메뉴 건너뛰기




Volumn 24, Issue 7, 2014, Pages 1147-1156

Dissection of thousands of cell type-specific enhancers identifies dinucleotide repeat motifs as general enhancer features

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

EID: 84901804887     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.169243.113     Document Type: Article
Times cited : (105)

References (70)
  • 1
    • 77955015475 scopus 로고    scopus 로고
    • Robust target gene discovery through transcriptome perturbations and genome-wide enhancer predictions in Drosophila uncovers a regulatory basis for sensory specification
    • Aerts S, Quan X-J, Claeys A, Naval Sanchez M, Tate P, Yan J, Hassan BA. 2010. Robust target gene discovery through transcriptome perturbations and genome-wide enhancer predictions in Drosophila uncovers a regulatory basis for sensory specification. PLoS Biol 8: e1000435.
    • (2010) PLoS Biol , vol.8
    • Aerts, S.1    Quan, X.-J.2    Claeys, A.3    Naval Sanchez, M.4    Tate, P.5    Yan, J.6    Hassan, B.A.7
  • 2
    • 84874381107 scopus 로고    scopus 로고
    • Genome-wide quantitative enhancer activity maps identified by STARR-seq
    • Arnold CD, Gerlach D, Stelzer C, Boryń ŁM, Rath M, Stark A. 2013. Genome-wide quantitative enhancer activity maps identified by STARR-seq. Science 339: 1074-1077.
    • (2013) Science , vol.339 , pp. 1074-1077
    • Arnold, C.D.1    Gerlach, D.2    Stelzer, C.3    Boryń, Ł.4    Rath, M.5    Stark, A.6
  • 4
    • 79958090979 scopus 로고    scopus 로고
    • DREME: Motif discovery in transcription factor ChIP-seq data
    • Bailey TL. 2011. DREME: motif discovery in transcription factor ChIP-seq data. Bioinformatics 27: 1653-1659.
    • (2011) Bioinformatics , vol.27 , pp. 1653-1659
    • Bailey, T.L.1
  • 5
    • 0019811465 scopus 로고
    • Expression of a β-globin gene is enhanced by remote SV40 DNA sequences
    • Banerji J, Rusconi S, Schaffner W. 1981. Expression of a β-globin gene is enhanced by remote SV40 DNA sequences. Cell 27: 299-308. (Pubitemid 12200499)
    • (1981) Cell , vol.27 , Issue.2 I , pp. 299-308
    • Banerji, J.1    Rusconi, S.2    Schaffner, W.3
  • 6
    • 77954063553 scopus 로고    scopus 로고
    • Dual-functioning transcription factors in the developmental gene network of Drosophila melanogaster
    • Bauer DC, Buske FA, Bailey TL. 2010. Dual-functioning transcription factors in the developmental gene network of Drosophila melanogaster. BMC Bioinformatics 11: 366.
    • (2010) BMC Bioinformatics , vol.11 , pp. 366
    • Bauer, D.C.1    Buske, F.A.2    Bailey, T.L.3
  • 8
    • 12744263842 scopus 로고    scopus 로고
    • Computational identification of developmental enhancers: Conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura
    • Berman BP, Pfeiffer BD, Laverty TR, Salzberg SL, Rubin GM, Eisen MB, Celniker SE. 2004. Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura. Genome Biol 5: R61.
    • (2004) Genome Biol , vol.5
    • Berman, B.P.1    Pfeiffer, B.D.2    Laverty, T.R.3    Salzberg, S.L.4    Rubin, G.M.5    Eisen, M.B.6    Celniker, S.E.7
  • 9
    • 34548690542 scopus 로고    scopus 로고
    • Functional architecture and evolution of transcriptional elements that drive gene coexpression
    • DOI 10.1126/science.1145893
    • Brown CD, Johnson DS, Sidow A. 2007. Functional architecture and evolution of transcriptional elements that drive gene coexpression. Science 317: 1557-1560. (Pubitemid 47417436)
    • (2007) Science , vol.317 , Issue.5844 , pp. 1557-1560
    • Brown, C.D.1    Johnson, D.S.2    Sidow, A.3
  • 10
    • 84868307469 scopus 로고    scopus 로고
    • Systematic elucidation and in vivo validation of sequences enriched in hindbrain transcriptional control
    • Burzynski GM, Reed X, Taher L, Stine ZE, Matsui T, Ovcharenko I, McCallion AS. 2012. Systematic elucidation and in vivo validation of sequences enriched in hindbrain transcriptional control. Genome Res 22: 2278-2289.
