메뉴 건너뛰기




Volumn 48, Issue 6, 2015, Pages 401-405

Plasma and intracellular pharmacokinetic-pharmacodynamic analysis of mycophenolic acid in de novo kidney transplant patients

Author keywords

Inosine monophosphate dehydrogenase (IMPDH); Intracellular MPA; Kidney transplantation; Mycophenolic acid; PBMC

Indexed keywords

ENZYME INHIBITOR; INOSINATE DEHYDROGENASE; MYCOPHENOLIC ACID;

EID: 84939978086     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2014.12.005     Document Type: Article
Times cited : (19)

References (26)
  • 1
    • 0034045586 scopus 로고    scopus 로고
    • Mycophenolate mofetil and its mechanisms of action
    • Allison A.C., Eugui E.M. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology 2000, 47:85-118.
    • (2000) Immunopharmacology , vol.47 , pp. 85-118
    • Allison, A.C.1    Eugui, E.M.2
  • 2
    • 0033816983 scopus 로고    scopus 로고
    • Assessment of mycophenolic acid-induced immunosuppression: a new approach
    • Millan O., Oppenheimer F., Brunet M., Vilardell J., Rojo I., Vives J., et al. Assessment of mycophenolic acid-induced immunosuppression: a new approach. Clin Chem 2000, 46:1376-1383.
    • (2000) Clin Chem , vol.46 , pp. 1376-1383
    • Millan, O.1    Oppenheimer, F.2    Brunet, M.3    Vilardell, J.4    Rojo, I.5    Vives, J.6
  • 3
    • 0036001236 scopus 로고    scopus 로고
    • Pharmacokinetics and protein adduct formation of the pharmacologically active acyl glucuronide metabolite of mycophenolic acid in pediatric renal transplant recipients
    • Shipkova M., Armstrong V.W., Weber L., Mehls O., Oellerich M., Tönshoff B. Pharmacokinetics and protein adduct formation of the pharmacologically active acyl glucuronide metabolite of mycophenolic acid in pediatric renal transplant recipients. Ther Drug Monit 2002, 24:390-399.
    • (2002) Ther Drug Monit , vol.24 , pp. 390-399
    • Shipkova, M.1    Armstrong, V.W.2    Weber, L.3    Mehls, O.4    Oellerich, M.5    Tönshoff, B.6
  • 4
    • 11144318750 scopus 로고    scopus 로고
    • Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism
    • Picard N., Ratanasavanh D., Premaud A., Le Meur Y., Marquet P. Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism. Drug Metab Dispos 2005, 33:139-146.
    • (2005) Drug Metab Dispos , vol.33 , pp. 139-146
    • Picard, N.1    Ratanasavanh, D.2    Premaud, A.3    Le Meur, Y.4    Marquet, P.5
  • 5
    • 17644377916 scopus 로고    scopus 로고
    • Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2
    • Hesselink D.A., van Hest R.M., Mathot R.A., Bonthuis F., Weimar W., de Bruin R.W., et al. Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2. Am J Transplant 2005, 5:987-994.
    • (2005) Am J Transplant , vol.5 , pp. 987-994
    • Hesselink, D.A.1    van Hest, R.M.2    Mathot, R.A.3    Bonthuis, F.4    Weimar, W.5    de Bruin, R.W.6
  • 6
    • 31444448077 scopus 로고    scopus 로고
    • Role of Mrp2 in the hepatic disposition of mycophenolic acid and its glucuronide metabolites: effect of cyclosporine
    • Westley I.S., Brogan L.R., Morris R.G., Evans A.M., Sallustio B.C. Role of Mrp2 in the hepatic disposition of mycophenolic acid and its glucuronide metabolites: effect of cyclosporine. Drug Metab Dispos 2006, 34:261-266.
    • (2006) Drug Metab Dispos , vol.34 , pp. 261-266
    • Westley, I.S.1    Brogan, L.R.2    Morris, R.G.3    Evans, A.M.4    Sallustio, B.C.5
  • 7
    • 80155171939 scopus 로고    scopus 로고
    • Influence of MRP2 on MPA pharmacokinetics in renal transplant recipients-results of the Pharmacogenomic Substudy within the Symphony Study
    • Lloberas N., Torras J., Cruzado J.M., Andreu F., Oppenheimer F., Sánchez-Plumed J., et al. Influence of MRP2 on MPA pharmacokinetics in renal transplant recipients-results of the Pharmacogenomic Substudy within the Symphony Study. Nephrol Dial Transplant 2011, 26:3784-3793.
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 3784-3793
    • Lloberas, N.1    Torras, J.2    Cruzado, J.M.3    Andreu, F.4    Oppenheimer, F.5    Sánchez-Plumed, J.6
  • 8
    • 79953811641 scopus 로고    scopus 로고
    • Inosine monophosphate dehydrogenase (IMPDH) activity as a pharmacodynamic biomarker of mycophenolic acid effects in pediatric kidney transplant recipients
