-
1
-
-
4444228888
-
-
World Health Organization. Available from: Accessed March 15, 2014
-
World Health Organization. Obesity and overweight. Available from: http: //www.who.int/mediacentre/factsheets/fs311/en/index.html. Accessed March 15, 2014.
-
Obesity and overweight
-
-
-
2
-
-
78650220733
-
Tackling of unhealthy diets, physical inactivity, and obesity: Health effects and cost-effectiveness
-
Cecchini M, Sassi F, Lauer JA, Lee YY, Guajardo-Barron V, Chisholm D. Tackling of unhealthy diets, physical inactivity, and obesity: health effects and cost-effectiveness. Lancet. 2010; 376(9754): 1775-1784.
-
(2010)
Lancet.
, vol.376
, Issue.9754
, pp. 1775-1784
-
-
Cecchini, M.1
Sassi, F.2
Lauer, J.A.3
Lee, Y.Y.4
Guajardo-Barron, V.5
Chisholm, D.6
-
3
-
-
70849120492
-
Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders
-
Heal DJ, Gosden J, Smith SL. Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders. Br J Clin Pharmacol. 2009; 68(6): 861-874.
-
(2009)
Br J Clin Pharmacol.
, vol.68
, Issue.6
, pp. 861-874
-
-
Heal, D.J.1
Gosden, J.2
Smith, S.L.3
-
4
-
-
84879420098
-
Obesity and the cardiorenal metabolic syndrome: Therapeutic modalities and their efficacy in improving cardiovascular and renal risk factors
-
Jindal A, Brietzke S, Sowers JR. Obesity and the cardiorenal metabolic syndrome: therapeutic modalities and their efficacy in improving cardiovascular and renal risk factors. Cardiorenal Med. 2012; 2(4): 314-327.
-
(2012)
Cardiorenal Med.
, vol.2
, Issue.4
, pp. 314-327
-
-
Jindal, A.1
Brietzke, S.2
Sowers, J.R.3
-
5
-
-
77950891085
-
Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes
-
Phung OJ, Scholle JM, Talwar M, etal. Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes. JAMA. 2010; 303(14): 1410-1418.
-
(2010)
JAMA.
, vol.303
, Issue.14
, pp. 1410-1418
-
-
Phung, O.J.1
Scholle, J.M.2
Talwar, M.3
-
7
-
-
77953181310
-
Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: Effects on glycaemic control and body weight
-
Zhang L, Feng Y, List J, Kasichayanula S, Pfister M. Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight. Diabetes Obes Metab. 2010; 12(6): 510-516.
-
(2010)
Diabetes Obes Metab.
, vol.12
, Issue.6
, pp. 510-516
-
-
Zhang, L.1
Feng, Y.2
List, J.3
Kasichayanula, S.4
Pfister, M.5
-
8
-
-
65349196064
-
Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
-
List JF, Woo V, Morales E, Tang W, Fiedorek FT. Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care. 2009; 32(4): 650-657.
-
(2009)
Diabetes Care.
, vol.32
, Issue.4
, pp. 650-657
-
-
List, J.F.1
Woo, V.2
Morales, E.3
Tang, W.4
Fiedorek, F.T.5
-
9
-
-
77957128949
-
SGLT2 inhibitors: Glucuretic treatment for type 2 diabetes
-
Bailey CJ. SGLT2 inhibitors: glucuretic treatment for type 2 diabetes. Br J Diabetes Vasc Dis. 2010; 10(4): 193-199.
-
(2010)
Br J Diabetes Vasc Dis.
, vol.10
, Issue.4
, pp. 193-199
-
-
Bailey, C.J.1
-
10
-
-
79651473537
-
Renal glucose reabsorption inhibitors to treat diabetes
-
Bailey CJ. Renal glucose reabsorption inhibitors to treat diabetes. Trends Pharmacol Sci. 2011; 32(2): 63-71.
-
(2011)
Trends Pharmacol Sci.
