메뉴 건너뛰기




Volumn 111, Issue , 2016, Pages 610-618

Intra-cellular immunosuppressive drugs monitoring: A step forward towards better therapeutic efficacy after organ transplantation?

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; EVEROLIMUS; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID; RAPAMYCIN; TACROLIMUS; CALCINEURIN INHIBITOR; TARGET OF RAPAMYCIN KINASE;

EID: 84979695833     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2016.07.027     Document Type: Review
Times cited : (50)

References (68)
  • 3
    • 0036208713 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of immunosuppressant drugs in clinical practice
    • (discussion 329)
    • [3] Kahan, B.D., Keown, P., Levy, G.A., Johnston, A., Therapeutic drug monitoring of immunosuppressant drugs in clinical practice. Clin. Ther. 24 (2002), 330–350 (discussion 329).
    • (2002) Clin. Ther. , vol.24 , pp. 330-350
    • Kahan, B.D.1    Keown, P.2    Levy, G.A.3    Johnston, A.4
  • 4
    • 10044246181 scopus 로고    scopus 로고
    • Therapeutic drug monitoring for everolimus in heart transplant recipients based on exposure-effect modeling
    • [4] Starling, R.C., Hare, J.M., Hauptman, P., McCurry, K.R., Mayer, H.W., Kovarik, J.M., Schmidli, H., Therapeutic drug monitoring for everolimus in heart transplant recipients based on exposure-effect modeling. Am. J. Transplant. 4 (2004), 2126–2131.
    • (2004) Am. J. Transplant. , vol.4 , pp. 2126-2131
    • Starling, R.C.1    Hare, J.M.2    Hauptman, P.3    McCurry, K.R.4    Mayer, H.W.5    Kovarik, J.M.6    Schmidli, H.7
  • 5
    • 34548812349 scopus 로고    scopus 로고
    • Therapeutic monitoring of calcineurin inhibitors for the nephrologist
    • [5] Schiff, J., Cole, E., Cantarovich, M., Therapeutic monitoring of calcineurin inhibitors for the nephrologist. Clin. J. Am. Soc. Nephrol. 2 (2007), 374–384.
    • (2007) Clin. J. Am. Soc. Nephrol. , vol.2 , pp. 374-384
    • Schiff, J.1    Cole, E.2    Cantarovich, M.3
  • 7
    • 84944441861 scopus 로고    scopus 로고
    • Sirolimus and everolimus in kidney transplantation
    • [7] Moes, D.J., Guchelaar, H.J., de Fijter, J.W., Sirolimus and everolimus in kidney transplantation. Drug Discov. Today 20 (2015), 1243–1249.
    • (2015) Drug Discov. Today , vol.20 , pp. 1243-1249
    • Moes, D.J.1    Guchelaar, H.J.2    de Fijter, J.W.3
  • 8
  • 9
    • 42049122605 scopus 로고    scopus 로고
    • Role of pharmacogenetics of immunosuppressive drugs in organ transplantation
    • [9] Thervet, E., Anglicheau, D., Legendre, C., Beaune, P., Role of pharmacogenetics of immunosuppressive drugs in organ transplantation. Ther. Drug Monit. 30 (2008), 143–150.
    • (2008) Ther. Drug Monit. , vol.30 , pp. 143-150
    • Thervet, E.1    Anglicheau, D.2    Legendre, C.3    Beaune, P.4
  • 10
    • 79959450420 scopus 로고    scopus 로고
    • Pharmacogenetics and individualized therapy in children: immunosuppressants, antidepressants, anticancer and anti-inflammatory drugs
    • [10] Elie, V., de Beaumais, T., Fakhoury, M., Jacqz-Aigrain, E., Pharmacogenetics and individualized therapy in children: immunosuppressants, antidepressants, anticancer and anti-inflammatory drugs. Pharmacogenomics 12 (2011), 827–843.
    • (2011) Pharmacogenomics , vol.12 , pp. 827-843
    • Elie, V.1    de Beaumais, T.2    Fakhoury, M.3    Jacqz-Aigrain, E.4
  • 12
    • 84876049583 scopus 로고    scopus 로고
    • Statistical tools for dose individualization of mycophenolic acid and tacrolimus co-administered during the first month after renal transplantation
    • [12] Musuamba, F.T., Mourad, M., Haufroid, V., De Meyer, M., Capron, A., Delattre, I.K., Verbeeck, R.K., Wallemacq, P., Statistical tools for dose individualization of mycophenolic acid and tacrolimus co-administered during the first month after renal transplantation. Br. J. Clin. Pharmacol. 75 (2013), 1277–1288.
