3
Sørensen, C.H.4
Jensen, T.5
Høiby, N.6
-
61
-
-
31344462167
-
Early rise of anti-Pseudomonas antibodies and a mucoid phenotype of Pseudomonas aeruginosa are risk factors for development of chronic lung infection – a case control study
-
Pressler, T., Frederiksen, B., Skov, M., Garred, P., Koch, C. & Høiby, N. (2006). Early rise of anti-Pseudomonas antibodies and a mucoid phenotype of Pseudomonas aeruginosa are risk factors for development of chronic lung infection – a case control study. J Cyst Fibros 5, 9–15
-
(2006)
J Cyst Fibros
, vol.5
, pp. 9-15
-
-
Pressler, T.1
Frederiksen, B.2
Skov, M.3
Garred, P.4
Koch, C.5
Høiby, N.6
-
62
-
-
57649159191
-
Diagnostic significance of measurements of specific IgG antibodies to Pseudomonas aeruginosa by three different serological methods
-
Scandinavian CF Study Consortium
-
Pressler, T., Karpati, F., Granström, M., Knudsen, P. K., Lindblad, A., Hjelte, L., Olesen, H. V., Meyer, P., Høiby, N. & Scandinavian CF Study Consortium (2009). Diagnostic significance of measurements of specific IgG antibodies to Pseudomonas aeruginosa by three different serological methods. J Cyst Fibros 8, 37–42
-
(2009)
J Cyst Fibros
, vol.8
, pp. 37-42
-
-
Pressler, T.1
Karpati, F.2
Granström, M.3
Knudsen, P.K.4
Lindblad, A.5
Hjelte, L.6
Olesen, H.V.7
Meyer, P.8
Høiby, N.9
-
63
-
-
0032474853
-
Adaptive radiation in a heterogeneous environment
-
Rainey, P. B. & Travisano, M. (1998). Adaptive radiation in a heterogeneous environment. Nature 394, 69–72
-
(1998)
Nature
, vol.394
, pp. 69-72
-
-
Rainey, P.B.1
Travisano, M.2
-
64
-
-
21044453410
-
Identity and effects of quorumsensing inhibitors produced by Penicillium species
-
Rasmussen, T. B., Skindersoe, M. E., Bjarnsholt, T., Phipps, R. K., Christensen, K. B., Jensen, P. O., Andersen, J. B., Koch, B., Larsen, T. O. & other authors (2005). Identity and effects of quorumsensing inhibitors produced by Penicillium species. Microbiology 151, 1325–1340
-
(2005)
Microbiology
, vol.151
, pp. 1325-1340
-
-
Rasmussen, T.B.1
Skindersoe, M.E.2
Bjarnsholt, T.3
Phipps, R.K.4
Christensen, K.B.5
Jensen, P.O.6
Ersen, J.B.7
Koch, B.8
Larsen, T.O.9
-
65
-
-
77955132055
-
Carbon catabolite repression in Pseudomonas: Optimizing metabolic versatility and interactions with the environment
-
Rojo, F. (2010). Carbon catabolite repression in Pseudomonas: optimizing metabolic versatility and interactions with the environment. FEMS Microbiol Rev 34, 658–684
-
(2010)
FEMS Microbiol Rev
, vol.34
, pp. 658-684
-
-
Rojo, F.1
-
66
-
-
84862648883
-
The micro-organisms in chronically infected end-stage and non-endstage cystic fibrosis patients
-
Rudkjøbing, V. B., Thomsen, T. R., Alhede, M., Kragh, K. N., Nielsen, P. H., Johansen, U. R., Givskov, M., Høiby, N. & Bjarnsholt, T. (2012). The micro-organisms in chronically infected end-stage and non-endstage cystic fibrosis patients. FEMS Immunol Med Microbiol 65, 236–244
-
(2012)
FEMS Immunol Med Microbiol
, vol.65
, pp. 236-244
-
-
Rudkjøbing, V.B.1
Thomsen, T.R.2
Alhede, M.3
Kragh, K.N.4
Nielsen, P.H.5
Johansen, U.R.6
Givskov, M.7
Høiby, N.8
Bjarnsholt, T.9
-
67
-
-
78549290620
-
Anaerobic physiology of Pseudomonas aeruginosa in the cystic fibrosis lung
-
Schobert, M. & Jahn, D. (2010). Anaerobic physiology of Pseudomonas aeruginosa in the cystic fibrosis lung. Int J Med Microbiol 300, 549–556
-
(2010)
Int J Med Microbiol
, vol.300
, pp. 549-556
-
-
Schobert, M.1
Jahn, D.2
-
68
-
-
84928014771
-
Origins of cystic fibrosis lung disease
-
Stoltz, D. A., Meyerholz, D. K. & Welsh, M. J. (2015). Origins of cystic fibrosis lung disease. N Engl J Med 372, 351–362
-
(2015)
N Engl J Med
, vol.372
, pp. 351-362
-
-
Stoltz, D.A.1
Meyerholz, D.K.2
Welsh, M.J.3
-
69
-
-
0027376171
-
Adult cystic fibrosis: Association of acute pulmonary exacerbations and increasing severity of lung disease with auxotrophic mutants of Pseudomonas aeruginosa
-
Taylor, R. F., Hodson, M. E. & Pitt, T. L. (1993). Adult cystic fibrosis: association of acute pulmonary exacerbations and increasing severity of lung disease with auxotrophic mutants of Pseudomonas aeruginosa. Thorax 48, 1002–1005
-
(1993)
Thorax
, vol.48
, pp. 1002-1005
-
-
