Resveratrol increases F508del-CFTR dependent salivary secretion in cystic fibrosis mice

Biology Open

Volumn 4, Issue 7, 2015, Pages 929-936

  Dhooghe, Barbara ^a   Bouckaert, Charlotte ^a   Capron, Arnaud ^b   Wallemacq, Pierre ^b   Leal, Teresinha ^a   Noel, Sabrina ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

CFTR; Cystic fibrosis; Mouse model; Pharmacology; Salivary secretion

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ISOPRENALINE; RESVERATROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY LABELING; ARTICLE; BETA ADRENERGIC STIMULATION; BODY WEIGHT; COMPARATIVE STUDY; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG BLOOD LEVEL; DRUG EFFECT; EPITHELIUM CELL; FEMALE; GENOTYPE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIMIT OF QUANTITATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SALIVATION; TIGHT JUNCTION;

EID: 84979769205     PISSN: None     EISSN: 20466390     Source Type: Journal    
DOI: 10.1242/bio.010967     Document Type: Article

References (35)

1. Alexander, N. S., Hatch, N., Zhang, S., Skinner, D., Fortenberry, J., Sorscher, E. J. and Woodworth, B. A. (2011). Resveratrol has salutary effects on mucociliary transport and inflammation in sinonasal epithelium. Laryngoscope 121, 1313-1319.
2. Balch, W. E., Roth, D. M. and Hutt, D. M. (2011). Emergent properties of proteostasis in managing cystic fibrosis. Cold Spring Harb. Perspect. Biol. 3, a004499.
3. Barbero, G. J. and Sibinga, M. S. (1962). Enlargement of the submaxillary salivary glands in cystic fibrosis. Pediatrics 29, 788-793.
4. Bebök, Z., Venglarik, C. J., Pánczeé, Z., Jilling, T., Kirk, K. L. and Sorscher, E. J. (1998). Activation ofΔF508 CFTR in an epithelial monolayer. Am. J. Physiol. Cell Physiol. 275, C599-C607.
5. Becq, F., Mall, M. A., Sheppard, D. N., Conese, M. and Zegarra-Moran, O. (2011). Pharmacological therapy for cystic fibrosis: from bench to bedside. J. Cyst. Fibros. 10 Suppl. 2, S129-S145.
6. Best, J. A. and Quinton, P. M. (2005). Salivary secretion assay for drug efficacy for cystic fibrosis in mice. Exp. Physiol. 90, 189-193.
7. Bhat, K. P. L. and Pezzuto, J. M. (2002). Cancer chemopreventive activity of resveratrol. Ann. N. Y. Acad. Sci. 957, 210-229.
8. Boat, T. F., Wiesman, U. N. and Pallavicini, J. C. (1974). Purification and properties of the calcium-precipitable protein in submaxillary saliva of normal and cystic fibrosis subjects. Pediatr. Res. 8, 531-539.
9. Donnelly, L. E., Newton, R., Kennedy, G. E., Fenwick, P. S., Leung, R. H. F., Ito, K., Russell, R. E. K. and Barnes, P. J. (2004). Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am. J. Physiol. Lung Cell. Mol. Physiol. 287, L774-L783.
10. Droebner, K. and Sandner, P. (2013). Modification of the salivary secretion assay in F508del mice-the murine equivalent of the human sweat test. J. Cyst. Fibros. 12, 630-637.
11. Hamdaoui, N., Baudoin-Legros, M., Kelly, M., Aissat, A., Moriceau, S., Vieu, D.-L., Colas, J., Fritsch, J., Edelman, A. and Planelles, G. (2011). Resveratrol rescues cAMP-dependentanionictransportinthecysticfibrosispancreaticcell lineCFPAC1. Br. J. Pharmacol. 163, 876-886.
12. Illek, B., Maurisse, R., Wahler, L., Kunzelmann, K., Fischer, H. and Gruenert, D. C. (2008). Cl transport in complemented CF bronchial epithelial cells correlates with CFTR mRNA expression levels. Cell Physiol Biochem. 22, 57-68.
13. Kasiotis, K. M., Pratsinis, H., Kletsas, D. and Haroutounian, S. A. (2013). Resveratrol and related stilbenes: their anti-aging and anti-angiogenic properties. Food Chem. Toxicol. 61, 112-120.
14. Legssyer, R., Huaux, F., Lebacq, J., Delos, M., Marbaix, E., Lebecque, P., Lison, D., Scholte, B. J., Wallemacq, P. and Leal, T. (2006). Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice. Respir. Res. 7, 134.
15. Lubamba, B., Lecourt, H., Lebacq, J., Lebecque, P., De Jonge, H., Wallemacq, P. and Leal, T. (2008). Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis. Am. J. Respir. Crit. Care Med. 177, 506-515.