    • (2013) Br. J. Clin. Pharmacol. , vol.75 , pp. 1277-1288
    • Musuamba, F.T.1    Mourad, M.2    Haufroid, V.3    De Meyer, M.4    Capron, A.5    Delattre, I.K.6    Verbeeck, R.K.7    Wallemacq, P.8
  • 13
    • 84900330189 scopus 로고    scopus 로고
    • Determination of the most influential sources of variability in tacrolimus trough blood concentrations in adult liver transplant recipients: a bottom-up approach
    • [13] Gerard, C., Stocco, J., Hulin, A., Blanchet, B., Verstuyft, C., Durand, F., Conti, F., Duvoux, C., Tod, M., Determination of the most influential sources of variability in tacrolimus trough blood concentrations in adult liver transplant recipients: a bottom-up approach. AAPS J. 16 (2014), 379–391.
    • (2014) AAPS J. , vol.16 , pp. 379-391
    • Gerard, C.1    Stocco, J.2    Hulin, A.3    Blanchet, B.4    Verstuyft, C.5    Durand, F.6    Conti, F.7    Duvoux, C.8    Tod, M.9
  • 15
    • 0036538694 scopus 로고    scopus 로고
    • Determination of p-gp and mrp1 expression and function in peripheral blood mononuclear cells in vivo
    • [15] Meaden, E.R., Hoggard, P.G., Khoo, S.H., Back, D.J., Determination of p-gp and mrp1 expression and function in peripheral blood mononuclear cells in vivo. J. Immunol. Methods 262 (2002), 159–165.
    • (2002) J. Immunol. Methods , vol.262 , pp. 159-165
    • Meaden, E.R.1    Hoggard, P.G.2    Khoo, S.H.3    Back, D.J.4
  • 16
    • 33749267293 scopus 로고    scopus 로고
    • Role of pharmacogenetics of atp-binding cassette transporters in the pharmacokinetics of drugs
    • [16] Cascorbi, I., Role of pharmacogenetics of atp-binding cassette transporters in the pharmacokinetics of drugs. Pharmacol. Ther. 112 (2006), 457–473.
    • (2006) Pharmacol. Ther. , vol.112 , pp. 457-473
    • Cascorbi, I.1
  • 17
    • 34249058785 scopus 로고    scopus 로고
    • Abcb1 genotype and pgp expression, function and therapeutic drug response: a critical review and recommendations for future research
    • [17] Leschziner, G.D., Andrew, T., Pirmohamed, M., Johnson, M.R., Abcb1 genotype and pgp expression, function and therapeutic drug response: a critical review and recommendations for future research. Pharmacogenomics J. 7 (2007), 154–179.
    • (2007) Pharmacogenomics J. , vol.7 , pp. 154-179
    • Leschziner, G.D.1    Andrew, T.2    Pirmohamed, M.3    Johnson, M.R.4
  • 19
    • 0033556408 scopus 로고    scopus 로고
    • Horsmans Y. Cyp 3a proteins are expressed in human neutrophils and lymphocytes but are not induced by rifampicin
    • [19] Starkel, P., Sempoux, C., Van Den Berge, V., Stevens, M., De Saeger, C., Desager, J.P., Horsmans Y. Cyp 3a proteins are expressed in human neutrophils and lymphocytes but are not induced by rifampicin. Life Sci. 64 (1999), 643–653.
    • (1999) Life Sci. , vol.64 , pp. 643-653
    • Starkel, P.1    Sempoux, C.2    Van Den Berge, V.3    Stevens, M.4    De Saeger, C.5    Desager, J.P.6
  • 20
    • 79151476298 scopus 로고    scopus 로고
    • Lc-ms/ms for immunosuppressant therapeutic drug monitoring
    • [20] Sallustio, B.C., Lc-ms/ms for immunosuppressant therapeutic drug monitoring. Bioanalysis 2 (2010), 1141–1153.
