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Volumn 42, Issue , 2016, Pages 48-55

Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ; NEUTRALIZING ANTIBODY; VIRUS ANTIBODY;

EID: 84979754039     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2016.05.012     Document Type: Review
Times cited : (75)

References (89)
  • 2
    • 84973472450 scopus 로고    scopus 로고
    • Orthomyxoviruses
    • D.M. Knipe P.M. Howley Lippincott Williams and Wilkins Philadelphia
    • 2 Palese, MLSaP., Orthomyxoviruses. Knipe, D.M., Howley, P.M., (eds.) Fields Virology, 2013, Lippincott Williams and Wilkins, Philadelphia.
    • (2013) Fields Virology
    • Palese, M.1
  • 3
    • 0034072605 scopus 로고    scopus 로고
    • Mismatch between the 1997/1998 influenza vaccine and the major epidemic A(H3N2) virus strain as the cause of an inadequate vaccine-induced antibody response to this strain in the elderly
    • 3 de Jong, J.C., Beyer, W.E., Palache, A.M., Rimmelzwaan, G.F., Osterhaus, A.D., Mismatch between the 1997/1998 influenza vaccine and the major epidemic A(H3N2) virus strain as the cause of an inadequate vaccine-induced antibody response to this strain in the elderly. J Med Virol 61 (2000), 94–99.
    • (2000) J Med Virol , vol.61 , pp. 94-99
    • de Jong, J.C.1    Beyer, W.E.2    Palache, A.M.3    Rimmelzwaan, G.F.4    Osterhaus, A.D.5
  • 4
    • 79960384534 scopus 로고    scopus 로고
    • Influenza A viruses: new research developments
    • 4 Medina, R.A., Garcia-Sastre, A., Influenza A viruses: new research developments. Nat Rev Microbiol 9 (2011), 590–603.
    • (2011) Nat Rev Microbiol , vol.9 , pp. 590-603
    • Medina, R.A.1    Garcia-Sastre, A.2
  • 7
    • 0020172113 scopus 로고
    • Evolution of influenza A and B viruses: conservation of structural features in the hemagglutinin genes
    • 7 Krystal, M., Elliott, R.M., Benz, E.W. Jr., Young, J.F., Palese, P., Evolution of influenza A and B viruses: conservation of structural features in the hemagglutinin genes. Proc Natl Acad Sci U S A 79 (1982), 4800–4804.
    • (1982) Proc Natl Acad Sci U S A , vol.79 , pp. 4800-4804
    • Krystal, M.1    Elliott, R.M.2    Benz, E.W.3    Young, J.F.4    Palese, P.5
  • 10
    • 84924060844 scopus 로고    scopus 로고
    • Advances in the development of influenza virus vaccines
    • 10 Krammer, F., Palese, P., Advances in the development of influenza virus vaccines. Nat Rev Drug Discov 14 (2015), 167–182.
    • (2015) Nat Rev Drug Discov , vol.14 , pp. 167-182
    • Krammer, F.1    Palese, P.2
  • 11
    • 84944203667 scopus 로고    scopus 로고
    • The quest for a universal flu vaccine: headless HA 2.0
    • 11 Krammer, F., The quest for a universal flu vaccine: headless HA 2.0. Cell Host Microbe 18 (2015), 395–397.
    • (2015) Cell Host Microbe , vol.18 , pp. 395-397
    • Krammer, F.1
  • 12
    • 0014515235 scopus 로고
    • Morphology of the isolated hemagglutinin and neuraminidase subunits of influenza virus
    • 12 Laver, W.G., Valentine, R.C., Morphology of the isolated hemagglutinin and neuraminidase subunits of influenza virus. Virology 38 (1969), 105–119.
    • (1969) Virology , vol.38 , pp. 105-119
    • Laver, W.G.1    Valentine, R.C.2
  • 13
    • 0028230805 scopus 로고
    • Modulation of immunodominant sites in influenza hemagglutinin compromise antigenic variation and select receptor-binding variant viruses
    • 13 Temoltzin-Palacios, F., Thomas, D.B., Modulation of immunodominant sites in influenza hemagglutinin compromise antigenic variation and select receptor-binding variant viruses. J Exp Med 179 (1994), 1719–1724.
