Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells

Cancer Cell

Volumn 29, Issue 6, 2016, Pages 859-873

  Dolma, Sonam ^a,b   Selvadurai, Hayden J ^a   Lan, Xiaoyang ^a,b   Lee, Lilian ^a   Kushida, Michelle ^a   Voisin, Veronique ^c   Whetstone, Heather ^a   So, Milly ^a   Aviv, Tzvi ^a   Park, Nicole ^a,b   Zhu, Xueming ^a   Xu, ChangJiang ^c   Head, Renee ^a   Rowland, Katherine J ^a   Bernstein, Mark ^c   Clarke, Ian D ^a,d   Bader, Gary ^b,c   Harrington, Lea ^e   Brumell, John H ^a,b   Tyers, Mike ^e   Dirks, Peter B ^a,b   more..

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d OCAD UNIVERSITY   (Canada)

^e INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (4 AMINOPHENYL)ETHYL] 4 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; BEMESETRON; CHLOROQUINE; CHOLESTEROL; DOPAMINE RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; FILIPIN; FORSKOLIN; IFENPRODIL TARTRATE; IVERMECTIN; L 741742; MAMMALIAN TARGET OF RAPAMYCIN; MG 624; MITOGEN ACTIVATED PROTEIN KINASE 1; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PNU 96415E; RAPAMYCIN; TEMOZOLOMIDE; TESMILIFENE; TROPANYL 3,5 DIMETHYLBENZOATE; TROPINE 2 (4 CHLOROPHENOXY)BUTANOATE; UNCLASSIFIED DRUG; DOPAMINE 4 RECEPTOR; DRD4 PROTEIN, HUMAN; MOLECULAR LIBRARY;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL VACUOLE; CELL VIABILITY; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG INHIBITION; DRUG POTENCY; DRUG POTENTIATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GLIOBLASTOMA; GLIOMA STEM CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL INHIBITION; NEURAL STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROGNOSIS; REGULATORY MECHANISM; SEROTONINERGIC SYSTEM; TUMOR GROWTH; TUMOR VOLUME; WESTERN BLOTTING; ADMINISTRATION AND DOSAGE; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN NEOPLASMS; CANCER STEM CELL; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; METABOLISM; MOLECULAR LIBRARY; PATHOLOGY; PHARMACOLOGY; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; TUMOR CELL CULTURE; TUMOR CELL LINE;

ANIMALS; AUTOPHAGY; BRAIN NEOPLASMS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MICE; NEOPLASTIC STEM CELLS; NEURAL STEM CELLS; RECEPTORS, DOPAMINE D4; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; SURVIVAL ANALYSIS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84979497803     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2016.05.002     Document Type: Article

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