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Volumn 4, Issue 7, 2016, Pages 574-581

Expanded and activated natural killer cells for immunotherapy of hepatocellular carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; INTERLEUKIN 2; NATURAL KILLER CELL RECEPTOR NKG2D; SORAFENIB; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CARBANILAMIDE DERIVATIVE; NICOTINAMIDE; PROTEIN KINASE INHIBITOR;

EID: 84979771531     PISSN: 23266066     EISSN: 23266074     Source Type: Journal    
DOI: 10.1158/2326-6066.CIR-15-0229     Document Type: Article
Times cited : (77)

References (47)
  • 1
    • 84918815964 scopus 로고    scopus 로고
    • Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
    • Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:E359-E86.
    • (2015) Int J Cancer , vol.136
    • Ferlay, J.1    Soerjomataram, I.2    Dikshit, R.3    Eser, S.4    Mathers, C.5    Rebelo, M.6
  • 2
    • 84859212951 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet 2012;379: 1245-55 .
    • (2012) Lancet , vol.379 , pp. 1245-1255
    • Forner, A.1    Llovet, J.M.2    Bruix, J.3
  • 3
    • 84860287080 scopus 로고    scopus 로고
    • Epidemiology of viral hepatitis and hepatocellular carcinoma
    • e1
    • El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 2012;142:1264-73 e1.
    • (2012) Gastroenterology , vol.142 , pp. 1264-1273
    • El-Serag, H.B.1
  • 4
    • 84880276248 scopus 로고    scopus 로고
    • Pathogenesis of chronic viral hepatitis: Differential roles of T cells and NK cells
    • Rehermann B. Pathogenesis of chronic viral hepatitis: Differential roles of T cells and NK cells. Nat Med 2013;19:859-68.
    • (2013) Nat Med , vol.19 , pp. 859-868
    • Rehermann, B.1
  • 5
    • 0019313239 scopus 로고
    • Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma
    • Brechot C, Pourcel C, Louise A, Rain B, Tiollais P. Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature 1980;286:533-5.
    • (1980) Nature , vol.286 , pp. 533-535
    • Brechot, C.1    Pourcel, C.2    Louise, A.3    Rain, B.4    Tiollais, P.5
  • 6
    • 0019311009 scopus 로고
    • Integration of hepatitis B virus sequences and their expression in a human hepatoma cell
    • Edman JC, Gray P, Valenzuela P, Rall LB, Rutter WJ. Integration of hepatitis B virus sequences and their expression in a human hepatoma cell. Nature 1980;286:535-8.
    • (1980) Nature , vol.286 , pp. 535-538
    • Edman, J.C.1    Gray, P.2    Valenzuela, P.3    Rall, L.B.4    Rutter, W.J.5
  • 7
    • 84862999344 scopus 로고    scopus 로고
    • Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
    • Sung WK, Zheng H, Li S, Chen R, Liu X, Li Y, et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet 2012; 44:765-9.
    • (2012) Nat Genet , vol.44 , pp. 765-769
    • Sung, W.K.1    Zheng, H.2    Li, S.3    Chen, R.4    Liu, X.5    Li, Y.6
  • 9
    • 84933277181 scopus 로고    scopus 로고
    • Advances in targeted therapies for hepatocellular carcinoma in the genomic era
    • Llovet JM, Villanueva A, Lachenmayer A, Finn RS. Advances in targeted therapies for hepatocellular carcinoma in the genomic era. Nat Rev Clin Oncol 2015;12:408-24.
    • (2015) Nat Rev Clin Oncol , vol.12 , pp. 408-424
    • Llovet, J.M.1    Villanueva, A.2    Lachenmayer, A.3    Finn, R.S.4
  • 10
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: A common denominator approach to cancer therapy
    • Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: A common denominator approach to cancer therapy. Cancer Cell 2015;27: 450-61.
    • (2015) Cancer Cell , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 11
    • 84928056873 scopus 로고    scopus 로고
    • The journey from discoveries in fundamental immunology to cancer immunotherapy
    • Miller JF, Sadelain M. The journey from discoveries in fundamental immunology to cancer immunotherapy. Cancer Cell 2015;27:439-49.