    • (1994) J Exp Med , vol.179 , pp. 1719-1724
    • Temoltzin-Palacios, F.1    Thomas, D.B.2
  • 14
    • 0019890491 scopus 로고
    • Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution
    • 14 Wilson, I.A., Skehel, J.J., Wiley, D.C., Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature 289 (1981), 366–373.
    • (1981) Nature , vol.289 , pp. 366-373
    • Wilson, I.A.1    Skehel, J.J.2    Wiley, D.C.3
  • 15
    • 0023915219 scopus 로고
    • Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid
    • 15 Weis, W., Brown, J.H., Cusack, S., Paulson, J.C., Skehel, J.J., Wiley, D.C., Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid. Nature 333 (1988), 426–431.
    • (1988) Nature , vol.333 , pp. 426-431
    • Weis, W.1    Brown, J.H.2    Cusack, S.3    Paulson, J.C.4    Skehel, J.J.5    Wiley, D.C.6
  • 17
    • 0028023726 scopus 로고
    • Structure of influenza haemagglutinin at the pH of membrane fusion
    • 17 Bullough, P.A., Hughson, F.M., Skehel, J.J., Wiley, D.C., Structure of influenza haemagglutinin at the pH of membrane fusion. Nature 371 (1994), 37–43.
    • (1994) Nature , vol.371 , pp. 37-43
    • Bullough, P.A.1    Hughson, F.M.2    Skehel, J.J.3    Wiley, D.C.4
  • 18
    • 0013979301 scopus 로고
    • Functional significance of sialidose during influenza virus multiplication
    • 18 Seto, J.T., Rott, R., Functional significance of sialidose during influenza virus multiplication. Virology 30 (1966), 731–737.
    • (1966) Virology , vol.30 , pp. 731-737
    • Seto, J.T.1    Rott, R.2
  • 19
    • 84863541193 scopus 로고    scopus 로고
    • Contribution of antibody production against neuraminidase to the protection afforded by influenza vaccines
    • 19 Marcelin, G., Sandbulte, M.R., Webby, R.J., Contribution of antibody production against neuraminidase to the protection afforded by influenza vaccines. Rev Med Virol 22 (2012), 267–279.
    • (2012) Rev Med Virol , vol.22 , pp. 267-279
    • Marcelin, G.1    Sandbulte, M.R.2    Webby, R.J.3
  • 20
    • 77956116079 scopus 로고    scopus 로고
    • Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assays
    • 20 Nguyen, H.T., Sheu, T.G., Mishin, V.P., Klimov, A.I., Gubareva, L.V., Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assays. Antimicrob Agents Chemother 54 (2010), 3671–3677.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 3671-3677
    • Nguyen, H.T.1    Sheu, T.G.2    Mishin, V.P.3    Klimov, A.I.4    Gubareva, L.V.5
  • 22
    • 0019860749 scopus 로고
    • Sequence relationships among the hemagglutinin genes of 12 subtypes of influenza A virus
    • 22 Air, G.M., Sequence relationships among the hemagglutinin genes of 12 subtypes of influenza A virus. Proc Natl Acad Sci U S A 78 (1981), 7639–7643.
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 7639-7643
    • Air, G.M.1
  • 24
    • 84872831242 scopus 로고    scopus 로고
    • Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities
    • 24 Zhu, X., Yu, W., McBride, R., Li, Y., Chen, L.M., Donis, R.O., Tong, S., Paulson, J.C., Wilson, I.A., Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities. Proc Natl Acad Sci U S A 110 (2013), 1458–1463.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 1458-1463
    • Zhu, X.1    Yu, W.2    McBride, R.3    Li, Y.4    Chen, L.M.5    Donis, R.O.6    Tong, S.7    Paulson, J.C.8    Wilson, I.A.9
  • 26
    • 0025359798 scopus 로고
    • Cocirculation of two distinct evolutionary lineages of influenza type B virus since 1983
    • 26 Rota, P.A., Wallis, T.R., Harmon, M.W., Rota, J.S., Kendal, A.P., Nerome, K., Cocirculation of two distinct evolutionary lineages of influenza type B virus since 1983. Virology 175 (1990), 59–68.