    • (2010) Bioanalysis , vol.2 , pp. 1141-1153
    • Sallustio, B.C.1
  • 21
    • 78650903858 scopus 로고    scopus 로고
    • The current role of liquid chromatography-tandem mass spectrometry in therapeutic drug monitoring of immunosuppressant and antiretroviral drugs
    • [21] Taylor, P.J., Tai, C.H., Franklin, M.E., Pillans, P.I., The current role of liquid chromatography-tandem mass spectrometry in therapeutic drug monitoring of immunosuppressant and antiretroviral drugs. Clin. Biochem. 44 (2011), 14–20.
    • (2011) Clin. Biochem. , vol.44 , pp. 14-20
    • Taylor, P.J.1    Tai, C.H.2    Franklin, M.E.3    Pillans, P.I.4
  • 23
    • 84884780217 scopus 로고    scopus 로고
    • Opportunity to monitor immunosuppressive drugs in peripheral blood mononuclear cells: where are we and where are we going
    • [23] Lemaitre, F., Antignac, M., Verdier, M.C., Bellissant, E., Fernandez, C., Opportunity to monitor immunosuppressive drugs in peripheral blood mononuclear cells: where are we and where are we going. Pharmacol. Res. 74 (2013), 109–112.
    • (2013) Pharmacol. Res. , vol.74 , pp. 109-112
    • Lemaitre, F.1    Antignac, M.2    Verdier, M.C.3    Bellissant, E.4    Fernandez, C.5
  • 24
    • 0028813323 scopus 로고
    • Early cellular rejection after orthotopic liver transplantation correlates with low concentrations of fk506 in hepatic tissue
    • [24] Sandborn, W.J., Lawson, G.M., Cody, T.J., Porayko, M.K., Hay, J.E., Gores, G.J., Steers, J.L., Krom, R.A., Wiesner, R.H., Early cellular rejection after orthotopic liver transplantation correlates with low concentrations of fk506 in hepatic tissue. Hepatology 21 (1995), 70–76.
    • (1995) Hepatology , vol.21 , pp. 70-76
    • Sandborn, W.J.1    Lawson, G.M.2    Cody, T.J.3    Porayko, M.K.4    Hay, J.E.5    Gores, G.J.6    Steers, J.L.7    Krom, R.A.8    Wiesner, R.H.9
  • 25
    • 34447515202 scopus 로고    scopus 로고
    • Validation of a liquid chromatography-mass spectrometric assay for tacrolimus in liver biopsies after hepatic transplantation: correlation with histopathologic staging of rejection
    • [25] Capron, A., Lerut, J., Verbaandert, C., Mathys, J., Ciccarelli, O., Vanbinst, R., Roggen, F., De Reyck, C., Lemaire, J., Wallemacq, P.E., Validation of a liquid chromatography-mass spectrometric assay for tacrolimus in liver biopsies after hepatic transplantation: correlation with histopathologic staging of rejection. Ther. Drug Monit. 29 (2007), 340–348.
    • (2007) Ther. Drug Monit. , vol.29 , pp. 340-348
    • Capron, A.1    Lerut, J.2    Verbaandert, C.3    Mathys, J.4    Ciccarelli, O.5    Vanbinst, R.6    Roggen, F.7    De Reyck, C.8    Lemaire, J.9    Wallemacq, P.E.10
  • 26
    • 34648857526 scopus 로고    scopus 로고
    • 1199 > a and 2677 > t/a polymorphisms of abcb1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation
    • [26] Elens, L., Capron, A., Kerckhove, V.V., Lerut, J., Mourad, M., Lison, D., Wallemacq, P., Haufroid, V., 1199 > a and 2677 > t/a polymorphisms of abcb1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation. Pharmacogenet. Genomics 17 (2007), 873–883.
    • (2007) Pharmacogenet. Genomics , vol.17 , pp. 873-883
    • Elens, L.1    Capron, A.2    Kerckhove, V.V.3    Lerut, J.4    Mourad, M.5    Lison, D.6    Wallemacq, P.7    Haufroid, V.8
  • 27
    • 84885018024 scopus 로고    scopus 로고
    • Validation of an lc-ms/ms method to measure tacrolimus in rat kidney and liver tissue and its application to human kidney biopsies
    • [27] Noll, B.D., Coller, J.K., Somogyi, A.A., Morris, R.G., Russ, G.R., Hesselink, D.A., Van Gelder, T., Sallustio, B.C., Validation of an lc-ms/ms method to measure tacrolimus in rat kidney and liver tissue and its application to human kidney biopsies. Ther. Drug Monit. 35 (2013), 617–623.