, vol.32
, Issue.2
, pp. 63-71
-
-
Bailey, C.J.1
-
11
-
-
83655184724
-
Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: Characterisation and comparison with other SGLT-2 inhibitors
-
Grempler R, Thomas L, Eckhardt M, etal. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab. 2012; 14(1): 83-90.
-
(2012)
Diabetes Obes Metab.
, vol.14
, Issue.1
, pp. 83-90
-
-
Grempler, R.1
Thomas, L.2
Eckhardt, M.3
-
12
-
-
83655167071
-
Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats
-
Thomas L, Grempler R, Eckhardt M, etal. Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats. Diabetes Obes Metab. 2012; 14(1): 94-96.
-
(2012)
Diabetes Obes Metab.
, vol.14
, Issue.1
, pp. 94-96
-
-
Thomas, L.1
Grempler, R.2
Eckhardt, M.3
-
13
-
-
33749643580
-
Evaluation of a simplified cafeteria model for the induction of insulin resistant obesity in rats
-
Dickinson K, North TJ, Anthony DM, Jones RB, Heal DJ. Evaluation of a simplified cafeteria model for the induction of insulin resistant obesity in rats. Int J Obes. 1998; 22 Suppl 3: S19.
-
(1998)
Int J Obes.
, vol.22
, Issue.SUPPL. 3
-
-
Dickinson, K.1
North, T.J.2
Anthony, D.M.3
Jones, R.B.4
Heal, D.J.5
-
14
-
-
33749364395
-
Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats
-
Fisas A, Codony X, Romero G, etal. Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats. Br J Pharmacol. 2006; 148(7): 973-983.
-
(2006)
Br J Pharmacol.
, vol.148
, Issue.7
, pp. 973-983
-
-
Fisas, A.1
Codony, X.2
Romero, G.3
-
15
-
-
80052943665
-
The utility of animal models to evaluate novel anti-obesity agents
-
Vickers SP, Jackson HC, Cheetham SC. The utility of animal models to evaluate novel anti-obesity agents. Br J Pharmacol. 2011; 164(4): 1248-1262.
-
(2011)
Br J Pharmacol.
, vol.164
, Issue.4
, pp. 1248-1262
-
-
Vickers, S.P.1
Jackson, H.C.2
Cheetham, S.C.3
-
16
-
-
84885952950
-
Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: A 24-week, randomized, double-blind, placebo-controlled trial
-
Häring HU, Merker L, Seewaldt-Becker E. Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial. Diabetes Care. 2013; 36(11): 3396-3404.
-
(2013)
Diabetes Care.
, vol.36
, Issue.11
, pp. 3396-3404
-
-
Häring, H.U.1
Merker, L.2
Seewaldt-Becker, E.3
-
17
-
-
84892488165
-
Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: A 24-week, randomized, placebo-controlled trial
-
Epub August 1
-
Kovacs CS, Seshiah V, Swallow R. Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial. Diabetes Obes Metab. Epub August 1, 2013.
-
(2013)
Diabetes Obes Metab.
-
-
Kovacs, C.S.1
Seshiah, V.2
Swallow, R.3
-
18
-
-
84903906839
-
-
Available from: Accessed March 15, 2014
-
Dickinson K, Mody N, Slater N, etal. The effect of chronic administration of sibutramine on body composition in dietary-induced, obese female Wistar rats-an evaluation of the Foss FoodScan™ analyser. 2008. Available from: http: //pa2online.org/abstract/abstract.jsp?abid=29118. Accessed March 15, 2014.
-
The effect of chronic administration of sibutramine on body composition in dietary-induced, obese female Wistar rats-an evaluation of the Foss FoodScan™ analyser. 2008
-
-
Dickinson, K.1
Mody, N.2
Slater, N.3
-
19
-
-
75749129885
-
Water consumption increases weight loss during a hypocaloric diet intervention in middle-aged and older adults
-
Dennis EA, Dengo AL, Comber DL, etal. Water consumption increases weight loss during a hypocaloric diet intervention in middle-aged and older adults. Obesity (Silver Spring). 2010; 18(2): 300-307.