    • (1990) Virology , vol.175 , pp. 59-68
    • Rota, P.A.1    Wallis, T.R.2    Harmon, M.W.3    Rota, J.S.4    Kendal, A.P.5    Nerome, K.6
  • 27
    • 82455181387 scopus 로고    scopus 로고
    • Targeting B cell responses in universal influenza vaccine design
    • 27 Kaur, K., Sullivan, M., Wilson, P.C., Targeting B cell responses in universal influenza vaccine design. Trends Immunol 32 (2011), 524–531.
    • (2011) Trends Immunol , vol.32 , pp. 524-531
    • Kaur, K.1    Sullivan, M.2    Wilson, P.C.3
  • 33
    • 84872026547 scopus 로고    scopus 로고
    • Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses
    • 33 Tsibane, T., Ekiert, D.C., Krause, J.C., Martinez, O., Crowe, J.E. Jr., Wilson, I.A., Basler, C.F., Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses. PLoS Pathog, 8, 2012, e1003067.
    • (2012) PLoS Pathog , vol.8 , pp. e1003067
    • Tsibane, T.1    Ekiert, D.C.2    Krause, J.C.3    Martinez, O.4    Crowe, J.E.5    Wilson, I.A.6    Basler, C.F.7
  • 37
    • 84867641531 scopus 로고    scopus 로고
    • Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity
    • 37 Lee, P.S., Yoshida, R., Ekiert, D.C., Sakai, N., Suzuki, Y., Takada, A., Wilson, I.A., Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity. Proc Natl Acad Sci U S A 109 (2012), 17040–17045.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 17040-17045
    • Lee, P.S.1    Yoshida, R.2    Ekiert, D.C.3    Sakai, N.4    Suzuki, Y.5    Takada, A.6    Wilson, I.A.7
  • 39
    • 63449125762 scopus 로고    scopus 로고
    • Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses
    • 39 Yoshida, R., Igarashi, M., Ozaki, H., Kishida, N., Tomabechi, D., Kida, H., Ito, K., Takada, A., Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses. PLoS Pathog, 5, 2009, e1000350.
    • (2009) PLoS Pathog , vol.5 , pp. e1000350
    • Yoshida, R.1    Igarashi, M.2    Ozaki, H.3    Kishida, N.4    Tomabechi, D.5    Kida, H.6    Ito, K.7    Takada, A.8
  • 40
    • 80053474133 scopus 로고    scopus 로고
    • A broadly neutralizing human monoclonal antibody that recognizes a conserved, novel epitope on the globular head of the influenza H1N1 virus hemagglutinin
    • 40 Krause, J.C., Tsibane, T., Tumpey, T.M., Huffman, C.J., Basler, C.F., Crowe, J.E. Jr., A broadly neutralizing human monoclonal antibody that recognizes a conserved, novel epitope on the globular head of the influenza H1N1 virus hemagglutinin. J Virol 85 (2011), 10905–10908.
    • (2011) J Virol , vol.85 , pp. 10905-10908
    • Krause, J.C.1    Tsibane, T.2    Tumpey, T.M.3    Huffman, C.J.4    Basler, C.F.5    Crowe, J.E.6
  • 41
    • 84875186505 scopus 로고    scopus 로고
    • A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin
    • 41 Xu, R., Krause, J.C., McBride, R., Paulson, J.C., Crowe, J.E. Jr., Wilson, I.A., A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin. Nat Struct Mol Biol 20 (2013), 363–370.
    • (2013) Nat Struct Mol Biol , vol.20 , pp. 363-370
    • Xu, R.1    Krause, J.C.2    McBride, R.3    Paulson, J.C.4    Crowe, J.E.5    Wilson, I.A.6
  • 42
    • 84930083052 scopus 로고    scopus 로고
    • Viral receptor-binding site antibodies with diverse germline origins
    • Schmidt et al., identify the signature motif for the receptor-binding site-specific antibodies.
