Follicular helper T cells are responsible for IgE responses to Der p 1 following house dust mite sensitization in mice

Clinical and Experimental Allergy

Volumn 46, Issue 8, 2016, Pages 1075-1082

  Noble, A ^a   Zhao, J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Der p 1; follicular helper T cell; house dust mite; IgE; Th2 cell

Indexed keywords

ALLERGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR5; DER P 1 ALLERGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; INDUCIBLE T CELL COSTIMULATOR; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 33; INTERLEUKIN 4; INTERLEUKIN 6 RECEPTOR; PROGRAMMED DEATH 1 LIGAND 1; PROTEIN BCL 6; UNCLASSIFIED DRUG;

AIRWAY; ALLERGIC AIRWAY INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATOPHAGOIDES; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; FEMALE; FLOW CYTOMETRY; GENE MUTATION; HELPER CELL; LYMPH NODE CELL; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION; SIGNAL TRANSDUCTION; SPLEEN CELL; TH2 CELL; WILD TYPE;

EID: 84979536739     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12750     Document Type: Article

References (34)

1. de Vries JE, Carballido JM, Sornasse T, Yssel H. Antagonizing the differentiation and functions of human T helper type 2 cells. Curr Opin Immunol 1995; 7:771–8.
2. Tangye SG, Ma CS, Brink R, Deenick EK. The good, the bad and the ugly - TFH cells in human health and disease. Nat Rev Immunol 2013; 13:412–26.
3. Robinson DS, Hamid Q, Ying S et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326:298–304.
4. Kroenke MA, Eto D, Locci M, Cho M, Davidson T, Haddad EK, et al. Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol 2012; 188:3734–44.
5. Suto A, Nakajima H, Hirose K et al. Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line Cε transcription of IL-4-stimulated B cells. Blood 2002; 100:4565–73.
6. Eto D, Lao C, DiToro D, Barnett B, Escobar TC, Kageyama R, et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS ONE 2011; 6:e17739.
7. Cameron L, Gounni AS, Frenkiel S, Lavigne F, Vercelli D, Hamid Q. Sε Sμ and Sε Sγ switch circles in human nasal mucosa following ex vivo allergen challenge: evidence for direct as well as sequential class switch recombination. J Immunol 2003; 171:3816–22.
8. + B lymphocytes limits their contribution to the classical memory response. J Exp Med 2013; 210:2755–71.
9. Wesemann DR, Magee JM, Boboila C et al. Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. J Exp Med 2011; 208:2733–46.
10. + T cell clones. J Exp Med 1991; 173:747–50.
11. Xiong H, Dolpady J, Wabl M, Curotto de Lafaille MA, Lafaille JJ. Sequential class switching is required for the generation of high affinity IgE antibodies. J Exp Med 2012; 209:353–64.
12. Harker JA, Lewis GM, Mack L, Zuniga EI. Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science 2011; 334:825–9.
13. Nurieva RI, Chung Y, Martinez GJ et al. Bcl6 mediates the development of T follicular helper cells. Science 2009; 325:1001–5.
14. Luthje K, Kallies A, Shimohakamada Y et al. The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol 2012; 13:491–8.
15. Fasnacht N, Greweling MC, Bollati-Fogolin M, Schippers A, Muller W. T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection. Eur J Immunol 2009; 39:2173–83.
16. Zhao J, Lloyd CM, Noble A. Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling. Mucosal Immunol 2013; 6:335–46.
17. + regulatory T cells in non-lymphopenic hosts. J Leukoc Biol 2007; 82:1053–61.
18. Kubinak JL, Petersen C, Stephens WZ et al. MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health. Cell Host Microbe 2015; 17:153–63.
19. + immunoregulatory cells in the graft-versus-host reaction: CD8 T cells activate dendritic cells to secrete interleukin-12/interleukin-18 and induce T helper 1 autoantibody. Immunology 2003; 109:476–86.
20. Piehler D, Eschke M, Schulze B et al. The IL-33 receptor (ST2) regulates early IL-13 production in fungus-induced allergic airway inflammation. Mucosal Immunol 2015; Nov 11. doi: 10.1038/mi.2015.106.
21. Vijayanand P, Seumois G, Simpson LJ et al. Interleukin-4 production by follicular helper T cells requires the conserved IL-4 enhancer hypersensitivity site V. Immunity 2012; 36:175–87.
22. Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol 2012; 13:58–66.
23. Endo Y, Hirahara K, Yagi R, Tumes DJ, Nakayama T. Pathogenic memory type Th2 cells in allergic inflammation. Trends Immunol 2014; 35:69–78.
24. Glatman Zaretsky A, Taylor JJ, King IL, Marshall FA, Mohrs M, Pearce EJ. T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med 2009; 206:991–9.
25. + B-cell memory in human subjects. J Allergy Clin Immunol 2013; 131:972–6.
26. Banwell ME, Robinson DS, Lloyd CM. Adenoid-derived TH2 cells reactive to allergen and recall antigen express CC chemokine receptor 4. J Allergy Clin Immunol 2003; 112:1155–61.
27. Silver JS, Hunter CA. gp130 at the nexus of inflammation, autoimmunity, and cancer. J Leukoc Biol 2010; 88:1145–56.
28. Bettelli E, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441:235–8.
29. Hollister K, Kusam S, Wu H et al. Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model. J Immunol 2013; 191:3705–11.
30. + T follicular helper cells. Eur J Immunol 2013; 43:3219–32.
31. Feng X, Wang D, Chen J et al. Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus. PLoS ONE 2012; 7:e51982.
32. Ueno H, Banchereau J, Vinuesa CG. Pathophysiology of T follicular helper cells in humans and mice. Nat Immunol 2015; 16:142–52.
33. + Th2 cells exacerbate murine allergic airway diseases with prominent eosinophilia. J Immunol 2015; 194:3583–93.
34. Krug N, Hohlfeld JM, Kirsten AM et al. Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N Engl J Med 2015; 372:1987–95.