    • (2015) Cancer Cell , vol.27 , pp. 439-449
    • Miller, J.F.1    Sadelain, M.2
  • 12
    • 84902244229 scopus 로고    scopus 로고
    • Immunotherapeutic approaches to hepatocellular carcinoma treatment
    • Miamen AG, Dong H, Roberts LR. Immunotherapeutic approaches to hepatocellular carcinoma treatment. Liver Cancer 2012;1:226-37.
    • (2012) Liver Cancer , vol.1 , pp. 226-237
    • Miamen, A.G.1    Dong, H.2    Roberts, L.R.3
  • 13
    • 84893152822 scopus 로고    scopus 로고
    • Spontaneous and therapeutic immune responses in hepatocellular carcinoma: Implications for current and future immunotherapies
    • Wirth TC. Spontaneous and therapeutic immune responses in hepatocellular carcinoma: Implications for current and future immunotherapies. Exp Rev Gastroenterol 2014;8:101-10.
    • (2014) Exp Rev Gastroenterol , vol.8 , pp. 101-110
    • Wirth, T.C.1
  • 14
    • 79958840661 scopus 로고    scopus 로고
    • Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines
    • Gehring AJ, Xue SA, Ho ZZ, Teoh D, Ruedl C, Chia A, et al. Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines. J Hepatol 2011;55:103-10.
    • (2011) J Hepatol , vol.55 , pp. 103-110
    • Gehring, A.J.1    Xue, S.A.2    Ho, Z.Z.3    Teoh, D.4    Ruedl, C.5    Chia, A.6
  • 15
    • 84884227487 scopus 로고    scopus 로고
    • A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus
    • Nucleic Acids
    • Koh S, Shimasaki N, Suwanarusk R, Ho ZZ, Chia A, Banu N, et al. A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus. Mol Ther (Nucleic Acids) 2013;2:e114.
    • (2013) Mol Ther , vol.2 , pp. e114
    • Koh, S.1    Shimasaki, N.2    Suwanarusk, R.3    Ho, Z.Z.4    Chia, A.5    Banu, N.6
  • 16
    • 84922268964 scopus 로고    scopus 로고
    • Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient
    • Qasim W, Brunetto M, Gehring AJ, Xue SA, Schurich A, Khakpoor A, et al. Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient. J Hepatol 2015;62:486-91.
    • (2015) J Hepatol , vol.62 , pp. 486-491
    • Qasim, W.1    Brunetto, M.2    Gehring, A.J.3    Xue, S.A.4    Schurich, A.5    Khakpoor, A.6
  • 18
    • 0037086131 scopus 로고    scopus 로고
    • Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    • Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002;295:2097-100.
    • (2002) Science , vol.295 , pp. 2097-2100
    • Ruggeri, L.1    Capanni, M.2    Urbani, E.3    Perruccio, K.4    Shlomchik, W.D.5    Tosti, A.6
  • 19
    • 77957734984 scopus 로고    scopus 로고
    • Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia
    • Cooley S, Weisdorf DJ, Guethlein LA, Klein JP, Wang T, Le CT, et al. Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia. Blood 2010;116:2411-9.
    • (2010) Blood , vol.116 , pp. 2411-2419
    • Cooley, S.1    Weisdorf, D.J.2    Guethlein, L.A.3    Klein, J.P.4    Wang, T.5    Le, C.T.6
  • 20
    • 20144388509 scopus 로고    scopus 로고
    • Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in cancer patients
    • Miller JS, Soignier Y, Panoskaltsis-Mortari A, McNearney SA, Yun GH, Fautsch SK, et al. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in cancer patients. Blood 2005;105: 3051-7.
    • (2005) Blood , vol.105 , pp. 3051-3057
    • Miller, J.S.1    Soignier, Y.2    Panoskaltsis-Mortari, A.3    McNearney, S.A.4    Yun, G.H.5    Fautsch, S.K.6
  • 21
    • 77949898005 scopus 로고    scopus 로고
    • NKAML: A pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia
    • Rubnitz JE, Inaba H, Ribeiro RC, Pounds S, Rooney B, Bell T, et al. NKAML: A pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. J Clin Oncol 2010;28:955-9.