    • 42•• Schmidt, A.G., Therkelsen, M.D., Stewart, S., Kepler, T.B., Liao, H.X., Moody, M.A., Haynes, B.F., Harrison, S.C., Viral receptor-binding site antibodies with diverse germline origins. Cell 161 (2015), 1026–1034 Schmidt et al., identify the signature motif for the receptor-binding site-specific antibodies.
    • (2015) Cell , vol.161 , pp. 1026-1034
    • Schmidt, A.G.1    Therkelsen, M.D.2    Stewart, S.3    Kepler, T.B.4    Liao, H.X.5    Moody, M.A.6    Haynes, B.F.7    Harrison, S.C.8
  • 45
    • 84924034216 scopus 로고    scopus 로고
    • Preexisting human antibodies neutralize recently emerged H7N9 influenza strains
    • The authors show that preexisting cross-reactive immunity offers protection against novel emerging influenza strains.
    • 45• Henry Dunand, C.J., Leon, P.E., Kaur, K., Tan, G.S., Zheng, N.Y., Andrews, S., Huang, M., Qu, X., Huang, Y., Salgado-Ferrer, M., et al. Preexisting human antibodies neutralize recently emerged H7N9 influenza strains. J Clin Invest 125 (2015), 1255–1268 The authors show that preexisting cross-reactive immunity offers protection against novel emerging influenza strains.
    • (2015) J Clin Invest , vol.125 , pp. 1255-1268
    • Henry Dunand, C.J.1    Leon, P.E.2    Kaur, K.3    Tan, G.S.4    Zheng, N.Y.5    Andrews, S.6    Huang, M.7    Qu, X.8    Huang, Y.9    Salgado-Ferrer, M.10
  • 49
    • 77649242815 scopus 로고    scopus 로고
    • Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins
    • 49 Wang, T.T., Tan, G.S., Hai, R., Pica, N., Petersen, E., Moran, T.M., Palese, P., Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins. PLoS Pathog, 6, 2010, e1000796.
    • (2010) PLoS Pathog , vol.6 , pp. e1000796
    • Wang, T.T.1    Tan, G.S.2    Hai, R.3    Pica, N.4    Petersen, E.5    Moran, T.M.6    Palese, P.7
  • 51
    • 84973488141 scopus 로고    scopus 로고
    • Neutralizing and non-neutralizing human H7N9 influenza vaccine-induced monoclonal antibodies offer protection in vivo
    • PMID: 27081859, in press This paper identifies protective non-neutralizing antibodies from vaccinated individuals. These antibodies target conserved epitopes on the HA protein and rely on Fc-FcγR interactions to mediate protection.
    • 51•• Henry Dunand, C.J., Leon, P.E., Huang, M., Choi, A., Chromikova, V., Ho, I.Y., Tan, G.S., Cruz, J., Hirsh, A., Zheng, N.Y., et al. Neutralizing and non-neutralizing human H7N9 influenza vaccine-induced monoclonal antibodies offer protection in vivo. Cell Host Microbe, 2016 PMID: 27081859, in press This paper identifies protective non-neutralizing antibodies from vaccinated individuals. These antibodies target conserved epitopes on the HA protein and rely on Fc-FcγR interactions to mediate protection.
    • (2016) Cell Host Microbe
    • Henry Dunand, C.J.1    Leon, P.E.2    Huang, M.3    Choi, A.4    Chromikova, V.5    Ho, I.Y.6    Tan, G.S.7    Cruz, J.8    Hirsh, A.9    Zheng, N.Y.10
  • 52
    • 84964864966 scopus 로고    scopus 로고
    • Broadly-reactive neutralizing and non-neutralizing antibodies directed against 2 the H7 influenza virus hemagglutinin reveal divergent mechanisms of protection
    • In press Tan et al., identify protective non-neutralizing antibodies in mice following H7 HA immunization that bind at the interface between the head and the stalk domain.