    • (2013) Ther. Drug Monit. , vol.35 , pp. 617-623
    • Noll, B.D.1    Coller, J.K.2    Somogyi, A.A.3    Morris, R.G.4    Russ, G.R.5    Hesselink, D.A.6    Van Gelder, T.7    Sallustio, B.C.8
  • 28
    • 0035724321 scopus 로고    scopus 로고
    • Validation of methods to study the distribution and protein binding of tacrolimus in human blood
    • [28] Zahir, H., Nand, R.A., Brown, K.F., Tattam, B.N., McLachlan, A.J., Validation of methods to study the distribution and protein binding of tacrolimus in human blood. J. Pharmacol. Toxicol. Methods 46 (2001), 27–35.
    • (2001) J. Pharmacol. Toxicol. Methods , vol.46 , pp. 27-35
    • Zahir, H.1    Nand, R.A.2    Brown, K.F.3    Tattam, B.N.4    McLachlan, A.J.5
  • 29
    • 4744361487 scopus 로고    scopus 로고
    • Changes in tacrolimus distribution in blood and plasma protein binding following liver transplantation
    • [29] Zahir, H., McCaughan, G., Gleeson, M., Nand, R.A., McLachlan, A.J., Changes in tacrolimus distribution in blood and plasma protein binding following liver transplantation. Ther. Drug Monit. 26 (2004), 506–515.
    • (2004) Ther. Drug Monit. , vol.26 , pp. 506-515
    • Zahir, H.1    McCaughan, G.2    Gleeson, M.3    Nand, R.A.4    McLachlan, A.J.5
  • 30
    • 1542329748 scopus 로고    scopus 로고
    • Factors affecting variability in distribution of tacrolimus in liver transplant recipients
    • [30] Zahir, H., McCaughan, G., Gleeson, M., Nand, R.A., McLachlan, A.J., Factors affecting variability in distribution of tacrolimus in liver transplant recipients. Br. J. Clin. Pharmacol. 57 (2004), 298–309.
    • (2004) Br. J. Clin. Pharmacol. , vol.57 , pp. 298-309
    • Zahir, H.1    McCaughan, G.2    Gleeson, M.3    Nand, R.A.4    McLachlan, A.J.5
  • 31
    • 38549174617 scopus 로고    scopus 로고
    • Tacrolimus lymphocyte vs blood trough level monitoring in de novo kidney transplant patients: clinical relevance
    • [31] Barbari, A., Masri, M., Stephan, A., Rizk, S., Khalil, L., Kamel, G., Tacrolimus lymphocyte vs blood trough level monitoring in de novo kidney transplant patients: clinical relevance. Exp. Clin. Transplant., 4, 2006, 58.
    • (2006) Exp. Clin. Transplant. , vol.4 , pp. 58
    • Barbari, A.1    Masri, M.2    Stephan, A.3    Rizk, S.4    Khalil, L.5    Kamel, G.6
  • 32
    • 38549105116 scopus 로고    scopus 로고
    • A novel approach in clinical immunosuppression monitoring: drug lymphocyte level
    • [32] Barbari, A., Masri, M., Stephan, A., Rizk, S., Younan, F., A novel approach in clinical immunosuppression monitoring: drug lymphocyte level. Exp. Clin. Transplant. 5 (2007), 643–648.
    • (2007) Exp. Clin. Transplant. , vol.5 , pp. 643-648
    • Barbari, A.1    Masri, M.2    Stephan, A.3    Rizk, S.4    Younan, F.5
  • 33
    • 65349136347 scopus 로고    scopus 로고
    • Validation of a liquid chromatography-mass spectrometric assay for tacrolimus in peripheral blood mononuclear cells
    • [33] Capron, A., Musuamba, F., Latinne, D., Mourad, M., Lerut, J., Haufroid, V., Wallemacq, P.E., Validation of a liquid chromatography-mass spectrometric assay for tacrolimus in peripheral blood mononuclear cells. Ther. Drug Monit. 31 (2009), 178–186.
