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Volumn 9, Issue 3, 2013, Pages

RFECS: A Random-Forest Based Algorithm for Enhancer Identification from Chromatin State

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DECISION TREES; FORECASTING; GENE EXPRESSION REGULATION; MAMMALS; STEM CELLS;

EID: 84876007572     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002968     Document Type: Article
Times cited : (181)

References (49)
  • 1
    • 77956495708 scopus 로고    scopus 로고
    • Transcriptional enhancers in animal development and evolution
    • Levine M, (2010) Transcriptional enhancers in animal development and evolution. Curr Biol 20: R754-763.
    • (2010) Curr Biol , vol.20
    • Levine, M.1
  • 2
    • 84856239091 scopus 로고    scopus 로고
    • Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development
    • Bonn S, Zinzen RP, Girardot C, Gustafson EH, Perez-Gonzalez A, et al. (2012) Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development. Nat Genet 44: 148-156.
    • (2012) Nat Genet , vol.44 , pp. 148-156
    • Bonn, S.1    Zinzen, R.P.2    Girardot, C.3    Gustafson, E.H.4    Perez-Gonzalez, A.5
  • 3
    • 65549104157 scopus 로고    scopus 로고
    • Histone modifications at human enhancers reflect global cell-type-specific gene expression
    • Heintzman ND, Hon GC, Hawkins RD, Kheradpour P, Stark A, et al. (2009) Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 459: 108-112.
    • (2009) Nature , vol.459 , pp. 108-112
    • Heintzman, N.D.1    Hon, G.C.2    Hawkins, R.D.3    Kheradpour, P.4    Stark, A.5
  • 4
    • 60149091656 scopus 로고    scopus 로고
    • ChIP-seq accurately predicts tissue-specific activity of enhancers
    • Visel A, Blow MJ, Li Z, Zhang T, Akiyama JA, et al. (2009) ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 457: 854-858.
    • (2009) Nature , vol.457 , pp. 854-858
    • Visel, A.1    Blow, M.J.2    Li, Z.3    Zhang, T.4    Akiyama, J.A.5
  • 5
    • 33847334699 scopus 로고    scopus 로고
    • Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
    • Heintzman ND, Stuart RK, Hon G, Fu Y, Ching CW, et al. (2007) Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet 39: 311-318.
    • (2007) Nat Genet , vol.39 , pp. 311-318
    • Heintzman, N.D.1    Stuart, R.K.2    Hon, G.3    Fu, Y.4    Ching, C.W.5
  • 6
    • 79955081425 scopus 로고    scopus 로고
    • PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers
    • Jin F, Li Y, Ren B, Natarajan R, (2011) PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers. Proc Natl Acad Sci U S A 108: 5290-5295.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5290-5295
    • Jin, F.1    Li, Y.2    Ren, B.3    Natarajan, R.4
  • 7
    • 77952367798 scopus 로고    scopus 로고
    • Widespread transcription at neuronal activity-regulated enhancers
    • Kim TK, Hemberg M, Gray JM, Costa AM, Bear DM, et al. (2010) Widespread transcription at neuronal activity-regulated enhancers. Nature 465: 182-187.
    • (2010) Nature , vol.465 , pp. 182-187
    • Kim, T.K.1    Hemberg, M.2    Gray, J.M.3    Costa, A.M.4    Bear, D.M.5
  • 8
    • 65749087932 scopus 로고    scopus 로고
    • An integrated approach to identifying cis-regulatory modules in the human genome
    • Won KJ, Agarwal S, Shen L, Shoemaker R, Ren B, et al. (2009) An integrated approach to identifying cis-regulatory modules in the human genome. PLoS One 4: e5501.
    • (2009) PLoS One , vol.4
    • Won, K.J.1    Agarwal, S.2    Shen, L.3    Shoemaker, R.4    Ren, B.5
  • 9
    • 84859018998 scopus 로고    scopus 로고
    • ReLA, a local alignment search tool for the identification of distal and proximal gene regulatory regions and their conserved transcription factor binding sites
    • Gonzalez S, Montserrat-Sentis B, Sanchez F, Puiggros M, Blanco E, et al. (2012) ReLA, a local alignment search tool for the identification of distal and proximal gene regulatory regions and their conserved transcription factor binding sites. Bioinformatics 28: 763-770.
    • (2012) Bioinformatics , vol.28 , pp. 763-770
    • Gonzalez, S.1    Montserrat-Sentis, B.2    Sanchez, F.3    Puiggros, M.4    Blanco, E.5
  • 10
    • 84859235405 scopus 로고    scopus 로고
    • A machine learning approach for identifying novel cell type-specific transcriptional regulators of myogenesis
    • Busser BW, Taher L, Kim Y, Tansey T, Bloom MJ, et al. (2012) A machine learning approach for identifying novel cell type-specific transcriptional regulators of myogenesis. PLoS Genet 8: e1002531.
