Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-β1

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 310, Issue 6, 2016, Pages H716-H724

  Mewhort, Holly E M ^a   Lipon, Brodie D ^a   Svystonyuk, Daniyil A ^a   Teng, Guoqi ^a   Guzzardi, David G ^a   Silva, Claudia ^b   Yong, V Wee ^b   Fedak, Paul W M ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Cardiac fibrosis; Cardiac myofibro blasts; Extracellular matrix; Inflammation; Remodeling

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; DISCOIDIN; DISCOIDIN DOMAIN RECEPTOR 2; FIBRONECTIN; GELATINASE B; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VIMENTIN; COLLAGEN; GEL; MMP9 PROTEIN, HUMAN; TGFB1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CELL ACTIVATION; CELL CONTACT; CELL INTERACTION; CELL VIABILITY; CLINICAL ARTICLE; COCULTURE; COLLAGEN FIBER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; HEART FIBROBLAST; HEART LEFT VENTRICLE; HEART MUSCLE BIOPSY; HEART RIGHT ATRIUM; HUMAN; HUMAN CELL; MALE; MICROENVIRONMENT; MONOCYTE; MYOFIBROBLAST; PARACRINE SIGNALING; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; CARDIAC MUSCLE; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL; HEART ATRIUM REMODELING; HEART VENTRICLE REMODELING; METABOLISM; ULTRASTRUCTURE;

ATRIAL REMODELING; COCULTURE TECHNIQUES; COLLAGEN; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; GELS; HUMANS; MATRIX METALLOPROTEINASE 9; MICROSCOPY, CONFOCAL; MONOCYTES; MYOCARDIUM; MYOFIBROBLASTS; TRANSFORMING GROWTH FACTOR BETA1; VENTRICULAR REMODELING;

EID: 84979536553     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00309.2015     Document Type: Article

References (42)