    • (2012) Genome Res , vol.22 , pp. 2278-2289
    • Burzynski, G.M.1    Reed, X.2    Taher, L.3    Stine, Z.E.4    Matsui, T.5    Ovcharenko, I.6    McCallion, A.S.7
  • 13
    • 0024740959 scopus 로고
    • Spatial regulation of zerknüllt: A dorsalventral patterning gene in Drosophila
    • Doyle HJ, Kraut R, Levine M. 1989. Spatial regulation of zerknüllt: a dorsalventral patterning gene in Drosophila. Genes Dev 3: 1518-1533.
    • (1989) Genes Dev , vol.3 , pp. 1518-1533
    • Doyle, H.J.1    Kraut, R.2    Levine, M.3
  • 14
    • 22344437987 scopus 로고    scopus 로고
    • Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach
    • Elemento O, Tavazoie S. 2005. Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach. Genome Biol 6: R18.
    • (2005) Genome Biol , vol.6
    • Elemento, O.1    Tavazoie, S.2
  • 15
    • 35348955882 scopus 로고    scopus 로고
    • A Universal Framework for Regulatory Element Discovery across All Genomes and Data Types
    • DOI 10.1016/j.molcel.2007.09.027, PII S1097276507006661
    • Elemento O, Slonim N, Tavazoie S. 2007. A universal framework for regulatory element discovery across all genomes and data types. Mol Cell 28: 337-350. (Pubitemid 47600005)
    • (2007) Molecular Cell , vol.28 , Issue.2 , pp. 337-350
    • Elemento, O.1    Slonim, N.2    Tavazoie, S.3
  • 16
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • The ENCODE Project Consortium
    • The ENCODE Project Consortium. 2012. An integrated encyclopedia of DNA elements in the human genome. Nature 489: 57-74.
    • (2012) Nature , vol.489 , pp. 57-74
  • 18
    • 0027944532 scopus 로고
    • The Trithorax-like gene encodes the Drosophila GAGA factor
    • DOI 10.1038/371806a0
    • Farkas G, Gausz J, Galloni M, Reuter G, Gyurkovics H, Karch F. 1994. The Trithorax-like gene encodes the Drosophila GAGA factor. Nature 371: 806-808. (Pubitemid 24333870)
    • (1994) Nature , vol.371 , Issue.6500 , pp. 806-808
    • Farkas, G.1    Gausz, J.2    Galloni, M.3    Reuter, G.4    Gyurkovics, H.5    Karch, F.6
  • 19
    • 30344439849 scopus 로고    scopus 로고
    • Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity
    • DOI 10.1016/j.cell.2005.10.042, PII S0092867405013954
    • Hallikas O, Palin K, Sinjushina N, Rautiainen R, Partanen J, Ukkonen E, Taipale J. 2006. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell 124: 47-59. (Pubitemid 43069309)
    • (2006) Cell , vol.124 , Issue.1 , pp. 47-59
    • Hallikas, O.1    Palin, K.2    Sinjushina, N.3    Rautiainen, R.4    Partanen, J.5    Ukkonen, E.6    Taipale, J.7
  • 21
    • 84863890567 scopus 로고    scopus 로고
    • Genomic approaches towards finding cis-regulatory modules in animals
    • Hardison RC, Taylor J. 2012. Genomic approaches towards finding cis-regulatory modules in animals. Nat Rev Genet 13: 469-483.
    • (2012) Nat Rev Genet , vol.13 , pp. 469-483
    • Hardison, R.C.1    Taylor, J.2
  • 22
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. 2010. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 38: 576-589.
    • (2010) Mol Cell , vol.38 , pp. 576-589
    • Heinz, S.1    Benner, C.2    Spann, N.3    Bertolino, E.4    Lin, Y.C.5    Laslo, P.6    Cheng, J.X.7    Murre, C.8    Singh, H.9    Glass, C.K.10
  • 23
    • 0024510279 scopus 로고
    • Topology and formation of triple-stranded H-DNA
    • Htun H, Dahlberg JE. 1989. Topology and formation of triple-stranded H-DNA. Science 243: 1571-1576. (Pubitemid 19090505)
    • (1989) Science , vol.243 , Issue.4898 , pp. 1571-1576
    • Htun, H.1    Dahlberg, J.E.2
  • 25
    • 0034284437 scopus 로고    scopus 로고
    • Repbase Update: A database and an electronic journal of repetitive elements
    • DOI 10.1016/S0168-9525(00)02093-X, PII S016895250002093X
    • Jurka J. 2000. Repbase update: a database and an electronic journal of repetitive elements. Trends Genet 16: 418-420. (Pubitemid 30665376)
    • (2000) Trends in Genetics , vol.16 , Issue.9 , pp. 418-420
    • Jurka, J.1
  • 27
    • 84860503075 scopus 로고    scopus 로고
    • HOT regions function as patterned developmental enhancers and have a distinct cis-regulatory signature
    • Kvon EZ, Stampfel G, Yáñez-Cuna JO, Dickson BJ, Stark A. 2012. HOT regions function as patterned developmental enhancers and have a distinct cis-regulatory signature. Genes Dev 26: 908-913.