    • (2012) PLoS Genet , vol.8
    • Busser, B.W.1    Taher, L.2    Kim, Y.3    Tansey, T.4    Bloom, M.J.5
  • 11
    • 84856575217 scopus 로고    scopus 로고
    • Predicting tissue specific cis-regulatory modules in the human genome using pairs of co-occurring motifs
    • Girgis HZ, Ovcharenko I, (2012) Predicting tissue specific cis-regulatory modules in the human genome using pairs of co-occurring motifs. BMC Bioinformatics 13: 25.
    • (2012) BMC Bioinformatics , vol.13 , pp. 25
    • Girgis, H.Z.1    Ovcharenko, I.2
  • 12
    • 71749103442 scopus 로고    scopus 로고
    • Comparative genomics of gene regulation-conservation and divergence of cis-regulatory information
    • Meireles-Filho AC, Stark A, (2009) Comparative genomics of gene regulation-conservation and divergence of cis-regulatory information. Curr Opin Genet Dev 19: 565-570.
    • (2009) Curr Opin Genet Dev , vol.19 , pp. 565-570
    • Meireles-Filho, A.C.1    Stark, A.2
  • 13
    • 38649123306 scopus 로고    scopus 로고
    • Ultraconservation identifies a small subset of extremely constrained developmental enhancers
    • Visel A, Prabhakar S, Akiyama JA, Shoukry M, Lewis KD, et al. (2008) Ultraconservation identifies a small subset of extremely constrained developmental enhancers. Nat Genet 40: 158-160.
    • (2008) Nat Genet , vol.40 , pp. 158-160
    • Visel, A.1    Prabhakar, S.2    Akiyama, J.A.3    Shoukry, M.4    Lewis, K.D.5
  • 14
    • 71749120382 scopus 로고    scopus 로고
    • Finding distal regulatory elements in the human genome
    • Heintzman ND, Ren B, (2009) Finding distal regulatory elements in the human genome. Curr Opin Genet Dev 19: 541-549.
    • (2009) Curr Opin Genet Dev , vol.19 , pp. 541-549
    • Heintzman, N.D.1    Ren, B.2
  • 15
  • 16
    • 0030207894 scopus 로고    scopus 로고
    • Versatile molecular glue. Transcriptional control
    • Janknecht R, Hunter T, (1996) Versatile molecular glue. Transcriptional control. Curr Biol 6: 951-954.
    • (1996) Curr Biol , vol.6 , pp. 951-954
    • Janknecht, R.1    Hunter, T.2
  • 17
    • 41949113742 scopus 로고    scopus 로고
    • The enhanceosome
    • Panne D, (2008) The enhanceosome. Curr Opin Struct Biol 18: 236-242.
    • (2008) Curr Opin Struct Biol , vol.18 , pp. 236-242
    • Panne, D.1
  • 18
    • 0032579292 scopus 로고    scopus 로고
    • Transcription factor-specific requirements for coactivators and their acetyltransferase functions
    • Korzus E, Torchia J, Rose DW, Xu L, Kurokawa R, et al. (1998) Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science 279: 703-707.
    • (1998) Science , vol.279 , pp. 703-707
    • Korzus, E.1    Torchia, J.2    Rose, D.W.3    Xu, L.4    Kurokawa, R.5
  • 19
    • 79955027617 scopus 로고    scopus 로고
    • Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart
    • He A, Kong SW, Ma Q, Pu WT, (2011) Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proc Natl Acad Sci U S A 108: 5632-5637.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5632-5637
    • He, A.1    Kong, S.W.2    Ma, Q.3    Pu, W.T.4
  • 20
    • 79952267284 scopus 로고    scopus 로고
    • High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells
    • Boyle AP, Song L, Lee BK, London D, Keefe D, et al. (2011) High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells. Genome Res 21: 456-464.
    • (2011) Genome Res , vol.21 , pp. 456-464
    • Boyle, A.P.1    Song, L.2    Lee, B.K.3    London, D.4    Keefe, D.5
  • 21
    • 38649099445 scopus 로고    scopus 로고
    • High-resolution mapping and characterization of open chromatin across the genome
    • Boyle AP, Davis S, Shulha HP, Meltzer P, Margulies EH, et al. (2008) High-resolution mapping and characterization of open chromatin across the genome. Cell 132: 311-322.
    • (2008) Cell , vol.132 , pp. 311-322
    • Boyle, A.P.1    Davis, S.2    Shulha, H.P.3    Meltzer, P.4    Margulies, E.H.5
  • 22
    • 34250305146 scopus 로고    scopus 로고
    • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    • Birney E, Stamatoyannopoulos JA, Dutta A, Guigo R, Gingeras TR, et al. (2007) Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447: 799-816.