    • (2009) Ther. Drug Monit. , vol.31 , pp. 178-186
    • Capron, A.1    Musuamba, F.2    Latinne, D.3    Mourad, M.4    Lerut, J.5    Haufroid, V.6    Wallemacq, P.E.7
  • 34
    • 77951608465 scopus 로고    scopus 로고
    • Cyp3a5 and abcb1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation
    • [34] Capron, A., Mourad, M., De Meyer, M., De Pauw, L., Eddour, D.C., Latinne, D., Elens, L., Haufroid, V., Wallemacq, P., Cyp3a5 and abcb1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation. Pharmacogenomics 11 (2010), 703–714.
    • (2010) Pharmacogenomics , vol.11 , pp. 703-714
    • Capron, A.1    Mourad, M.2    De Meyer, M.3    De Pauw, L.4    Eddour, D.C.5    Latinne, D.6    Elens, L.7    Haufroid, V.8    Wallemacq, P.9
  • 35
    • 84897983523 scopus 로고    scopus 로고
    • Abcb1 1199 genetic polymorphism (rs2229109) influences the intracellular accumulation of tacrolimus in hek293 and k562 recombinant cell lines
    • [35] Dessilly, G., Elens, L., Panin, N., Capron, A., Decottignies, A., Demoulin, J.B., Haufroid, V., Abcb1 1199 genetic polymorphism (rs2229109) influences the intracellular accumulation of tacrolimus in hek293 and k562 recombinant cell lines. PLoS One, 9, 2014, e 91555.
    • (2014) PLoS One , vol.9 , pp. 91555
    • Dessilly, G.1    Elens, L.2    Panin, N.3    Capron, A.4    Decottignies, A.5    Demoulin, J.B.6    Haufroid, V.7
  • 36
    • 83955165904 scopus 로고    scopus 로고
    • Correlation of tacrolimus levels in peripheral blood mononuclear cells with histological staging of rejection after liver transplantation: preliminary results of a prospective study
    • [36] Capron, A., Lerut, J., Latinne, D., Rahier, J., Haufroid, V., Wallemacq, P., Correlation of tacrolimus levels in peripheral blood mononuclear cells with histological staging of rejection after liver transplantation: preliminary results of a prospective study. Transpl. Int. 25 (2012), 41–47.
    • (2012) Transpl. Int. , vol.25 , pp. 41-47
    • Capron, A.1    Lerut, J.2    Latinne, D.3    Rahier, J.4    Haufroid, V.5    Wallemacq, P.6
  • 37
    • 84884352957 scopus 로고    scopus 로고
    • Monitoring of tacrolimus concentrations in peripheral blood mononuclear cells: application to cardiac transplant recipients
    • [37] Lemaitre, F., Antignac, M., Fernandez, C., Monitoring of tacrolimus concentrations in peripheral blood mononuclear cells: application to cardiac transplant recipients. Clin. Biochem. 46 (2013), 1538–1541.
    • (2013) Clin. Biochem. , vol.46 , pp. 1538-1541
    • Lemaitre, F.1    Antignac, M.2    Fernandez, C.3
  • 39
    • 84923039383 scopus 로고    scopus 로고
    • An uplc-ms/ms method coupled with automated on-line spe for quantification of tacrolimus in peripheral blood mononuclear cells
    • [39] Pensi, D., De Nicolo, A., Pinon, M., Calvo, P.L., Nonnato, A., Brunati, A., Di Perri, G., D'Avolio, A., An uplc-ms/ms method coupled with automated on-line spe for quantification of tacrolimus in peripheral blood mononuclear cells. J. Pharm. Biomed. Anal. 107 (2015), 512–517.
    • (2015) J. Pharm. Biomed. Anal. , vol.107 , pp. 512-517
    • Pensi, D.1    De Nicolo, A.2    Pinon, M.3    Calvo, P.L.4    Nonnato, A.5    Brunati, A.6    Di Perri, G.7    D'Avolio, A.8
  • 40
    • 0024587025 scopus 로고
    • Distribution of cyclosporin a metabolites among plasma and cells in whole blood: effect of temperature, hematocrit, and metabolite concentration
    • [40] Lensmeyer, G.L., Wiebe, D.A., Carlson, I.H., Distribution of cyclosporin a metabolites among plasma and cells in whole blood: effect of temperature, hematocrit, and metabolite concentration. Clin. Chem. 35 (1989), 56–63.