    • (2012) Genes Dev , vol.26 , pp. 908-913
    • Kvon, E.Z.1    Stampfel, G.2    Yáñez-Cuna, J.O.3    Dickson, B.J.4    Stark, A.5
  • 28
  • 29
    • 83055181959 scopus 로고    scopus 로고
    • Discriminative prediction of mammalian enhancers from DNA sequence
    • Lee D, Karchin R, Beer MA. 2011. Discriminative prediction of mammalian enhancers from DNA sequence. Genome Res 21: 2167-2180.
    • (2011) Genome Res , vol.21 , pp. 2167-2180
    • Lee, D.1    Karchin, R.2    Beer, M.A.3
  • 30
    • 77956495708 scopus 로고    scopus 로고
    • Transcriptional enhancers in animal development and evolution
    • Levine M. 2010. Transcriptional enhancers in animal development and evolution. Curr Biol 20: R754-R763.
    • (2010) Curr Biol , vol.20
    • Levine, M.1
  • 31
    • 0242407645 scopus 로고    scopus 로고
    • The large Maf factor traffic jam controls gonad morphogenesis in Drosophila
    • DOI 10.1038/ncb1058
    • Li MA, Alls JD, Avancini RM, Koo K, Godt D. 2003. The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila. Nat Cell Biol 5: 994-1000. (Pubitemid 37406913)
    • (2003) Nature Cell Biology , vol.5 , Issue.11 , pp. 994-1000
    • Li, M.A.1    Alls, J.D.2    Avancini, R.M.3    Koo, K.4    Godt, D.5
  • 34
    • 0035228215 scopus 로고    scopus 로고
    • BioProspector: Discovering conserved DNA motifs in upstream regulatory regions of co-expressed genes
    • Liu X, Brutlag DL, Liu JS. 2001. BioProspector: discovering conserved DNA motifs in upstream regulatory regions of co-expressed genes. Pac Symp Biocomput 127-138.
    • (2001) Pac Symp Biocomput , pp. 127-138
    • Liu, X.1    Brutlag, D.L.2    Liu, J.S.3
  • 35
  • 38
    • 78349270572 scopus 로고    scopus 로고
    • A GA microsatellite in the Fli1 promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis
    • Morris EE, Amria MY, Kistner-Griffin E, Svenson JL, Kamen DL, Gilkeson GS, Nowling TK. 2010. A GA microsatellite in the Fli1 promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis. Arthritis Res Ther 12: R212.
    • (2010) Arthritis Res Ther , vol.12
    • Morris, E.E.1    Amria, M.Y.2    Kistner-Griffin, E.3    Svenson, J.L.4    Kamen, D.L.5    Gilkeson, G.S.6    Nowling, T.K.7
  • 42
    • 0037061482 scopus 로고    scopus 로고
    • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
    • DOI 10.1038/nature735
    • Rämet M, Manfruelli P, Pearson A, Mathey-Prevot B, Ezekowitz RAB. 2002. Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature 416: 644-648. (Pubitemid 34406766)
    • (2002) Nature , vol.416 , Issue.6881 , pp. 644-648
    • Ramet, M.1    Manfruelli, P.2    Pearson, A.3    Mathey-Prevot, B.4    Ezekowitz, R.A.B.5
  • 43
    • 0030451622 scopus 로고    scopus 로고
    • A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila
    • Rehorn KP, Thelen H, Michelson AM, Reuter R. 1996. A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila. Development 122: 4023-4031. (Pubitemid 27039735)
    • (1996) Development , vol.122 , Issue.12 , pp. 4023-4031
    • Rehorn, K.-P.1    Thelen, H.2    Michelson, A.M.3    Reuter, R.4
  • 44
    • 0031787969 scopus 로고    scopus 로고
    • Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation
    • DOI 10.1038/nbt1098-939
    • Roth FP, Hughes JD, Estep PW, Church GM. 1998. Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation. Nat Biotechnol 16: 939-945. (Pubitemid 28483622)
    • (1998) Nature Biotechnology , vol.16 , Issue.10 , pp. 939-945
    • Roth, F.P.1    Hughes, J.D.2    Estep, P.W.3    Church, G.M.4
  • 45
    • 14844341770 scopus 로고    scopus 로고
    • Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb
    • DOI 10.1242/dev.01613
    • Sagai T, Hosoya M, Mizushina Y, Tamura M, Shiroishi T. 2005. Elimination of a long-range cis-regulatorymodule causes complete loss of limb-specific Shh expression and truncation of the mouse limb. Development 132: 797-803. (Pubitemid 40352838)
    • (2005) Development , vol.132 , Issue.4 , pp. 797-803
    • Sagai, T.1    Hosoya, M.2    Mizushina, Y.3    Tamura, M.4    Shiroishi, T.5
  • 47
    • 0015328565 scopus 로고
    • Cell lines derived from late embryonic stages of Drosophila melanogaster
    • Schneider I. 1972. Cell lines derived from late embryonic stages of Drosophila melanogaster. J Embryol Exp Morphol 27: 353-365.