    • (2007) Nature , vol.447 , pp. 799-816
    • Birney, E.1    Stamatoyannopoulos, J.A.2    Dutta, A.3    Guigo, R.4    Gingeras, T.R.5
  • 23
    • 62849085018 scopus 로고    scopus 로고
    • Prediction of regulatory elements in mammalian genomes using chromatin signatures
    • Won KJ, Chepelev I, Ren B, Wang W, (2008) Prediction of regulatory elements in mammalian genomes using chromatin signatures. BMC Bioinformatics 9: 547.
    • (2008) BMC Bioinformatics , vol.9 , pp. 547
    • Won, K.J.1    Chepelev, I.2    Ren, B.3    Wang, W.4
  • 24
    • 77954204584 scopus 로고    scopus 로고
    • Discover regulatory DNA elements using chromatin signatures and artificial neural network
    • Firpi HA, Ucar D, Tan K, (2010) Discover regulatory DNA elements using chromatin signatures and artificial neural network. Bioinformatics 26: 1579-1586.
    • (2010) Bioinformatics , vol.26 , pp. 1579-1586
    • Firpi, H.A.1    Ucar, D.2    Tan, K.3
  • 25
    • 79955583542 scopus 로고    scopus 로고
    • Mapping and analysis of chromatin state dynamics in nine human cell types
    • Ernst J, Kheradpour P, Mikkelsen TS, Shoresh N, Ward LD, et al. (2011) Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 473: 43-49.
    • (2011) Nature , vol.473 , pp. 43-49
    • Ernst, J.1    Kheradpour, P.2    Mikkelsen, T.S.3    Shoresh, N.4    Ward, L.D.5
  • 26
    • 84872495357 scopus 로고    scopus 로고
    • Genome-wide enhancer prediction from epigenetic signatures using genetic algorithm-optimized support vector machines
    • Fernandez M, Miranda-Saavedra D, (2012) Genome-wide enhancer prediction from epigenetic signatures using genetic algorithm-optimized support vector machines. Nucleic Acids Res 40: e77.
    • (2012) Nucleic Acids Res , vol.40
    • Fernandez, M.1    Miranda-Saavedra, D.2
  • 27
    • 34250307630 scopus 로고    scopus 로고
    • The landscape of histone modifications across 1% of the human genome in five human cell lines
    • Koch CM, Andrews RM, Flicek P, Dillon SC, Karaoz U, et al. (2007) The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Res 17: 691-707.
    • (2007) Genome Res , vol.17 , pp. 691-707
    • Koch, C.M.1    Andrews, R.M.2    Flicek, P.3    Dillon, S.C.4    Karaoz, U.5
  • 28
    • 78650747491 scopus 로고    scopus 로고
    • Discovery and characterization of chromatin states for systematic annotation of the human genome
    • Ernst J, Kellis M, (2010) Discovery and characterization of chromatin states for systematic annotation of the human genome. Nat Biotechnol 28: 817-825.
    • (2010) Nat Biotechnol , vol.28 , pp. 817-825
    • Ernst, J.1    Kellis, M.2
  • 29
    • 84864462544 scopus 로고    scopus 로고
    • A map of the cis-regulatory sequences in the mouse genome
    • Shen Y, Yue F, McCleary DF, Ye Z, Edsall L, et al. (2012) A map of the cis-regulatory sequences in the mouse genome. Nature 488: 116-20.
    • (2012) Nature , vol.488 , pp. 116-120
    • Shen, Y.1    Yue, F.2    McCleary, D.F.3    Ye, Z.4    Edsall, L.5
  • 31
    • 0035478854 scopus 로고    scopus 로고
    • Random Forests
    • Breiman L, (2001) Random Forests. Machine Learning 45: 5-32.
    • (2001) Machine Learning , vol.45 , pp. 5-32
    • Breiman, L.1
  • 33
    • 0036643067 scopus 로고    scopus 로고
    • Estimating generalization error on two-class datasets using out-of-bag estimates
    • Bylander T, (2002) Estimating generalization error on two-class datasets using out-of-bag estimates. Machine Learning 48: 287-297.
    • (2002) Machine Learning , vol.48 , pp. 287-297
    • Bylander, T.1
  • 35
    • 77956685340 scopus 로고    scopus 로고
    • Classifying Very-High-Dimensional Data with Random Forests of Oblique Decision Trees
    • In: Guillet F, Ritschard G, Zighed D, Briand H, editors. Springer Berlin/Heidelberg
    • Do T-N, Lenca P, Lallich S, Pham N-K (2010) Classifying Very-High-Dimensional Data with Random Forests of Oblique Decision Trees In: Guillet F, Ritschard G, Zighed D, Briand H, editors. Advances in Knowledge Discovery and Management. Springer Berlin/Heidelberg. pp. 39-55.