    • (1989) Clin. Chem. , vol.35 , pp. 56-63
    • Lensmeyer, G.L.1    Wiebe, D.A.2    Carlson, I.H.3
  • 41
    • 0027279807 scopus 로고
    • Erythrocyte uptake and protein binding of cyclosporin a (cya) in human blood: factors affecting cya concentration in erythrocytes
    • [41] Shibata, N., Shimakawa, H., Minouchi, T., Yamaji, A., Erythrocyte uptake and protein binding of cyclosporin a (cya) in human blood: factors affecting cya concentration in erythrocytes. Biol. Pharm. Bull. 16 (1993), 702–707.
    • (1993) Biol. Pharm. Bull. , vol.16 , pp. 702-707
    • Shibata, N.1    Shimakawa, H.2    Minouchi, T.3    Yamaji, A.4
  • 42
    • 0036054540 scopus 로고    scopus 로고
    • Distribution of cyclosporin in organ transplant recipients
    • [42] Akhlaghi, F., Trull, A.K., Distribution of cyclosporin in organ transplant recipients. Clin. Pharmacokinet. 41 (2002), 615–637.
    • (2002) Clin. Pharmacokinet. , vol.41 , pp. 615-637
    • Akhlaghi, F.1    Trull, A.K.2
  • 43
    • 0026697204 scopus 로고
    • Hepatic allograft cyclosporine concentration is independent of the route of cyclosporine administration and correlates with the occurrence of early cellular rejection
    • [43] Sandborn, W.J., Lawson, G.M., Krom, R.A., Wiesner, R.H., Hepatic allograft cyclosporine concentration is independent of the route of cyclosporine administration and correlates with the occurrence of early cellular rejection. Hepatology 15 (1992), 1086–1091.
    • (1992) Hepatology , vol.15 , pp. 1086-1091
    • Sandborn, W.J.1    Lawson, G.M.2    Krom, R.A.3    Wiesner, R.H.4
  • 44
  • 45
    • 0034908838 scopus 로고    scopus 로고
    • Cyclosporine lymphocyte versus whole blood pharmacokinetic monitoring: correlation with histological findings
    • [45] Barbari, A., Masri, M.A., Stephan, A., Mokhbat, J., Kilani, H., Rizk, S., Kamel, G., Joubran, N., Cyclosporine lymphocyte versus whole blood pharmacokinetic monitoring: correlation with histological findings. Transplant. Proc. 33 (2001), 2782–2785.
    • (2001) Transplant. Proc. , vol.33 , pp. 2782-2785
    • Barbari, A.1    Masri, M.A.2    Stephan, A.3    Mokhbat, J.4    Kilani, H.5    Rizk, S.6    Kamel, G.7    Joubran, N.8
  • 46
    • 0242637231 scopus 로고    scopus 로고
    • Cyclosporine lymphocyte level and lymphocyte count: new guidelines for tailoring immunosuppressive therapy
    • [46] Barbari, A., Stephan, A., Masri, M., Mourad, N., Kamel, G., Kilani, H., Karam, A., Daya, I.A., Cyclosporine lymphocyte level and lymphocyte count: new guidelines for tailoring immunosuppressive therapy. Transplant. Proc. 35 (2003), 2742–2744.
    • (2003) Transplant. Proc. , vol.35 , pp. 2742-2744
    • Barbari, A.1    Stephan, A.2    Masri, M.3    Mourad, N.4    Kamel, G.5    Kilani, H.6    Karam, A.7    Daya, I.A.8
  • 49
    • 37048998528 scopus 로고    scopus 로고
    • Cyclosporine monitoring in peripheral blood mononuclear cells: feasibility and interest: a prospective study on 20 renal transplant recipients
    • [49] Lepage, J.M., Lelong-Boulouard, V., Lecouf, A., Debruyne, D., Hurault de Ligny, B., Coquerel, A., Cyclosporine monitoring in peripheral blood mononuclear cells: feasibility and interest: a prospective study on 20 renal transplant recipients. Transplant. Proc. 39 (2007), 3109–3110.