    • 52• Tan, G.S., Leon, P.E., Albrecht, R.A., Margine, I., Hirsh, A., Bahl, J., Krammer, F., Broadly-reactive neutralizing and non-neutralizing antibodies directed against 2 the H7 influenza virus hemagglutinin reveal divergent mechanisms of protection. PLoS Pathog, 2016 In press Tan et al., identify protective non-neutralizing antibodies in mice following H7 HA immunization that bind at the interface between the head and the stalk domain.
    • (2016) PLoS Pathog
    • Tan, G.S.1    Leon, P.E.2    Albrecht, R.A.3    Margine, I.4    Hirsh, A.5    Bahl, J.6    Krammer, F.7
  • 54
    • 84943394845 scopus 로고    scopus 로고
    • High antibody-dependent cellular cytotoxicity antibody titers to H5N1 and H7N9 avian influenza A viruses in healthy US adults and older children
    • 54 Terajima, M., Co, M.D., Cruz, J., Ennis, F.A., High antibody-dependent cellular cytotoxicity antibody titers to H5N1 and H7N9 avian influenza A viruses in healthy US adults and older children. J Infect Dis 212 (2015), 1052–1060.
    • (2015) J Infect Dis , vol.212 , pp. 1052-1060
    • Terajima, M.1    Co, M.D.2    Cruz, J.3    Ennis, F.A.4
  • 55
    • 84906670725 scopus 로고    scopus 로고
    • An H7N1 influenza virus vaccine induces broadly reactive antibody responses against H7N9 in humans
    • 55 Krammer, F., Jul-Larsen, A., Margine, I., Hirsh, A., Sjursen, H., Zambon, M., Cox, R.J., An H7N1 influenza virus vaccine induces broadly reactive antibody responses against H7N9 in humans. Clin Vaccine Immunol 21 (2014), 1153–1163.
    • (2014) Clin Vaccine Immunol , vol.21 , pp. 1153-1163
    • Krammer, F.1    Jul-Larsen, A.2    Margine, I.3    Hirsh, A.4    Sjursen, H.5    Zambon, M.6    Cox, R.J.7
  • 56
    • 80054780343 scopus 로고    scopus 로고
    • H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination
    • 56 Moody, M.A., Zhang, R., Walter, E.B., Woods, C.W., Ginsburg, G.S., McClain, M.T., Denny, T.N., Chen, X., Munshaw, S., Marshall, D.J., et al. H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination. PLoS One, 6, 2011, e25797.
    • (2011) PLoS One , vol.6 , pp. e25797
    • Moody, M.A.1    Zhang, R.2    Walter, E.B.3    Woods, C.W.4    Ginsburg, G.S.5    McClain, M.T.6    Denny, T.N.7    Chen, X.8    Munshaw, S.9    Marshall, D.J.10
  • 59
    • 84872924387 scopus 로고    scopus 로고
    • 1976 and 2009 H1N1 influenza virus vaccines boost anti-hemagglutinin stalk antibodies in humans
    • 59 Miller, M.S., Tsibane, T., Krammer, F., Hai, R., Rahmat, S., Basler, C.F., Palese, P., 1976 and 2009 H1N1 influenza virus vaccines boost anti-hemagglutinin stalk antibodies in humans. J Infect Dis 207 (2013), 98–105.
    • (2013) J Infect Dis , vol.207 , pp. 98-105
    • Miller, M.S.1    Tsibane, T.2    Krammer, F.3    Hai, R.4    Rahmat, S.5    Basler, C.F.6    Palese, P.7
  • 65
    • 0023244108 scopus 로고
    • Immunologic response to the influenza virus neuraminidase is influenced by prior experience with the associated viral hemagglutinin. I. Studies in human vaccines
    • 65 Kilbourne, E.D., Cerini, C.P., Khan, M.W., Mitchell, J.W. Jr., Ogra, P.L., Immunologic response to the influenza virus neuraminidase is influenced by prior experience with the associated viral hemagglutinin. I. Studies in human vaccines. J Immunol 138 (1987), 3010–3013.