    • (2010) J Clin Oncol , vol.28 , pp. 955-959
    • Rubnitz, J.E.1    Inaba, H.2    Ribeiro, R.C.3    Pounds, S.4    Rooney, B.5    Bell, T.6
  • 22
    • 84887427672 scopus 로고    scopus 로고
    • Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma
    • Cui J, Wang N, Zhao H, Jin H, Wang G, Niu C, et al. Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma. Int J Cancer 2014;134:342-51.
    • (2014) Int J Cancer , vol.134 , pp. 342-351
    • Cui, J.1    Wang, N.2    Zhao, H.3    Jin, H.4    Wang, G.5    Niu, C.6
  • 23
    • 84930018607 scopus 로고    scopus 로고
    • Adjuvant immunotherapy with autologous cytokine-induced killer cells for hepatocellular carcinoma
    • e6
    • Lee JH, Lee JH, Lim YS, Yeon JE, Song TJ, Yu SJ, et al. Adjuvant immunotherapy with autologous cytokine-induced killer cells for hepatocellular carcinoma. Gastroenterology 2015;148:1383-91 e6.
    • (2015) Gastroenterology , vol.148 , pp. 1383-1391
    • Lee, J.H.1    Lee, J.H.2    Lim, Y.S.3    Yeon, J.E.4    Song, T.J.5    Yu, S.J.6
  • 24
    • 22044456688 scopus 로고    scopus 로고
    • Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells
    • Imai C, Iwamoto S, Campana D. Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood 2005;106:376-83.
    • (2005) Blood , vol.106 , pp. 376-383
    • Imai, C.1    Iwamoto, S.2    Campana, D.3
  • 25
    • 65949111530 scopus 로고    scopus 로고
    • Expansion of highly cytotoxic human natural killer cells for cancer cell therapy
    • Fujisaki H, Kakuda H, Shimasaki N, Imai C, Ma J, Lockey T, et al. Expansion of highly cytotoxic human natural killer cells for cancer cell therapy. Cancer Res 2009;69:4010-7.
    • (2009) Cancer Res , vol.69 , pp. 4010-4017
    • Fujisaki, H.1    Kakuda, H.2    Shimasaki, N.3    Imai, C.4    Ma, J.5    Lockey, T.6
  • 26
    • 84875469893 scopus 로고    scopus 로고
    • A chimeric receptor with NKG2D specificity enhances natural killer cell activation and killing of tumor cells
    • Chang YH, Connolly J, Shimasaki N, Mimura K, Kono K, Campana D. A chimeric receptor with NKG2D specificity enhances natural killer cell activation and killing of tumor cells. Cancer Res 2013;73:1777-86.
    • (2013) Cancer Res , vol.73 , pp. 1777-1786
    • Chang, Y.H.1    Connolly, J.2    Shimasaki, N.3    Mimura, K.4    Kono, K.5    Campana, D.6
  • 28
    • 77951683908 scopus 로고    scopus 로고
    • Effect of NKG2D ligand expression on host immune responses
    • Champsaur M, Lanier LL. Effect of NKG2D ligand expression on host immune responses. Immunol Rev 2010;235:267-85.
    • (2010) Immunol Rev , vol.235 , pp. 267-285
    • Champsaur, M.1    Lanier, L.L.2
  • 30
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    • Groh V, Wu J, Yee C, Spies T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 2002;419:734-8.
    • (2002) Nature , vol.419 , pp. 734-738
    • Groh, V.1    Wu, J.2    Yee, C.3    Spies, T.4
  • 32
    • 84857050018 scopus 로고    scopus 로고
    • Chemokine-driven lymphocyte infiltration: An early intratumoural event determining longterm survival in resectable hepatocellular carcinoma
    • Chew V, Chen J, Lee D, Loh E, Lee J, Lim KH, et al. Chemokine-driven lymphocyte infiltration: An early intratumoural event determining longterm survival in resectable hepatocellular carcinoma. Gut 2012;61:427-38.