    • (2007) Transplant. Proc. , vol.39 , pp. 3109-3110
    • Lepage, J.M.1    Lelong-Boulouard, V.2    Lecouf, A.3    Debruyne, D.4    Hurault de Ligny, B.5    Coquerel, A.6
  • 50
    • 34548412680 scopus 로고    scopus 로고
    • Quantification of cyclosporine a in peripheral blood mononuclear cells by liquid chromatography-electrospray mass spectrometry using a column-switching approach
    • [50] Ansermot, N., Fathi, M., Veuthey, J.L., Desmeules, J., Hochstrasser, D., Rudaz, S., Quantification of cyclosporine a in peripheral blood mononuclear cells by liquid chromatography-electrospray mass spectrometry using a column-switching approach. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 857 (2007), 92–99.
    • (2007) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.857 , pp. 92-99
    • Ansermot, N.1    Fathi, M.2    Veuthey, J.L.3    Desmeules, J.4    Hochstrasser, D.5    Rudaz, S.6
  • 53
    • 34249653069 scopus 로고    scopus 로고
    • Determination of ciclosporin a and its six main metabolites in isolated t-lymphocytes and whole blood using liquid chromatography-tandem mass spectrometry
    • [53] Falck, P., Guldseth, H., Asberg, A., Midtvedt, K., Reubsaet, J.L., Determination of ciclosporin a and its six main metabolites in isolated t-lymphocytes and whole blood using liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 852 (2007), 345–352.
    • (2007) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.852 , pp. 345-352
    • Falck, P.1    Guldseth, H.2    Asberg, A.3    Midtvedt, K.4    Reubsaet, J.L.5
  • 54
    • 38549095084 scopus 로고    scopus 로고
    • Declining intracellular t-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients
    • [54] Falck, P., Asberg, A., Guldseth, H., Bremer, S., Akhlaghi, F., Reubsaet, J.L., Pfeffer, P., Hartmann, A., Midtvedt, K., Declining intracellular t-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients. Transplantation 85 (2008), 179–184.
    • (2008) Transplantation , vol.85 , pp. 179-184
    • Falck, P.1    Asberg, A.2    Guldseth, H.3    Bremer, S.4    Akhlaghi, F.5    Reubsaet, J.L.6    Pfeffer, P.7    Hartmann, A.8    Midtvedt, K.9
  • 55
    • 58149354277 scopus 로고    scopus 로고
    • Reduced elimination of cyclosporine a in elderly (>65 years) kidney transplant recipients
    • [55] Falck, P., Asberg, A., Byberg, K.T., Bremer, S., Bergan, S., Reubsaet, J.L., Midtvedt, K., Reduced elimination of cyclosporine a in elderly (>65 years) kidney transplant recipients. Transplantation 86 (2008), 1379–1383.
    • (2008) Transplantation , vol.86 , pp. 1379-1383
    • Falck, P.1    Asberg, A.2    Byberg, K.T.3    Bremer, S.4    Bergan, S.5    Reubsaet, J.L.6    Midtvedt, K.7
  • 58
    • 34248559596 scopus 로고    scopus 로고
    • An assay for the determination of sirolimus levels in the lymphocyte of transplant patients
    • [58] Masri, M., Rizk, S., Barbari, A., Stephan, A., Kamel, G., Rost, M., An assay for the determination of sirolimus levels in the lymphocyte of transplant patients. Transplant. Proc. 39 (2007), 1204–1206.
    • (2007) Transplant. Proc. , vol.39 , pp. 1204-1206
    • Masri, M.1    Rizk, S.2    Barbari, A.3    Stephan, A.4    Kamel, G.5    Rost, M.6
  • 60
    • 84861223638 scopus 로고    scopus 로고
    • Everolimus quantification in peripheral blood mononuclear cells using ultra high performance liquid chromatography tandem mass spectrometry
    • [60] Roullet-Renoleau, F., Lemaitre, F., Antignac, M., Zahr, N., Farinotti, R., Fernandez, C., Everolimus quantification in peripheral blood mononuclear cells using ultra high performance liquid chromatography tandem mass spectrometry. J. Pharm. Biomed. Anal. 66 (2012), 278–281.