    • (1987) J Immunol , vol.138 , pp. 3010-3013
    • Kilbourne, E.D.1    Cerini, C.P.2    Khan, M.W.3    Mitchell, J.W.4    Ogra, P.L.5
  • 66
    • 80455168614 scopus 로고    scopus 로고
    • Why do influenza virus subtypes die out?. A hypothesis
    • 66 Palese, P., Wang, T.T., Why do influenza virus subtypes die out?. A hypothesis. MBio, 2011, 2.
    • (2011) MBio , pp. 2
    • Palese, P.1    Wang, T.T.2
  • 67
    • 84863115945 scopus 로고    scopus 로고
    • Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses
    • 67 Pica, N., Hai, R., Krammer, F., Wang, T.T., Maamary, J., Eggink, D., Tan, G.S., Krause, J.C., Moran, T., Stein, C.R., et al. Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses. Proc Natl Acad Sci U S A 109 (2012), 2573–2578.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 2573-2578
    • Pica, N.1    Hai, R.2    Krammer, F.3    Wang, T.T.4    Maamary, J.5    Eggink, D.6    Tan, G.S.7    Krause, J.C.8    Moran, T.9    Stein, C.R.10
  • 68
    • 84862026523 scopus 로고    scopus 로고
    • Adaptive pathways of zoonotic influenza viruses: from exposure to establishment in humans
    • Ellebedy et al., report that antibodies and memory B cells directed against the HA stalk domain are prevalent in humans and that H5N1 vaccination induces broadly-reactive stalk antibodies.
    • 68• Reperant, L.A., Kuiken, T., Osterhaus, A.D., Adaptive pathways of zoonotic influenza viruses: from exposure to establishment in humans. Vaccine 30 (2012), 4419–4434 Ellebedy et al., report that antibodies and memory B cells directed against the HA stalk domain are prevalent in humans and that H5N1 vaccination induces broadly-reactive stalk antibodies.
    • (2012) Vaccine , vol.30 , pp. 4419-4434
    • Reperant, L.A.1    Kuiken, T.2    Osterhaus, A.D.3
  • 69
    • 84954245342 scopus 로고    scopus 로고
    • Immune history profoundly affects broadly protective B cell responses to influenza
    • The study shows that preexisting head antibodies are immunodominant, preventing clear access to the stalk and that stalk-reactive antibodies are couterselected due to polyreactivity.
    • 69•• Andrews, S.F., Huang, Y., Kaur, K., Popova, L.I., Ho, I.Y., Pauli, N.T., Henry Dunand, C.J., Taylor, W.M., Lim, S., Huang, M., et al. Immune history profoundly affects broadly protective B cell responses to influenza. Sci Transl Med, 7, 2015, 316ra192 The study shows that preexisting head antibodies are immunodominant, preventing clear access to the stalk and that stalk-reactive antibodies are couterselected due to polyreactivity.
    • (2015) Sci Transl Med , vol.7 , pp. 316ra192
    • Andrews, S.F.1    Huang, Y.2    Kaur, K.3    Popova, L.I.4    Ho, I.Y.5    Pauli, N.T.6    Henry Dunand, C.J.7    Taylor, W.M.8    Lim, S.9    Huang, M.10
  • 70
    • 84937527515 scopus 로고    scopus 로고
    • High-affinity H7 head and stalk domain-specific antibody responses to an inactivated influenza H7N7 vaccine after priming with live attenuated influenza vaccine
    • 70 Halliley, J.L., Khurana, S., Krammer, F., Fitzgerald, T., Coyle, E.M., Chung, K.Y., Baker, S.F., Yang, H., Martinez-Sobrido, L., Treanor, J.J., et al. High-affinity H7 head and stalk domain-specific antibody responses to an inactivated influenza H7N7 vaccine after priming with live attenuated influenza vaccine. J Infect Dis 212 (2015), 1270–1278.
