메뉴 건너뛰기




Volumn 10, Issue , 2016, Pages

Opening up the blackbox: An interpretable deep neural network-based classifier for cell-type specific enhancer predictions

Author keywords

ChIP seq; Cis regulatory modules (CRMs); Deep neural networks (DNNs); Enhancer prediction; Genomic enhancers; Histone modifications; Interpretability of blackbox models

Indexed keywords

HISTONE;

EID: 84979675872     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/s12918-016-0302-3     Document Type: Article
Times cited : (35)

References (46)
  • 1
    • 77149139820 scopus 로고    scopus 로고
    • Enhancers: the abundance and function of regulatory sequences beyond promoters
    • Bulger M, Groudine M. Enhancers: the abundance and function of regulatory sequences beyond promoters. Dev Biol. 2010;339(2):250-7.
    • (2010) Dev Biol , vol.339 , Issue.2 , pp. 250-257
    • Bulger, M.1    Groudine, M.2
  • 2
    • 53149107845 scopus 로고    scopus 로고
    • Chromatin insulators: regulatory mechanisms and epigenetic inheritance
    • Bushey AM, Dorman ER, Corces VG. Chromatin insulators: regulatory mechanisms and epigenetic inheritance. Mol Cell. 2008;32(1):1-9.
    • (2008) Mol Cell , vol.32 , Issue.1 , pp. 1-9
    • Bushey, A.M.1    Dorman, E.R.2    Corces, V.G.3
  • 3
  • 5
    • 0019811465 scopus 로고
    • Expression of a β-globin gene is enhanced by remote SV40 DNA sequences
    • Banerji J, Rusconi S, Schaffner W. Expression of a β-globin gene is enhanced by remote SV40 DNA sequences. Cell. 1981;27(2):299-308.
    • (1981) Cell , vol.27 , Issue.2 , pp. 299-308
    • Banerji, J.1    Rusconi, S.2    Schaffner, W.3
  • 7
    • 79551655285 scopus 로고    scopus 로고
    • Functional and mechanistic diversity of distal transcription enhancers
    • Bulger M, Groudine M. Functional and mechanistic diversity of distal transcription enhancers. Cell. 2011;144(3):327-39.
    • (2011) Cell , vol.144 , Issue.3 , pp. 327-339
    • Bulger, M.1    Groudine, M.2
  • 8
    • 79952901680 scopus 로고    scopus 로고
    • Enhancer function: new insights into the regulation of tissue-specific gene expression
    • Ong C-T, Corces VG. Enhancer function: new insights into the regulation of tissue-specific gene expression. Nat Rev Genet. 2011;12(4):283-93.
    • (2011) Nat. Rev. Genet , vol.12 , Issue.4 , pp. 283-293
    • Ong, C.-T.1    Corces, V.G.2
  • 9
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • Consortium TEP. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012;489(7414):57-74.
    • (2012) Nature , vol.489 , Issue.7414 , pp. 57-74
    • Consortium, T.E.P.1
  • 18
    • 84897138228 scopus 로고    scopus 로고
    • Looping back to leap forward: transcription enters a new era
    • Levine M, Cattoglio C, Tjian R. Looping back to leap forward: transcription enters a new era. Cell. 2014;157(1):13-25.
    • (2014) Cell , vol.157 , Issue.1 , pp. 13-25
    • Levine, M.1    Cattoglio, C.2    Tjian, R.3
  • 19
    • 84860379799 scopus 로고    scopus 로고
    • Enhancer and promoter interactions-long distance calls
    • Krivega I, Dean A. Enhancer and promoter interactions-long distance calls. Curr Opin Genet Dev. 2012;22(2):79-85.
    • (2012) Curr. Opin. Genet. Dev , vol.22 , Issue.2 , pp. 79-85
    • Krivega, I.1    Dean, A.2
  • 21
    • 84901757306 scopus 로고    scopus 로고