    • Fukuda T., Goebel J., Thøgersen H., Maseck D., Cox S., Logan B., et al. Inosine monophosphate dehydrogenase (IMPDH) activity as a pharmacodynamic biomarker of mycophenolic acid effects in pediatric kidney transplant recipients. J Clin Pharmacol 2011, 51:309-320.
    • (2011) J Clin Pharmacol , vol.51 , pp. 309-320
    • Fukuda, T.1    Goebel, J.2    Thøgersen, H.3    Maseck, D.4    Cox, S.5    Logan, B.6
  • 10
    • 0029099726 scopus 로고
    • Demonstration of induction of erythrocyte inosine monophosphate dehydrogenase activity in Ribavirin-treated patients using a high performance liquid chromatography linked method
    • Montero C., Duley J.A., Fairbanks L.D., McBride M.B., Micheli V., Cant A.J., et al. Demonstration of induction of erythrocyte inosine monophosphate dehydrogenase activity in Ribavirin-treated patients using a high performance liquid chromatography linked method. Clin Chim Acta 1995, 14(238):169-178.
    • (1995) Clin Chim Acta , vol.14 , Issue.238 , pp. 169-178
    • Montero, C.1    Duley, J.A.2    Fairbanks, L.D.3    McBride, M.B.4    Micheli, V.5    Cant, A.J.6
  • 11
    • 0035664199 scopus 로고    scopus 로고
    • Non-radioactive determination of inosine 5'-monophosphate dehydrogenase (IMPDH) in peripheral mononuclear cells
    • Glander P., Braun K.P., Hambach P., Bauer S., Mai I., Roots I., et al. Non-radioactive determination of inosine 5'-monophosphate dehydrogenase (IMPDH) in peripheral mononuclear cells. Clin Biochem 2001, 34:543-549.
    • (2001) Clin Biochem , vol.34 , pp. 543-549
    • Glander, P.1    Braun, K.P.2    Hambach, P.3    Bauer, S.4    Mai, I.5    Roots, I.6
  • 12
    • 0034120621 scopus 로고    scopus 로고
    • Development and application of a high-performance liquid chromatography-based assay for determination of the activity of inosine 5'-monophosphate dehydrogenase in whole blood and isolated mononuclear cells
    • Albrecht W., Storck M., Pfetsch E., Martin W., Abendroth D. Development and application of a high-performance liquid chromatography-based assay for determination of the activity of inosine 5'-monophosphate dehydrogenase in whole blood and isolated mononuclear cells. Ther Drug Monit 2000, 22:283-294.
    • (2000) Ther Drug Monit , vol.22 , pp. 283-294
    • Albrecht, W.1    Storck, M.2    Pfetsch, E.3    Martin, W.4    Abendroth, D.5
  • 14
    • 0031926842 scopus 로고    scopus 로고
    • Pharmacokinetics of mycophenolic acid (MPA) and determinants of MPA free fraction in pediatric and adult renal transplant recipients. German study group on Mycophenolate Mofetil Therapy in Pediatric Renal Transplant Recipients
    • Weber L.T., Shipkova M., Lamersdorf T., Niedmann P.D., Wiesel M., Mandelbaum A., et al. Pharmacokinetics of mycophenolic acid (MPA) and determinants of MPA free fraction in pediatric and adult renal transplant recipients. German study group on Mycophenolate Mofetil Therapy in Pediatric Renal Transplant Recipients. J Am Soc Nephrol 1998, 9:1511-1520.
    • (1998) J Am Soc Nephrol , vol.9 , pp. 1511-1520
    • Weber, L.T.1    Shipkova, M.2    Lamersdorf, T.3    Niedmann, P.D.4    Wiesel, M.5    Mandelbaum, A.6
  • 15
    • 0029058395 scopus 로고
    • Mycophenolic acid binding to human serum albumin: characterization and relation to pharmacodynamics
    • Nowak I., Shaw L.M. Mycophenolic acid binding to human serum albumin: characterization and relation to pharmacodynamics. Clin Chem 1995, 41:1011-1017.
    • (1995) Clin Chem , vol.41 , pp. 1011-1017
    • Nowak, I.1    Shaw, L.M.2
  • 16
    • 0033040712 scopus 로고    scopus 로고
    • Measurement of mycophenolate mofetil plasma levels after heart transplantation and a potential side effect of high levels
    • Dubrey S.W., Holt D.W., Banner N. Measurement of mycophenolate mofetil plasma levels after heart transplantation and a potential side effect of high levels. Ther Drug Monit 1999, 21:325-326.
    • (1999) Ther Drug Monit , vol.21 , pp. 325-326
    • Dubrey, S.W.1    Holt, D.W.2    Banner, N.3
  • 17
    • 67651121811 scopus 로고    scopus 로고
    • Improved assay for the nonradioactive determination of inosine 5'-monophosphate dehydrogenase activity in peripheral blood mononuclear cells
    • Glander P., Sombogaard F., Budde K., van Gelder T., Ham-bach P., Liefeldt L., et al. Improved assay for the nonradioactive determination of inosine 5'-monophosphate dehydrogenase activity in peripheral blood mononuclear cells. Ther Drug Monit 2009, 31:351-359.