16. Lubamba, B., Lebacq, J., Lebecque, P., Vanbever, R., Leonard, A., Wallemacq, P. and Leal, T. (2009). Airway delivery of low-dose miglustat normalizes nasal potential difference in F508del cystic fibrosis mice. Am. J. Respir. Crit. Care Med. 179, 1022-1028.
17. Mandel, I. D., Eriv, A., Kutscher, A., Denning, C., Thompson, R. H., Jr, Kessler, W. and Zegarelli, E. (1969). Calcium and phosphorus levels in submaxillary saliva: changes in cystic fibrosis and in asthma. Clin. Pediatr. 8, 161-164.
18. Melvin, J. E. (1999). Chloride channels and salivary gland function. Crit. Rev. Oral Biol. Med. 10, 199-209.
19. Melvin, J. E., Yule, D., Shuttleworth, T. and Begenisich, T. (2005). Regulation of fluid and electrolyte secretion in salivary gland acinar cells. Annu. Rev. Physiol. 67, 445-469.
20. Nicklas, W., Baneux, P., Boot, R., Decelle, T., Deeny, A. A., Fumanelli, M. and Illgen-Wilcke, B.; FELASAWorking Group on Health Monitoring of Rodent and Rabbit Colonies. (2002). Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units. Lab. Anim. 36, 20-42.
21. Noel, S., Strale, P.-O., Dannhoffer, L., Wilke, M., DeJonge, H., Rogier, C., Mettey, Y. and Becq, F. (2008). Stimulation of salivary secretion in vivo by CFTR potentiators in Cftr+/+ and Cftr-/- mice. J. Cyst. Fibros. 7, 128-133.
22. Park, S.-J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L. et al. (2012). Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148, 421-433.
23. Pasyk, S., Molinski, S., Ahmadi, S., Ramjeesingh, M., Huan, L. J., Chin, S., Du, K., Yeger, H., Taylor, P., Moran, M. F. and Bear, C. E. (2015). The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation. Proteomics 15, 447-461.
24. Planas, J. M., Alfaras, I., Colom, H. and Juan, M. E. (2012). The bioavailability and distribution of trans-resveratrol are constrained by ABC transporters. Arch. Biochem. Biophys. 527, 67-73.
25. Quinton, P., Molyneux, L., Ip, W., Dupuis, A., Avolio, J., Tullis, E., Conrad, D., Shamsuddin, A. K., Durie, P. and Gonska, T. (2012). Beta-adrenergic sweat secretion as a diagnostic test for cystic fibrosis. Am. J. Respir. Crit. Care Med. 186, 732-739.
26. Qureshi, N., Morrison, D. C. and Reis, J. (2012). Proteasome protease mediated regulation of cytokine induction and inflammation. Biochim. Biophys. Acta 1823, 2087-2093.
27. Robert, R., Carlile, G. W., Liao, J., Balghi, H., Lesimple, P., Liu, N., Kus, B., Rotin, D., Wilke, M., de Jonge, H. R. et al. (2010). Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine. Mol. Pharmacol. 77, 922-930.
28. Saussereau, E. L., Roussel, D., Diallo, S., Debarbieux, L., Edelman, A. and Sermet-Gaudelus, I. (2013). Characterization of nasal potential difference in cftr knockout and F508del-CFTR mice. PLoS ONE 8, e57317.
29. Shackleford, J. M. and Bentley, H. P.Jr. (1964). Carbohydrate histochemistry of the salivary glands and pancreas in cystic fibrosis. J. Histochem. Cytochem. 12, 512-521.
30. van Doorninck, J. H., French, P. J., Verbeek, E., Peters, R. H., Morreau, H., Bijman, J. and Scholte, B. J. (1995). A mouse model for the cystic fibrosis delta F508 mutation. EMBO J. 14, 4403-4411.
31. Wang, Y., Li, Y., Liu, X. and Cho, W. C. S. (2013). Genetic and epigenetic studies for determining molecular targets of natural product anticancer agents. Curr. Cancer Drug Targets 13, 506-518.
32. Wilke, M., Bot, A., Jorna, H., Scholte, B. J. and de Jonge, H. R. (2012). Rescue of murine F508del CFTR activity in native intestine by low temperature and proteasome inhibitors. PLoS ONE 7, e52070.
33. Wu, J. M. and Hsieh, T.-C. (2011). Resveratrol: a cardioprotective substance. Ann. N. Y. Acad. Sci. 1215, 16-21.
34. Xu, W., Hui, C., Yu, S. S. B., Jing, C. and Chan, H. C. (2011). MicroRNAs and cystic fibrosis-an epigenetic perspective. Cell Biol. Int. 35, 463-466.
35. Yang, S., Yu, B., Sui, Y., Zhang, Y., Wang, X., Hou, S., Ma, T. and Yang, H. (2013). CFTR chloride channel is a molecular target of the natural cancer preventive agent resveratrol. Pharmazie 68, 772-776.