    • (2010) Advances in Knowledge Discovery and Management , pp. 39-55
    • Do, T.-N.1    Lenca, P.2    Lallich, S.3    Pham, N.-K.4
  • 37
    • 75249087100 scopus 로고    scopus 로고
    • edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
    • Robinson MD, McCarthy DJ, Smyth GK, (2010) edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26: 139-140.
    • (2010) Bioinformatics , vol.26 , pp. 139-140
    • Robinson, M.D.1    McCarthy, D.J.2    Smyth, G.K.3
  • 38
    • 84861911346 scopus 로고    scopus 로고
    • Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb
    • Cotney J, Leng J, Oh S, Demare LE, Reilly SK, et al. (2012) Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Genome Res 22: 1069-1080.
    • (2012) Genome Res , vol.22 , pp. 1069-1080
    • Cotney, J.1    Leng, J.2    Oh, S.3    Demare, L.E.4    Reilly, S.K.5
  • 39
    • 80053188808 scopus 로고    scopus 로고
    • Enhancers in embryonic stem cells are enriched for transposable elements and genetic variations associated with cancers
    • Teng L, Firpi HA, Tan K, (2011) Enhancers in embryonic stem cells are enriched for transposable elements and genetic variations associated with cancers. Nucleic Acids Res 39: 7371-7379.
    • (2011) Nucleic Acids Res , vol.39 , pp. 7371-7379
    • Teng, L.1    Firpi, H.A.2    Tan, K.3
  • 41
    • 69449102464 scopus 로고    scopus 로고
    • Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
    • Wang Z, Zang C, Cui K, Schones DE, Barski A, et al. (2009) Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 138: 1019-1031.
    • (2009) Cell , vol.138 , pp. 1019-1031
    • Wang, Z.1    Zang, C.2    Cui, K.3    Schones, D.E.4    Barski, A.5
  • 42
    • 79955550445 scopus 로고    scopus 로고
    • A user's guide to the encyclopedia of DNA elements (ENCODE)
    • A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol 9: e1001046.
    • PLoS Biol , vol.9
  • 44
    • 33745416080 scopus 로고    scopus 로고
    • Genome-scale mapping of DNase I sensitivity in vivo using tiling DNA microarrays
    • Sabo PJ, Kuehn MS, Thurman R, Johnson BE, Johnson EM, et al. (2006) Genome-scale mapping of DNase I sensitivity in vivo using tiling DNA microarrays. Nat Methods 3: 511-518.
    • (2006) Nat Methods , vol.3 , pp. 511-518
    • Sabo, P.J.1    Kuehn, M.S.2    Thurman, R.3    Johnson, B.E.4    Johnson, E.M.5
  • 45
    • 34249026300 scopus 로고    scopus 로고
    • High-resolution profiling of histone methylations in the human genome
    • Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, et al. (2007) High-resolution profiling of histone methylations in the human genome. Cell 129: 823-837.
    • (2007) Cell , vol.129 , pp. 823-837
    • Barski, A.1    Cuddapah, S.2    Cui, K.3    Roh, T.Y.4    Schones, D.E.5
  • 46
    • 46249112085 scopus 로고    scopus 로고
    • Combinatorial patterns of histone acetylations and methylations in the human genome
    • Wang Z, Zang C, Rosenfeld JA, Schones DE, Barski A, et al. (2008) Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet 40: 897-903.
    • (2008) Nat Genet , vol.40 , pp. 897-903
    • Wang, Z.1    Zang, C.2    Rosenfeld, J.A.3    Schones, D.E.4    Barski, A.5
  • 47
    • 77953809032 scopus 로고    scopus 로고
    • Distinct epigenomic landscapes of pluripotent and lineage-committed human cells
    • Hawkins RD, Hon GC, Lee LK, Ngo Q, Lister R, et al. (2010) Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell 6: 479-491.
    • (2010) Cell Stem Cell , vol.6 , pp. 479-491
    • Hawkins, R.D.1    Hon, G.C.2    Lee, L.K.3    Ngo, Q.4    Lister, R.5
  • 48
    • 55549118625 scopus 로고    scopus 로고
    • ChromaSig: a probabilistic approach to finding common chromatin signatures in the human genome
    • Hon G, Ren B, Wang W, (2008) ChromaSig: a probabilistic approach to finding common chromatin signatures in the human genome. PLoS Comput Biol 4: e1000201.
    • (2008) PLoS Comput Biol , vol.4
    • Hon, G.1    Ren, B.2    Wang, W.3
  • 49
    • 9444225935 scopus 로고    scopus 로고
    • Java Treeview-extensible visualization of microarray data
    • Saldanha AJ, (2004) Java Treeview-extensible visualization of microarray data. Bioinformatics 20: 3246-3248.
    • (2004) Bioinformatics , vol.20 , pp. 3246-3248
    • Saldanha, A.J.1


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