    • (2012) Gut , vol.61 , pp. 427-438
    • Chew, V.1    Chen, J.2    Lee, D.3    Loh, E.4    Lee, J.5    Lim, K.H.6
  • 33
    • 84870915632 scopus 로고    scopus 로고
    • Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients
    • Chew V, Tow C, Huang C, Bard-Chapeau E, Copeland NG, Jenkins NA, et al. Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients. J Natl Cancer Inst 2012;104:1796-807.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1796-1807
    • Chew, V.1    Tow, C.2    Huang, C.3    Bard-Chapeau, E.4    Copeland, N.G.5    Jenkins, N.A.6
  • 34
    • 84855946380 scopus 로고    scopus 로고
    • Reduced NKG2D ligand expression in hepato cellular carcinoma correlates with early recurrence
    • Kamimura H, Yamagiwa S, Tsuchiya A, Takamura M, Matsuda Y, Ohkoshi S, et al. Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence. J Hepatol 2012;56:381-8.
    • (2012) J Hepatol , vol.56 , pp. 381-388
    • Kamimura, H.1    Yamagiwa, S.2    Tsuchiya, A.3    Takamura, M.4    Matsuda, Y.5    Ohkoshi, S.6
  • 35
    • 77951945662 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma with adeno- Associated virus encoding interleukin- 15 superagonist
    • Chang CM, Lo CH, Shih YM, Chen Y, WuPY, Tsuneyama K, et al. Treatment of hepatocellular carcinoma with adeno- Associated virus encoding interleukin- 15 superagonist. Hum Gene Ther 2010;21:611-21.
    • (2010) Hum Gene Ther , vol.21 , pp. 611-621
    • Chang, C.M.1    Lo, C.H.2    Shih, Y.M.3    Chen, Y.4    Wu, P.Y.5    Tsuneyama, K.6
  • 36
    • 33644517272 scopus 로고    scopus 로고
    • Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans
    • Ishiyama K, Ohdan H, Ohira M, Mitsuta H, Arihiro K, Asahara T. Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans. Hepatology 2006;43: 362-72.
    • (2006) Hepatology , vol.43 , pp. 362-372
    • Ishiyama, K.1    Ohdan, H.2    Ohira, M.3    Mitsuta, H.4    Arihiro, K.5    Asahara, T.6
  • 37
    • 84895475681 scopus 로고    scopus 로고
    • Vivo proof of concept of adoptive immunotherapy for hepatocellular carcinoma using allogeneic suicide gene-modified killer cells
    • Leboeuf C, Mailly L, Wu T, Bour G, Durand S, Brignon N, et al. In vivo proof of concept of adoptive immunotherapy for hepatocellular carcinoma using allogeneic suicide gene-modified killer cells. Mol Ther 2014;22:634-44.
    • (2014) Mol Ther , vol.22 , pp. 634-644
    • Leboeuf, C.1    Mailly, L.2    Wu, T.3    Bour, G.4    Durand, S.5    Brignon, N.6
  • 38
    • 84866501841 scopus 로고    scopus 로고
    • Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications
    • Lapteva N, Durett AG, Sun J, Rollins LA, Huye LL, Fang J, et al. Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications. Cytotherapy 2012;14:1131-43.
    • (2012) Cytotherapy , vol.14 , pp. 1131-1143
    • Lapteva, N.1    Durett, A.G.2    Sun, J.3    Rollins, L.A.4    Huye, L.L.5    Fang, J.6
  • 39
    • 76249129410 scopus 로고    scopus 로고
    • The kinase inhibitors sunitinib and sorafenib differentially affect NK cell antitumor reactivity in vitro
    • Krusch M, Salih J, Schlicke M, Baessler T, Kampa KM, Mayer F, et al. The kinase inhibitors sunitinib and sorafenib differentially affect NK cell antitumor reactivity in vitro. J Immunol 2009;183: 8286-94.
    • (2009) J Immunol , vol.183 , pp. 8286-8294
    • Krusch, M.1    Salih, J.2    Schlicke, M.3    Baessler, T.4    Kampa, K.M.5    Mayer, F.6
  • 40
    • 84873652957 scopus 로고    scopus 로고
    • Suppression of natural killer cells by sorafenib contributes to prometastatic effects in hepatocellular carcinoma
    • Zhang QB, Sun HC, Zhang KZ, Jia QA, Bu Y, Wang M, et al. Suppression of natural killer cells by sorafenib contributes to prometastatic effects in hepatocellular carcinoma. PloS One 2013;8:e55945.