    • (1972) J Embryol Exp Morphol , vol.27 , pp. 353-365
    • Schneider, I.1
  • 48
    • 0026744792 scopus 로고
    • Regulation of even-skipped stripe 2 in the Drosophila embryo
    • Small S, Blair A, Levine M. 1992. Regulation of even-skipped stripe 2 in the Drosophila embryo. EMBO J 11: 4047-4057.
    • (1992) EMBO J , vol.11 , pp. 4047-4057
    • Small, S.1    Blair, A.2    Levine, M.3
  • 50
    • 84865249952 scopus 로고    scopus 로고
    • Transcription factors: From enhancer binding to developmental control
    • Spitz F, Furlong EEM. 2012. Transcription factors: from enhancer binding to developmental control. Nat Rev Genet 13: 613-626.
    • (2012) Nat Rev Genet , vol.13 , pp. 613-626
    • Spitz, F.1    Furlong, E.E.M.2
  • 52
    • 0034072450 scopus 로고    scopus 로고
    • DNA binding sites: Representation and discovery
    • Stormo GD. 2000. DNA binding sites: representation and discovery. Bioinformatics 16: 16-23. (Pubitemid 30204197)
    • (2000) Bioinformatics , vol.16 , Issue.1 , pp. 16-23
    • Stormo, G.D.1
  • 53
    • 84875196326 scopus 로고    scopus 로고
    • Determinants of nucleosome positioning
    • Struhl K, Segal E. 2013. Determinants of nucleosome positioning. Nat Struct Mol Biol 20: 267-273.
    • (2013) Nat Struct Mol Biol , vol.20 , pp. 267-273
    • Struhl, K.1    Segal, E.2
  • 55
    • 77950580571 scopus 로고    scopus 로고
    • Structural rules and complex regulatory circuitry constrain expression of a Notch- and EGFR-regulated eye enhancer
    • Swanson CI, Evans NC, Barolo S. 2010. Structural rules and complex regulatory circuitry constrain expression of a Notch- and EGFR-regulated eye enhancer. Dev Cell 18: 359-370.
    • (2010) Dev Cell , vol.18 , pp. 359-370
    • Swanson, C.I.1    Evans, N.C.2    Barolo, S.3
  • 56
    • 0029617947 scopus 로고
    • Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome
    • DOI 10.1016/0092-8674(95)90136-1
    • Thanos D, Maniatis T. 1995. Virus induction of human IFN β gene expression requires the assembly of an enhanceosome. Cell 83: 1091-1100. (Pubitemid 26007801)
    • (1995) Cell , vol.83 , Issue.7 , pp. 1091-1100
    • Thanos, D.1    Maniatis, T.2
  • 58
    • 0028055116 scopus 로고
    • ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor
    • DOI 10.1038/367525a0
    • Tsukiyama T, Becker PB, Wu C. 1994. ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor. Nature 367: 525-532. (Pubitemid 24055509)
    • (1994) Nature , vol.367 , Issue.6463 , pp. 525-532
    • Tsukiyama, T.1    Becker, P.B.2    Wu, C.3
  • 61
    • 20544451800 scopus 로고    scopus 로고
    • Dinucleotide repeats negatively modulate the promoter activity of Cyr61 and is unstable in hepatocellular carcinoma patients
    • DOI 10.1038/sj.onc.1208550
    • Wang B, Ren J, Ooi LLPJ, Chong SS, Lee CGL. 2005. Dinucleotide repeats negatively modulate the promoter activity of Cyr61 and is unstable in hepatocellular carcinoma patients. Oncogene 24: 3999-4008. (Pubitemid 40896412)
    • (2005) Oncogene , vol.24 , Issue.24 , pp. 3999-4008
    • Wang, B.1    Ren, J.2    Ooi, L.L.P.J.3    Chong, S.S.4    Lee, C.G.L.5
  • 63
    • 41449086977 scopus 로고    scopus 로고
    • Systematic identification of mammalian regulatory motifs' target genes and functions
    • DOI 10.1038/nmeth.1188, PII NMETH.1188
    • Warner JB, Philippakis AA, Jaeger SA, He FS, Lin J, Bulyk ML. 2008. Systematic identification of mammalian regulatory motifs' target genes and functions. Nat Methods 5: 347-353. (Pubitemid 351459368)
    • (2008) Nature Methods , vol.5 , Issue.4 , pp. 347-353
    • Warner, J.B.1    Philippakis, A.A.2    Jaeger, S.A.3    He, F.S.4    Lin, J.5    Bulyk, M.L.6
  • 64
    • 84866983699 scopus 로고    scopus 로고
    • A model of spatially restricted transcription in opposing gradients of activators and repressors
    • White MA, Parker DS, Barolo S, Cohen BA. 2012. A model of spatially restricted transcription in opposing gradients of activators and repressors. Mol Syst Biol 8: 1-9.