    • (2015) J Infect Dis , vol.212 , pp. 1270-1278
    • Halliley, J.L.1    Khurana, S.2    Krammer, F.3    Fitzgerald, T.4    Coyle, E.M.5    Chung, K.Y.6    Baker, S.F.7    Yang, H.8    Martinez-Sobrido, L.9    Treanor, J.J.10
  • 71
    • 84960155923 scopus 로고    scopus 로고
    • Age dependence and isotype specificity of influenza virus hemagglutinin stalk-reactive antibodies in humans
    • 71 Nachbagauer, R., Choi, A., Izikson, R., Cox, M.M., Palese, P., Krammer, F., Age dependence and isotype specificity of influenza virus hemagglutinin stalk-reactive antibodies in humans. MBio, 2016, 7.
    • (2016) MBio , pp. 7
    • Nachbagauer, R.1    Choi, A.2    Izikson, R.3    Cox, M.M.4    Palese, P.5    Krammer, F.6
  • 73
    • 84883856356 scopus 로고    scopus 로고
    • Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis
    • 73 Miller, M.S., Gardner, T.J., Krammer, F., Aguado, L.C., Tortorella, D., Basler, C.F., Palese, P., Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis. Sci Transl Med, 5, 2013, 198ra107.
    • (2013) Sci Transl Med , vol.5 , pp. 198ra107
    • Miller, M.S.1    Gardner, T.J.2    Krammer, F.3    Aguado, L.C.4    Tortorella, D.5    Basler, C.F.6    Palese, P.7
  • 74
    • 0020626189 scopus 로고
    • Preparation of influenza virus subviral particles lacking the HA1 subunit of hemagglutinin: unmasking of cross-reactive HA2 determinants
    • 74 Graves, P.N., Schulman, J.L., Young, J.F., Palese, P., Preparation of influenza virus subviral particles lacking the HA1 subunit of hemagglutinin: unmasking of cross-reactive HA2 determinants. Virology 126 (1983), 106–116.
    • (1983) Virology , vol.126 , pp. 106-116
    • Graves, P.N.1    Schulman, J.L.2    Young, J.F.3    Palese, P.4
  • 77
    • 84937696301 scopus 로고    scopus 로고
    • Restricted, canonical, stereotyped and convergent immunoglobulin responses
    • 77 Henry Dunand, C.J., Wilson, P.C., Restricted, canonical, stereotyped and convergent immunoglobulin responses. Philos Trans R Soc Lond B Biol Sci, 2015, 370.
    • (2015) Philos Trans R Soc Lond B Biol Sci , pp. 370
    • Henry Dunand, C.J.1    Wilson, P.C.2
  • 78
    • 84901687604 scopus 로고    scopus 로고
    • Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses
    • The authors identify the key residues used by VH1–69 stalk-reactive antibodies.
    • 78•• Avnir, Y., Tallarico, A.S., Zhu, Q., Bennett, A.S., Connelly, G., Sheehan, J., Sui, J., Fahmy, A., Huang, C.Y., Cadwell, G., et al. Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses. PLoS Pathog, 10, 2014, e1004103 The authors identify the key residues used by VH1–69 stalk-reactive antibodies.
    • (2014) PLoS Pathog , vol.10 , pp. e1004103
    • Avnir, Y.1    Tallarico, A.S.2    Zhu, Q.3    Bennett, A.S.4    Connelly, G.5    Sheehan, J.6    Sui, J.7    Fahmy, A.8    Huang, C.Y.9    Cadwell, G.10
  • 79
    • 84896917279 scopus 로고    scopus 로고
    • Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages
    • 79 Whittle, J.R., Wheatley, A.K., Wu, L., Lingwood, D., Kanekiyo, M., Ma, S.S., Narpala, S.R., Yassine, H.M., Frank, G.M., Yewdell, J.W., et al. Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages. J Virol 88 (2014), 4047–4057.
    • (2014) J Virol , vol.88 , pp. 4047-4057
    • Whittle, J.R.1    Wheatley, A.K.2    Wu, L.3    Lingwood, D.4    Kanekiyo, M.5    Ma, S.S.6    Narpala, S.R.7    Yassine, H.M.8    Frank, G.M.9    Yewdell, J.W.10
  • 83
    • 84885953445 scopus 로고    scopus 로고
    • Influenza virus hemagglutinin stalk-based antibodies and vaccines
    • 83 Krammer, F., Palese, P., Influenza virus hemagglutinin stalk-based antibodies and vaccines. Curr Opin Virol 3 (2013), 521–530.