1. Arnold JM, Liu P, Demers C, Dorian P, Giannetti N, Haddad H, Heckman GA, Howlett JG, Ignaszewski A, Johnstone DE, Jong P, McKelvie RS, Moe GW, Parker JD, Rao V, Ross HJ, Sequeira EI, Svendsen AM, Teo K, Tsuyuki RT, White M. Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: Diagnosis and management. Can J Cardiol 22: 23-45, 2006.
2. Brown RD, Ambler SK, Mitchell MD, Long CS. The cardiac fibroblast: therapeutic target in myocardial remodeling and failure. Annu Rev Phar-macol Toxicol 45: 657-687, 2005.
3. Dasch JR, Pace DR, Waegell W, Inenaga D, Ellingsworth L. Mono-clonal antibodies recognizing transforming growth factor-. Bioactivity neutralization and transforming growth factor beta 2 affinity purification. J Immunol 142: 1536-1541, 1989.
4. Dixon DL, Griggs KM, Bersten AD, De Pasquale CG. Systemic inflammation and cell activation reflects morbidity in chronic heart failure. Cytokine 56: 593-599, 2011.
5. Dobaczewski M, Chen W, Frangogiannis NG. Transforming growth factor (TGF)-signaling in cardiac remodeling. J Mol Cell Cardiol 51: 600-606, 2011.
6. Fedak PWM, Verma S, Weisel RD, Li RK. Cardiac remodeling and failure: from molecules to man (Part I). Cardiovasc Pathol 14: 1-11, 2005.
7. Fontes ML, Mathew JP, Rinder HM, Zelterman D, Smith BR, Rinder CS. Multicenter Study of Perioperative Ischemia (McSPI) Research Group. Atrial fibrillation after cardiac surgery/cardiopulmonary bypass is associated with monocyte activation. Anesth Analg 101: 17-23, 2005.
8. Frangogiannis NG. Inflammation in cardiac injury, repair and regenera-tion. Curr Opin Cardiol 30: 240-245, 2015.
9. Fujiu K, Nagai R. Contributions of cardiomyocyte-cardiac fibroblast-immune cell interactions in heart failure development. Basic Res Cardiol 108: 357, 2013.
10. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Magid D, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Nichol G, Paynter NP, Schreiner PJ, Sorlie PD, Stein J, Turan TN, Virani SS, Wong ND, Woo D, Turner MB, on behalf of the American Heart Association Statistics Committee, and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics— 2013 Update: a report from the American Heart Association. Circulation 127: e6-e245, 2013.
11. Graham HK, Horn M, Trafford AW. Extracellular matrix profiles in the progression to heart failure. Acta Physiol (Oxf) 194: 3-21, 2008.
12. Hong YJ, Jeong MH, Ahn Y, Yoon NS, Lee SR, Hong SN, Moon JY, Kim KH, Park HW, Kim JH, Cho JG, Park JC, Kang JC. Relationship between peripheral monocytosis and nonrecovery of left ventricular func-tion in patients with left ventricular dysfunction complicated with acute myocardial infarction. Circ J 71: 1219-1224, 2007.
13. Hu YF, Yeh HI, Tsao HM, Tai CT, Lin YJ, Chang SL, Lo LW, Tuan TC, Tzeng CH, Huang SH, Lin YK, Chen SA. Impact of circulating monocyte CD36 level on atrial fibrillation and subsequent catheter abla-tion. Heart Rhythm 8: 650-656, 2011.
14. Ikeuchi M, Tsutsui H, Shiomi T, Matsusaka H, Matsushima S, Wen J, Kubota T, Takeshita A. Inhibition of TGF-beta signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction. Cardiovasc Res 64: 526-535, 2004.
15. Iyer RP, Patterson NL, Fields GB, Lindsey ML. The history of matrix metalloproteinases: milestones, myths, and misperceptions. Am J Physiol Heart Circ Physiol 303: H919-H930, 2012.
16. Kempf T, Zarbock A, Vestweber D, Wollert KC. Anti-inflammatory mechanisms and therapeutic opportunities in myocardial infarct healing. J Mol Med 90: 361-369, 2012.
17. Kempf T, Zarbock A, Widera C, Butz S, Stadtmann A, Rossaint J, Bolomini-Vittori M, Korf-Klingebiel M, Napp LC, Hansen B, Kan-wischer A, Bavendiek U, Beutel G, Hapke M, Sauer MG, Laudanna C, Hogg N, Vestweber D, Wollert KC. GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med 17: 581-588, 2011.
18. Lambert JM, Lopez EF, Lindsey ML. Macrophage roles following myocardial infarction. Int J Cardiol 130: 147-158, 2008.
19. Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol 32: 2045-2051, 2012.
20. Lijnen P, Petrov V, Rumilla K, Fagard R. Transforming growth factor-beta 1 promotes contraction of collagen gel by cardiac fibroblasts through their differentiation into myofibroblasts. Methods Find Exp Clin Pharmacol 25: 79-86, 2003.
21. Lubbe WJ, Zhou ZY, Fu W, Zuzga D, Schulz S, Fridman R, Muschel RJ, Waldman SA, Pitari GM. Tumor epithelial cell matrix metallopro-teinase 9 is a target for antimetastatic therapy in colorectal cancer. Clin Cancer Res 12: 1876-1882, 2006.