    • (2009) Ther Drug Monit , vol.31 , pp. 351-359
    • Glander, P.1    Sombogaard, F.2    Budde, K.3    van Gelder, T.4    Ham-bach, P.5    Liefeldt, L.6
  • 18
    • 84889658931 scopus 로고    scopus 로고
    • Mycophenolic acid quantification in human peripheral blood mononuclear cells using liquid chromatography-tandem mass spectrometry
    • Nguyen Thi M.T., Capron A., Mourad M., Wallemacq P. Mycophenolic acid quantification in human peripheral blood mononuclear cells using liquid chromatography-tandem mass spectrometry. Clin Biochem 2013, 46:1909-1911.
    • (2013) Clin Biochem , vol.46 , pp. 1909-1911
    • Nguyen Thi, M.T.1    Capron, A.2    Mourad, M.3    Wallemacq, P.4
  • 19
    • 28244431736 scopus 로고    scopus 로고
    • Clinical pharmacokinetic and pharmacodynamic monitoring for mycophenolate mofetil
    • Ku Y.M., McCartan M., Collier D. Clinical pharmacokinetic and pharmacodynamic monitoring for mycophenolate mofetil. J Pharm Pract 2005, 18:422-431.
    • (2005) J Pharm Pract , vol.18 , pp. 422-431
    • Ku, Y.M.1    McCartan, M.2    Collier, D.3
  • 20
    • 0029864837 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of mycophenolate mofetil in healthy subjects after single-dose oral and intravenous administration
    • Bullingham R., Monroe S., Nicholls A., Hale M. Pharmacokinetics and bioavailability of mycophenolate mofetil in healthy subjects after single-dose oral and intravenous administration. J Clin Pharmacol 1996, 36:315-324.
    • (1996) J Clin Pharmacol , vol.36 , pp. 315-324
    • Bullingham, R.1    Monroe, S.2    Nicholls, A.3    Hale, M.4
  • 21
    • 83955165904 scopus 로고    scopus 로고
    • Correlation of tacrolimus levels in peripheral blood mononuclear cells with histological staging of rejection after liver transplantation: preliminary results of a prospective study
    • Capron A., Lerut J., Latinne D., Rahier J., Haufroid V., Wallemacq P. Correlation of tacrolimus levels in peripheral blood mononuclear cells with histological staging of rejection after liver transplantation: preliminary results of a prospective study. Transpl Int 2012, 25:41-47.
    • (2012) Transpl Int , vol.25 , pp. 41-47
    • Capron, A.1    Lerut, J.2    Latinne, D.3    Rahier, J.4    Haufroid, V.5    Wallemacq, P.6
  • 22
    • 84884780217 scopus 로고    scopus 로고
    • Opportunity to monitor immunosuppressive drugs in peripheral blood mononuclear cells: where are we and where are we going?
    • Lemaitre F., Antignac M., Verdier M.C., Bellissant E., Fernandez C. Opportunity to monitor immunosuppressive drugs in peripheral blood mononuclear cells: where are we and where are we going?. Pharmacol Res 2013, 74:109-112.
    • (2013) Pharmacol Res , vol.74 , pp. 109-112
    • Lemaitre, F.1    Antignac, M.2    Verdier, M.C.3    Bellissant, E.4    Fernandez, C.5
  • 23
    • 55249127693 scopus 로고    scopus 로고
    • Long-term pharmacokinetics of mycophenolic acid in pediatric renal transplant recipients over 3years posttransplant
    • Weber L.T., Hoecker B., Armstrong V.W., Oellerich M., Tönshoff B. Long-term pharmacokinetics of mycophenolic acid in pediatric renal transplant recipients over 3years posttransplant. Ther Drug Monit 2008, 30:570-575.
    • (2008) Ther Drug Monit , vol.30 , pp. 570-575
    • Weber, L.T.1    Hoecker, B.2    Armstrong, V.W.3    Oellerich, M.4    Tönshoff, B.5
  • 25
    • 27644524478 scopus 로고    scopus 로고
    • Mycophenolate mofetil in pediatric renal transplantation
    • Ettenger R., Sarwal M.M. Mycophenolate mofetil in pediatric renal transplantation. Transplantation 2005, 80(Suppl.):S201-S210.
    • (2005) Transplantation , vol.80 , pp. S201-S210
    • Ettenger, R.1    Sarwal, M.M.2
  • 26
    • 72949123024 scopus 로고    scopus 로고
    • Inosine monophosphate dehydrogenase variability in renal transplant patients on long-term mycophenolate mofetil therapy
    • Chiarelli L.R., Molinaro M., Libetta C., Tinelli C., Cosmai L., Valentini G., et al. Inosine monophosphate dehydrogenase variability in renal transplant patients on long-term mycophenolate mofetil therapy. Br J Clin Pharmacol 2010, 69:38-50.
    • (2010) Br J Clin Pharmacol , vol.69 , pp. 38-50
    • Chiarelli, L.R.1    Molinaro, M.2    Libetta, C.3    Tinelli, C.4    Cosmai, L.5    Valentini, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.