    • (2012) Mol Syst Biol , vol.8 , pp. 1-9
    • White, M.A.1    Parker, D.S.2    Barolo, S.3    Cohen, B.A.4
  • 65
    • 84880362638 scopus 로고    scopus 로고
    • Massively parallel in vivo enhancer assay reveals that highly local features determine the cisregulatory function of ChIP-seq peaks
    • White MA, Myers CA, Corbo JC, Cohen BA. 2013. Massively parallel in vivo enhancer assay reveals that highly local features determine the cisregulatory function of ChIP-seq peaks. Proc Natl Acad Sci 110: 11952-11957.
    • (2013) Proc Natl Acad Sci , vol.110 , pp. 11952-11957
    • White, M.A.1    Myers, C.A.2    Corbo, J.C.3    Cohen, B.A.4
  • 66
    • 0034796040 scopus 로고    scopus 로고
    • Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions
    • DOI 10.1016/S1097-2765(01)00345-8
    • Xiao H, Sandaltzopoulos R, Wang HM, Hamiche A, Ranallo R, Lee KM, Fu D, Wu C. 2001. Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions. Mol Cell 8: 531-543. (Pubitemid 32946931)
    • (2001) Molecular Cell , vol.8 , Issue.3 , pp. 531-543
    • Xiao, H.1    Sandaltzopoulos, R.2    Wang, H.-M.3    Hamiche, A.4    Ranallo, R.5    Lee, K.-M.6    Fu, D.7    Wu, C.8
  • 67
    • 84865257761 scopus 로고    scopus 로고
    • Uncovering cis-regulatory sequence requirements for context-specific transcription factor binding
    • Yáñez-Cuna JO, Dinh HQ, Kvon EZ, Shlyueva D, Stark A. 2012. Uncovering cis-regulatory sequence requirements for context-specific transcription factor binding. Genome Res 22: 2018-2030.
    • (2012) Genome Res , vol.22 , pp. 2018-2030
    • Yáñez-Cuna, J.O.1    Dinh, H.Q.2    Kvon, E.Z.3    Shlyueva, D.4    Stark, A.5
  • 68
    • 84871693720 scopus 로고    scopus 로고
    • Deciphering the transcriptional cisregulatory code
    • Yáñez-Cuna JO, Kvon EZ, Stark A. 2013. Deciphering the transcriptional cisregulatory code. Trends Genet 29: 11-22.
    • (2013) Trends Genet , vol.29 , pp. 11-22
    • Yáñez-Cuna, J.O.1    Kvon, E.Z.2    Stark, A.3
  • 69
    • 36949030484 scopus 로고    scopus 로고
    • Predicting gene expression from sequence: A reexamination
    • Yuan Y, Guo L, Shen L, Liu JS. 2007. Predicting gene expression from sequence: a reexamination. PLoS Comput Biol 3: e243.
    • (2007) PLoS Comput Biol , vol.3
    • Yuan, Y.1    Guo, L.2    Shen, L.3    Liu, J.S.4
  • 70
    • 70449132583 scopus 로고    scopus 로고
    • Combinatorial binding predicts spatio-temporal cis-regulatory activity
    • Zinzen RP, Girardot C, Gagneur J, Braun M, Furlong EEM. 2009. Combinatorial binding predicts spatio-temporal cis-regulatory activity. Nature 462: 65-70.
    • (2009) Nature , vol.462 , pp. 65-70
    • Zinzen, R.P.1    Girardot, C.2    Gagneur, J.3    Braun, M.4    Furlong, E.E.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.