Evolutionary remodeling of global regulatory networks during long-term bacterial adaptation to human hosts

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 19, 2013, Pages 7766-7771

  Damkiær, Søren ^a   Yang, Lei ^a,b   Molin, Søren ^a   Jelsbak, Lars ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Chronic infection; Epistasis; Evolution of regulatory networks; Gene expression; Microbial evolution

Indexed keywords

ALGT PROTEIN; BACTERIAL PROTEIN; CEFTAZIDIME; MUCA PROTEIN; RPOD PROTEIN; SIGMA FACTOR RPON; TOBRAMYCIN; UNCLASSIFIED DRUG;

AIRWAY; AMINO ACID SUBSTITUTION; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BACTERIUM MUTANT; CYSTIC FIBROSIS; FRAMESHIFT MUTATION; GENE DELETION; GENE REGULATORY NETWORK; HUMAN; MOLECULAR EVOLUTION; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

CHRONIC INFECTION; EPISTASIS; EVOLUTION OF REGULATORY NETWORKS; GENE EXPRESSION; MICROBIAL EVOLUTION;

BACTERIAL PROTEINS; CYSTIC FIBROSIS; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; GENE REGULATORY NETWORKS; GENOME, BACTERIAL; HUMANS; PHENOTYPE; PHYLOGENY; POINT MUTATION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RNA POLYMERASE SIGMA 54; SIGMA FACTOR; TIME FACTORS; TRANS-ACTIVATORS;

EID: 84877339385     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1221466110     Document Type: Article

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