22. Ma Y, de Castro Brás LE, Toba H, Iyer RP, Hall ME, Winniford MD, Lange RA, Tyagi SC, Lindsey ML. Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling. Pflügers Arch 466: 1113-1127, 2014.
23. Maekawa Y, Anzai T, Yoshikawa T, Asakura Y, Takahashi T, Ishikawa S, Mitamura H, Ogawa S. Prognostic significance of periph-eral monocytosis after reperfused acute myocardial infarction:a possible role for left ventricular remodeling. J Am Coll Cardiol 39: 241-246, 2002.
24. Mohammadi H, Janmey PA, McCulloch CA. Biomaterials. Biomateri-als 35: 1138-1149, 2014.
25. Mohammadi H, Pinto VI, Wang Y, Hinz B, Janmey PA, McCulloch CA. Filamin A mediates wound closure by promoting elastic deformation and maintenance of tension in the collagen matrix. J Invest Dermatol 135: 2852-2861, 2015.
26. Murphy-Ullrich JE. The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state? J Clin Invest 107: 785-790, 2001.
27. Nahrendorf M, Pittet MJ, Swirski FK. Monocytes: protagonists of infarct inflammation and repair after myocardial infarction. Circulation 121: 2437-2445, 2010.
28. Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ. The healing myocar-dium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 204: 3037-3047, 2007.
29. Ngu JMC, Teng G, Meijndert HC, Mewhort HE, Turnbull JD, Stetler-Stevenson WG, Fedak PWM. Human cardiac fibroblast extra-cellular matrix remodeling: dual effects of tissue inhibitor of metallopro-teinase-2. Cardiovasc Pathol 23: 335-343, 2014.
30. Opie LH, Commerford PJ, Gersh BJ, Pfeffer MA. Controversies in ventricular remodelling. Lancet 367: 356-367, 2006.
31. Pinto VI, Mohammadi H, Lee WS, Cheung AH, McCulloch CA. PAK1 is involved in sensing the orientation of collagen stiffness gradients in mouse fibroblasts. Biochim Biophys Acta 1853: 2526-2538, 2015.
32. Rosenkranz S. TGF-1 and angiotensin networking in cardiac remodel-ing. Cardiovasc Res 63: 423-432, 2004.
33. Sundararaj KP, Samuvel DJ, Li Y, Sanders JJ, Lopes-Virella MF, Huang Y. Interleukin-6 released from fibroblasts is essential for up-regulation of matrix metalloproteinase-1 expression by U937 macrophages in coculture. J Biol Chem 284: 13,714-13,724, 2009.
34. Suzuki A, Fukuzawa K, Yamashita T, Yoshida A, Sasaki N, Emoto T, Takei A, Fujiwara R, Nakanishi T, Yamashita S, Matsumoto A, Konishi H, Ichibori H, Inoue N, Hirata KI. Circulating intermediate CD14 CD16 monocytes are increased in patients with atrial fibrilla-tion and reflect functional remodeling of left atrium. JAC 65: A466, 2015.
35. Teng G, Svystonyuk D, Mewhort HEM, Turnbull JD, Belke DD, Duff HJ, Fedak PWM. Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis. Am J Physiol Heart Circ Physiol 308: H1564-H1574, 2015.
36. Tieu BC, Lee C, Sun H, LeJeune W, Recinos 3rd A, Ju X, Spratt H, Guo DC, Milewicz D, Tilton RG, Brasier AR. An adventitial IL-6/1 amplifica-tion loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice. J Clin Invest 119: 3637-3651, 2009.
37. Tsai TH, Lin YC, Sun CK, Chung SY, Chai HT, Yang CH, Chen SM, Hang CL, Chen CJ, Chua S, Wu CJ, Leu S, Yip HK. Prognostic value of circulating dead monocytes in patients with acute st-elevation myocar-dial infarction undergoing primary percutaneous coronary intervention. Cardiology 117: 131-139, 2010.
38. Tsutamoto T, Hisanaga T, Wada A, Maeda K, Ohnishi M, Fukai D, Mabuchi N, Sawaki M, Kinoshita M. Interleukin-6 spillover in the periph-eral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol 31: 391-398, 1998.
39. Velagaleti RS, Pencina MJ, Murabito JM, Wang TJ, Parikh NI, D’Agostino RB, Levy D, Kannel WB, Vasan RS. Long-term trends in the incidence of heart failure after myocardial infarction. Circulation 118: 2057-2062, 2008.
40. Wahl SM, Hunt DA, Wakefield LM, McCartney-Francis N, Wahl LM, Roberts AB, Sporn MB. Transforming growth factor type induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci USA 84: 5788-5792, 1987.
41. Wrigley BJ, Lip GYH, Shantsila E. The role of monocytes and inflam-mation in the pathophysiology of heart failure. Eur J Heart Fail 13: 1161-1171, 2011.
42. Yamamoto T, Eckes B, Mauch C, Hartmann K, Krieg T. Monocyte chemoattractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1 alpha loop. J Immunol 164: 6174-6179, 2000.