-
(2010)
Obesity (Silver Spring).
, vol.18
, Issue.2
, pp. 300-307
-
-
Dennis, E.A.1
Dengo, A.L.2
Comber, D.L.3
-
20
-
-
77956284607
-
Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects
-
James WP, Caterson ID, Coutinho W. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med. 2010; 363(10): 905-917.
-
(2010)
N Engl J Med.
, vol.363
, Issue.10
, pp. 905-917
-
-
James, W.P.1
Caterson, I.D.2
Coutinho, W.3
-
21
-
-
77952672353
-
The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: Comparison to sibutramine and rimonabant
-
Hansen HH, Hansen G, Tang-Christensen M, etal. The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant. Eur J Pharmacol. 2010; 636(1-3): 88-95.
-
(2010)
Eur J Pharmacol.
, vol.636
, Issue.1-3
, pp. 88-95
-
-
Hansen, H.H.1
Hansen, G.2
Tang-Christensen, M.3
-
22
-
-
0030147221
-
A double-blind randomized placebo-controlled trial of sibutramine
-
Bray GA, Ryan DH, Gordon D, Heidingsfelder S, Cerise F, Wilson K. A double-blind randomized placebo-controlled trial of sibutramine. Obes Res. 1996; 4(3): 263-270.
-
(1996)
Obes Res.
, vol.4
, Issue.3
, pp. 263-270
-
-
Bray, G.A.1
Ryan, D.H.2
Gordon, D.3
Heidingsfelder, S.4
Cerise, F.5
Wilson, K.6
-
23
-
-
0036211099
-
Evaluation of the safety and efficacy of sibutramine, orlistat and metformin in the treatment of obesity
-
Gokcel A, Gumurdulu Y, Karakose H, etal. Evaluation of the safety and efficacy of sibutramine, orlistat and metformin in the treatment of obesity. Diabetes Obes Metab. 2002; 4(1): 49-55.
-
(2002)
Diabetes Obes Metab.
, vol.4
, Issue.1
, pp. 49-55
-
-
Gokcel, A.1
Gumurdulu, Y.2
Karakose, H.3
-
24
-
-
0032543870
-
Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients
-
Sjöström L, Rissanen A, Andersen T. Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. Lancet. 1998; 352(9123): 167-172.
-
(1998)
Lancet.
, vol.352
, Issue.9123
, pp. 167-172
-
-
Sjöström, L.1
Rissanen, A.2
Andersen, T.3
-
25
-
-
38549105092
-
Comparison of the effects of sibutramine and orlistat on body weight, food and water intake and body composition in dietary-induced obese rats
-
Poster presented at: October 23-27, San Diego, CA
-
Jackson HC, Dickinson K, Jones RB, Schumacher C, Jensen C. Comparison of the effects of sibutramine and orlistat on body weight, food and water intake and body composition in dietary-induced obese rats. Poster presented at: Society for Neuroscience Meeting; October 23-27, 2004; San Diego, CA.
-
(2004)
Society for Neuroscience Meeting
-
-
Jackson, H.C.1
Dickinson, K.2
Jones, R.B.3
Schumacher, C.4
Jensen, C.5
-
26
-
-
58549089324
-
The long-term influence of orlistat on dietary intake in obese subjects with components of metabolic syndrome
-
Svendsen M, Helgeland M, Tonstad S. The long-term influence of orlistat on dietary intake in obese subjects with components of metabolic syndrome. J Hum Nutr Diet. 2009; 22(1): 55-63.
-
(2009)
J Hum Nutr Diet.
, vol.22
, Issue.1
, pp. 55-63
-
-
Svendsen, M.1
Helgeland, M.2
Tonstad, S.3
-
27
-
-
0346219295
-
Effect of thiazolidinediones on body weight in patients with diabetes mellitus
-
Fonseca V. Effect of thiazolidinediones on body weight in patients with diabetes mellitus. Am J Med. 2003; 115 Suppl 8A: 42S-48S.