    • (2012) J. Pharm. Biomed. Anal. , vol.66 , pp. 278-281
    • Roullet-Renoleau, F.1    Lemaitre, F.2    Antignac, M.3    Zahr, N.4    Farinotti, R.5    Fernandez, C.6
  • 61
    • 84941905600 scopus 로고    scopus 로고
    • Closer to the site of action: everolimus concentrations in peripheral blood mononuclear cells correlate well with whole blood concentrations
    • [61] Robertsen, I., Vethe, N.T., Midtvedt, K., Falck, P., Christensen, H., Asberg, A., Closer to the site of action: everolimus concentrations in peripheral blood mononuclear cells correlate well with whole blood concentrations. Ther. Drug Monit. 37 (2015), 675–680.
    • (2015) Ther. Drug Monit. , vol.37 , pp. 675-680
    • Robertsen, I.1    Vethe, N.T.2    Midtvedt, K.3    Falck, P.4    Christensen, H.5    Asberg, A.6
  • 62
  • 63
    • 84889658931 scopus 로고    scopus 로고
    • Mycophenolic acid quantification in human peripheral blood mononuclear cells using liquid chromatography–tandem mass spectrometry
    • [63] Nguyen Thi, M.T., Capron, A., Mourad, M., Wallemacq, P., Mycophenolic acid quantification in human peripheral blood mononuclear cells using liquid chromatography–tandem mass spectrometry. Clin. Biochem. 46 (2013), 1909–1911.
    • (2013) Clin. Biochem. , vol.46 , pp. 1909-1911
    • Nguyen Thi, M.T.1    Capron, A.2    Mourad, M.3    Wallemacq, P.4
  • 64
    • 84939978086 scopus 로고    scopus 로고
    • Plasma and intracellular pharmacokinetic-pharmacodynamic analysis of mycophenolic acid in de novo kidney transplant patients
    • [64] Thi, M.T., Mourad, M., Capron, A., Tshinanu, F.M., Vincent, M.F., Wallemacq, P., Plasma and intracellular pharmacokinetic-pharmacodynamic analysis of mycophenolic acid in de novo kidney transplant patients. Clin. Biochem. 48 (2015), 401–405.
    • (2015) Clin. Biochem. , vol.48 , pp. 401-405
    • Thi, M.T.1    Mourad, M.2    Capron, A.3    Tshinanu, F.M.4    Vincent, M.F.5    Wallemacq, P.6
  • 66
    • 84889670020 scopus 로고    scopus 로고
    • Comparison of three methods for peripheral blood mononuclear cells separation
    • [66] Saumet, A.M.T.F., Capron, A., Nguyen Thi, M.T., Wallemacq, P., Comparison of three methods for peripheral blood mononuclear cells separation. Ther. Drug Monit., 33, 2011, 1.
    • (2011) Ther. Drug Monit. , vol.33 , pp. 1
    • Saumet, A.M.T.F.1    Capron, A.2    Nguyen Thi, M.T.3    Wallemacq, P.4
  • 67
    • 79956329914 scopus 로고    scopus 로고
    • Evaluation of the mean corpuscular volume of peripheral blood mononuclear cells of hiv patients by a coulter counter to determine intracellular drug concentrations
    • [67] Simiele, M., D'Avolio, A., Baietto, L., Siccardi, M., Sciandra, M., Agati, S., Cusato, J., Bonora, S., Di Perri, G., Evaluation of the mean corpuscular volume of peripheral blood mononuclear cells of hiv patients by a coulter counter to determine intracellular drug concentrations. Antimicrob. Agents Chemother. 55 (2011), 2976–2978.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 2976-2978
    • Simiele, M.1    D'Avolio, A.2    Baietto, L.3    Siccardi, M.4    Sciandra, M.5    Agati, S.6    Cusato, J.7    Bonora, S.8    Di Perri, G.9
  • 68
    • 0018717551 scopus 로고
    • Discontinuous density gradient separation of human mononuclear leucocytes using percoll as gradient medium
    • [68] Ulmer, A.J., Flad, H.D., Discontinuous density gradient separation of human mononuclear leucocytes using percoll as gradient medium. J. Immunol. Methods 30 (1979), 1–10.
    • (1979) J. Immunol. Methods , vol.30 , pp. 1-10
    • Ulmer, A.J.1    Flad, H.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.