    • Genomics: Predicting enhancers by their sequence
    • Rusk N. Genomics: Predicting enhancers by their sequence. Nat Methods. 2014;11(6):606-607.
    • (2014) Nat Methods , vol.11 , Issue.6 , pp. 606-607
    • Rusk, N.1
  • 22
    • 84901804887 scopus 로고    scopus 로고
    • Dissection of thousands of cell type-specific enhancers identifies dinucleotide repeat motifs as general enhancer features
    • Yáñez-Cuna JO, Arnold CD, Stampfel G, Boryń ŁM, Gerlach D, Rath M, Stark A. Dissection of thousands of cell type-specific enhancers identifies dinucleotide repeat motifs as general enhancer features. Genome Res. 2014;24(7):1147-1156.
    • (2014) Genome Res , vol.24 , Issue.7 , pp. 1147-1156
    • Yáñez-Cuna, J.O.1    Arnold, C.D.2    Stampfel, G.3    Boryń, M.4    Gerlach, D.5    Rath, M.6    Stark, A.7
  • 23
    • 84899450857 scopus 로고    scopus 로고
    • Transcriptional enhancers: from properties to genome-wide predictions
    • Shlyueva D, Stampfel G, Stark A. Transcriptional enhancers: from properties to genome-wide predictions. Nat Rev Genet. 2014;15(4):272-86.
    • (2014) Nat Rev Genet , vol.15 , Issue.4 , pp. 272-286
    • Shlyueva, D.1    Stampfel, G.2    Stark, A.3
  • 25
    • 68949213578 scopus 로고    scopus 로고
    • Insights from genomic profiling of transcription factors
    • Farnham PJ. Insights from genomic profiling of transcription factors. Nat Rev Genet. 2009;10(9):605-16.
    • (2009) Nat Rev Genet , vol.10 , Issue.9 , pp. 605-616
    • Farnham, P.J.1
  • 26
    • 84865249952 scopus 로고    scopus 로고
    • Transcription factors: from enhancer binding to developmental control
    • Spitz F, Furlong EE. Transcription factors: from enhancer binding to developmental control. Nat Rev Gen. 2012;13(9):613-26.
    • (2012) Nat Rev Gen , vol.13 , Issue.9 , pp. 613-626
    • Spitz, F.1    Furlong, E.E.2
  • 27
    • 84865257761 scopus 로고    scopus 로고
    • Uncovering cis-regulatory sequence requirements for context-specific transcription factor binding
    • Yáñez-Cuna JO, Dinh HQ, Kvon EZ, Shlyueva D, Stark A. Uncovering cis-regulatory sequence requirements for context-specific transcription factor binding. Genome Res. 2012;22(10):2018-30.
    • (2012) Genome Res , vol.22 , Issue.10 , pp. 2018-2030
    • Yáñez-Cuna, J.O.1    Dinh, H.Q.2    Kvon, E.Z.3    Shlyueva, D.4    Stark, A.5
  • 28
    • 71749120382 scopus 로고    scopus 로고
    • Finding distal regulatory elements in the human genome
    • Heintzman ND, Ren B. Finding distal regulatory elements in the human genome. Curr Opin Genet Dev. 2009;19(6):541-9.
    • (2009) Curr. Opin. Genet. Dev , vol.19 , Issue.6 , pp. 541-549
    • Heintzman, N.D.1    Ren, B.2
  • 29
    • 12744263842 scopus 로고    scopus 로고
    • Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura
    • Berman BP, Pfeiffer BD, Laverty TR, Salzberg SL, Rubin GM, Eisen MB, Celniker SE. Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura. Genome Biol. 2004;5(9):R61.
    • (2004) Genome Biol , vol.5 , Issue.9 , pp. R61
    • Berman, B.P.1    Pfeiffer, B.D.2    Laverty, T.R.3    Salzberg, S.L.4    Rubin, G.M.5    Eisen, M.B.6    Celniker, S.E.7
  • 30
    • 0034916613 scopus 로고    scopus 로고
    • p300/CBP proteins: HATs for transcriptional bridges and scaffolds
    • Chan HM, La Thangue NB. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J Cell Sci. 2001;114(13):2363-73.