    • (2013) PloS One , vol.8 , pp. e55945
    • Zhang, Q.B.1    Sun, H.C.2    Zhang, K.Z.3    Jia, Q.A.4    Bu, Y.5    Wang, M.6
  • 41
    • 84879111551 scopus 로고    scopus 로고
    • Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells
    • Sprinzl MF, Reisinger F, Puschnik A, Ringelhan M, Ackermann K, Hartmann D, et al. Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells. Hepatology 2013;57:2358-68.
    • (2013) Hepatology , vol.57 , pp. 2358-2368
    • Sprinzl, M.F.1    Reisinger, F.2    Puschnik, A.3    Ringelhan, M.4    Ackermann, K.5    Hartmann, D.6
  • 42
    • 77950613332 scopus 로고    scopus 로고
    • Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down regulating a disintegrin and metalloproteinase 9
    • Kohga K, Takehara T, Tatsumi T, Ishida H, Miyagi T, Hosui A, et al. Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by downregulating a disintegrin and metalloproteinase 9. Hepatology 2010;51: 1264-73.
    • (2010) Hepatology , vol.51 , pp. 1264-1273
    • Kohga, K.1    Takehara, T.2    Tatsumi, T.3    Ishida, H.4    Miyagi, T.5    Hosui, A.6
  • 43
    • 84877581134 scopus 로고    scopus 로고
    • MRI-monitored transcatheter intra- Arterial delivery of spio-labeled natural killer cells to hepatocellular carcinoma preclinical studies in a rodent model
    • Sheu AY, Zhang ZL, Omary RA, Larson AC. MRI-monitored transcatheter intra- Arterial delivery of spio-labeled natural killer cells to hepatocellular carcinoma preclinical studies in a rodent model. Invest Radiol 2013; 48:492-9.
    • (2013) Invest Radiol , vol.48 , pp. 492-499
    • Sheu, A.Y.1    Zhang, Z.L.2    Omary, R.A.3    Larson, A.C.4
  • 44
    • 84922401074 scopus 로고    scopus 로고
    • Prevention of hepatitis C virus infection by adoptive allogeneic immunotherapy using suicide gene-modified lymphocytes: An in vitro proof-of concept
    • Leboeuf C, Roser-Schilder J, Lambotin M, Durand S, Wu T, Fauvelle C, et al. Prevention of hepatitis C virus infection by adoptive allogeneic immunotherapy using suicide gene-modified lymphocytes: An in vitro proof-of concept. Gene Ther 2015;22:172-80.
    • (2015) Gene Ther , vol.22 , pp. 172-180
    • Leboeuf, C.1    Roser-Schilder, J.2    Lambotin, M.3    Durand, S.4    Wu, T.5    Fauvelle, C.6
  • 45
    • 84913555946 scopus 로고    scopus 로고
    • Innate and adaptive immune responses in HCV infections
    • Heim MH, Thimme R. Innate and adaptive immune responses in HCV infections. J Hepat 2014;61:S14-S25.
    • (2014) J Hepat , vol.61 , pp. S14-S25
    • Heim, M.H.1    Thimme, R.2
  • 46
    • 84883746075 scopus 로고    scopus 로고
    • NK cells: A double-edged sword in chronic hepatitis B virus infection
    • Maini MK, Peppa D. NK cells: A double-edged sword in chronic hepatitis B virus infection. Front Immunol 2013;4:57.
    • (2013) Front Immunol , vol.4 , pp. 57
    • Maini, M.K.1    Peppa, D.2
  • 47
    • 70449381373 scopus 로고    scopus 로고
    • Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice
    • Ohira M, Ishiyama K, Tanaka Y, Doskali M, Igarashi Y, Tashiro H, et al. Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice. J Clin Invest 2009;119:3226-35.
    • (2009) J Clin Invest , vol.119 , pp. 3226-3235
    • Ohira, M.1    Ishiyama, K.2    Tanaka, Y.3    Doskali, M.4    Igarashi, Y.5    Tashiro, H.6


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