    • (2013) Curr Opin Virol , vol.3 , pp. 521-530
    • Krammer, F.1    Palese, P.2
  • 84
    • 84878611784 scopus 로고    scopus 로고
    • Chimeric hemagglutinin influenza virus vaccine constructs elicit broadly protective stalk-specific antibodies
    • 84 Krammer, F., Pica, N., Hai, R., Margine, I., Palese, P., Chimeric hemagglutinin influenza virus vaccine constructs elicit broadly protective stalk-specific antibodies. J Virol 87 (2013), 6542–6550.
    • (2013) J Virol , vol.87 , pp. 6542-6550
    • Krammer, F.1    Pica, N.2    Hai, R.3    Margine, I.4    Palese, P.5
  • 86
    • 84909641121 scopus 로고    scopus 로고
    • Live attenuated H7N7 influenza vaccine primes for a vigorous antibody response to inactivated H7N7 influenza vaccine
    • 86 Babu, T.M., Levine, M., Fitzgerald, T., Luke, C., Sangster, M.Y., Jin, H., Topham, D., Katz, J., Treanor, J., Subbarao, K., Live attenuated H7N7 influenza vaccine primes for a vigorous antibody response to inactivated H7N7 influenza vaccine. Vaccine 32 (2014), 6798–6804.
    • (2014) Vaccine , vol.32 , pp. 6798-6804
    • Babu, T.M.1    Levine, M.2    Fitzgerald, T.3    Luke, C.4    Sangster, M.Y.5    Jin, H.6    Topham, D.7    Katz, J.8    Treanor, J.9    Subbarao, K.10
  • 87
    • 84890554900 scopus 로고    scopus 로고
    • Adjuvants and immunization strategies to induce influenza virus hemagglutinin stalk antibodies
    • 87 Goff, P.H., Eggink, D., Seibert, C.W., Hai, R., Martinez-Gil, L., Krammer, F., Palese, P., Adjuvants and immunization strategies to induce influenza virus hemagglutinin stalk antibodies. PLoS One, 8, 2013, e79194.
    • (2013) PLoS One , vol.8 , pp. e79194
    • Goff, P.H.1    Eggink, D.2    Seibert, C.W.3    Hai, R.4    Martinez-Gil, L.5    Krammer, F.6    Palese, P.7
  • 88
    • 84959349464 scopus 로고    scopus 로고
    • Novel universal influenza virus vaccine approaches
    • 88 Krammer, F., Novel universal influenza virus vaccine approaches. Curr Opin Virol 17 (2016), 95–103.
    • (2016) Curr Opin Virol , vol.17 , pp. 95-103
    • Krammer, F.1
  • 89
    • 84965127880 scopus 로고    scopus 로고
    • Cryo-electron microscopy structures of chimeric hemagglutinin displayed on a universal influenza vaccine candidate
    • This paper reports the first three-dimensional (3D) visualization of chimeric hemagglutinin proteins displayed on the surface of the influenza virus, in the context of a candidate universal influenza vaccine.
    • 89•• Tran, E.E., Podolsky, K.A., Bartesaghi, A., Kuybeda, O., Grandinetti, G., Wohlbold, T.J., Tan, G.S., Nachbagauer, R., Palese, P., Krammer, F., et al. Cryo-electron microscopy structures of chimeric hemagglutinin displayed on a universal influenza vaccine candidate. MBio, 2016, 7 This paper reports the first three-dimensional (3D) visualization of chimeric hemagglutinin proteins displayed on the surface of the influenza virus, in the context of a candidate universal influenza vaccine.
    • (2016) MBio , pp. 7
    • Tran, E.E.1    Podolsky, K.A.2    Bartesaghi, A.3    Kuybeda, O.4    Grandinetti, G.5    Wohlbold, T.J.6    Tan, G.S.7    Nachbagauer, R.8    Palese, P.9    Krammer, F.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.