    • (2001) J Cell Sci , vol.114 , Issue.13 , pp. 2363-2373
    • Chan, H.M.1    Thangue, N.B.2
  • 34
    • 62849085018 scopus 로고    scopus 로고
    • Prediction of regulatory elements in mammalian genomes using chromatin signatures
    • Won K-J, Chepelev I, Ren B, Wang W. Prediction of regulatory elements in mammalian genomes using chromatin signatures. BMC Bioinformatics. 2008;9(1):547.
    • (2008) BMC Bioinformatics , vol.9 , Issue.1 , pp. 547
    • Won, K.-J.1    Chepelev, I.2    Ren, B.3    Wang, W.4
  • 35
    • 77954204584 scopus 로고    scopus 로고
    • Discover regulatory DNA elements using chromatin signatures and artificial neural network
    • Firpi HA, Ucar D, Tan K. Discover regulatory DNA elements using chromatin signatures and artificial neural network. Bioinformatics. 2010;26(13):1579-86.
    • (2010) Bioinformatics , vol.26 , Issue.13 , pp. 1579-1586
    • Firpi, H.A.1    Ucar, D.2    Tan, K.3
  • 36
    • 84872495357 scopus 로고    scopus 로고
    • Genome-wide enhancer prediction from epigenetic signatures using genetic algorithm-optimized support vector machines
    • Fernández M, Miranda-Saavedra D. Genome-wide enhancer prediction from epigenetic signatures using genetic algorithm-optimized support vector machines. Nucleic Acids Res. 2012;40(10):e77-7.
    • (2012) Nucleic Acids Res , vol.40 , Issue.10 , pp. e77-e87
    • Fernández, M.1    Miranda-Saavedra, D.2
  • 38
    • 0013125561 scopus 로고    scopus 로고
    • Feature selection with neural networks
    • Leray P, Gallinari P. Feature selection with neural networks. Behaviormetrika. 1999;26(1):145-66.
    • (1999) Behaviormetrika , vol.26 , Issue.1 , pp. 145-166
    • Leray, P.1    Gallinari, P.2
  • 39
    • 84943143082 scopus 로고    scopus 로고
    • DEEP: a general computational framework for predicting enhancers
    • Kleftogiannis D, Kalnis P, Bajic VB. DEEP: a general computational framework for predicting enhancers. Nucleic Acids Res. 2015;43(1):e6-e6.
    • (2015) Nucleic Acids Res , vol.43 , Issue.1 , pp. e6-e16
    • Kleftogiannis, D.1    Kalnis, P.2    Bajic, V.B.3
  • 40
    • 84876836223 scopus 로고    scopus 로고
    • Modification of enhancer chromatin: what, how, and why?
    • Calo E, Wysocka J. Modification of enhancer chromatin: what, how, and why? Mol Cell. 2013;49(5):825-37.
    • (2013) Mol Cell , vol.49 , Issue.5 , pp. 825-837
    • Calo, E.1    Wysocka, J.2
  • 41
    • 77951770756 scopus 로고    scopus 로고
    • BEDTools: a flexible suite of utilities for comparing genomic features
    • Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010;26(6):841-2.
    • (2010) Bioinformatics , vol.26 , Issue.6 , pp. 841-842
    • Quinlan, A.R.1    Hall, I.M.2
  • 42
    • 84897406127 scopus 로고    scopus 로고
    • A promoter-level mammalian expression atlas
    • Consortium TF. A promoter-level mammalian expression atlas. Nature. 2014;507(7493):462-70.
    • (2014) Nature , vol.507 , Issue.7493 , pp. 462-470
    • Consortium, T.F.1
  • 45
    • 57249084011 scopus 로고    scopus 로고
    • Visualizing data using t-SNE
    • 2579-2605.
    • Van der Maaten L, Hinton G. Visualizing data using t-SNE. J Mach Learn Res. 2008;9(2579-2605):85.
    • (2008) J. Mach. Learn. Res , vol.9 , pp. 85
    • Maaten, L.1    Hinton, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.