-
(2003)
Am J Med.
, vol.115
, Issue.SUPPL. 8
-
-
Fonseca, V.1
-
28
-
-
71749118034
-
Adiponectin and energy homeostasis: Consensus and controversy
-
Dridi S, Taouis M. Adiponectin and energy homeostasis: consensus and controversy. J Nutr Biochem. 2009; 20(11): 831-839.
-
(2009)
J Nutr Biochem.
, vol.20
, Issue.11
, pp. 831-839
-
-
Dridi, S.1
Taouis, M.2
-
29
-
-
52149122485
-
Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats
-
Rodríguez A, Catalán V, Becerril S, etal. Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats. Life Sci. 2008; 83(15-16): 540-549.
-
(2008)
Life Sci.
, vol.83
, Issue.15-16
, pp. 540-549
-
-
Rodríguez, A.1
Catalán, V.2
Becerril, S.3
-
30
-
-
52649083832
-
Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models
-
Fujimori Y, Katsuno K, Nakashima I, Ishikawa-Takemura Y, Fujikura H, Isaji M. Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther. 2008; 327(1): 268-276.
-
(2008)
J Pharmacol Exp Ther.
, vol.327
, Issue.1
, pp. 268-276
-
-
Fujimori, Y.1
Katsuno, K.2
Nakashima, I.3
Ishikawa-Takemura, Y.4
Fujikura, H.5
Isaji, M.6
-
31
-
-
53349152409
-
Effect of weight-reducing agents on glycaemic parameters and progression to type 2 diabetes: A review
-
Lloret-Linares C, Greenfield JR, Czernichow S. Effect of weight-reducing agents on glycaemic parameters and progression to type 2 diabetes: a review. Diabet Med. 2008; 25(10): 1142-1150.
-
(2008)
Diabet Med.
, vol.25
, Issue.10
, pp. 1142-1150
-
-
Lloret-Linares, C.1
Greenfield, J.R.2
Czernichow, S.3
-
32
-
-
0030759773
-
Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat
-
Jackson HC, Bearham MC, Hutchins LJ, Mazurkiewicz SE, Needham AM, Heal DJ. Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat. Br J Pharmacol. 1997; 121(8): 1613-1618.
-
(1997)
Br J Pharmacol.
, vol.121
, Issue.8
, pp. 1613-1618
-
-
Jackson, H.C.1
Bearham, M.C.2
Hutchins, L.J.3
Mazurkiewicz, S.E.4
Needham, A.M.5
Heal, D.J.6
-
33
-
-
84858020943
-
Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
-
Bolinder J, Ljunggren Ö, Kullberg J, etal. Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. Clin Endocrinol Metab. 2012; 97(3): 1020-1031.
-
(2012)
Clin Endocrinol Metab.
, vol.97
, Issue.3
, pp. 1020-1031
-
-
Bolinder, J.1
Ljunggren, Ö.2
Kullberg, J.3
-
34
-
-
84891851923
-
Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: An active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes
-
Ferrannini E, Berk A, Hantel S, etal. Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes. Diabetes Care. 2013; 36(12): 4015-4021.
-
(2013)
Diabetes Care.
, vol.36
, Issue.12
, pp. 4015-4021
-
-
Ferrannini, E.1
Berk, A.2
Hantel, S.3
-
35
-
-
84860183617
-
A novel approach to control hyperglycemia in type 2 diabetes: Sodium glucose co-transport (SGLT) inhibitors: Systematic review and meta-analysis of randomized trials
-
Musso G, Gambino R, Cassader M, Pagano G. A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials. Ann Med. 2012; 44(4): 375-393.
-
(2012)
Ann Med.
, vol.44
, Issue.4
, pp. 375-393
-
-
Musso, G.1
Gambino, R.2
Cassader, M.3
Pagano, G.4
|