Taylor, R.F.1
Hodson, M.E.2
Pitt, T.L.3
-
70
-
-
0029134774
-
Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: Criteria for bacterial strain typing
-
Tenover, F. C., Arbeit, R. D., Goering, R. V., Mickelsen, P. A., Murray, B. E., Persing, D. H. & Swaminathan, B. (1995). Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 33, 2233–2239
-
(1995)
J Clin Microbiol
, vol.33
, pp. 2233-2239
-
-
Tenover, F.C.1
Arbeit, R.D.2
Goering, R.V.3
Mickelsen, P.A.4
Murray, B.E.5
Persing, D.H.6
Swaminathan, B.7
-
71
-
-
0033837207
-
Increased sputum amino acid concentrations and auxotrophy of Pseudomonas aeruginosa in severe cystic fibrosis lung disease
-
Thomas, S. R., Ray, A., Hodson, M. E. & Pitt, T. L. (2000). Increased sputum amino acid concentrations and auxotrophy of Pseudomonas aeruginosa in severe cystic fibrosis lung disease. Thorax 55, 795–797
-
(2000)
Thorax
, vol.55
, pp. 795-797
-
-
Thomas, S.R.1
Ray, A.2
Hodson, M.E.3
Pitt, T.L.4
-
72
-
-
0025100949
-
The rpoN gene product of Pseudomonas aeruginosa is required for expression of diverse genes, including the flagellin gene
-
Totten, P. A., Lara, J. C. & Lory, S. (1990). The rpoN gene product of Pseudomonas aeruginosa is required for expression of diverse genes, including the flagellin gene. J Bacteriol 172, 389–396
-
(1990)
J Bacteriol
, vol.172
, pp. 389-396
-
-
Totten, P.A.1
Lara, J.C.2
Lory, S.3
-
73
-
-
84861009211
-
Initial Pseudomonas aeruginosa infection in patients with cystic fibrosis: Characteristics of eradicated and persistent isolates
-
Tramper-Stranders, G. A., van der Ent, C. K., Molin, S., Yang, L., Hansen, S. K., Rau, M. H., Ciofu, O., Johansen, H. K. & Wolfs, T. F. W. (2012). Initial Pseudomonas aeruginosa infection in patients with cystic fibrosis: characteristics of eradicated and persistent isolates. Clin Microbiol Infect 18, 567–574
-
(2012)
Clin Microbiol Infect
, vol.18
, pp. 567-574
-
-
Tramper-Stranders, G.A.1
Van Der Ent, C.K.2
Molin, S.3
Yang, L.4
Hansen, S.K.5
Rau, M.H.6
Ciofu, O.7
Johansen, H.K.8
Wolfs, T.9
-
74
-
-
80052337933
-
Identification of C4- dicarboxylate transport systems in Pseudomonas aeruginosa
-
Valentini, M., Storelli, N. & Lapouge, K. (2011). Identification of C4- dicarboxylate transport systems in Pseudomonas aeruginosa. PAO1J Bacteriol 193, 4307–4316
-
(2011)
PAO1J Bacteriol
, vol.193
, pp. 4307-4316
-
-
Valentini, M.1
Storelli, N.2
Lapouge, K.3
-
75
-
-
0000361721
-
The identification of atypical strains of Pseudomonas aeruginosa
-
Wahba, A. H. & Darrell, J. H. (1965). The identification of atypical strains of Pseudomonas aeruginosa. J Gen Microbiol 38, 329–342
-
(1965)
J Gen Microbiol
, vol.38
, pp. 329-342
-
-
Wahba, A.H.1
Darrell, J.H.2
-
76
-
-
84875748411
-
Phenotypic heterogeneity of Pseudomonas aeruginosa populations in a cystic fibrosis patient
-
Workentine, M. L., Sibley, C. D., Glezerson, B., Purighalla, S., Norgaard-Gron, J. C., Parkins, M. D., Rabin, H. R. & Surette, M. G. (2013). Phenotypic heterogeneity of Pseudomonas aeruginosa populations in a cystic fibrosis patient. PLoS One 8, e60225
-
(2013)
Plos One
-
-
Workentine, M.L.1
Sibley, C.D.2
Glezerson, B.3
Purighalla, S.4
Norgaard-Gron, J.C.5
Parkins, M.D.6
Rabin, H.R.7
Surette, M.G.8
-
77
-
-
41949122329
-
In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections
-
Yang, L., Haagensen, J. A. J., Jelsbak, L., Johansen, H. K., Sternberg, C., Høiby, N. & Molin, S. (2008). In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections. J Bacteriol 190, 2767–2776
-
(2008)
J Bacteriol
, vol.190
, pp. 2767-2776
-
-
Yang, L.1
Haagensen, J.2
Jelsbak, L.3
Johansen, H.K.4
Sternberg, C.5
Høiby, N.6
Molin, S.7
-
78
-
-
79956307094
-
Evolutionary dynamics of bacteria in a human host environment
-
Yang, L., Jelsbak, L., Marvig, R. L., Damkiær, S., Workman, C. T., Rau, M. H., Hansen, S. K., Folkesson, A., Johansen, H. K. & other authors (2011). Evolutionary dynamics of bacteria in a human host environment. Proc Natl Acad Sci USA 108, 7481–7486.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 7481-7486
-
-
Yang, L.1
Jelsbak, L.2
Marvig, R.L.3
Damkiær, S.4
Workman, C.T.5
Rau, M.H.6
Hansen, S.K.7
Folkesson, A.8
Johansen, H.K.9
|